1SE0
| Crystal structure of DIAP1 BIR1 bound to a Grim peptide | 分子名称: | Apoptosis 1 inhibitor, Cell death protein Grim, ZINC ION | 著者 | Yan, N, Wu, J.W, Shi, Y. | 登録日 | 2004-02-15 | 公開日 | 2004-04-27 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim. Nat.Struct.Mol.Biol., 11, 2004
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1SDZ
| Crystal structure of DIAP1 BIR1 bound to a Reaper peptide | 分子名称: | Apoptosis 1 inhibitor, Reaper, ZINC ION | 著者 | Yan, N, Wu, J.W, Shi, Y. | 登録日 | 2004-02-15 | 公開日 | 2004-04-27 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim. Nat.Struct.Mol.Biol., 11, 2004
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1TY4
| Crystal structure of a CED-9/EGL-1 complex | 分子名称: | Apoptosis regulator ced-9, EGg Laying defective EGL-1, programmed cell death activator | 著者 | Yan, N, Gu, L, Kokel, D, Xue, D, Shi, Y. | 登録日 | 2004-07-07 | 公開日 | 2004-09-28 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural, Biochemical, and Functional Analyses of CED-9 Recognition by the Proapoptotic Proteins EGL-1 and CED-4 Mol.Cell, 15, 2004
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2FP3
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2A5Y
| Structure of a CED-4/CED-9 complex | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Apoptosis regulator ced-9, MAGNESIUM ION, ... | 著者 | Yan, N, Liu, Q, Hao, Q, Gu, L, Shi, Y. | 登録日 | 2005-07-01 | 公開日 | 2005-10-11 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structure of the CED-4-CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans. Nature, 437, 2005
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4GJP
| Crystal structure of the TAL effector dHax3 bound to dsDNA containing repetitive methyl-CpG | 分子名称: | DNA (5'-D(*AP*GP*AP*GP*AP*CP*GP*CP*GP*AP*AP*GP*GP*GP*AP*CP*A)-3'), DNA (5'-D(*TP*GP*TP*CP*CP*CP*TP*TP*(5CM)P*GP*(5CM)P*GP*TP*CP*TP*CP*T)-3'), Hax3, ... | 著者 | Yan, N, Deng, D, Yan, C.Y, Yin, P, Pan, X.J, Shi, Y.G. | 登録日 | 2012-08-10 | 公開日 | 2012-10-03 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Crystal structure of a protein complex To be Published
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4GJR
| Crystal structure of the TAL effector dHax3 bound to methylated dsDNA | 分子名称: | DNA (5'-D(*AP*GP*GP*GP*AP*GP*GP*TP*AP*GP*AP*GP*GP*GP*AP*CP*A)-3'), DNA (5'-D(*TP*GP*TP*CP*CP*CP*TP*(5CM)P*TP*AP*(5CM)P*CP*TP*CP*(5CM)P*CP*T)-3'), Hax3 | 著者 | Yan, N, Deng, D, Yan, C.Y, Yin, P, Pan, X.J, Shi, Y.G. | 登録日 | 2012-08-10 | 公開日 | 2012-10-03 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Crystal structure of a protein complex To be Published
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6P2J
| Dimeric structure of ACAT1 | 分子名称: | S-{(3R,5R,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9Z)-octadec-9-enethioate (non-preferred name), Sterol O-acyltransferase 1 | 著者 | Yan, N, Qian, H.W. | 登録日 | 2019-05-21 | 公開日 | 2020-05-20 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis for catalysis and substrate specificity of human ACAT1. Nature, 581, 2020
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6P2P
| Tetrameric structure of ACAT1 | 分子名称: | S-{(3R,5R,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9Z)-octadec-9-enethioate (non-preferred name), Sterol O-acyltransferase 1 | 著者 | Yan, N, Qian, H.W. | 登録日 | 2019-05-21 | 公開日 | 2020-05-20 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural basis for catalysis and substrate specificity of human ACAT1. Nature, 581, 2020
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7MIY
| Human N-type voltage-gated calcium channel Cav2.2 at 3.1 Angstrom resolution | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Yan, N, Gao, S, Yao, X. | 登録日 | 2021-04-18 | 公開日 | 2021-07-07 | 最終更新日 | 2021-08-18 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structure of human Ca v 2.2 channel blocked by the painkiller ziconotide. Nature, 596, 2021
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7MIX
| Human N-type voltage-gated calcium channel Cav2.2 in the presence of ziconotide at 3.0 Angstrom resolution | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Yan, N, Gao, S, Yao, X. | 登録日 | 2021-04-18 | 公開日 | 2021-07-07 | 最終更新日 | 2021-08-18 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structure of human Ca v 2.2 channel blocked by the painkiller ziconotide. Nature, 596, 2021
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8X93
| P/Q type calcium channel in complex with omega-Agatoxin IVA | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Yan, N, Li, Z, Cong, Y, Wu, T, Wang, T. | 登録日 | 2023-11-29 | 公開日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (2.92 Å) | 主引用文献 | Structural basis for different omega-agatoxin IVA sensitivities of the P-type and Q-type Ca v 2.1 channels. Cell Res., 2024
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8XMO
| Voltage-gated sodium channel Nav1.7 variant M4 | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Yan, N, Li, Z, Wu, Q, Huang, G. | 登録日 | 2023-12-27 | 公開日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.39 Å) | 主引用文献 | Dissection of the structure-function relationship of Na v channels. Proc.Natl.Acad.Sci.USA, 121, 2024
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8X90
| P/Q type calcium channel | 分子名称: | 1,2-DIDECANOYL-SN-GLYCERO-3-[PHOSPHO-L-SERINE], 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Yan, N, Li, Z, Cong, Y, Wu, T, Wang, T. | 登録日 | 2023-11-29 | 公開日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (2.95 Å) | 主引用文献 | Structural basis for different omega-agatoxin IVA sensitivities of the P-type and Q-type Ca v 2.1 channels. Cell Res., 2024
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8XMM
| Voltage-gated sodium channel Nav1.7 variant M9 | 分子名称: | (2S,3R,4E)-2-(acetylamino)-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | 著者 | Yan, N, Li, Z, Wu, Q, Huang, G. | 登録日 | 2023-12-27 | 公開日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (2.89 Å) | 主引用文献 | Dissection of the structure-function relationship of Na v channels. Proc.Natl.Acad.Sci.USA, 121, 2024
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8XMN
| Voltage-gated sodium channel Nav1.7 variant M2 | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Yan, N, Li, Z, Wu, Q, Huang, G. | 登録日 | 2023-12-27 | 公開日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.37 Å) | 主引用文献 | Dissection of the structure-function relationship of Na v channels. Proc.Natl.Acad.Sci.USA, 121, 2024
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8X91
| P/Q type calcium channel in complex with omega-conotoxin MVIIC | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Yan, N, Li, Z, Cong, Y, Wu, T, Wang, T. | 登録日 | 2023-11-29 | 公開日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.11 Å) | 主引用文献 | Structural basis for different omega-agatoxin IVA sensitivities of the P-type and Q-type Ca v 2.1 channels. Cell Res., 2024
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6DMB
| Cryo-EM structure of human Ptch1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ... | 著者 | Yan, N, Gong, X, Qian, H.W. | 登録日 | 2018-06-04 | 公開日 | 2018-07-11 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Structural basis for the recognition of Sonic Hedgehog by human Patched1. Science, 361, 2018
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6DMY
| Cryo-EM structure of human Ptch1 and ShhN complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Yan, N, Gong, X, Qian, H.W. | 登録日 | 2018-06-05 | 公開日 | 2018-07-11 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural basis for the recognition of Sonic Hedgehog by human Patched1. Science, 361, 2018
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6DMO
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7W9K
| Cryo-EM structure of human Nav1.7-beta1-beta2 complex at 2.2 angstrom resolution | 分子名称: | (2S,3R,4E)-2-(acetylamino)-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | 著者 | Yan, N, Huang, G, Liu, D, Wei, P, Shen, H. | 登録日 | 2021-12-09 | 公開日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (2.2 Å) | 主引用文献 | High-resolution structures of human Na v 1.7 reveal gating modulation through alpha-pi helical transition of S6 IV. Cell Rep, 39, 2022
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7W9L
| Cryo-EM structure of human Nav1.7(E406K)-beta1-beta2 complex | 分子名称: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | 著者 | Yan, N, Huang, G, Liu, D, Wei, P, Shen, H. | 登録日 | 2021-12-10 | 公開日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | High-resolution structures of human Na v 1.7 reveal gating modulation through alpha-pi helical transition of S6 IV. Cell Rep, 39, 2022
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3NEG
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3NEF
| High-resolution pyrabactin-bound PYL1 structure | 分子名称: | 4-bromo-N-(pyridin-2-ylmethyl)naphthalene-1-sulfonamide, Abscisic acid receptor PYL1 | 著者 | Yan, N. | 登録日 | 2010-06-08 | 公開日 | 2010-06-16 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Functional mechanism of the ABA agonist pyrabactin J.Biol.Chem., 285, 2010
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3NR4
| Pyrabactin-bound PYL2 | 分子名称: | 4-bromo-N-(pyridin-2-ylmethyl)naphthalene-1-sulfonamide, Abscisic acid receptor PYL2 | 著者 | Yan, N. | 登録日 | 2010-06-30 | 公開日 | 2010-07-14 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.006 Å) | 主引用文献 | Single amino acid alteration between Valine and Isoleucine determines the distinct pyrabactin selectivity by PYL1 and PYL2 J.Biol.Chem., 285, 2010
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