5IZ6
 
 | | Protein-protein interaction | | 分子名称: | Adenomatous polyposis coli protein, DI(HYDROXYETHYL)ETHER, PHQ-ALA-GLY-GLU-ALA-LEU-TYR-GLU-NH2, ... | | 著者 | Zhao, Y, Jiang, H, Yang, X, Jiang, F, Song, K, Zhang, J. | | 登録日 | 2016-03-25 | | 公開日 | 2017-07-05 | | 最終更新日 | 2024-04-17 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration.
Nat. Chem. Biol., 13, 2017
|
|
6R8P
 | | Notum fragment 723 | | 分子名称: | 2-(2-methylphenoxy)-~{N}-pyridin-3-yl-ethanamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, ... | | 著者 | Zhao, Y, Jones, E.Y. | | 登録日 | 2019-04-02 | | 公開日 | 2019-05-08 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen.
Medchemcomm, 10, 2019
|
|
8JGU
 | |
8JGR
 | |
8JGW
 | |
8JGX
 | |
8JGT
 | |
8JGP
 | |
8JGO
 | |
8JGQ
 | |
6T2H
 | | Furano[2,3-d]prymidine amides as Notum inhibitors | | 分子名称: | 1,2-ETHANEDIOL, 2-[[(4~{S})-5-chloranyl-6-methyl-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-4-yl]sulfanyl]ethanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Zhao, Y, Jones, E.Y. | | 登録日 | 2019-10-08 | | 公開日 | 2020-01-01 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.41 Å) | | 主引用文献 | Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors.
Bioorg.Med.Chem.Lett., 30, 2020
|
|
6T2K
 | | Furano[2,3-d]prymidine amides as Notum inhibitors | | 分子名称: | 1,2-ETHANEDIOL, 2-(6-chloranyl-7-cyclopropyl-thieno[3,2-d]pyrimidin-4-yl)sulfanylethanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Zhao, Y, Jones, E.Y. | | 登録日 | 2019-10-08 | | 公開日 | 2020-01-01 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | | 主引用文献 | Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors.
Bioorg.Med.Chem.Lett., 30, 2020
|
|
8BT7
 | | Notum Inhibitor ARUK3004903 | | 分子名称: | 1,2-ETHANEDIOL, 1-[3,4-bis(chloranyl)-5-methyl-indol-1-yl]ethanone, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Zhao, Y, Jones, E.Y, Fish, P. | | 登録日 | 2022-11-28 | | 公開日 | 2022-12-14 | | 最終更新日 | 2023-06-28 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Designed switch from covalent to non-covalent inhibitors of carboxylesterase Notum activity.
Eur.J.Med.Chem., 251, 2023
|
|
8BT0
 | | Notum Inhibitor ARUK3005518 | | 分子名称: | (3~{a}~{S})-2,2-bis(fluoranyl)-3~{a},4-dihydro-3~{H}-pyrrolo[1,2-a]indol-1-one, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Zhao, Y, Jones, E.Y, Fish, P. | | 登録日 | 2022-11-27 | | 公開日 | 2022-12-14 | | 最終更新日 | 2023-06-28 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Designed switch from covalent to non-covalent inhibitors of carboxylesterase Notum activity.
Eur.J.Med.Chem., 251, 2023
|
|
8BTH
 | | Notum Inhibitor ARUK3004552 | | 分子名称: | 1,2-ETHANEDIOL, 1-(2,3-dihydroindol-1-yl)prop-2-en-1-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Zhao, Y, Jones, E.Y, Fish, P. | | 登録日 | 2022-11-28 | | 公開日 | 2022-12-14 | | 最終更新日 | 2023-06-28 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Designed switch from covalent to non-covalent inhibitors of carboxylesterase Notum activity.
Eur.J.Med.Chem., 251, 2023
|
|
8BT8
 | | Notum Inhibitor ARUK3004048 | | 分子名称: | 1,2-ETHANEDIOL, 1-indol-1-ylethanone, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Zhao, Y, Jones, E.Y, Fish, P. | | 登録日 | 2022-11-28 | | 公開日 | 2022-12-28 | | 最終更新日 | 2023-07-19 | | 実験手法 | X-RAY DIFFRACTION (1.28 Å) | | 主引用文献 | Designed switch from covalent to non-covalent inhibitors of carboxylesterase Notum activity.
Eur.J.Med.Chem., 251, 2023
|
|
8BTC
 | | Notum Inhibitor ARUK3004558 | | 分子名称: | 1,2-ETHANEDIOL, 1-[4,5-bis(chloranyl)-2,3-dihydroindol-1-yl]ethanone, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Zhao, Y, Jones, E.Y, Fish, P. | | 登録日 | 2022-11-28 | | 公開日 | 2022-12-14 | | 最終更新日 | 2023-06-28 | | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | | 主引用文献 | Designed switch from covalent to non-covalent inhibitors of carboxylesterase Notum activity.
Eur.J.Med.Chem., 251, 2023
|
|
8BSZ
 | | Notum Inhibitor ARUK3005522 | | 分子名称: | (3~{a}~{R})-2,3,3~{a},4-tetrahydropyrrolo[1,2-a]indol-1-one, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Zhao, Y, Jones, E.Y, Fish, P. | | 登録日 | 2022-11-27 | | 公開日 | 2022-12-14 | | 最終更新日 | 2023-06-28 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Designed switch from covalent to non-covalent inhibitors of carboxylesterase Notum activity.
Eur.J.Med.Chem., 251, 2023
|
|
8BTE
 | | Notum Inhibitor ARUK3004470 | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, ... | | 著者 | Zhao, Y, Jones, E.Y, Fish, P. | | 登録日 | 2022-11-28 | | 公開日 | 2022-12-14 | | 最終更新日 | 2023-06-28 | | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | | 主引用文献 | Designed switch from covalent to non-covalent inhibitors of carboxylesterase Notum activity.
Eur.J.Med.Chem., 251, 2023
|
|
8BSR
 | | Notum Inhibitor ARUK3006562 | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, ... | | 著者 | Zhao, Y, Jones, E.Y, Fish, P. | | 登録日 | 2022-11-26 | | 公開日 | 2022-12-14 | | 最終更新日 | 2023-06-28 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | Designed switch from covalent to non-covalent inhibitors of carboxylesterase Notum activity.
Eur.J.Med.Chem., 251, 2023
|
|
8BSQ
 | | Notum Inhibitor ARUK3006561 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, Palmitoleoyl-protein carboxylesterase NOTUM, ... | | 著者 | Zhao, Y, Jones, E.Y, Fish, P. | | 登録日 | 2022-11-26 | | 公開日 | 2022-12-14 | | 最終更新日 | 2023-06-28 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | Designed switch from covalent to non-covalent inhibitors of carboxylesterase Notum activity.
Eur.J.Med.Chem., 251, 2023
|
|
8BSP
 | | Notum Inhibitor ARUK3006560 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, Palmitoleoyl-protein carboxylesterase NOTUM, ... | | 著者 | Zhao, Y, Jones, E.Y, Fish, P. | | 登録日 | 2022-11-26 | | 公開日 | 2022-12-14 | | 最終更新日 | 2023-06-28 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Designed switch from covalent to non-covalent inhibitors of carboxylesterase Notum activity.
Eur.J.Med.Chem., 251, 2023
|
|
8BT2
 | | Notum Inhibitor ARUK3004876 | | 分子名称: | 1,2-ETHANEDIOL, 1-[5-chloranyl-4-(trifluoromethyl)-2,3-dihydroindol-1-yl]ethanone, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Zhao, Y, Jones, E.Y, Fish, P. | | 登録日 | 2022-11-27 | | 公開日 | 2022-12-14 | | 最終更新日 | 2023-06-28 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Designed switch from covalent to non-covalent inhibitors of carboxylesterase Notum activity.
Eur.J.Med.Chem., 251, 2023
|
|
8BTA
 | | Notum Inhibitor ARUK3004308 | | 分子名称: | 1,2-ETHANEDIOL, 1-(4-chloranyl-2,3-dihydroindol-1-yl)ethanone, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Zhao, Y, Jones, E.Y, Fish, P. | | 登録日 | 2022-11-28 | | 公開日 | 2022-12-14 | | 最終更新日 | 2023-06-28 | | 実験手法 | X-RAY DIFFRACTION (1.34 Å) | | 主引用文献 | Designed switch from covalent to non-covalent inhibitors of carboxylesterase Notum activity.
Eur.J.Med.Chem., 251, 2023
|
|
8BTI
 | | Notum Inhibitor ARUK3004556 | | 分子名称: | 1,2-ETHANEDIOL, 1-(4-chloranylindol-1-yl)-2-methoxy-ethanone, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Zhao, Y, Jones, E.Y, Fish, P. | | 登録日 | 2022-11-28 | | 公開日 | 2022-12-14 | | 最終更新日 | 2023-06-28 | | 実験手法 | X-RAY DIFFRACTION (1.31 Å) | | 主引用文献 | Designed switch from covalent to non-covalent inhibitors of carboxylesterase Notum activity.
Eur.J.Med.Chem., 251, 2023
|
|
