8GJ9
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8GJA
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![BU of 8gja by Molmil](/molmil-images/mine/8gja) | RAD51C-XRCC3 structure | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, RAD51C, ... | Authors: | Arvai, A.S, Tainer, J.A, Williams, G, Longo, M.A. | Deposit date: | 2023-03-15 | Release date: | 2023-08-16 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | RAD51C-XRCC3 structure and cancer patient mutations define DNA replication roles. Nat Commun, 14, 2023
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8GJ8
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![BU of 8gj8 by Molmil](/molmil-images/mine/8gj8) | RAD51C C-terminal domain | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, RAD51C | Authors: | Arvai, A.S, Tainer, J.A, Williams, G. | Deposit date: | 2023-03-15 | Release date: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | RAD51C-XRCC3 structure and cancer patient mutations define DNA replication roles. Nat Commun, 14, 2023
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4D9S
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![BU of 4d9s by Molmil](/molmil-images/mine/4d9s) | Crystal structure of Arabidopsis thaliana UVR8 (UV Resistance locus 8) | Descriptor: | UVB-resistance protein UVR8 | Authors: | Arvai, A.S, Christie, J.M, Pratt, A.J, Hitomi, K, Getzoff, E.D. | Deposit date: | 2012-01-11 | Release date: | 2012-04-04 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.701 Å) | Cite: | Plant UVR8 Photoreceptor Senses UV-B by Tryptophan-Mediated Disruption of Cross-Dimer Salt Bridges. Science, 335, 2012
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3K3K
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![BU of 3k3k by Molmil](/molmil-images/mine/3k3k) | Crystal structure of dimeric abscisic acid (ABA) receptor pyrabactin resistance 1 (PYR1) with ABA-bound closed-lid and ABA-free open-lid subunits | Descriptor: | (2Z,4E)-5-[(1S)-1-hydroxy-2,6,6-trimethyl-4-oxocyclohex-2-en-1-yl]-3-methylpenta-2,4-dienoic acid, Abscisic acid receptor PYR1 | Authors: | Arvai, A.S, Hitomi, K, Getzoff, E.D. | Deposit date: | 2009-10-02 | Release date: | 2009-11-17 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural mechanism of abscisic acid binding and signaling by dimeric PYR1. Science, 326, 2009
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6X1Z
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![BU of 6x1z by Molmil](/molmil-images/mine/6x1z) | Mre11 dimer in complex with small molecule modulator PFMJ | Descriptor: | (5Z)-5-[(3,4-dimethoxyphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, MAGNESIUM ION, ... | Authors: | Arvai, A.S, Moiani, D, Tainer, J.A. | Deposit date: | 2020-05-19 | Release date: | 2020-06-10 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Fragment- and structure-based drug discovery for developing therapeutic agents targeting the DNA Damage Response. Prog.Biophys.Mol.Biol., 163, 2021
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6X1Y
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![BU of 6x1y by Molmil](/molmil-images/mine/6x1y) | Mre11 dimer in complex with small molecule modulator PFMI | Descriptor: | (5Z)-5-[(3-methoxyphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Nuclease SbcCD subunit D | Authors: | Arvai, A.S, Moiani, D, Tainer, J.A. | Deposit date: | 2020-05-19 | Release date: | 2020-06-10 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Fragment- and structure-based drug discovery for developing therapeutic agents targeting the DNA Damage Response. Prog.Biophys.Mol.Biol., 163, 2021
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1DKS
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![BU of 1dks by Molmil](/molmil-images/mine/1dks) | CKSHS1: HUMAN CYCLIN DEPENDENT KINASE SUBUNIT, TYPE 1 IN COMPLEX WITH PHOSPHATE | Descriptor: | CYCLIN DEPENDENT KINASE SUBUNIT, TYPE 1, PHOSPHATE ION | Authors: | Bourne, Y, Arvai, A.S, Tainer, J.A. | Deposit date: | 1995-11-22 | Release date: | 1996-03-08 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Crystal structure of the human cell cycle protein CksHs1: single domain fold with similarity to kinase N-lobe domain. J.Mol.Biol., 249, 1995
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1DKT
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![BU of 1dkt by Molmil](/molmil-images/mine/1dkt) | CKSHS1: HUMAN CYCLIN DEPENDENT KINASE SUBUNIT, TYPE 1 COMPLEX WITH METAVANADATE | Descriptor: | CYCLIN DEPENDENT KINASE SUBUNIT, TYPE 1, META VANADATE | Authors: | Bourne, Y, Arvai, A.S, Tainer, J.A. | Deposit date: | 1995-11-22 | Release date: | 1996-03-08 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Crystal structure of the human cell cycle protein CksHs1: single domain fold with similarity to kinase N-lobe domain. J.Mol.Biol., 249, 1995
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3SOK
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![BU of 3sok by Molmil](/molmil-images/mine/3sok) | Dichelobacter nodosus pilin FimA | Descriptor: | Fimbrial protein | Authors: | Arvai, A.S, Craig, L, Hartung, S, Wood, T, Kolappan, S, Shin, D.S, Tainer, J.A. | Deposit date: | 2011-06-30 | Release date: | 2011-11-02 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Ultrahigh Resolution and Full-length Pilin Structures with Insights for Filament Assembly, Pathogenic Functions, and Vaccine Potential. J.Biol.Chem., 286, 2011
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3UMV
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![BU of 3umv by Molmil](/molmil-images/mine/3umv) | Eukaryotic Class II CPD photolyase structure reveals a basis for improved UV-tolerance in plants | Descriptor: | 1,2-ETHANEDIOL, Deoxyribodipyrimidine photo-lyase, FLAVIN-ADENINE DINUCLEOTIDE, ... | Authors: | Arvai, A.S, Hitomi, K, Getzoff, E.D, Tainer, J.A. | Deposit date: | 2011-11-14 | Release date: | 2011-12-21 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.705 Å) | Cite: | Eukaryotic Class II Cyclobutane Pyrimidine Dimer Photolyase Structure Reveals Basis for Improved Ultraviolet Tolerance in Plants. J.Biol.Chem., 287, 2012
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3CRW
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![BU of 3crw by Molmil](/molmil-images/mine/3crw) | XPD_APO | Descriptor: | HEXACYANOFERRATE(3-), XPD/Rad3 related DNA helicase | Authors: | Fan, L, Arvai, A.S, Tainer, J.A. | Deposit date: | 2008-04-07 | Release date: | 2008-06-10 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (4 Å) | Cite: | XPD helicase structures and activities: insights into the cancer and aging phenotypes from XPD mutations. Cell(Cambridge,Mass.), 133, 2008
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3CRV
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![BU of 3crv by Molmil](/molmil-images/mine/3crv) | XPD_Helicase | Descriptor: | CITRATE ANION, GLYCEROL, IRON/SULFUR CLUSTER, ... | Authors: | Fan, L, Arvai, A.S, Tainer, J.A. | Deposit date: | 2008-04-07 | Release date: | 2008-06-10 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | XPD helicase structures and activities: insights into the cancer and aging phenotypes from XPD mutations. Cell(Cambridge,Mass.), 133, 2008
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4P94
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![BU of 4p94 by Molmil](/molmil-images/mine/4p94) | The crystal structure of the soluble domain of Sulfolobus acidocaldarius FlaF (residues 35-164) | Descriptor: | Conserved flagellar protein F, SODIUM ION | Authors: | Tsai, C.-L, Arvai, A.S, Ishida, J.P, Tainer, J.A. | Deposit date: | 2014-04-02 | Release date: | 2015-04-22 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.651 Å) | Cite: | FlaF Is a beta-Sandwich Protein that Anchors the Archaellum in the Archaeal Cell Envelope by Binding the S-Layer Protein. Structure, 23, 2015
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4PPE
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![BU of 4ppe by Molmil](/molmil-images/mine/4ppe) | human RNF4 RING domain | Descriptor: | E3 ubiquitin-protein ligase RNF4, ZINC ION | Authors: | Perry, J.J, Arvai, A.S, Hitomi, C, Tainer, J.A. | Deposit date: | 2014-02-26 | Release date: | 2014-03-26 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | RNF4 interacts with both SUMO and nucleosomes to promote the DNA damage response. Embo Rep., 15, 2014
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1MRP
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![BU of 1mrp by Molmil](/molmil-images/mine/1mrp) | FERRIC-BINDING PROTEIN FROM HAEMOPHILUS INFLUENZAE | Descriptor: | FE (III) ION, FERRIC IRON BINDING PROTEIN, PHOSPHATE ION | Authors: | Bruns, C.M, Nowalk, A.J, Arvai, A.S, Mctigue, M.A, Vaughan, K.G, Mietzner, T.A, Mcree, D.E. | Deposit date: | 1997-05-14 | Release date: | 1998-01-28 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structure of Haemophilus influenzae Fe(+3)-binding protein reveals convergent evolution within a superfamily. Nat.Struct.Biol., 4, 1997
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1UGH
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![BU of 1ugh by Molmil](/molmil-images/mine/1ugh) | CRYSTAL STRUCTURE OF HUMAN URACIL-DNA GLYCOSYLASE IN COMPLEX WITH A PROTEIN INHIBITOR: PROTEIN MIMICRY OF DNA | Descriptor: | PROTEIN (URACIL-DNA GLYCOSYLASE INHIBITOR), PROTEIN (URACIL-DNA GLYCOSYLASE) | Authors: | Mol, C.D, Arvai, A.S, Sanderson, R.J, Slupphaug, G, Kavli, B, Krokan, H.E, Mosbaugh, D.W, Tainer, J.A. | Deposit date: | 1999-02-05 | Release date: | 1999-02-16 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of human uracil-DNA glycosylase in complex with a protein inhibitor: protein mimicry of DNA. Cell(Cambridge,Mass.), 82, 1995
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1QOM
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![BU of 1qom by Molmil](/molmil-images/mine/1qom) | MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DIMER (DELTA 65) WITH SWAPPED N-TERMINAL HOOK | Descriptor: | 5,6,7,8-TETRAHYDROBIOPTERIN, NITRIC OXIDE SYNTHASE, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Crane, B.R, Rosenfeld, R.A, Arvai, A.S, Tainer, J.A, Stuehr, D.J, Getzoff, E.D. | Deposit date: | 1999-11-15 | Release date: | 1999-12-15 | Last modified: | 2019-10-09 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | N-Terminal Domain Swapping and Metal Ion Binding in Nitric Oxide Synthase Dimerization Embo J., 18, 1999
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6ASC
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![BU of 6asc by Molmil](/molmil-images/mine/6asc) | Mre11 dimer in complex with Endonuclease inhibitor PFM04 | Descriptor: | (5E)-3-butyl-5-[(4-hydroxyphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one, 1,2-ETHANEDIOL, MANGANESE (II) ION, ... | Authors: | Moiani, D, Arvai, A.S, Tainer, J.A. | Deposit date: | 2017-08-24 | Release date: | 2018-03-07 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Targeting Allostery with Avatars to Design Inhibitors Assessed by Cell Activity: Dissecting MRE11 Endo- and Exonuclease Activities. Meth. Enzymol., 601, 2018
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5UM9
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![BU of 5um9 by Molmil](/molmil-images/mine/5um9) | Flap endonuclease 1 (FEN1) D86N with 5'-flap substrate DNA and Sm3+ | Descriptor: | DNA (5'-D(*AP*CP*CP*GP*TP*CP*C)-3'), DNA (5'-D(*AP*CP*TP*CP*TP*GP*CP*CP*TP*CP*AP*AP*GP*AP*CP*GP*GP*T)-3'), DNA (5'-D(P*TP*CP*TP*TP*GP*AP*GP*GP*CP*AP*GP*AP*GP*T)-3'), ... | Authors: | Tsutakawa, S.E, Arvai, A.S, Tainer, J.A. | Deposit date: | 2017-01-26 | Release date: | 2017-06-28 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.805 Å) | Cite: | Phosphate steering by Flap Endonuclease 1 promotes 5'-flap specificity and incision to prevent genome instability. Nat Commun, 8, 2017
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8TLY
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8TUK
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![BU of 8tuk by Molmil](/molmil-images/mine/8tuk) | Alvinella ASCC1 KH and Phosphodiesterase/Ligase Domain | Descriptor: | 1,2-ETHANEDIOL, Activating signal cointegrator 1 complex subunit 1, IMIDAZOLE | Authors: | Tsutakawa, S.E, Tainer, J.A, Arvai, A.S, Chinnam, N.B. | Deposit date: | 2023-08-16 | Release date: | 2024-07-10 | Method: | X-RAY DIFFRACTION (1.15 Å) | Cite: | ASCC1 structures and bioinformatics reveal a novel helix-clasp-helix RNA-binding motif linked to a two-histidine phosphodiesterase. J.Biol.Chem., 300, 2024
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4YDS
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4ZBH
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5K97
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![BU of 5k97 by Molmil](/molmil-images/mine/5k97) | Flap endonuclease 1 (FEN1) D233N with cleaved product fragment and Sm3+ | Descriptor: | 1,2-ETHANEDIOL, DNA (5'-D(*AP*CP*CP*GP*TP*CP*C)-3'), DNA (5'-D(*AP*CP*TP*CP*TP*GP*CP*CP*TP*CP*AP*AP*GP*AP*CP*GP*GP*T)-3'), ... | Authors: | Tsutakawa, S.E, Arvai, A.S, Tainer, J.A. | Deposit date: | 2016-05-31 | Release date: | 2017-06-28 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.102 Å) | Cite: | Phosphate steering by Flap Endonuclease 1 promotes 5'-flap specificity and incision to prevent genome instability. Nat Commun, 8, 2017
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