1AL5
 
 | | A-TRACT RNA DODECAMER, NMR, 12 STRUCTURES | | 分子名称: | RNA (5'-R(*CP*GP*CP*AP*AP*AP*UP*UP*UP*GP*CP*G)-3') | | 著者 | Conte, M.R, Conn, G.L, Brown, T, Lane, A.N. | | 登録日 | 1997-06-11 | | 公開日 | 1997-12-17 | | 最終更新日 | 2021-11-03 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Conformational properties and thermodynamics of the RNA duplex r(CGCAAAUUUGCG)2: comparison with the DNA analogue d(CGCAAATTTGCG)2.
Nucleic Acids Res., 25, 1997
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1BAX
 | | MASON-PFIZER MONKEY VIRUS MATRIX PROTEIN, NMR, AVERAGE STRUCTURE | | 分子名称: | M-PMV MATRIX PROTEIN | | 著者 | Conte, M.R, Klikova, M, Hunter, E, Ruml, T, Matthews, S. | | 登録日 | 1998-04-20 | | 公開日 | 1998-06-17 | | 最終更新日 | 2024-04-10 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The three-dimensional solution structure of the matrix protein from the type D retrovirus, the Mason-Pfizer monkey virus, and implications for the morphology of retroviral assembly.
EMBO J., 16, 1997
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2G2K
 | | NMR structure of an N-terminal fragment of the eukaryotic initiation factor 5 (eIF5) | | 分子名称: | Eukaryotic translation initiation factor 5 | | 著者 | Conte, M.R, Kelly, G, Babon, J, Sanfelice, D, Smerdon, S.J, Proud, C.G. | | 登録日 | 2006-02-16 | | 公開日 | 2006-06-13 | | 最終更新日 | 2021-11-10 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure of the eukaryotic initiation factor (eIF) 5 reveals a fold common to several translation factors
Biochemistry, 45, 2006
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1SAA
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1QM9
 | | NMR, REPRESENTATIVE STRUCTURE | | 分子名称: | POLYPYRIMIDINE TRACT-BINDING PROTEIN | | 著者 | Conte, M.R, Grune, T, Curry, S, Matthews, S. | | 登録日 | 1999-09-22 | | 公開日 | 2000-07-03 | | 最終更新日 | 2011-07-13 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure of Tandem RNA Recognition Motifs from Polypyrimidine Tract Binding Protein Reveals Novel Features of the Rrm Fold
Embo J., 19, 2000
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6I9B
 | | NMR structure of the La module from human LARP4A | | 分子名称: | La-related protein 4 | | 著者 | Conte, M.R, Martino, L, Atkinson, R.A, Kelly, G, Cruz-Gallardo, I, De Tito, S, Trotta, R. | | 登録日 | 2018-11-22 | | 公開日 | 2019-03-13 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | LARP4A recognizes polyA RNA via a novel binding mechanism mediated by disordered regions and involving the PAM2w motif, revealing interplay between PABP, LARP4A and mRNA.
Nucleic Acids Res., 47, 2019
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2L8K
 | | NMR Structure of the Arterivirus nonstructural protein 7 alpha (nsp7 alpha) | | 分子名称: | Non-structural protein 7 | | 著者 | Conte, M.R, Gaudin, C, Manolaridis, I, Tucker, P.W, Kelly, G. | | 登録日 | 2011-01-19 | | 公開日 | 2011-07-06 | | 最終更新日 | 2023-02-08 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure and Genetic Analysis of the Arterivirus Nonstructural Protein 7{alpha}.
J.Virol., 85, 2011
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6I5G
 | | X-ray structure of human soluble Epoxide Hydrolase C-terminal Domain (hsEH CTD)in complex with 15d-PGJ2 | | 分子名称: | (5E,14E)-11-oxoprosta-5,9,12,14-tetraen-1-oic acid, 1,2-ETHANEDIOL, Bifunctional epoxide hydrolase 2 | | 著者 | Abis, G, Kopec, J, Yue, W.W, Conte, M.R. | | 登録日 | 2018-11-13 | | 公開日 | 2019-05-29 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | 15-deoxy-Delta12,14-Prostaglandin J2inhibits human soluble epoxide hydrolase by a dual orthosteric and allosteric mechanism.
Commun Biol, 2, 2019
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6I5E
 | | X-ray structure of apo human soluble Epoxide Hydrolase C-terminal Domain (hsEH CTD) | | 分子名称: | Bifunctional epoxide hydrolase 2 | | 著者 | Abis, G, Kopec, J, Yue, W.W, Conte, M.R. | | 登録日 | 2018-11-13 | | 公開日 | 2019-05-29 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | 15-deoxy-Delta12,14-Prostaglandin J2inhibits human soluble epoxide hydrolase by a dual orthosteric and allosteric mechanism.
Commun Biol, 2, 2019
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2MTG
 | | Solution structure of the RRM1 of human LARP6 | | 分子名称: | La-related protein 6 | | 著者 | Martino, L, Atkinson, A.R, Kelly, G, Conte, M.R. | | 登録日 | 2014-08-18 | | 公開日 | 2014-12-24 | | 最終更新日 | 2015-01-28 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Synergic interplay of the La motif, RRM1 and the interdomain linker of LARP6 in the recognition of collagen mRNA expands the RNA binding repertoire of the La module.
Nucleic Acids Res., 43, 2015
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2MTF
 | | Solution structure of the La motif of human LARP6 | | 分子名称: | La-related protein 6 | | 著者 | Martino, L, Salisbury, N.JH, Atkinson, A.R, Kelly, G, Conte, M.R. | | 登録日 | 2014-08-18 | | 公開日 | 2014-12-24 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Synergic interplay of the La motif, RRM1 and the interdomain linker of LARP6 in the recognition of collagen mRNA expands the RNA binding repertoire of the La module.
Nucleic Acids Res., 43, 2015
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2VON
 | | Crystal structure of N-terminal domains of Human La protein complexed with RNA oligomer AUAAUUU | | 分子名称: | 5'-R(*AP*UP*AP*AP*UP*UP*UP)-3', LUPUS LA PROTEIN | | 著者 | Kotik-Kogan, O, Valentine, E.R, Sanfelice, D, Conte, M.R, Curry, S. | | 登録日 | 2008-02-19 | | 公開日 | 2008-05-06 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural Analysis Reveals Conformational Plasticity in the Recognition of RNA 3' Ends by the Human La Protein.
Structure, 16, 2008
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2VOD
 | | Crystal structure of N-terminal domains of Human La protein complexed with RNA oligomer AUAUUUU | | 分子名称: | 5'-R(*AP*UP*AP*UP*UP*UP*UP)-3', LUPUS LA PROTEIN | | 著者 | Kotik-Kogan, O, Valentine, E.R, Sanfelice, D, Conte, M.R, Curry, S. | | 登録日 | 2008-02-15 | | 公開日 | 2008-05-06 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural Analysis Reveals Conformational Plasticity in the Recognition of RNA 3' Ends by the Human La Protein.
Structure, 16, 2008
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2VOP
 | | Crystal structure of N-terminal domains of Human La protein complexed with RNA oligomer AUUUU | | 分子名称: | 5'-R(*AP*UP*UP*UP*UP)-3', LUPUS LA PROTEIN, SULFATE ION | | 著者 | Kotik-Kogan, O, Valentine, E.R, Sanfelice, D, Conte, M.R, Curry, S. | | 登録日 | 2008-02-19 | | 公開日 | 2008-05-06 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structural Analysis Reveals Conformational Plasticity in the Recognition of RNA 3' Ends by the Human La Protein.
Structure, 16, 2008
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2VOO
 | | Crystal structure of N-terminal domains of Human La protein complexed with RNA oligomer UUUUUUUU | | 分子名称: | 5'-R(*UP*UP*UP*UP*UP*UP*UP)-3', LUPUS LA PROTEIN | | 著者 | Kotik-Kogan, O, Valentine, E.R, Sanfelice, D, Conte, M.R, Curry, S. | | 登録日 | 2008-02-19 | | 公開日 | 2008-05-06 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural Analysis Reveals Conformational Plasticity in the Recognition of RNA 3' Ends by the Human La Protein.
Structure, 16, 2008
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2KFW
 | | Solution structure of full-length SlyD from E.coli | | 分子名称: | FKBP-type peptidyl-prolyl cis-trans isomerase slyD | | 著者 | Martino, L, He, Y, Hands-Taylor, K.L, Valentine, E.R, Kelly, G, Giancola, C, Conte, M.R. | | 登録日 | 2009-02-28 | | 公開日 | 2009-09-15 | | 最終更新日 | 2020-02-26 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The interaction of the Escherichia coli protein SlyD with nickel ions illuminates the mechanism of regulation of its peptidyl-prolyl isomerase activity.
Febs J., 276, 2009
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1SJQ
 | | NMR Structure of RRM1 from Human Polypyrimidine Tract Binding Protein Isoform 1 (PTB1) | | 分子名称: | Polypyrimidine tract-binding protein 1 | | 著者 | Simpson, P.J, Monie, T.P, Szendroi, A, Davydova, N, Tyzack, J.K, Conte, M.R, Read, C.M, Cary, P.D, Svergun, D.I, Konarev, P.V, Petoukhov, M.V, Curry, S, Matthews, S.J. | | 登録日 | 2004-03-04 | | 公開日 | 2004-09-14 | | 最終更新日 | 2022-03-02 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure and RNA Interactions of the N-Terminal RRM Domains of PTB
Structure, 12, 2004
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1S7A
 | | NMR structure of the La motif of human La protein | | 分子名称: | Lupus La protein | | 著者 | Alfano, C, Sanfelice, D, Babon, J, Kelly, G, Jacks, A, Curry, S, Conte, M.R. | | 登録日 | 2004-01-29 | | 公開日 | 2004-04-06 | | 最終更新日 | 2022-03-02 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural analysis of cooperative RNA binding by the La motif and central RRM domain of human La protein.
Nat.Struct.Mol.Biol., 11, 2004
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1S79
 | | Solution structure of the central RRM of human La protein | | 分子名称: | Lupus La protein | | 著者 | Alfano, C, Sanfelice, D, Babon, J, Kelly, G, Jacks, A, Curry, S, Conte, M.R. | | 登録日 | 2004-01-29 | | 公開日 | 2004-04-06 | | 最終更新日 | 2022-03-02 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural analysis of cooperative RNA binding by the La motif and central RRM domain of human La protein.
Nat.Struct.Mol.Biol., 11, 2004
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1OWX
 | | Solution structure of the C-terminal RRM of human La (La225-334) | | 分子名称: | Lupus La protein | | 著者 | Jacks, A, Babon, J, Kelly, G, Manolaridis, I, Cary, P.D, Curry, S, Conte, M.R. | | 登録日 | 2003-03-31 | | 公開日 | 2003-07-29 | | 最終更新日 | 2022-02-23 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure of the C-terminal domain of human La protein reveals a novel RNA recognition motif coupled to a helical nuclear retention element
Structure, 11, 2003
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1SJR
 | | NMR Structure of RRM2 from Human Polypyrimidine Tract Binding Protein Isoform 1 (PTB1) | | 分子名称: | Polypyrimidine tract-binding protein 1 | | 著者 | Simpson, P.J, Monie, T.P, Szendroi, A, Davydova, N, Tyzack, J.K, Conte, M.R, Read, C.M, Cary, P.D, Svergun, D.I, Konarev, P.V, Petoukhov, M.V, Curry, S, Matthews, S.J. | | 登録日 | 2004-03-04 | | 公開日 | 2004-09-14 | | 最終更新日 | 2022-03-02 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure and RNA Interactions of the N-Terminal RRM Domains of PTB
Structure, 12, 2004
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6GJ4
 | | Tubulin-6j complex | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5-(quinolin-5-yl)naphtho[2,3-b]pyrrolo[1,2-d][1,4]oxazepin-4-yl acetate, CALCIUM ION, ... | | 著者 | Brindisi, M, Ulivieri, C, Alfano, G, Gemma, S, Balaguer, F.d.A, Khan, T, Grillo, A, Chemi, G, Menchon, G, Prota, A.E, Olieric, N, Agell, D.L, Barasoain, I, Diaz, J.F, Nebbioso, A, Conte, M.R, Lopresti, L, Magnano, S, Amet, R, Kinsella, P, Zisterer, D.M, Ibrahim, O, O'Sullivan, J, Morbidelli, L, Spaccapelo, R, Baldari, C, Butini, S, Novellino, E, Campiani, G, Altucci, L, Steinmetz, M.O, Brogi, S. | | 登録日 | 2018-05-16 | | 公開日 | 2018-12-05 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents.
Eur J Med Chem, 162, 2018
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5IFM
 | | Human NONO (p54nrb) Homodimer | | 分子名称: | CHLORIDE ION, GLYCEROL, Non-POU domain-containing octamer-binding protein, ... | | 著者 | Knott, G.J, Bond, C.S. | | 登録日 | 2016-02-26 | | 公開日 | 2016-11-09 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | A crystallographic study of human NONO (p54(nrb)): overcoming pathological problems with purification, data collection and noncrystallographic symmetry.
Acta Crystallogr D Struct Biol, 72, 2016
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6Y7Y
 | | Fragments KCL_771 and KCL_802 in complex with MAP kinase p38-alpha | | 分子名称: | (2-azanyl-2-adamantyl)methanol, 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE, 6-[2,5-bis(oxidanylidene)pyrrolidin-1-yl]pyridine-3-sulfonamide, ... | | 著者 | De Nicola, G.F, Nichols, C.E. | | 登録日 | 2020-03-02 | | 公開日 | 2020-03-11 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | | 主引用文献 | Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes.
J.Med.Chem., 63, 2020
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6Y80
 | | Fragment KCL_916 in complex with MAP kinase p38-alpha | | 分子名称: | 1-(2-adamantylmethyl)-3-ethyl-guanidine, 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE, CALCIUM ION, ... | | 著者 | De Nicola, G.F, Nichols, C.E. | | 登録日 | 2020-03-02 | | 公開日 | 2020-03-11 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.24 Å) | | 主引用文献 | Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes.
J.Med.Chem., 63, 2020
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