6W32
| Crystal structure of Sfh5 | Descriptor: | PROTOPORPHYRIN IX CONTAINING FE, Phosphatidylinositol transfer protein SFH5 | Authors: | Gulten, G, Khan, D, Aggarwal, A, Krieger, I, Sacchettini, J.C, Bankaitis, V.A. | Deposit date: | 2020-03-08 | Release date: | 2020-11-25 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | A Sec14-like phosphatidylinositol transfer protein paralog defines a novel class of heme-binding proteins. Elife, 9, 2020
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3Q8G
| Resurrection of a functional phosphatidylinositol transfer protein from a pseudo-Sec14 scaffold by directed evolution | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, CRAL-TRIO domain-containing protein YKL091C, GLYCEROL | Authors: | Ortlund, E.A, Schaaf, G, Bankaitis, V.A. | Deposit date: | 2011-01-06 | Release date: | 2011-02-23 | Last modified: | 2023-05-31 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Resurrection of a functional phosphatidylinositol transfer protein from a pseudo-Sec14 scaffold by directed evolution. Mol.Biol.Cell, 22, 2011
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1AUA
| PHOSPHATIDYLINOSITOL TRANSFER PROTEIN SEC14P FROM SACCHAROMYCES CEREVISIAE | Descriptor: | PHOSPHATIDYLINOSITOL TRANSFER PROTEIN SEC14P, octyl beta-D-glucopyranoside | Authors: | Sha, B, Phillips, S.E, Bankaitis, V.A, Luo, M. | Deposit date: | 1997-08-20 | Release date: | 1997-12-24 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of the Saccharomyces cerevisiae phosphatidylinositol-transfer protein. Nature, 391, 1998
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6DII
| Structure of Arabidopsis Fatty Acid Amide Hydrolase in Complex with methyl linolenyl fluorophosphonate | Descriptor: | Fatty acid amide hydrolase, methyl-9Z,12Z,15Z-octadecatrienylphosphonofluoridate | Authors: | Aziz, M, Wang, X, Tripathi, A, Bankaitis, V, Chapman, K.D. | Deposit date: | 2018-05-23 | Release date: | 2019-03-27 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural analysis of a plant fatty acid amide hydrolase provides insights into the evolutionary diversity of bioactive acylethanolamides. J.Biol.Chem., 294, 2019
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6DHV
| Structure of Arabidopsis Fatty Acid Amide Hydrolase | Descriptor: | Fatty acid amide hydrolase | Authors: | Aziz, M, Wang, X, Tripathi, A, Bankaitis, V, Chapman, K.D. | Deposit date: | 2018-05-21 | Release date: | 2019-03-27 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.099 Å) | Cite: | Structural analysis of a plant fatty acid amide hydrolase provides insights into the evolutionary diversity of bioactive acylethanolamides. J.Biol.Chem., 294, 2019
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4M8Z
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3B7Q
| Crystal Structure of Yeast Sec14 Homolog Sfh1 in Complex with Phosphatidylcholine | Descriptor: | (4S,7R)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSAN-1-AMINIUM 4-OXIDE, GLYCEROL, PHOSPHATE ION, ... | Authors: | Ortlund, E.A, Schaaf, G, Redinbo, M.R, Bankaitis, V. | Deposit date: | 2007-10-31 | Release date: | 2008-02-19 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Functional anatomy of phospholipid binding and regulation of phosphoinositide homeostasis by proteins of the sec14 superfamily Mol.Cell, 29, 2008
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3B74
| Crystal Structure of Yeast Sec14 Homolog Sfh1 in Complex with Phosphatidylethanolamine | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Uncharacterized protein YKL091C | Authors: | Ortlund, E.A, Schaaf, G, Redinbo, M.R, Bankaitis, V. | Deposit date: | 2007-10-30 | Release date: | 2008-02-19 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Functional anatomy of phospholipid binding and regulation of phosphoinositide homeostasis by proteins of the sec14 superfamily Mol.Cell, 29, 2008
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3B7N
| Crystal Structure of Yeast Sec14 Homolog Sfh1 in Complex with Phosphatidylinositol | Descriptor: | (1R)-2-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}-1-[(octadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, ACETATE ION, PHOSPHATE ION, ... | Authors: | Ortlund, E.A, Schaaf, G, Redinbo, M.R, Bankaitis, V. | Deposit date: | 2007-10-31 | Release date: | 2008-02-19 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Functional anatomy of phospholipid binding and regulation of phosphoinositide homeostasis by proteins of the sec14 superfamily Mol.Cell, 29, 2008
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3B7Z
| Crystal Structure of Yeast Sec14 Homolog Sfh1 in Complex with Phosphatidylcholine or Phosphatidylinositol | Descriptor: | (1R)-2-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}-1-[(octadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, (4S,7R)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSAN-1-AMINIUM 4-OXIDE, Uncharacterized protein YKL091C | Authors: | Ortlund, E.A, Schaaf, G, Redinbo, M.R, Bankaitis, V. | Deposit date: | 2007-10-31 | Release date: | 2008-02-19 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Functional anatomy of phospholipid binding and regulation of phosphoinositide homeostasis by proteins of the sec14 superfamily Mol.Cell, 29, 2008
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7ZGB
| Structure of yeast Sec14p with NPPM112 | Descriptor: | 4-fluoranyl-~{N}-[(4-pyrrolidin-1-ylphenyl)methyl]benzamide, SEC14 cytosolic factor | Authors: | Hong, Z, Johnen, P, Schaaf, G, Bono, F. | Deposit date: | 2022-04-03 | Release date: | 2023-01-25 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Mechanisms by which small molecules of diverse chemotypes arrest Sec14 lipid transfer activity. J.Biol.Chem., 299, 2023
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7ZG9
| Structure of yeast Sec14p with himbacine | Descriptor: | Himbacine, SEC14 cytosolic factor | Authors: | Hong, Z, Johnen, P, Schaaf, G, Bono, F. | Deposit date: | 2022-04-03 | Release date: | 2023-01-25 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.764 Å) | Cite: | Mechanisms by which small molecules of diverse chemotypes arrest Sec14 lipid transfer activity. J.Biol.Chem., 299, 2023
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7ZGA
| Structure of yeast Sec14p with ergoline | Descriptor: | SEC14 cytosolic factor, ~{O}9-methyl ~{O}4-[2,2,2-tris(chloranyl)ethyl] (5~{a}~{S},6~{a}~{S},9~{R},10~{a}~{S})-7-methyl-3-nitro-5,5~{a},6,6~{a},8,9,10,10~{a}-octahydroindolo[4,3-fg]quinoline-4,9-dicarboxylate | Authors: | Hong, Z, Johnen, P, Schaaf, G, Bono, F. | Deposit date: | 2022-04-03 | Release date: | 2023-01-25 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.302 Å) | Cite: | Mechanisms by which small molecules of diverse chemotypes arrest Sec14 lipid transfer activity. J.Biol.Chem., 299, 2023
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7ZGC
| Structure of yeast Sec14p with NPPM481 | Descriptor: | (4-chloranyl-3-nitro-phenyl)-[4-(2-fluorophenyl)piperazin-1-yl]methanone, PHOSPHATE ION, SEC14 cytosolic factor | Authors: | Hong, Z, Johnen, P, Schaaf, G, Bono, F. | Deposit date: | 2022-04-03 | Release date: | 2023-01-25 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.236 Å) | Cite: | Mechanisms by which small molecules of diverse chemotypes arrest Sec14 lipid transfer activity. J.Biol.Chem., 299, 2023
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7ZGD
| Structure of yeast Sec14p with NPPM244 | Descriptor: | (4-bromanyl-3-nitro-phenyl)-[4-(2-fluorophenyl)piperazin-1-yl]methanone, SEC14 cytosolic factor | Authors: | Hong, Z, Johnen, P, Schaaf, G, Bono, F. | Deposit date: | 2022-04-03 | Release date: | 2023-01-25 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | Mechanisms by which small molecules of diverse chemotypes arrest Sec14 lipid transfer activity. J.Biol.Chem., 299, 2023
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6F0E
| Structure of yeast Sec14p with a picolinamide compound | Descriptor: | SEC14 cytosolic factor, ~{N}-(1,3-benzodioxol-5-ylmethyl)-5-bromanyl-3-fluoranyl-pyridine-2-carboxamide | Authors: | Hong, Z, Johnen, P, Schaaf, G, Bono, F. | Deposit date: | 2017-11-20 | Release date: | 2018-01-17 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Target Identification and Mechanism of Action of Picolinamide and Benzamide Chemotypes with Antifungal Properties. Cell Chem Biol, 25, 2018
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