3EY4
| Further studies with the 2-amino-1,3-thiazol-4(5H)-one class of 11-hydroxysteroid dehydrogenase type 1 (11-HSD1) inhibitors: Reducing pregnane X receptor (PXR) activity and exploring activity in a monkey pharmacodynamic model | 分子名称: | (5S)-2-{[(1S)-1-(4-fluorophenyl)ethyl]amino}-5-(1-hydroxy-1-methylethyl)-5-methyl-1,3-thiazol-4(5H)-one, 11-beta-Hydroxysteroid Dehydrogenase 1, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Zhang, J.D, Jordan, S.R, Li, V. | 登録日 | 2008-10-17 | 公開日 | 2008-11-11 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Further studies with the 2-amino-1,3-thiazol-4(5H)-one class of 11-hydroxysteroid dehydrogenase type 1 (11-HSD1) inhibitors: Reducing pregnane X receptor (PXR) activity and exploring activity in a monkey pharmacodynamic model To be Published, 2008
|
|
5TOJ
| Crystal structure of the RSV F glycoprotein in complex with the neutralizing single-domain antibody F-VHH-4 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion glycoprotein F0, Fibritin chimera, ... | 著者 | Gilman, M.S.A, Kabeche, S.C, McLellan, J.S. | 登録日 | 2016-10-17 | 公開日 | 2017-02-22 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state. Nat Commun, 8, 2017
|
|
5TP3
| |
5TOK
| Crystal structure of the RSV F glycoprotein in complex with the neutralizing single-domain antibody F-VHH-L66 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion glycoprotein F0, Fibritin chimera, ... | 著者 | Gilman, M.S.A, Kabeche, S.C, McLellan, J.S. | 登録日 | 2016-10-17 | 公開日 | 2017-02-22 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | 主引用文献 | Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state. Nat Commun, 8, 2017
|
|
5V8O
| Discovery of a high affinity inhibitor of cGAS | 分子名称: | 5-phenyltetrazolo[1,5-a]pyrimidin-7-ol, Cyclic GMP-AMP synthase, ZINC ION | 著者 | Hall, J. | 登録日 | 2017-03-22 | 公開日 | 2017-09-27 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay. PLoS ONE, 12, 2017
|
|
2XE3
| OmpC28 | 分子名称: | OUTER MEMBRANE PORIN C, octyl beta-D-glucopyranoside | 著者 | Lou, H, Naismith, J.H. | 登録日 | 2010-05-10 | 公開日 | 2010-05-19 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Altered Antibiotic Transport in Ompc Mutants Isolated from a Series of Clinical Strains of Multi-Drug Resistant E. Coli. Plos One, 6, 2011
|
|
2XE5
| |
2XG6
| |
2XE2
| |
2XE1
| |
3BZU
| Crystal structure of human 11-beta-hydroxysteroid dehydrogenase(HSD1) in complex with NADP and thiazolone inhibitor | 分子名称: | (5S)-2-{[(1S)-1-(2-fluorophenyl)ethyl]amino}-5-methyl-5-(trifluoromethyl)-1,3-thiazol-4(5H)-one, Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Min, X, Sudom, A, Xu, H, Wang, Z, Walker, N.P. | 登録日 | 2008-01-18 | 公開日 | 2008-06-10 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Structural characterization and pharmacodynamic effects of an orally active 11beta-hydroxysteroid dehydrogenase type 1 inhibitor. Chem.Biol.Drug Des., 71, 2008
|
|
7AMN
| Structure of LuxR with DNA (repression) | 分子名称: | DNA (5'-D(P*TP*AP*TP*TP*GP*AP*TP*AP*AP*AP*AP*TP*TP*AP*TP*CP*AP*AP*TP*AP*A)-3'), DNA (5'-D(P*TP*TP*AP*TP*TP*GP*AP*TP*AP*AP*TP*TP*TP*TP*AP*TP*CP*AP*AP*TP*A)-3'), HTH-type transcriptional regulator LuxR | 著者 | Liu, B, Reverter, D. | 登録日 | 2020-10-09 | 公開日 | 2021-03-31 | 最終更新日 | 2021-04-14 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Binding site profiles and N-terminal minor groove interactions of the master quorum-sensing regulator LuxR enable flexible control of gene activation and repression. Nucleic Acids Res., 49, 2021
|
|
7AMT
| Structure of LuxR with DNA (activation) | 分子名称: | DNA (5'-D(P*AP*TP*AP*AP*TP*GP*AP*CP*AP*TP*TP*AP*CP*TP*GP*TP*AP*TP*AP*TP*A)-3'), DNA (5'-D(P*TP*AP*TP*AP*TP*AP*CP*AP*GP*TP*AP*AP*TP*GP*TP*CP*AP*TP*TP*AP*T)-3'), HTH-type transcriptional regulator LuxR | 著者 | Liu, B, Reverter, D. | 登録日 | 2020-10-09 | 公開日 | 2021-03-31 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Binding site profiles and N-terminal minor groove interactions of the master quorum-sensing regulator LuxR enable flexible control of gene activation and repression. Nucleic Acids Res., 49, 2021
|
|
7XX4
| designed glycosyltransferase | 分子名称: | Oleandomycin glycosyltransferase, URIDINE-5'-DIPHOSPHATE-GLUCOSE | 著者 | Lu, M, Wu, X. | 登録日 | 2022-05-28 | 公開日 | 2023-06-14 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | 主引用文献 | Design of a chimeric glycosyltransferase OleD for the site-specific O-monoglycosylation of 3-hydroxypyridine in nosiheptide. Microb Biotechnol, 16, 2023
|
|
8JPX
| |
4C8T
| Xenopus ZNRF3 ectodomain crystal form I | 分子名称: | E3 UBIQUITIN-PROTEIN LIGASE ZNRF3 | 著者 | Zebisch, M, Jones, E.Y. | 登録日 | 2013-10-01 | 公開日 | 2013-11-20 | 最終更新日 | 2013-11-27 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural and Molecular Basis of Znrf3/Rnf43 Transmembrane Ubiquitin Ligase Inhibition by the Wnt Agonist R-Spondin. Nat.Commun., 4, 2013
|
|
4C85
| zebrafish ZNRF3 ectodomain crystal form II | 分子名称: | E3 UBIQUITIN-PROTEIN LIGASE ZNRF3 | 著者 | Zebisch, M, Jones, E.Y. | 登録日 | 2013-09-30 | 公開日 | 2013-11-20 | 最終更新日 | 2013-11-27 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural and Molecular Basis of Znrf3/Rnf43 Transmembrane Ubiquitin Ligase Inhibition by the Wnt Agonist R-Spondin. Nat.Commun., 4, 2013
|
|
4C8C
| mouse ZNRF3 ectodomain crystal form III | 分子名称: | E3 UBIQUITIN-PROTEIN LIGASE ZNRF3 | 著者 | Zebisch, M, Jones, E.Y. | 登録日 | 2013-09-30 | 公開日 | 2013-11-20 | 最終更新日 | 2013-11-27 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural and Molecular Basis of Znrf3/Rnf43 Transmembrane Ubiquitin Ligase Inhibition by the Wnt Agonist R-Spondin. Nat.Commun., 4, 2013
|
|
4C8A
| mouse ZNRF3 ectodomain crystal form II | 分子名称: | E3 UBIQUITIN-PROTEIN LIGASE ZNRF3 | 著者 | Zebisch, M, Jones, E.Y. | 登録日 | 2013-09-30 | 公開日 | 2013-11-20 | 最終更新日 | 2013-11-27 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural and Molecular Basis of Znrf3/Rnf43 Transmembrane Ubiquitin Ligase Inhibition by the Wnt Agonist R-Spondin. Nat.Commun., 4, 2013
|
|
4C8V
| Xenopus RSPO2 Fu1-Fu2 crystal form I | 分子名称: | R-SPONDIN-2 | 著者 | Zebisch, M, Jones, E.Y. | 登録日 | 2013-10-01 | 公開日 | 2013-11-20 | 最終更新日 | 2019-10-16 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural and Molecular Basis of Znrf3/Rnf43 Transmembrane Ubiquitin Ligase Inhibition by the Wnt Agonist R-Spondin. Nat.Commun., 4, 2013
|
|
4C9U
| |
4C9E
| |
4C8U
| Xenopus ZNRF3 ectodomain crystal form II | 分子名称: | BROMIDE ION, E3 UBIQUITIN-PROTEIN LIGASE ZNRF3 | 著者 | Zebisch, M, Jones, E.Y. | 登録日 | 2013-10-01 | 公開日 | 2013-11-20 | 最終更新日 | 2019-10-16 | 実験手法 | X-RAY DIFFRACTION (3.01 Å) | 主引用文献 | Structural and Molecular Basis of Znrf3/Rnf43 Transmembrane Ubiquitin Ligase Inhibition by the Wnt Agonist R-Spondin. Nat.Commun., 4, 2013
|
|
4C8W
| Xenopus RSPO2 Fu1-Fu2 crystal form II | 分子名称: | R-SPONDIN-2 | 著者 | Zebisch, M, Jones, E.Y. | 登録日 | 2013-10-01 | 公開日 | 2013-11-20 | 最終更新日 | 2013-11-27 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structural and Molecular Basis of Znrf3/Rnf43 Transmembrane Ubiquitin Ligase Inhibition by the Wnt Agonist R-Spondin. Nat.Commun., 4, 2013
|
|
4C8P
| |