3DTG
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3DTF
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2BI0
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![BU of 2bi0 by Molmil](/molmil-images/mine/2bi0) | RV0216, A conserved hypothetical protein from Mycobacterium tuberculosis that is essential for bacterial survival during infection, has a double hotdogfold | Descriptor: | CHLORIDE ION, HYPOTHETICAL PROTEIN RV0216 | Authors: | Castell, A, Johansson, P, Unge, T, Jones, T.A, Backbro, K. | Deposit date: | 2005-01-20 | Release date: | 2005-04-25 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Rv0216, a Conserved Hypothetical Protein from Mycobacterium Tuberculosis that is Essential for Bacterial Survival During Infection, Has a Double Hotdog Fold Protein Sci., 14, 2005
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3JZ6
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![BU of 3jz6 by Molmil](/molmil-images/mine/3jz6) | Crystal structure of Mycobacterium smegmatis Branched Chain Aminotransferase in complex with pyridoxal-5'-phosphate at 1.9 angstrom. | Descriptor: | Branched-chain amino acid aminotransferase, GLYCEROL, PYRIDOXAL-5'-PHOSPHATE | Authors: | Castell, A, Mille, C, Unge, T. | Deposit date: | 2009-09-23 | Release date: | 2010-05-05 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural analysis of mycobacterial branched-chain aminotransferase: implications for inhibitor design. Acta Crystallogr.,Sect.D, 66, 2010
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3TWP
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![BU of 3twp by Molmil](/molmil-images/mine/3twp) | Crystal structure of M. tuberculosis TrpD in complex with an inhibitor | Descriptor: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 2-HYDROXYBENZOIC ACID, Anthranilate phosphoribosyltransferase, ... | Authors: | Castell, A, Short, F.L, Lott, J.S. | Deposit date: | 2011-09-22 | Release date: | 2012-09-26 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition. Biochemistry, 52, 2013
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3UU1
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![BU of 3uu1 by Molmil](/molmil-images/mine/3uu1) | Anthranilate phosphoribosyltransferase (trpD) from Mycobacterium tuberculosis (complex with inhibitor ACS142) | Descriptor: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 2-amino-3,5-dimethylbenzoic acid, Anthranilate phosphoribosyltransferase, ... | Authors: | Castell, A, Short, F.L, Lott, J.S. | Deposit date: | 2011-11-27 | Release date: | 2012-12-12 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition. Biochemistry, 52, 2013
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3QR9
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3QS8
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![BU of 3qs8 by Molmil](/molmil-images/mine/3qs8) | Anthranilate phosphoribosyltransferase (trpD) from Mycobacterium tuberculosis (complex with inhibitor ACS174) | Descriptor: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 2-benzylbenzoic acid, Anthranilate phosphoribosyltransferase, ... | Authors: | Castell, A, Short, F.L, Lott, J.S, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2011-02-20 | Release date: | 2012-08-22 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition. Biochemistry, 52, 2013
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3QSA
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![BU of 3qsa by Molmil](/molmil-images/mine/3qsa) | Anthranilate phosphoribosyltransferase (trpD) from Mycobacterium tuberculosis (complex with inhibitor TAMU-A7) | Descriptor: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 4,4,4-trifluoro-1-(4-methoxyphenyl)butane-1,3-dione, Anthranilate phosphoribosyltransferase, ... | Authors: | Castell, A, Short, F.L, Lott, J.S, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2011-02-20 | Release date: | 2012-08-22 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.18 Å) | Cite: | Inhibition of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase by blocking of an active site entrance tunnel. To be Published
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3QQS
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![BU of 3qqs by Molmil](/molmil-images/mine/3qqs) | Anthranilate phosphoribosyltransferase (TRPD) from Mycobacterium tuberculosis (complex with inhibitor ACS172) | Descriptor: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 2,2'-iminodibenzoic acid, Anthranilate phosphoribosyltransferase, ... | Authors: | Castell, A, Short, F.L, Lott, J.S, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2011-02-16 | Release date: | 2012-08-22 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition. Biochemistry, 52, 2013
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3R88
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![BU of 3r88 by Molmil](/molmil-images/mine/3r88) | Anthranilate phosphoribosyltransferase (trpD) from Mycobacterium tuberculosis (complex with inhibitor ACS145) | Descriptor: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 2-amino-4,5-dimethoxybenzoic acid, Anthranilate phosphoribosyltransferase, ... | Authors: | Castell, A, Short, F.L, Lott, J.S. | Deposit date: | 2011-03-23 | Release date: | 2012-09-26 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition. Biochemistry, 52, 2013
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3R6C
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![BU of 3r6c by Molmil](/molmil-images/mine/3r6c) | Anthranilate phosphoribosyltransferase (trpD) from Mycobacterium tuberculosis (complex with inhibitor ACS179) | Descriptor: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 8-methoxyphenanthro[3,4-d][1,3]dioxole-5,6-dicarboxylic acid, Anthranilate phosphoribosyltransferase, ... | Authors: | Castell, A, Short, F.L, Lott, J.S, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2011-03-21 | Release date: | 2012-09-26 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition. Biochemistry, 52, 2013
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6F84
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![BU of 6f84 by Molmil](/molmil-images/mine/6f84) | AKR1B1 at 2.55 MGy radiation dose. | Descriptor: | Aldose reductase, CITRIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Castellvi, A, Juanhuix, J. | Deposit date: | 2017-12-12 | Release date: | 2019-03-13 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.09 Å) | Cite: | Efficacy of aldose reductase inhibitors is affected by oxidative stress induced under X-ray irradiation. Sci Rep, 9, 2019
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6F8O
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![BU of 6f8o by Molmil](/molmil-images/mine/6f8o) | AKR1B1 at 3.45 MGy radiation dose. | Descriptor: | Aldose reductase, CITRIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Castellvi, A, Juanhuix, J. | Deposit date: | 2017-12-13 | Release date: | 2019-03-13 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.17 Å) | Cite: | Efficacy of aldose reductase inhibitors is affected by oxidative stress induced under X-ray irradiation. Sci Rep, 9, 2019
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6F81
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![BU of 6f81 by Molmil](/molmil-images/mine/6f81) | AKR1B1 at 0.75 MGy radiation dose. | Descriptor: | Aldose reductase, CITRIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Castellvi, A, Juanhuix, J. | Deposit date: | 2017-12-12 | Release date: | 2019-03-13 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (0.97 Å) | Cite: | Efficacy of aldose reductase inhibitors is affected by oxidative stress induced under X-ray irradiation. Sci Rep, 9, 2019
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6F7R
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![BU of 6f7r by Molmil](/molmil-images/mine/6f7r) | AKR1B1 at 0.03 MGy radiation dose. | Descriptor: | Aldose reductase, CITRIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Castellvi, A, Juanhuix, J. | Deposit date: | 2017-12-11 | Release date: | 2019-03-13 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (0.92 Å) | Cite: | Efficacy of aldose reductase inhibitors is affected by oxidative stress induced under X-ray irradiation. Sci Rep, 9, 2019
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6F82
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![BU of 6f82 by Molmil](/molmil-images/mine/6f82) | AKR1B1 at 1.65 MGy radiation dose. | Descriptor: | Aldose reductase, CITRIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Castellvi, A, Juanhuix, J. | Deposit date: | 2017-12-12 | Release date: | 2019-03-13 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.03 Å) | Cite: | Efficacy of aldose reductase inhibitors is affected by oxidative stress induced under X-ray irradiation. Sci Rep, 9, 2019
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7QK7
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![BU of 7qk7 by Molmil](/molmil-images/mine/7qk7) | Crystal structure of the APO form of ALDH1A3 | Descriptor: | Aldehyde dehydrogenase family 1 member A3, DI(HYDROXYETHYL)ETHER, GLYCEROL | Authors: | Castellvi, A, Farres, J. | Deposit date: | 2021-12-17 | Release date: | 2022-04-20 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.289 Å) | Cite: | Structural and biochemical evidence that ATP inhibits the cancer biomarker human aldehyde dehydrogenase 1A3. Commun Biol, 5, 2022
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7QK8
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![BU of 7qk8 by Molmil](/molmil-images/mine/7qk8) | Crystal structure of the ALDH1A3-NAD+ complex | Descriptor: | Aldehyde dehydrogenase family 1 member A3, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | Authors: | Castellvi, A, Farres, J. | Deposit date: | 2021-12-17 | Release date: | 2022-04-20 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.893 Å) | Cite: | Structural and biochemical evidence that ATP inhibits the cancer biomarker human aldehyde dehydrogenase 1A3. Commun Biol, 5, 2022
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7QK9
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![BU of 7qk9 by Molmil](/molmil-images/mine/7qk9) | Crystal structure of the ALDH1A3-ATP complex | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Aldehyde dehydrogenase family 1 member A3, DI(HYDROXYETHYL)ETHER, ... | Authors: | Castellvi, A, Farres, J. | Deposit date: | 2021-12-17 | Release date: | 2022-04-20 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.782 Å) | Cite: | Structural and biochemical evidence that ATP inhibits the cancer biomarker human aldehyde dehydrogenase 1A3. Commun Biol, 5, 2022
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4OWQ
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![BU of 4owq by Molmil](/molmil-images/mine/4owq) | Anthranilate phosphoribosyl transferase from Mycobacterium tuberculosis in complex with 3-methylanthranilate, PRPP and Magnesium | Descriptor: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 2-azanyl-3-methyl-benzoic acid, Anthranilate phosphoribosyltransferase, ... | Authors: | Castell, A, Cookson, T.V.M, Short, F.L, Lott, J.S. | Deposit date: | 2014-02-03 | Release date: | 2014-04-23 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis. Biochem.J., 461, 2014
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4OWU
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![BU of 4owu by Molmil](/molmil-images/mine/4owu) | Anthranilate phosphoribosyl transferase from Mycobacterium tuberculosis in complex with 5-methylanthranilate, PRPP and Magnesium | Descriptor: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 2-azanyl-5-methyl-benzoic acid, Anthranilate phosphoribosyltransferase, ... | Authors: | Castell, A, Cookson, T.V.M, Short, F.L, Lott, J.S. | Deposit date: | 2014-02-03 | Release date: | 2014-04-23 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis. Biochem.J., 461, 2014
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4OWM
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![BU of 4owm by Molmil](/molmil-images/mine/4owm) | Anthranilate phosphoribosyl transferase from Mycobacterium tuberculosis in complex with 3-fluoroanthranilate, PRPP and Magnesium | Descriptor: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 2-azanyl-3-fluoranyl-benzoic acid, Anthranilate phosphoribosyltransferase, ... | Authors: | Castell, A, Cookson, T.V.M, Short, F.L, Lott, J.S. | Deposit date: | 2014-02-02 | Release date: | 2014-04-23 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis. Biochem.J., 461, 2014
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4OWN
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![BU of 4own by Molmil](/molmil-images/mine/4own) | Anthranilate phosphoribosyl transferase from Mycobacterium tuberculosis in complex with 5-fluoroanthranilate, PRPP and Magnesium | Descriptor: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 2-amino-5-fluorobenzoic acid, Anthranilate phosphoribosyltransferase, ... | Authors: | Castell, A, Cookson, T.V.M, Short, F.L, Lott, J.S. | Deposit date: | 2014-02-02 | Release date: | 2014-04-23 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.11 Å) | Cite: | Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis. Biochem.J., 461, 2014
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4OWV
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![BU of 4owv by Molmil](/molmil-images/mine/4owv) | Anthranilate phosphoribosyl transferase from Mycobacterium tuberculosis in complex with anthranilate | Descriptor: | 2-AMINOBENZOIC ACID, Anthranilate phosphoribosyltransferase, GLYCEROL, ... | Authors: | Castell, A, Cookson, T.V.M, Short, F.L, Lott, J.S. | Deposit date: | 2014-02-04 | Release date: | 2014-04-23 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis. Biochem.J., 461, 2014
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