6TC8

2'-F-arabinoguanosine and 2'-F-riboguanosine modified hybrid type G-quadruplex with V-loop

Summary for 6TC8

• Entry DOI: 10.2210/pdb6tc8/pdb
• Related: 6RS3
• NMR Information: BMRB: 34444
• Descriptor: DNA (5'-D(*GP*GP*GP*AP*TP*GP*GP*GP*AP*CP*AP*CP*AP*(GFL)P*(GF2)P*GP*GP*AP*CP*GP*GP*G)-3') (1 entity in total)
• Functional Keywords: g-quadruplex, v-loop, dna
• Biological source: synthetic construct
• Total number of polymer chains: 1
• Total formula weight: 7008.47

Authors

Haase, L.,Weisz, K. (deposition date: 2019-11-05, release date: 2020-03-25, Last modification date: 2024-05-15)

Primary citation

Haase, L.,Weisz, K.
Switching the type of V-loop in sugar-modified G-quadruplexes through altered fluorine interactions.
Chem.Commun.(Camb.), 56:4539-4542, 2020

PubMed Abstract: Mixed 2'-F-riboguanosine and 2'-F-arabinoguanosine disubstitutions of a hybrid-type G-quadruplex are found to induce a refolding into two alternative structures with different types of V-loops upon positional exchange of the two G analogs. While conformational preferences of the incorporated G surrogates fail to fully account for the observed rearrangements, additional hydrogen bonds with a fluorine acceptor are suggested to be critical determinants of the two distinct V-loop conformers imposing different tetrad polarities.

PubMed: 32202271
DOI: 10.1039/d0cc01285h

Experimental method

SOLUTION NMR