6KQD
 
 | | Thermus thermophilus initial transcription complex comprising sigma A and 5'-OH RNA of 3 nt | | 分子名称: | 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE, DNA (5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*CP*AP*GP*GP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G*)-3'), ... | | 著者 | Zhang, Y, Li, L, Ebright, R.H. | | 登録日 | 2019-08-17 | | 公開日 | 2020-03-11 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription.
Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
6KQM
 | | Thermus thermophilus initial transcription complex comprising sigma A and 5'-triphosphate RNA of 5 nt | | 分子名称: | DNA (5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G*)-3'), DNA-directed RNA polymerase subunit alpha, ... | | 著者 | Zhang, Y, Li, L, Ebright, R.H. | | 登録日 | 2019-08-18 | | 公開日 | 2020-03-11 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.197 Å) | | 主引用文献 | RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription.
Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
6KQG
 | | Thermus thermophilus initial transcription complex comprising sigma A and 5'-OH RNA of 6 nt | | 分子名称: | DNA (5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G*)-3'), DNA-directed RNA polymerase subunit alpha, ... | | 著者 | Zhang, Y, Li, L, Ebright, R.H. | | 登録日 | 2019-08-17 | | 公開日 | 2020-03-11 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.783 Å) | | 主引用文献 | RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription.
Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
6KQL
 | | Thermus thermophilus initial transcription complex comprising sigma A and 5'-triphosphate RNA of 4 nt | | 分子名称: | DNA (5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*G*)-3'), DNA-directed RNA polymerase subunit alpha, ... | | 著者 | Zhang, Y, Li, L, Ebright, R.H. | | 登録日 | 2019-08-18 | | 公開日 | 2020-03-11 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.89 Å) | | 主引用文献 | RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription.
Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
6KQH
 | | Thermus thermophilus initial transcription complex comprising sigma A and 5'-OH RNA of 7 nt | | 分子名称: | DNA (5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G*)-3'), DNA-directed RNA polymerase subunit alpha, ... | | 著者 | Zhang, Y, Li, L, Ebright, R.H. | | 登録日 | 2019-08-17 | | 公開日 | 2020-03-11 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.18 Å) | | 主引用文献 | RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription.
Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
6KQN
 | | Thermus thermophilus initial transcription complex comprising sigma A and 5'-triphosphate RNA of 6 nt | | 分子名称: | DNA (5'-D(*CP*CP*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G*)-3'), DNA-directed RNA polymerase subunit alpha, ... | | 著者 | Zhang, Y, Li, L, Ebright, R.H. | | 登録日 | 2019-08-18 | | 公開日 | 2020-03-11 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.489 Å) | | 主引用文献 | RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription.
Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
6KQF
 | | Thermus thermophilus initial transcription complex comprising sigma A and 5'-OH RNA of 5 nt | | 分子名称: | DNA (5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G*)-3'), DNA-directed RNA polymerase subunit alpha, ... | | 著者 | Zhang, Y, Li, L, Ebright, R.H. | | 登録日 | 2019-08-17 | | 公開日 | 2020-03-11 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription.
Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
6L74
 | | Thermus thermophilus initial transcription complex comprising sigma A and 5'-triphosphate RNA of 2 nt | | 分子名称: | DNA (5'-D(*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*C)-3'), DNA-directed RNA polymerase subunit alpha, ... | | 著者 | Zhang, Y, Li, L, Ebright, R.H. | | 登録日 | 2019-10-31 | | 公開日 | 2020-03-11 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.12 Å) | | 主引用文献 | RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription.
Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
6LK5
 | | MLKL mutant - T357ES358D | | 分子名称: | Mixed lineage kinase domain-like protein | | 著者 | Wang, H.Y, Li, S, Zhang, Y. | | 登録日 | 2019-12-18 | | 公開日 | 2020-12-23 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | The MLKL kinase-like domain dimerization is an indispensable step of mammalian MLKL activation in necroptosis signaling.
Cell Death Dis, 12, 2021
|
|
6LTS
 | |
6LK6
 | | MLKL mutant - T357AS358A | | 分子名称: | Mixed lineage kinase domain-like protein | | 著者 | Wang, H, Li, S, Zhang, Y. | | 登録日 | 2019-12-18 | | 公開日 | 2020-12-23 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | | 主引用文献 | The MLKL kinase-like domain dimerization is an indispensable step of mammalian MLKL activation in necroptosis signaling.
Cell Death Dis, 12, 2021
|
|
6MIU
 | |
6MJ7
 | | Crystal structure of p62 ZZ domain in complex with free arginine | | 分子名称: | 1,4-DIETHYLENE DIOXIDE, ARGININE, Sequestosome-1, ... | | 著者 | Ahn, J, Zhang, Y, Kutateladze, T.G. | | 登録日 | 2018-09-20 | | 公開日 | 2018-10-31 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.412 Å) | | 主引用文献 | ZZ-dependent regulation of p62/SQSTM1 in autophagy.
Nat Commun, 9, 2018
|
|
6O1E
 | | The crystal structure of human MORC3 ATPase-CW in complex with AMPPNP | | 分子名称: | MAGNESIUM ION, MORC family CW-type zinc finger protein 3, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | 著者 | Klein, B.J, Zhang, Y, Kutateladze, T.G. | | 登録日 | 2019-02-19 | | 公開日 | 2019-03-20 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | | 主引用文献 | Mechanism for autoinhibition and activation of the MORC3 ATPase.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
|
|
6O5W
 | | Crystal structure of MORC3 CW domain fused with viral influenza A NS1 peptide | | 分子名称: | NS1-linked peptide,MORC family CW-type zinc finger protein 3, ZINC ION | | 著者 | Ahn, J, Zhang, Y, Vann, K.R, Kutateleadze, T. | | 登録日 | 2019-03-04 | | 公開日 | 2019-05-08 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.412 Å) | | 主引用文献 | MORC3 Is a Target of the Influenza A Viral Protein NS1.
Structure, 27, 2019
|
|
7EU8
 | | Structure of the human GluN1-GluN2B NMDA receptor in complex with S-ketamine,glycine and glutamate | | 分子名称: | (2~{S})-2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | | 著者 | Zhang, T, Zhang, Y, Zhu, S. | | 登録日 | 2021-05-16 | | 公開日 | 2021-07-28 | | 最終更新日 | 2022-10-26 | | 実験手法 | ELECTRON MICROSCOPY (4.07 Å) | | 主引用文献 | Structural basis of ketamine action on human NMDA receptors.
Nature, 596, 2021
|
|
7KHJ
 | |
7KHK
 | |
7KHG
 | | Crystal structure of KIT kinase domain with a small molecule inhibitor, PLX3397 | | 分子名称: | 5-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-N-{[6-(trifluoromethyl)pyridin-3-yl]methyl}pyridin-2-amine, Mast/stem cell growth factor receptor Kit | | 著者 | Zhang, Y. | | 登録日 | 2020-10-21 | | 公開日 | 2021-07-07 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Association of Combination of Conformation-Specific KIT Inhibitors With Clinical Benefit in Patients With Refractory Gastrointestinal Stromal Tumors: A Phase 1b/2a Nonrandomized Clinical Trial.
Jama Oncol, 7, 2021
|
|
5WVM
 | | Crystal structure of baeS cocrystallized with 2 mM indole | | 分子名称: | Maltose-binding periplasmic protein,Two-component system sensor kinase, SULFATE ION | | 著者 | Wang, W, Zhang, Y, Rang, T, Xu, D. | | 登録日 | 2016-12-26 | | 公開日 | 2018-01-03 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Crystal structure of the sensor domain of BaeS from Serratia marcescens FS14
Proteins, 85, 2017
|
|
5WVN
 | | Crystal structure of MBS-BaeS fusion protein | | 分子名称: | Maltose-binding periplasmic protein,Two-component system sensor kinase, SULFATE ION | | 著者 | Wang, W, Zhang, Y, Ran, T, Xu, D. | | 登録日 | 2016-12-26 | | 公開日 | 2018-01-03 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Crystal structure of the sensor domain of BaeS from Serratia marcescens FS14
Proteins, 85, 2017
|
|
5X21
 | | Crystal structure of Thermus thermophilus transcription initiation complex with GpA and pseudouridimycin (PUM) | | 分子名称: | (1S)-1,4-anhydro-5-[(N-carbamimidoylglycyl-N~2~-hydroxy-L-glutaminyl)amino]-5-deoxy-1-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-D-ribitol, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | | 著者 | Zhang, Y, Ebright, R. | | 登録日 | 2017-01-29 | | 公開日 | 2017-07-05 | | 最終更新日 | 2022-10-12 | | 実験手法 | X-RAY DIFFRACTION (3.323 Å) | | 主引用文献 | Antibacterial Nucleoside-Analog Inhibitor of Bacterial RNA Polymerase.
Cell, 169, 2017
|
|
5X22
 | |
7VMW
 | | Crystal structure of LimF prenyltransferase bound with a peptide substrate and GSPP | | 分子名称: | GERANYL S-THIOLODIPHOSPHATE, LynF/TruF/PatF family peptide O-prenyltransferase, MAGNESIUM ION, ... | | 著者 | Hamada, K, Kobayashi, S, Okada, C, Zhang, Y, Inoue, S, Goto, Y, Suga, H, Ogata, K, Sengoku, T. | | 登録日 | 2021-10-09 | | 公開日 | 2022-08-03 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | | 主引用文献 | LimF is a versatile prenyltransferase for histidine-C-geranylation on diverse non-natural substrates
Nat Catal, 2022
|
|
7VMY
 | | Crystal structure of LimF prenyltransferase bound with GSPP | | 分子名称: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GERANYL S-THIOLODIPHOSPHATE, LynF/TruF/PatF family peptide O-prenyltransferase, ... | | 著者 | Hamada, K, Kobayashi, S, Okada, C, Zhang, Y, Inoue, S, Goto, Y, Suga, H, Ogata, K, Sengoku, T. | | 登録日 | 2021-10-09 | | 公開日 | 2022-08-03 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | | 主引用文献 | LimF is a versatile prenyltransferase for histidine-C-geranylation on diverse non-natural substrates
Nat Catal, 2022
|
|
