4PRO
 
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1Z5V
 | | Crystal structure of human gamma-tubulin bound to GTPgammaS | | Descriptor: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, Tubulin gamma-1 chain | | Authors: | Aldaz, H.A, Rice, L.M, Stearns, T, Agard, D.A. | | Deposit date: | 2005-03-20 | | Release date: | 2005-05-31 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.71 Å) | | Cite: | Insights into microtubule nucleation from the crystal structure of human gamma-tubulin.
Nature, 435, 2005
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1Z5W
 | | Crystal Structure of gamma-tubulin bound to GTP | | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Tubulin gamma-1 chain | | Authors: | Aldaz, H.A, Rice, L.M, Stearns, T, Agard, D.A. | | Deposit date: | 2005-03-20 | | Release date: | 2005-05-31 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Insights into microtubule nucleation from the crystal structure of human gamma-tubulin.
Nature, 435, 2005
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3URE
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3URC
 | | T181G mutant of alpha-Lytic Protease | | Descriptor: | Alpha-lytic protease, GLYCEROL, SULFATE ION | | Authors: | Kelch, B.A, Agard, D.A. | | Deposit date: | 2011-11-22 | | Release date: | 2012-05-23 | | Last modified: | 2019-07-17 | | Method: | X-RAY DIFFRACTION (1.1 Å) | | Cite: | Functional modulation of a protein folding landscape via side-chain distortion.
Proc.Natl.Acad.Sci.USA, 109, 2012
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3URD
 | | T181A mutant of alpha-Lytic Protease | | Descriptor: | Alpha-lytic protease, GLYCEROL, SULFATE ION | | Authors: | Kelch, B.A, Agard, D.A. | | Deposit date: | 2011-11-22 | | Release date: | 2012-05-23 | | Last modified: | 2019-07-17 | | Method: | X-RAY DIFFRACTION (1.08 Å) | | Cite: | Functional modulation of a protein folding landscape via side-chain distortion.
Proc.Natl.Acad.Sci.USA, 109, 2012
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4IPE
 | | Crystal structure of mitochondrial Hsp90 (TRAP1) with AMPPNP | | Descriptor: | COBALT (II) ION, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | Authors: | Partridge, J.R, Lavery, L.A, Agard, D.A. | | Deposit date: | 2013-01-09 | | Release date: | 2014-01-22 | | Last modified: | 2014-08-27 | | Method: | X-RAY DIFFRACTION (2.289 Å) | | Cite: | Structural asymmetry in the closed state of mitochondrial Hsp90 (TRAP1) supports a two-step ATP hydrolysis mechanism.
Mol.Cell, 53, 2014
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4J0B
 | | Structure of mitochondrial Hsp90 (TRAP1) with ADP-BeF3 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, COBALT (II) ION, ... | | Authors: | Partridge, J.R, Lavery, L.A, Agard, D.A. | | Deposit date: | 2013-01-30 | | Release date: | 2014-01-22 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.352 Å) | | Cite: | Structural asymmetry in the closed state of mitochondrial Hsp90 (TRAP1) supports a two-step ATP hydrolysis mechanism.
Mol.Cell, 53, 2014
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4IVG
 | | Crystal structure of mitochondrial Hsp90 (TRAP1) NTD-Middle domain dimer with AMPPNP | | Descriptor: | MAGNESIUM ION, PHOSPHATE ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | Authors: | Partridge, J.R, Lavery, L.A, Agard, D.A. | | Deposit date: | 2013-01-22 | | Release date: | 2014-01-22 | | Last modified: | 2014-08-27 | | Method: | X-RAY DIFFRACTION (1.749 Å) | | Cite: | Structural asymmetry in the closed state of mitochondrial Hsp90 (TRAP1) supports a two-step ATP hydrolysis mechanism.
Mol.Cell, 53, 2014
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4IYN
 | | Structure of mitochondrial Hsp90 (TRAP1) with ADP-ALF4- | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, COBALT (II) ION, MAGNESIUM ION, ... | | Authors: | Partridge, J.R, Lavery, L.A, Agard, D.A. | | Deposit date: | 2013-01-28 | | Release date: | 2014-01-22 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.312 Å) | | Cite: | Structural asymmetry in the closed state of mitochondrial Hsp90 (TRAP1) supports a two-step ATP hydrolysis mechanism.
Mol.Cell, 53, 2014
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3CB2
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3J4S
 | | Helical Model of TubZ-Bt four-stranded filament | | Descriptor: | FtsZ/tubulin-related protein, GUANOSINE-5'-DIPHOSPHATE | | Authors: | Montabana, E.A, Agard, D.A. | | Deposit date: | 2013-10-03 | | Release date: | 2014-02-19 | | Last modified: | 2024-02-28 | | Method: | ELECTRON MICROSCOPY (6.8 Å) | | Cite: | Bacterial tubulin TubZ-Bt transitions between a two-stranded intermediate and a four-stranded filament upon GTP hydrolysis.
Proc.Natl.Acad.Sci.USA, 111, 2014
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3J9I
 | | Thermoplasma acidophilum 20S proteasome | | Descriptor: | Proteasome subunit alpha, Proteasome subunit beta | | Authors: | Li, X, Mooney, P, Zheng, S, Booth, C, Braunfeld, M.B, Gubbens, S, Agard, D.A, Cheng, Y. | | Deposit date: | 2015-02-02 | | Release date: | 2015-02-18 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Electron counting and beam-induced motion correction enable near-atomic-resolution single-particle cryo-EM.
Nat.Methods, 10, 2013
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1L2I
 | | Human Estrogen Receptor alpha Ligand-binding Domain in Complex with (R,R)-5,11-cis-diethyl-5,6,11,12-tetrahydrochrysene-2,8-diol and a Glucocorticoid Receptor Interacting Protein 1 NR box II Peptide | | Descriptor: | (R,R)-5,11-CIS-DIETHYL-5,6,11,12-TETRAHYDROCHRYSENE-2,8-DIOL, CHLORIDE ION, ESTROGEN RECEPTOR, ... | | Authors: | Shiau, A.K, Barstad, D, Radek, J.T, Meyers, M.J, Nettles, K.W, Katzenellenbogen, B.S, Katzenellenbogen, J.A, Agard, D.A, Greene, G.L. | | Deposit date: | 2002-02-21 | | Release date: | 2002-05-01 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism.
Nat.Struct.Biol., 9, 2002
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3ERD
 | | HUMAN ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH DIETHYLSTILBESTROL AND A GLUCOCORTICOID RECEPTOR INTERACTING PROTEIN 1 NR BOX II PEPTIDE | | Descriptor: | ACETIC ACID, CHLORIDE ION, DIETHYLSTILBESTROL, ... | | Authors: | Shiau, A.K, Barstad, D, Loria, P.M, Cheng, L, Kushner, P.J, Agard, D.A, Greene, G.L. | | Deposit date: | 1999-03-31 | | Release date: | 1999-04-08 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.03 Å) | | Cite: | The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen.
Cell(Cambridge,Mass.), 95, 1998
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1LPE
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3ERT
 | | HUMAN ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH 4-HYDROXYTAMOXIFEN | | Descriptor: | 4-HYDROXYTAMOXIFEN, PROTEIN (ESTROGEN RECEPTOR ALPHA) | | Authors: | Shiau, A.K, Barstad, D, Loria, P.M, Cheng, L, Kushner, P.J, Agard, D.A, Greene, G.L. | | Deposit date: | 1999-03-30 | | Release date: | 1999-04-08 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen.
Cell(Cambridge,Mass.), 95, 1998
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3PRO
 | | ALPHA-LYTIC PROTEASE COMPLEXED WITH C-TERMINAL TRUNCATED PRO REGION | | Descriptor: | 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE, ALPHA-LYTIC PROTEASE | | Authors: | Sauter, N.K, Mau, T, Rader, S.D, Agard, D.A. | | Deposit date: | 1998-08-26 | | Release date: | 1999-04-27 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structure of alpha-lytic protease complexed with its pro region.
Nat.Struct.Biol., 5, 1998
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6XLF
 | | Full-length Hsc82 in complex with Aha1 in the presence of AMP-PNP | | Descriptor: | ATP-dependent molecular chaperone HSC82, Hsp90 co-chaperone AHA1, MAGNESIUM ION, ... | | Authors: | Liu, Y.X, Sun, M, Myasnikov, A.G, Elnatan, D, Agard, D.A. | | Deposit date: | 2020-06-28 | | Release date: | 2021-06-30 | | Method: | ELECTRON MICROSCOPY (3.15 Å) | | Cite: | Cryo-EM structures reveal a multistep mechanism of Hsp90 activation by co-chaperone Aha1
To Be Published
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6XLC
 | | Full-length Hsc82 bound to AMPPNP | | Descriptor: | ATP-dependent molecular chaperone HSC82, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | Authors: | Liu, Y.X, Sun, M, Myasnikov, A.G, Elnatan, D, Agard, D.A. | | Deposit date: | 2020-06-28 | | Release date: | 2021-06-30 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.66 Å) | | Cite: | Full-length Hsc82 bound to AMPPNP
To Be Published
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6XLB
 | | Apo full-length Hsc82 in complex with Aha1 | | Descriptor: | ATP-dependent molecular chaperone HSC82, Hsp90 co-chaperone AHA1 | | Authors: | Liu, Y.X, Sun, M, Myasnikov, A.G, Elnatan, D, Agard, D.A. | | Deposit date: | 2020-06-28 | | Release date: | 2021-06-30 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Apo full-length Hsc82 in complex with Aha1
To Be Published
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6XLG
 | | Full-length Hsc82 in complex with two Aha1 CTD in the presence of ATPgammaS | | Descriptor: | ATP-dependent molecular chaperone HSC82, Hsp90 co-chaperone AHA1, MAGNESIUM ION, ... | | Authors: | Liu, Y.X, Sun, M, Myasnikov, A.G, Elnatan, D, Agard, D.A. | | Deposit date: | 2020-06-28 | | Release date: | 2021-06-30 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (2.71 Å) | | Cite: | Cryo-EM structures reveal a multistep mechanism of Hsp90 activation by co-chaperone Aha1
To Be Published
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6XLE
 | | Full-length Hsc82 in complex with two Aha1 CTD in the presence of AMP-PNP | | Descriptor: | ATP-dependent molecular chaperone HSC82, Hsp90 co-chaperone AHA1, MAGNESIUM ION, ... | | Authors: | Liu, Y.X, Sun, M, Myasnikov, A.G, Elnatan, D, Agard, D.A. | | Deposit date: | 2020-06-28 | | Release date: | 2021-06-30 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (2.74 Å) | | Cite: | Cryo-EM structures reveal a multistep mechanism of Hsp90 activation by co-chaperone Aha1
To Be Published
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6XLH
 | | Asymmetric hydrolysis state of Hsc82 in complex with Aha1 bound with ADP and ATPgammaS | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent molecular chaperone HSC82, Hsp90 co-chaperone AHA1, ... | | Authors: | Liu, Y.X, Sun, M, Myasnikov, A.G, Elnatan, D, Agard, D.A. | | Deposit date: | 2020-06-28 | | Release date: | 2021-06-30 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (2.83 Å) | | Cite: | Cryo-EM structures reveal a multistep mechanism of Hsp90 activation by co-chaperone Aha1
To Be Published
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6XLD
 | | Full-length Hsc82 in complex with Aha1 CTD in the presence of AMPPNP | | Descriptor: | ATP-dependent molecular chaperone HSC82, Hsp90 co-chaperone AHA1, MAGNESIUM ION, ... | | Authors: | Liu, Y.X, Sun, M, Myasnikov, A.G, Elnatan, D, Agard, D.A. | | Deposit date: | 2020-06-28 | | Release date: | 2021-06-30 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.66 Å) | | Cite: | Full-length Hsc82 in complex with Aha1 CTD in the presence of AMPPNP
To Be Published
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