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6YEP
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BU of 6yep by Molmil
LNA modified G-quadruplex with flipped G-tract and central tetrad
Descriptor: DNA (5'-D(*GP*GP*GP*AP*TP*GP*GP*GP*AP*CP*AP*CP*AP*G)-R(P*(LCG))-D(P*GP*GP*AP*CP*GP*GP*G)-3')
Authors:Weisz, K, Haase, L.
Deposit date:2020-03-25
Release date:2020-09-02
Last modified:2020-10-21
Method:SOLUTION NMR
Cite:Locked nucleic acid building blocks as versatile tools for advanced G-quadruplex design.
Nucleic Acids Res., 48, 2020
6YCV
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BU of 6ycv by Molmil
2'-F-riboguanosine and LNA modified hybrid type G-quadruplex with V-loop
Descriptor: DNA (5'-D(*GP*GP*GP*AP*TP*GP*GP*GP*AP*CP*AP*CP*AP*(GF2))-R(P*(LCG))-D(P*GP*GP*AP*CP*GP*GP*G)-3')
Authors:Weisz, K, Haase, L.
Deposit date:2020-03-19
Release date:2020-09-02
Last modified:2020-10-21
Method:SOLUTION NMR
Cite:Locked nucleic acid building blocks as versatile tools for advanced G-quadruplex design.
Nucleic Acids Res., 48, 2020
7PER
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BU of 7per by Molmil
Model of the inner ring of the human nuclear pore complex
Descriptor: Nuclear pore complex protein Nup155, Nuclear pore complex protein Nup205, Nuclear pore complex protein Nup93, ...
Authors:Schuller, A.P, Wojtynek, M, Mankus, D, Tatli, M, Kronenberg-Tenga, R, Regmi, S.G, Dasso, M, Weis, K, Medalia, O, Schwartz, T.U.
Deposit date:2021-08-11
Release date:2021-10-20
Last modified:2021-11-24
Method:ELECTRON MICROSCOPY (35 Å)
Cite:The cellular environment shapes the nuclear pore complex architecture.
Nature, 598, 2021
7PEQ
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BU of 7peq by Molmil
Model of the outer rings of the human nuclear pore complex
Descriptor: Nuclear pore complex protein Nup107, Nuclear pore complex protein Nup133, Nuclear pore complex protein Nup160, ...
Authors:Schuller, A.P, Wojtynek, M, Mankus, D, Tatli, M, Kronenberg-Tenga, R, Regmi, S.G, Dasso, M, Weis, K, Medalia, O, Schwartz, T.U.
Deposit date:2021-08-11
Release date:2021-10-20
Last modified:2021-11-24
Method:ELECTRON MICROSCOPY (35 Å)
Cite:The cellular environment shapes the nuclear pore complex architecture.
Nature, 598, 2021
3GFP
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BU of 3gfp by Molmil
Structure of the C-terminal domain of the DEAD-box protein Dbp5
Descriptor: DEAD box protein 5
Authors:Erzberger, J.P, Dossani, Z.Y, Weirich, C.S, Weis, K, Berger, J.M.
Deposit date:2009-02-27
Release date:2009-09-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of the C-terminus of the mRNA export factor Dbp5 reveals the interaction surface for the ATPase activator Gle1
Proc.Natl.Acad.Sci.USA, 106, 2009
1XIP
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BU of 1xip by Molmil
Crystal Structure of the N-terminal Domain of Nup159
Descriptor: Nucleoporin NUP159
Authors:Weirich, C.S, Erzberger, J.P, Berger, J.M, Weis, K.
Deposit date:2004-09-21
Release date:2004-12-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The N-Terminal Domain of Nup159 Forms a beta-Propeller that Functions in mRNA Export by Tethering the Helicase Dbp5 to the Nuclear Pore
Mol.Cell, 16, 2004
1QGR
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BU of 1qgr by Molmil
STRUCTURE OF IMPORTIN BETA BOUND TO THE IBB DOMAIN OF IMPORTIN ALPHA (II CRYSTAL FORM, GROWN AT LOW PH)
Descriptor: PROTEIN (IMPORTIN ALPHA-2 SUBUNIT), PROTEIN (IMPORTIN BETA SUBUNIT)
Authors:Cingolani, G, Petosa, C, Weis, K, Muller, C.W.
Deposit date:1999-05-04
Release date:1999-05-24
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of importin-beta bound to the IBB domain of importin-alpha.
Nature, 399, 1999
1QGK
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BU of 1qgk by Molmil
STRUCTURE OF IMPORTIN BETA BOUND TO THE IBB DOMAIN OF IMPORTIN ALPHA
Descriptor: PROTEIN (IMPORTIN ALPHA-2 SUBUNIT), PROTEIN (IMPORTIN BETA SUBUNIT)
Authors:Cingolani, G, Petosa, C, Weis, K, Muller, C.W.
Deposit date:1999-04-29
Release date:1999-05-24
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of importin-beta bound to the IBB domain of importin-alpha.
Nature, 399, 1999
3PEU
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BU of 3peu by Molmil
S. cerevisiae Dbp5 L327V C-terminal domain bound to Gle1 H337R and IP6
Descriptor: ATP-dependent RNA helicase DBP5, GLYCEROL, INOSITOL HEXAKISPHOSPHATE, ...
Authors:Montpetit, B, Thomsen, N.D, Helmke, K.J, Seeliger, M.A, Berger, J.M, Weis, K.
Deposit date:2010-10-27
Release date:2011-03-23
Last modified:2020-10-14
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP(6) in mRNA export.
Nature, 472, 2011
3PEW
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BU of 3pew by Molmil
S. cerevisiae Dbp5 L327V bound to RNA and ADP BeF3
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ATP-dependent RNA helicase DBP5, BERYLLIUM TRIFLUORIDE ION, ...
Authors:Montpetit, B, Thomsen, N.D, Helmke, K.J, Seeliger, M.A, Berger, J.M, Weis, K.
Deposit date:2010-10-27
Release date:2011-03-23
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.501 Å)
Cite:A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP(6) in mRNA export.
Nature, 472, 2011
3PEV
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BU of 3pev by Molmil
S. cerevisiae Dbp5 L327V C-terminal domain bound to Gle1 and IP6
Descriptor: ATP-dependent RNA helicase DBP5, GLYCEROL, INOSITOL HEXAKISPHOSPHATE, ...
Authors:Montpetit, B, Thomsen, N.D, Helmke, K.J, Seeliger, M.A, Berger, J.M, Weis, K.
Deposit date:2010-10-27
Release date:2011-03-23
Last modified:2020-10-14
Method:X-RAY DIFFRACTION (2.499 Å)
Cite:A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP(6) in mRNA export.
Nature, 472, 2011
3PEY
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BU of 3pey by Molmil
S. cerevisiae Dbp5 bound to RNA and ADP BeF3
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ATP-dependent RNA helicase DBP5, BERYLLIUM TRIFLUORIDE ION, ...
Authors:Montpetit, B, Thomsen, N.D, Helmke, K.J, Seeliger, M.A, Berger, J.M, Weis, K.
Deposit date:2010-10-27
Release date:2011-03-23
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.401 Å)
Cite:A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP(6) in mRNA export.
Nature, 472, 2011
3RRM
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BU of 3rrm by Molmil
S. cerevisiae dbp5 l327v bound to nup159, gle1 h337r, ip6 and adp
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ATP-dependent RNA helicase DBP5, INOSITOL HEXAKISPHOSPHATE, ...
Authors:Montpetit, B, Thomsen, N.D, Helmke, K.J, Seeliger, M.A, Berger, J.M, Weis, K.
Deposit date:2011-04-29
Release date:2011-05-18
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP6 in mRNA export.
Nature, 472, 2011
3RRN
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BU of 3rrn by Molmil
S. cerevisiae dbp5 l327v bound to gle1 h337r and ip6
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ATP-dependent RNA helicase DBP5, INOSITOL HEXAKISPHOSPHATE, ...
Authors:Montpetit, B, Thomsen, N.D, Helmke, K.J, Seeliger, M.A, Berger, J.M, Weis, K.
Deposit date:2011-04-29
Release date:2011-05-18
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (4.001 Å)
Cite:A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP6 in mRNA export.
Nature, 472, 2011
6R9K
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BU of 6r9k by Molmil
A quadruplex hybrid structure with lpp loop orientation and 3 syn residues
Descriptor: DNA (25-MER)
Authors:Karg, B, Weisz, K.
Deposit date:2019-04-03
Release date:2019-07-03
Last modified:2021-06-23
Method:SOLUTION NMR
Cite:Duplex-Guided Refolding into Novel G-Quadruplex (3+1) Hybrid Conformations.
Angew.Chem.Int.Ed.Engl., 58, 2019
6R9L
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BU of 6r9l by Molmil
A quadruplex hybrid structure with lpp loop orientation and 5 syn residues
Descriptor: DNA (25-MER)
Authors:Karg, B, Weisz, K.
Deposit date:2019-04-03
Release date:2019-07-03
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Duplex-Guided Refolding into Novel G-Quadruplex (3+1) Hybrid Conformations.
Angew.Chem.Int.Ed.Engl., 58, 2019
6BIT
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BU of 6bit by Molmil
SIRPalpha antibody complex
Descriptor: KWAR23 Fab heavy chain, KWAR23 Fab light chain, Tyrosine-protein phosphatase non-receptor type substrate 1
Authors:Ring, N.G, Herndler-Brandstetter, D, Weiskopf, K, Shan, L, Volkmer, J.P, George, B.M, Lietzenmayer, M, McKenna, K.M, Naik, T.J, McCarty, A, Zheng, Y, Ring, A.M, Flavell, R.A, Weissman, I.L.
Deposit date:2017-11-03
Release date:2017-12-06
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (2.191 Å)
Cite:Anti-SIRP alpha antibody immunotherapy enhances neutrophil and macrophage antitumor activity.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
7O1H
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BU of 7o1h by Molmil
Hybrid-2R quadruplex-duplex with (-p-p-l) topology and 3 syn residues
Descriptor: DNA (31-MER)
Authors:Mohr, S, Vianney, Y.M, Weisz, K.
Deposit date:2021-03-29
Release date:2021-05-19
Last modified:2021-07-28
Method:SOLUTION NMR
Cite:Expanding the Topological Landscape by a G-Column Flip of a Parallel G-Quadruplex.
Chemistry, 27, 2021
6TC8
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BU of 6tc8 by Molmil
2'-F-arabinoguanosine and 2'-F-riboguanosine modified hybrid type G-quadruplex with V-loop
Descriptor: DNA (5'-D(*GP*GP*GP*AP*TP*GP*GP*GP*AP*CP*AP*CP*AP*(GFL)P*(GF2)P*GP*GP*AP*CP*GP*GP*G)-3')
Authors:Haase, L, Weisz, K.
Deposit date:2019-11-05
Release date:2020-03-25
Last modified:2020-05-06
Method:SOLUTION NMR
Cite:Switching the type of V-loop in sugar-modified G-quadruplexes through altered fluorine interactions.
Chem.Commun.(Camb.), 56, 2020
6TCG
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BU of 6tcg by Molmil
2'-F-riboguanosine and 2'-F-arabinoguanosine modified G-quadruplex with V-loop and all-syn G-tract
Descriptor: DNA (5'-D(*GP*GP*GP*AP*TP*GP*GP*GP*AP*CP*AP*CP*AP*(GF2)P*(GFL)P*GP*GP*AP*CP*GP*GP*G)-3')
Authors:Haase, L, Weisz, K.
Deposit date:2019-11-06
Release date:2020-03-25
Last modified:2020-05-06
Method:SOLUTION NMR
Cite:Switching the type of V-loop in sugar-modified G-quadruplexes through altered fluorine interactions.
Chem.Commun.(Camb.), 56, 2020
7PNG
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BU of 7png by Molmil
Solution structure of 1:1 complex of an indoloquinoline derivative SYUIQ-5 to parallel quadruplex-duplex (Q-D) hybrid
Descriptor: DNA (37-MER), ~{N}-(5~{H}-indolo[3,2-b]quinolin-11-yl)-~{N}',~{N}'-dimethyl-propane-1,3-diamine
Authors:Vianney, Y.M, Weisz, K.
Deposit date:2021-09-06
Release date:2021-12-29
Last modified:2022-02-16
Method:SOLUTION NMR
Cite:Indoloquinoline Ligands Favor Intercalation at Quadruplex-Duplex Interfaces.
Chemistry, 28, 2022
7PNE
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BU of 7pne by Molmil
Parallel Q-D hybrid with 3' duplex stem-loop as a lateral snapback loop
Descriptor: TTAMycdup-3sbl
Authors:Vianney, Y.M, Weisz, K.
Deposit date:2021-09-06
Release date:2021-12-29
Last modified:2022-02-16
Method:SOLUTION NMR
Cite:Indoloquinoline Ligands Favor Intercalation at Quadruplex-Duplex Interfaces.
Chemistry, 28, 2022
5MBR
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BU of 5mbr by Molmil
Quadruplex with flipped tetrad formed by a human telomeric sequence
Descriptor: G-quadruplex formed by a human telomeric sequence modified with 2'-fluoro-2'-deoxyriboguanosine
Authors:Dickerhoff, J, Haase, L, Langel, W, Weisz, K.
Deposit date:2016-11-08
Release date:2017-04-19
Last modified:2019-05-08
Method:SOLUTION NMR
Cite:Tracing Effects of Fluorine Substitutions on G-Quadruplex Conformational Changes.
ACS Chem. Biol., 12, 2017
5MCR
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BU of 5mcr by Molmil
Quadruplex with flipped tetrad formed by an artificial sequence
Descriptor: Artificial quadruplex with propeller, diagonal and lateral loop
Authors:Dickerhoff, J, Haase, L, Langel, W, Weisz, K.
Deposit date:2016-11-10
Release date:2017-04-19
Last modified:2019-05-08
Method:SOLUTION NMR
Cite:Tracing Effects of Fluorine Substitutions on G-Quadruplex Conformational Changes.
ACS Chem. Biol., 12, 2017
1GS9
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BU of 1gs9 by Molmil
Apolipoprotein E4, 22k domain
Descriptor: APOLIPOPROTEIN E
Authors:Verderame, J.R, Kantardjieff, K, Segelke, B, Weisgraber, K, Rupp, B.
Deposit date:2002-01-02
Release date:2003-06-11
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal Structure of the 22K Domain of Human Apolipoprotein E4
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