6NK5
 
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6NK7
 | | Electron Cryo-Microscopy of Chikungunya in Complex with Mouse Mxra8 Receptor | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Capsid protein, E1 glycoprotein, ... | | Authors: | Basore, K, Kim, A.S, Nelson, C.A, Fremont, D.H, Center for Structural Genomics of Infectious Diseases (CSGID) | | Deposit date: | 2019-01-04 | | Release date: | 2019-05-22 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (4.99 Å) | | Cite: | Cryo-EM Structure of Chikungunya Virus in Complex with the Mxra8 Receptor.
Cell, 177, 2019
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6NK6
 | | Electron Cryo-Microscopy Of Chikungunya VLP in complex with mouse Mxra8 receptor | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Capsid protein, E1 glycoprotein, ... | | Authors: | Basore, K, Kim, A.S, Nelson, C.A, Fremont, D.H, Center for Structural Genomics of Infectious Diseases (CSGID) | | Deposit date: | 2019-01-04 | | Release date: | 2019-05-22 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (4.06 Å) | | Cite: | Cryo-EM Structure of Chikungunya Virus in Complex with the Mxra8 Receptor.
Cell, 177, 2019
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7N1H
 | | CryoEM structure of Venezuelan equine encephalitis virus VLP in complex with the LDLRAD3 receptor | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Capsid, ... | | Authors: | Basore, K, Nelson, C.A, Fremont, D.H, Center for Structural Genomics of Infectious Diseases (CSGID) | | Deposit date: | 2021-05-27 | | Release date: | 2021-10-13 | | Last modified: | 2021-11-10 | | Method: | ELECTRON MICROSCOPY (4.3 Å) | | Cite: | Structure of Venezuelan equine encephalitis virus in complex with the LDLRAD3 receptor.
Nature, 598, 2021
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7N1I
 | | CryoEM structure of Venezuelan equine encephalitis virus VLP | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Capsid, E1 envelope glycoprotein, ... | | Authors: | Basore, K, Nelson, C.A, Fremont, D.H, Center for Structural Genomics of Infectious Diseases (CSGID) | | Deposit date: | 2021-05-27 | | Release date: | 2021-10-13 | | Last modified: | 2021-11-10 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | Structure of Venezuelan equine encephalitis virus in complex with the LDLRAD3 receptor.
Nature, 598, 2021
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5XZE
 | | Mouse cGAS bound to the inhibitor RU332 | | Descriptor: | (3R)-3-[1-(3H-1lambda~4~,3-benzothiazol-2-yl)-5-hydroxy-3-methyl-1H-pyrazol-4-yl]-2-benzofuran-1(3H)-one, Cyclic GMP-AMP synthase, DNA (5'-D(*AP*AP*AP*TP*TP*GP*CP*CP*GP*AP*AP*GP*AP*CP*G)-3'), ... | | Authors: | Vincent, J, Adura, C, Gao, P, Luz, A, Lama, L, Asano, Y, Okamoto, R, Imaeda, T, Aida, J, Rothamel, K, Gogakos, T, Steinberg, J, Reasoner, S, Aso, K, Tuschl, T, Patel, D.J, Glickman, J.F, Ascano, M. | | Deposit date: | 2017-07-12 | | Release date: | 2017-10-11 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.177 Å) | | Cite: | Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice.
Nat Commun, 8, 2017
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5XZG
 | | Mouse cGAS bound to the inhibitor RU521 | | Descriptor: | 2-(4,5-dichloro-1H-benzimidazol-2-yl)-5-methyl-4-[(1R)-3-oxo-1,3-dihydro-2-benzofuran-1-yl]-1,2-dihydro-3H-pyrazol-3-one, Cyclic GMP-AMP synthase, DNA (5'-D(*AP*AP*AP*TP*TP*GP*CP*CP*GP*AP*AP*GP*AP*CP*G)-3'), ... | | Authors: | Vincent, J, Adura, C, Gao, P, Luz, A, Lama, L, Asano, Y, Okamoto, R, Imaeda, T, Aida, J, Rothamel, K, Gogakos, T, Steinberg, J, Reasoner, S, Aso, K, Tuschl, T, Patel, D.J, Glickman, J.F, Ascano, M. | | Deposit date: | 2017-07-12 | | Release date: | 2017-10-11 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.828 Å) | | Cite: | Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice.
Nat Commun, 8, 2017
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5XZB
 | | Mouse cGAS bound to the inhibitor RU365 | | Descriptor: | (3R)-3-[1-(1H-benzimidazol-2-yl)-5-hydroxy-3-methyl-1H-pyrazol-4-yl]-2-benzofuran-1(3H)-one, Cyclic GMP-AMP synthase, DNA (5'-D(*AP*AP*AP*TP*TP*GP*CP*CP*GP*AP*AP*GP*AP*CP*G)-3'), ... | | Authors: | Vincent, J, Adura, C, Gao, P, Luz, A, Lama, L, Asano, Y, Okamoto, R, Imaeda, T, Aida, J, Rothamel, K, Gogakos, T, Steinberg, J, Reasoner, S, Aso, K, Tuschl, T, Patel, D.J, Glickman, J.F, Ascano, M. | | Deposit date: | 2017-07-12 | | Release date: | 2017-08-09 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.13 Å) | | Cite: | Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice.
Nat Commun, 8, 2017
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1EAK
 | | Catalytic domain of proMMP-2 E404Q mutant | | Descriptor: | 72 KDA TYPE IV COLLAGENASE, CALCIUM ION, INHIBITOR PEPTIDE, ... | | Authors: | Bergmann, U, Tuuttila, A, Tryggvason, K, Morgunova, E. | | Deposit date: | 2001-07-12 | | Release date: | 2002-08-22 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.66 Å) | | Cite: | Crystal Structure of Human Mmp-2 Reveals a New P
To be Published
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1EZT
 | | HIGH-RESOLUTION SOLUTION STRUCTURE OF FREE RGS4 BY NMR | | Descriptor: | REGULATOR OF G-PROTEIN SIGNALING 4 | | Authors: | Moy, F.J, Chanda, P.K, Cockett, M.I, Edris, W, Jones, P.G, Mason, K, Semus, S, Powers, R. | | Deposit date: | 2000-05-11 | | Release date: | 2001-01-15 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | NMR structure of free RGS4 reveals an induced conformational change upon binding Galpha.
Biochemistry, 39, 2000
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1EZY
 | | HIGH-RESOLUTION SOLUTION STRUCTURE OF FREE RGS4 BY NMR | | Descriptor: | REGULATOR OF G-PROTEIN SIGNALING 4 | | Authors: | Moy, F.J, Chanda, P.K, Cockett, M.I, Edris, W, Jones, P.G, Mason, K, Semus, S, Powers, R. | | Deposit date: | 2000-05-12 | | Release date: | 2001-01-15 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | NMR structure of free RGS4 reveals an induced conformational change upon binding Galpha.
Biochemistry, 39, 2000
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8G3G
 | | CryoEM structure of yeast recombination mediator Rad52 | | Descriptor: | DNA repair and recombination protein RAD52 | | Authors: | Deveryshetty, J, Basore, K, Rau, M, Fitzpatrick, J.A.J, Antony, E. | | Deposit date: | 2023-02-07 | | Release date: | 2023-11-15 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Yeast Rad52 is a homodecamer and possesses BRCA2-like bipartite Rad51 binding modes.
Nat Commun, 14, 2023
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1BR9
 | | HUMAN TISSUE INHIBITOR OF METALLOPROTEINASE-2 | | Descriptor: | METALLOPROTEINASE-2 INHIBITOR | | Authors: | Tuuttila, A, Morgunova, E, Bergmann, U, Lindqvist, Y, Tryggvason, K, Schneider, G. | | Deposit date: | 1998-08-28 | | Release date: | 1999-05-04 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Three-dimensional structure of human tissue inhibitor of metalloproteinases-2 at 2.1 A resolution.
J.Mol.Biol., 284, 1998
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1CK7
 | | GELATINASE A (FULL-LENGTH) | | Descriptor: | CALCIUM ION, CHLORIDE ION, PROTEIN (GELATINASE A), ... | | Authors: | Morgunova, E, Tuuttila, A, Bergmann, U, Isupov, M, Lindqvist, Y, Schneider, G, Tryggvason, K. | | Deposit date: | 1999-04-28 | | Release date: | 1999-08-25 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structure of human pro-matrix metalloproteinase-2: activation mechanism revealed.
Science, 284, 1999
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2OY3
 | | Crystal structure analysis of the monomeric SRCR domain of mouse MARCO | | Descriptor: | MAGNESIUM ION, Macrophage receptor MARCO | | Authors: | Ojala, J.R.M, Pikkarainen, T, Tuuttila, A, Sandalova, T, Tryggvason, K. | | Deposit date: | 2007-02-21 | | Release date: | 2007-04-17 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.78 Å) | | Cite: | Crystal structure of the cysteine-rich domain of scavenger receptor MARCO reveals the presence of a basic and an acidic cluster that both contribute to ligand recognition.
J.Biol.Chem., 282, 2007
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2OYA
 | | Crystal structure analysis of the dimeric form of the SRCR domain of mouse MARCO | | Descriptor: | Macrophage receptor MARCO, SULFATE ION | | Authors: | Ojala, J.R.M, Pikkarainen, T, Tuuttila, A, Sandalova, T, Tryggvason, K. | | Deposit date: | 2007-02-21 | | Release date: | 2007-04-17 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.77 Å) | | Cite: | Crystal structure of the cysteine-rich domain of scavenger receptor MARCO reveals the presence of a basic and an acidic cluster that both contribute to ligand recognition.
J.Biol.Chem., 282, 2007
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1N8Z
 | | Crystal structure of extracellular domain of human HER2 complexed with Herceptin Fab | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Herceptin Fab (antibody) - heavy chain, Herceptin Fab (antibody) - light chain, ... | | Authors: | Cho, H.-S, Mason, K, Ramyar, K.X, Stanley, A.M, Gabelli, S.B, Denney Jr, D.W, Leahy, D.J. | | Deposit date: | 2002-11-21 | | Release date: | 2003-02-18 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.52 Å) | | Cite: | Structure of the Extracellular Region of HER2 Alone and in Complex with the Herceptin Fab
Nature, 421, 2003
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1N8Y
 | | Crystal structure of the extracellular region of rat HER2 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, protooncoprotein | | Authors: | Cho, H.-S, Mason, K, Ramyar, K.X, Stanley, A.M, Gabelli, S.B, Denney Jr, D.W, Leahy, D.J. | | Deposit date: | 2002-11-21 | | Release date: | 2003-02-18 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structure of the Extracellular Region of HER2 Alone and in complex with the Herceptin Fab
Nature, 421, 2003
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8TN9
 | | Structural architecture of the acidic region of the B domain of coagulation factor V | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Coagulation factor V | | Authors: | Mohammed, B.M, Basore, K, Summers, B, Pelc, L.A, Di Cera, E. | | Deposit date: | 2023-08-01 | | Release date: | 2023-10-04 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.05 Å) | | Cite: | Structural architecture of the acidic region of the B domain of coagulation factor V.
J.Thromb.Haemost., 22, 2024
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8UF7
 | | Cryo-EM structure of POmAb, a Type-I anti-prothrombin antiphospholipid antibody, bound to kringle-1 of human prothrombin | | Descriptor: | POmAb Heavy Chain, POmAb Light Chain, Prothrombin | | Authors: | Kumar, S, Summers, B, Basore, K, Pozzi, N. | | Deposit date: | 2023-10-03 | | Release date: | 2024-02-14 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Cryo-EM structure and functional basis of prothrombin recognition by a type I antiprothrombin antiphospholipid antibody.
Blood, 143, 2024
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8FPT
 | | STRUCTURE OF ALPHA-SYNUCLEIN FIBRILS DERIVED FROM HUMAN LEWY BODY DEMENTIA TISSUE | | Descriptor: | Alpha-synuclein | | Authors: | Barclay, A.M, Dhavale, D.D, Borcik, C.G, Rau, M.J, Basore, K, Milchberg, M.H, Warmuth, O.A, Kotzbauer, P.T, Rienstra, C.M, Schwieters, C.D. | | Deposit date: | 2023-01-05 | | Release date: | 2023-02-22 | | Last modified: | 2024-05-15 | | Method: | SOLID-STATE NMR | | Cite: | Structure of alpha-synuclein fibrils derived from human Lewy body dementia tissue.
Biorxiv, 2023
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4PP7
 | | Highly Potent and Selective 3-N-methylquinazoline-4(3H)-one Based Inhibitors of B-RafV600E Kinase | | Descriptor: | N-{2,4-difluoro-3-[methyl(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}propane-1-sulfonamide, Serine/threonine-protein kinase B-raf | | Authors: | Wenglowsky, S, Ren, L, Grina, J, Hansen, J.D, Laird, E.R, Moreno, D, Dinkel, V, Gloor, S.L, Hastings, G, Rana, S, Rasor, K, Sturgis, H.L, Voegtli, W.C, Vigers, G.P.A, Willis, B, Mathieu, S, Rudolph, J. | | Deposit date: | 2014-02-26 | | Release date: | 2014-04-09 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | Highly potent and selective 3-N-methylquinazoline-4(3H)-one based inhibitors of B-Raf(V600E) kinase.
Bioorg.Med.Chem.Lett., 24, 2014
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1GXD
 | | proMMP-2/TIMP-2 complex | | Descriptor: | 72 KDA TYPE IV COLLAGENASE, CALCIUM ION, METALLOPROTEINASE INHIBITOR 2, ... | | Authors: | Morgunova, E, Tuuttila, A, Bergmann, U, Tryggvason, K. | | Deposit date: | 2002-04-02 | | Release date: | 2002-07-09 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structural Insight Into the Complex Formation of Latent Matrix Metalloproteinase 2 with Tissue Inhibitor of Metalloproteinase 2
Proc.Natl.Acad.Sci.USA, 99, 2002
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2ZIS
 | | Crystal Structure of rat protein farnesyltransferase complexed with a bezoruran inhibitor and FPP | | Descriptor: | 3-{2-[(S)-(4-cyanophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl]-5-nitro-1-benzofuran-7-yl}benzonitrile, ACETIC ACID, FARNESYL DIPHOSPHATE, ... | | Authors: | Fukami, T.A, Sogabe, S, Nagata, Y, Kondoh, O, Ishii, N. | | Deposit date: | 2008-02-22 | | Release date: | 2009-02-24 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Synthesis and structure-activity relationships of novel benzofuran farnesyltransferase inhibitors
Bioorg.Med.Chem.Lett., 19, 2009
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2ZIR
 | | Crystal Structure of rat protein farnesyltransferase complexed with a benzofuran inhibitor and FPP | | Descriptor: | 2-[(S)-(4-chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl]-N-morpholin-4-yl-7-phenyl-1-benzofuran-5-carboxamide, FARNESYL DIPHOSPHATE, GLYCEROL, ... | | Authors: | Fukami, T.A, Sogabe, S, Nagata, Y, Kondoh, O, Ishii, N. | | Deposit date: | 2008-02-22 | | Release date: | 2009-02-24 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Synthesis and structure-activity relationships of novel benzofuran farnesyltransferase inhibitors
Bioorg.Med.Chem.Lett., 19, 2009
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