1UPU
| STRUCTURE OF THE URACIL PHOSPHORIBOSYLTRANSFERASE, MUTANT C128V, BOUND TO PRODUCT URIDINE-1-MONOPHOSPHATE (UMP) | Descriptor: | PHOSPHATE ION, URACIL PHOSPHORIBOSYLTRANSFERASE, URIDINE-5'-MONOPHOSPHATE | Authors: | Schumacher, M.A, Carter, D, Scott, D, Roos, D, Ullman, B, Brennan, R.G. | Deposit date: | 1998-04-16 | Release date: | 1999-05-11 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structures of Toxoplasma gondii uracil phosphoribosyltransferase reveal the atomic basis of pyrimidine discrimination and prodrug binding. EMBO J., 17, 1998
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1UPF
| STRUCTURE OF THE URACIL PHOSPHORIBOSYLTRANSFERASE, MUTANT C128V BOUND TO THE DRUG 5-FLUOROURACIL | Descriptor: | 5-FLUOROURACIL, SULFATE ION, URACIL PHOSPHORIBOSYLTRANSFERASE | Authors: | Schumacher, M.A, Carter, D, Scott, D, Roos, D, Ullman, B, Brennan, R.G. | Deposit date: | 1998-06-17 | Release date: | 1999-06-22 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structures of Toxoplasma gondii uracil phosphoribosyltransferase reveal the atomic basis of pyrimidine discrimination and prodrug binding. EMBO J., 17, 1998
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1VPW
| STRUCTURE OF THE PURR MUTANT, L54M, BOUND TO HYPOXANTHINE AND PURF OPERATOR DNA | Descriptor: | DNA (5'-D(*TP*AP*CP*GP*CP*AP*AP*AP*CP*GP*TP*TP*TP*GP*CP*GP*T )-3'), HYPOXANTHINE, PURINE REPRESSOR | Authors: | Arvidson, D.N, Lu, F, Faber, C, Zalkin, H, Brennan, R.G. | Deposit date: | 1998-02-27 | Release date: | 1998-06-17 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The structure of PurR mutant L54M shows an alternative route to DNA kinking. Nat.Struct.Biol., 5, 1998
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2BOW
| MULTIDRUG-BINDING DOMAIN OF TRANSCRIPTION ACTIVATOR BMRR IN COMPLEX WITH A LIGAND, TETRAPHENYLPHOSPHONIUM | Descriptor: | MANGANESE (II) ION, MULTIDRUG-EFFLUX TRANSPORTER 1 REGULATOR BMRR, SULFATE ION, ... | Authors: | Zheleznova, E.E, Markham, P.N, Neyfakh, A.A, Brennan, R.G. | Deposit date: | 1998-08-06 | Release date: | 1999-08-06 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural basis of multidrug recognition by BmrR, a transcription activator of a multidrug transporter. Cell(Cambridge,Mass.), 96, 1999
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2BSQ
| FitAB bound to DNA | Descriptor: | IR36, FORWARD STRAND, REVERSE STRAND, ... | Authors: | Mattison, K, Wilbur, J.S, So, M, Brennan, R.G. | Deposit date: | 2005-05-23 | Release date: | 2006-08-24 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structure of Fitab from Neisseria Gonorrhoeae Bound to DNA Reveals a Tetramer of Toxin-Antitoxin Heterodimers Containing Pin Domains and Ribbon-Helix-Helix Motifs. J.Biol.Chem., 281, 2006
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2DTZ
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2EV0
| Bacillus subtilis manganese transport regulator (MNTR) bound to cadmium | Descriptor: | CADMIUM ION, Transcriptional regulator mntR | Authors: | Kliegman, J.I, Griner, S.L, Helmann, J.D, Brennan, R.G, Glasfeld, A. | Deposit date: | 2005-10-30 | Release date: | 2006-03-07 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Structural Basis for the Metal-Selective Activation of the Manganese Transport Regulator of Bacillus subtilis. Biochemistry, 45, 2006
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2EV5
| Bacillus subtilis manganese transport regulator (MNTR) bound to calcium | Descriptor: | CALCIUM ION, Transcriptional regulator mntR | Authors: | Kliegman, J.I, Griner, S.L, Helmann, J.D, Brennan, R.G, Glasfeld, A. | Deposit date: | 2005-10-31 | Release date: | 2006-03-07 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural Basis for the Metal-Selective Activation of the Manganese Transport Regulator of Bacillus subtilis. Biochemistry, 45, 2006
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1DH3
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1DBR
| HYPOXANTHINE GUANINE XANTHINE | Descriptor: | HYPOXANTHINE GUANINE XANTHINE PHOSPHORIBOSYLTRANSFERASE, MAGNESIUM ION | Authors: | Schumacher, M.A, Carter, D, Roos, D, Ullman, B, Brennan, R.G. | Deposit date: | 1996-02-13 | Release date: | 1997-12-03 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structures of Toxoplasma gondii HGXPRTase reveal the catalytic role of a long flexible loop. Nat.Struct.Biol., 3, 1996
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1DBQ
| DNA-BINDING REGULATORY PROTEIN | Descriptor: | MAGNESIUM ION, PURINE REPRESSOR | Authors: | Schumacher, M.A, Choi, K.Y, Lu, F, Zalkin, H, Brennan, R.G. | Deposit date: | 1996-02-13 | Release date: | 1996-12-07 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Mechanism of corepressor-mediated specific DNA binding by the purine repressor. Cell(Cambridge,Mass.), 83, 1995
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4Z5H
| HipB(S29A)-O2 20mer complex | Descriptor: | Antitoxin HipB, DNA (5'-D(*TP*TP*AP*TP*CP*CP*TP*CP*AP*CP*TP*AP*AP*AP*GP*GP*AP*TP*AP*A)-3') | Authors: | Min, J, Brennan, R.G, Schumacher, M.A. | Deposit date: | 2015-04-02 | Release date: | 2016-07-06 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Molecular mechanism on hipBA gene regulation. To be published
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1EXJ
| CRYSTAL STRUCTURE OF TRANSCRIPTION ACTIVATOR BMRR, FROM B. SUBTILIS, BOUND TO 21 BASE PAIR BMR OPERATOR AND TPP | Descriptor: | DNA (5'-D(*AP*CP*CP*CP*TP*CP*CP*CP*CP*TP*TP*AP*GP*GP*GP*GP*AP*GP*GP*GP*T)-3'), MULTIDRUG-EFFLUX TRANSPORTER REGULATOR, SODIUM ION, ... | Authors: | Zheleznova-Heldwein, E.E, Brennan, R.G. | Deposit date: | 2000-05-02 | Release date: | 2001-01-24 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal structure of the transcription activator BmrR bound to DNA and a drug. Nature, 409, 2001
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4Z5C
| HipB-O3 21mer complex | Descriptor: | Antitoxin HipB, DNA (5'-D(*TP*TP*TP*AP*TP*CP*CP*CP*GP*TP*AP*GP*AP*GP*CP*GP*GP*AP*TP*AP*A)-3'), DNA (5'-D(*TP*TP*TP*AP*TP*CP*CP*GP*CP*TP*CP*TP*AP*CP*GP*GP*GP*AP*TP*A)-3') | Authors: | Min, J, Brennan, R.G, Schumacher, M.A. | Deposit date: | 2015-04-02 | Release date: | 2016-07-06 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Molecular mechanism on hipBA gene regulation. To be published
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1EXI
| CRYSTAL STRUCTURE OF TRANSCRIPTION ACTIVATOR BMRR, FROM B. SUBTILIS, BOUND TO 21 BASE PAIR BMR OPERATOR AND TPSB | Descriptor: | DNA (5'-D(*AP*CP*CP*CP*TP*CP*CP*CP*CP*TP*TP*AP*GP*GP*GP*GP*AP*GP*GP*GP*T)-3'), MULTIDRUG-EFFLUX TRANSPORTER REGULATOR, TETRAPHENYLANTIMONIUM ION, ... | Authors: | Zheleznova-Heldwein, E.E, Brennan, R.G. | Deposit date: | 2000-05-02 | Release date: | 2001-01-24 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3.12 Å) | Cite: | Crystal structure of the transcription activator BmrR bound to DNA and a drug. Nature, 409, 2001
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4Z59
| HipB-O4 20mer complex | Descriptor: | Antitoxin HipB, DNA (5'-D(*TP*TP*AP*TP*CP*CP*GP*CP*GP*AP*TP*CP*GP*CP*GP*GP*AP*TP*AP*A)-3') | Authors: | Min, J, Brennan, R.G, Schumacher, M.A. | Deposit date: | 2015-04-02 | Release date: | 2016-07-06 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Molecular mechanism on hipBA gene regulation. To be published
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4Z5D
| HipB-O4 21mer complex | Descriptor: | Antitoxin HipB, DNA (5'-D(*TP*TP*TP*AP*TP*CP*CP*GP*CP*GP*AP*TP*CP*GP*CP*GP*GP*AP*TP*A)-3'), DNA (5'-D(*TP*TP*TP*AP*TP*CP*CP*GP*CP*GP*AP*TP*CP*GP*CP*GP*GP*AP*TP*AP*A)-3') | Authors: | Min, J, Brennan, R.G, Schumacher, M.A. | Deposit date: | 2015-04-02 | Release date: | 2016-07-06 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Molecular mechanism on hipBA gene regulation. To be published
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4Z58
| HipB-O3 20mer complex | Descriptor: | Antitoxin HipB, DNA (5'-D(*TP*TP*AP*TP*CP*CP*GP*CP*TP*CP*TP*AP*CP*GP*GP*GP*AP*TP*AP*A)-3') | Authors: | Min, J, Brennan, R.G, Schumacher, M.A. | Deposit date: | 2015-04-02 | Release date: | 2016-07-06 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Molecular mechanism on hipBA gene regulation. To be published
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3D71
| Crystal structure of E253Q BMRR bound to 22 base pair promoter site | Descriptor: | BMR promoter DNA, CITRATE ANION, IMIDAZOLE, ... | Authors: | Newberry, K.J, Huffman, J.L, Brennan, R.G. | Deposit date: | 2008-05-20 | Release date: | 2008-08-26 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structures of BmrR-Drug Complexes Reveal a Rigid Multidrug Binding Pocket and Transcription Activation through Tyrosine Expulsion J.Biol.Chem., 283, 2008
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7TEC
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5U56
| Structure of Francisella tularensis heterodimeric SspA (MglA-SspA) | Descriptor: | GLYCEROL, Macrophage growth locus A, PENTAETHYLENE GLYCOL, ... | Authors: | Cuthbert, B.J, Schumacher, M.A, Brennan, R.G. | Deposit date: | 2016-12-06 | Release date: | 2017-08-16 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Dissection of the molecular circuitry controlling virulence in Francisella tularensis. Genes Dev., 31, 2017
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5U51
| Structure of Francisella tularensis heterodimeric SspA (MglA-SspA) in complex with ppGpp | Descriptor: | GLYCEROL, GUANOSINE-5',3'-TETRAPHOSPHATE, MAGNESIUM ION, ... | Authors: | Cuthbert, B.J, Schumacher, M.A, Brennan, R.G. | Deposit date: | 2016-12-06 | Release date: | 2017-08-16 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Dissection of the molecular circuitry controlling virulence in Francisella tularensis. Genes Dev., 31, 2017
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5UK7
| Escherichia coli Hfq bound to dsDNA | Descriptor: | DNA (5'-D(P*CP*GP*GP*CP*AP*AP*AP*AP*AP*AP*CP*GP*GP*CP*AP*AP*AP*AP*AP*A)-3'), DNA (5'-D(P*TP*TP*TP*TP*TP*TP*GP*CP*CP*GP*TP*TP*TP*TP*TP*TP*GP*CP*CP*G)-3'), RNA-binding protein Hfq, ... | Authors: | Orans, J, Kovach, A.R, Brennan, R.G. | Deposit date: | 2017-01-20 | Release date: | 2018-05-09 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal structure of Escherichia coli Hfq DNA complex reveals multifunctional nucleic acid binding site To Be Published
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5HJZ
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5HK3
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