2GMS
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![BU of 2gms by Molmil](/molmil-images/mine/2gms) | E coli GDP-4-keto-6-deoxy-D-mannose-3-dehydratase with bound hydrated PLP | Descriptor: | MAGNESIUM ION, Putative pyridoxamine 5-phosphate-dependent dehydrase, Wbdk, ... | Authors: | Cook, P.D, Thoden, J.B, Holden, H.M. | Deposit date: | 2006-04-07 | Release date: | 2006-09-05 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The structure of GDP-4-keto-6-deoxy-D-mannose-3-dehydratase: a unique coenzyme B6-dependent enzyme. Protein Sci., 15, 2006
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2GMU
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![BU of 2gmu by Molmil](/molmil-images/mine/2gmu) | Crystal structure of E coli GDP-4-keto-6-deoxy-D-mannose-3-dehydratase complexed with PLP-glutamate ketimine intermediate | Descriptor: | MAGNESIUM ION, N-({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)-D-GLUTAMIC ACID, Putative pyridoxamine 5-phosphate-dependent dehydrase, ... | Authors: | Cook, P.D, Thoden, J.B, Holden, H.M. | Deposit date: | 2006-04-07 | Release date: | 2006-09-05 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The structure of GDP-4-keto-6-deoxy-D-mannose-3-dehydratase: a unique coenzyme B6-dependent enzyme. Protein Sci., 15, 2006
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3B8X
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![BU of 3b8x by Molmil](/molmil-images/mine/3b8x) | Crystal structure of GDP-4-keto-6-deoxymannose-3-dehydratase (ColD) H188N mutant with bound GDP-perosamine | Descriptor: | 1,2-ETHANEDIOL, Pyridoxamine 5-phosphate-dependent dehydrase, SODIUM ION, ... | Authors: | Cook, P.D, Holden, H.M. | Deposit date: | 2007-11-02 | Release date: | 2007-11-27 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | GDP-4-Keto-6-deoxy-D-mannose 3-Dehydratase, Accommodating a Sugar Substrate in the Active Site. J.Biol.Chem., 283, 2008
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3BN1
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![BU of 3bn1 by Molmil](/molmil-images/mine/3bn1) | Crystal structure of GDP-perosamine synthase | Descriptor: | 2-OXOGLUTARIC ACID, ACETATE ION, Perosamine synthetase, ... | Authors: | Cook, P.D, Holden, H.M. | Deposit date: | 2007-12-13 | Release date: | 2008-03-18 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | GDP-Perosamine Synthase: Structural Analysis and Production of a Novel Trideoxysugar Biochemistry, 47, 2008
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2R0T
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![BU of 2r0t by Molmil](/molmil-images/mine/2r0t) | |
6X3B
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![BU of 6x3b by Molmil](/molmil-images/mine/6x3b) | |
5WK0
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![BU of 5wk0 by Molmil](/molmil-images/mine/5wk0) | |
4WBD
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![BU of 4wbd by Molmil](/molmil-images/mine/4wbd) | The crystal structure of BshC from Bacillus subtilis complexed with citrate and ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BSHC, CITRIC ACID, ... | Authors: | Cook, P.D, VanDuinen, A.J, Winchell, K.R. | Deposit date: | 2014-09-03 | Release date: | 2014-12-31 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.77 Å) | Cite: | X-ray Crystallographic Structure of BshC, a Unique Enzyme Involved in Bacillithiol Biosynthesis. Biochemistry, 54, 2015
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6P2T
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![BU of 6p2t by Molmil](/molmil-images/mine/6p2t) | BshB from Bacillus subtilis complexed with citrate | Descriptor: | CITRIC ACID, N-acetyl-alpha-D-glucosaminyl L-malate deacetylase 1, SODIUM ION, ... | Authors: | Cook, P.D, Meloche, C.E. | Deposit date: | 2019-05-22 | Release date: | 2020-01-08 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.853 Å) | Cite: | X-ray crystallographic structure of BshB, the zinc-dependent deacetylase involved in bacillithiol biosynthesis. Protein Sci., 29, 2020
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5D01
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![BU of 5d01 by Molmil](/molmil-images/mine/5d01) | |
5D00
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![BU of 5d00 by Molmil](/molmil-images/mine/5d00) | Crystal structure of BshA from B. subtilis complexed with N-acetylglucosaminyl-malate and UMP | Descriptor: | (2S)-2-{[2-acetamido-2-deoxy-alpha-D-glucopyranosyl]oxy}butanedioic acid, N-acetyl-alpha-D-glucosaminyl L-malate synthase, PHOSPHATE ION, ... | Authors: | Cook, P.D, Winchell, K.R. | Deposit date: | 2015-08-01 | Release date: | 2016-09-07 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | A Structural, Functional, and Computational Analysis of BshA, the First Enzyme in the Bacillithiol Biosynthesis Pathway. Biochemistry, 55, 2016
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7RZB
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![BU of 7rzb by Molmil](/molmil-images/mine/7rzb) | BrxA from Staphylococcus aureus with bacillithiol mixed disulfide | Descriptor: | (2S)-2-{[2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranosyl]oxy}butanedioic acid, Bacillithiol system oxidoreductase, YphP/YqiW family, ... | Authors: | Cook, P.D, McHugh, C.S. | Deposit date: | 2021-08-27 | Release date: | 2022-04-13 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structure of BrxA from Staphylococcus aureus, a bacilliredoxin involved in redox homeostasis in Firmicutes. Acta Crystallogr.,Sect.F, 78, 2022
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4NB2
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![BU of 4nb2 by Molmil](/molmil-images/mine/4nb2) | Crystal Structure of FosB from Staphylococcus aureus at 1.89 Angstrom Resolution - Apo structure | Descriptor: | Metallothiol transferase FosB, SULFATE ION | Authors: | Cook, P.D, Thompson, M.K, Goodman, M.C, Jagessar, K, Harp, J, Keithly, M.E, Armstrong, R.N. | Deposit date: | 2013-10-22 | Release date: | 2014-02-26 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Structure and Function of the Genomically Encoded Fosfomycin Resistance Enzyme, FosB, from Staphylococcus aureus. Biochemistry, 53, 2014
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4NB1
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![BU of 4nb1 by Molmil](/molmil-images/mine/4nb1) | Crystal Structure of FosB from Staphylococcus aureus at 1.80 Angstrom Resolution with L-Cysteine-Cys9 Disulfide | Descriptor: | CYSTEINE, Metallothiol transferase FosB, SULFATE ION | Authors: | Cook, P.D, Thompson, M.K, Goodman, M.C, Jagessar, K, Harp, J, Keithly, M.E, Armstrong, R.N. | Deposit date: | 2013-10-22 | Release date: | 2014-02-26 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure and Function of the Genomically Encoded Fosfomycin Resistance Enzyme, FosB, from Staphylococcus aureus. Biochemistry, 53, 2014
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3DR7
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![BU of 3dr7 by Molmil](/molmil-images/mine/3dr7) | GDP-perosamine synthase from Caulobacter crescentus with bound GDP-3-deoxyperosamine | Descriptor: | (2R,3S,5S,6R)-5-amino-3-hydroxy-6-methyl-oxan-2-yl, 1,2-ETHANEDIOL, Putative perosamine synthetase | Authors: | Holden, H.M, Cook, P.D, Carney, A.E. | Deposit date: | 2008-07-10 | Release date: | 2008-10-14 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Accommodation of GDP-linked sugars in the active site of GDP-perosamine synthase Biochemistry, 47, 2008
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3DR4
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![BU of 3dr4 by Molmil](/molmil-images/mine/3dr4) | GDP-perosamine synthase K186A mutant from Caulobacter crescentus with bound sugar ligand | Descriptor: | 1,2-ETHANEDIOL, Putative perosamine synthetase, [(2R,3S,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S,4S,5S,6R)-3,4-dihydroxy-5-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]-6-methyltetrahydro-2H-pyran-2-yl dihydrogen diphosphate | Authors: | Holden, H.M, Cook, P.D, Carney, A.E. | Deposit date: | 2008-07-10 | Release date: | 2008-10-14 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Accommodation of GDP-linked sugars in the active site of GDP-perosamine synthase Biochemistry, 47, 2008
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3GR9
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![BU of 3gr9 by Molmil](/molmil-images/mine/3gr9) | Crystal structure of ColD H188K S187N | Descriptor: | 2-OXOGLUTARIC ACID, ColD | Authors: | Holden, H.M, Cook, P.D, Kubiak, R.L, Toomey, D.P. | Deposit date: | 2009-03-25 | Release date: | 2009-06-16 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Two Site-Directed Mutations Are Required for the Conversion of a Sugar Dehydratase into an Aminotransferase. Biochemistry, 48, 2009
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6ULL
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![BU of 6ull by Molmil](/molmil-images/mine/6ull) | BshB from Bacillus subtilis complexed with a substrate analogue | Descriptor: | (2S)-2-({2-deoxy-2-[(hydroxycarbamoyl)amino]-alpha-D-glucopyranosyl}oxy)butanedioic acid, N-acetyl-alpha-D-glucosaminyl L-malate deacetylase 1, SULFATE ION, ... | Authors: | Cook, P.D, Castleman, M.M, Woodward, R.L. | Deposit date: | 2019-10-08 | Release date: | 2020-01-08 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | X-ray crystallographic structure of BshB, the zinc-dependent deacetylase involved in bacillithiol biosynthesis. Protein Sci., 29, 2020
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6D9T
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![BU of 6d9t by Molmil](/molmil-images/mine/6d9t) | BshA from Staphylococcus aureus complexed with UDP | Descriptor: | Glycosyl transferase, URIDINE-5'-DIPHOSPHATE | Authors: | Royer, C.R, Cook, P.D. | Deposit date: | 2018-04-30 | Release date: | 2019-05-08 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A structural and functional analysis of the glycosyltransferase BshA from Staphylococcus aureus: Insights into the reaction mechanism and regulation of bacillithiol production. Protein Sci., 28, 2019
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471D
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![BU of 471d by Molmil](/molmil-images/mine/471d) | CRYSTAL STRUCTURE AND IMPROVED ANTISENSE PROPERTIES OF 2'-O-(2-METHOXYETHYL)-RNA | Descriptor: | MAGNESIUM ION, RNA (5'-R(*(C43)P*(G48)P*(C43)P*(G48)P*(A44)P*(A44)P*(U36)P*(U36)P*(C43)P*(G48)P*(C43)P*(G48))-3') | Authors: | Teplova, M, Minasov, G, Tereshko, V, Inamati, G, Cook, P.D, Egli, M. | Deposit date: | 1999-04-29 | Release date: | 1999-05-12 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structure and improved antisense properties of 2'-O-(2-methoxyethyl)-RNA. Nat.Struct.Biol., 6, 1999
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469D
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![BU of 469d by Molmil](/molmil-images/mine/469d) | CRYSTAL STRUCTURE AND IMPROVED ANTISENSE PROPERTIES OF 2'-O-(2-METHOXYETHYL)-RNA | Descriptor: | MAGNESIUM ION, RNA (5'-R(*(C43)P*(G48)P*(C43)P*(G48)P*(A44)P*(A44)P*(U36)P*(U36)P*(C43)P*(G48)P*(C43)P*(G48))-3') | Authors: | Teplova, M, Minasov, G, Tereshko, V, Inamati, G, Cook, P.D, Egli, M. | Deposit date: | 1999-04-29 | Release date: | 1999-05-12 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal structure and improved antisense properties of 2'-O-(2-methoxyethyl)-RNA. Nat.Struct.Biol., 6, 1999
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468D
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![BU of 468d by Molmil](/molmil-images/mine/468d) | CRYSTAL STRUCTURE AND IMPROVED ANTISENSE PROPERTIES OF 2'-O-(2-METHOXYETHYL)-RNA | Descriptor: | MAGNESIUM ION, RNA (5'-R(*(C43)P*(G48)P*(C43)P*(G48)P*(A44)P*(A44)P*(U36)P*(U36)P*(C43)P*(G48)P*(C43)P*(G48))-3') | Authors: | Teplova, M, Minasov, G, Tereshko, V, Inamati, G, Cook, P.D, Egli, M. | Deposit date: | 1999-04-29 | Release date: | 1999-05-12 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure and improved antisense properties of 2'-O-(2-methoxyethyl)-RNA. Nat.Struct.Biol., 6, 1999
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470D
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![BU of 470d by Molmil](/molmil-images/mine/470d) | CRYSTAL STRUCTURE AND IMPROVED ANTISENSE PROPERTIES OF 2'-O-(2-METHOXYETHYL)-RNA | Descriptor: | MAGNESIUM ION, RNA (5'-R(*(C43)P*(G48)P*(C43)P*(G48)P*(A44)P*(A44)P*(U36)P*(U36)P*(C43)P*(G48)P*(C43)P*(G48))-3') | Authors: | Teplova, M, Minasov, G, Tereshko, V, Inamati, G, Cook, P.D, Egli, M. | Deposit date: | 1999-04-29 | Release date: | 1999-05-12 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Crystal structure and improved antisense properties of 2'-O-(2-methoxyethyl)-RNA. Nat.Struct.Biol., 6, 1999
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3R3E
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![BU of 3r3e by Molmil](/molmil-images/mine/3r3e) | The glutathione bound structure of YqjG, a glutathione transferase homolog from Escherichia coli K-12 | Descriptor: | GLUTATHIONE, SULFATE ION, Uncharacterized protein yqjG | Authors: | Branch, M.C, Cook, P.D, Harp, J.M, Armstrong, R.N. | Deposit date: | 2011-03-15 | Release date: | 2012-03-14 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.205 Å) | Cite: | Crystal Structure Analysis of yqjG from Escherichia Coli K-12 To be Published
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1D9F
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![BU of 1d9f by Molmil](/molmil-images/mine/1d9f) | CRYSTAL STRUCTURE OF THE COMPLEX OF DNA POLYMERASE I KLENOW FRAGMENT WITH DNA TETRAMER CARRYING 2'-O-(3-AMINOPROPYL)-RNA MODIFICATION 5'-D(TT)-AP(U)-D(T)-3' | Descriptor: | DNA POLYMERASE I, DNA/RNA (5'-D(*TP*TP)-R(*(U31)P)-D(*T)-3'), SULFATE ION, ... | Authors: | Teplova, M, Wallace, S.T, Tereshko, V, Minasov, G, Simons, A.M, Cook, P.D, Manoharan, M, Egli, M. | Deposit date: | 1999-10-27 | Release date: | 1999-12-02 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural origins of the exonuclease resistance of a zwitterionic RNA. Proc.Natl.Acad.Sci.USA, 96, 1999
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