3KUC
 
 | | Complex of Rap1A(E30D/K31E)GDP with RafRBD(A85K/N71R) | | 分子名称: | CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Filchtinski, D, Sharabi, O, Rueppel, A, Vetter, I.R, Herrmann, C, Shifman, J.M. | | 登録日 | 2009-11-27 | | 公開日 | 2010-03-23 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | | 主引用文献 | What makes Ras an efficient molecular switch: a computational, biophysical, and structural study of Ras-GDP interactions with mutants of Raf.
J.Mol.Biol., 399, 2010
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3L8Y
 | | Complex of Ras with cyclen | | 分子名称: | 1,4,7,10-tetraazacyclododecane, CALCIUM ION, GTPase HRas, ... | | 著者 | Rosnizeck, I.C, Graf, T, Spoerner, M, Traenkle, J, Filchtinski, D, Herrmann, C, Gremer, L, Vetter, I.R, Wittinghofer, A, Koenig, B, Kalbitzer, H.R. | | 登録日 | 2010-01-04 | | 公開日 | 2011-01-05 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | | 主引用文献 | Stabilizing a weak binding state for effectors in the human ras protein by cyclen complexes
Angew.Chem.Int.Ed.Engl., 49, 2010
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3LVQ
 | | The crystal structure of ASAP3 in complex with Arf6 in transition state | | 分子名称: | ALUMINUM FLUORIDE, Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3, ... | | 著者 | Ismail, S.A, Vetter, I.R, Sot, B, Wittinghofer, A. | | 登録日 | 2010-02-22 | | 公開日 | 2010-06-09 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (3.38 Å) | | 主引用文献 | The structure of an Arf-ArfGAP complex reveals a Ca2+ regulatory mechanism
Cell(Cambridge,Mass.), 141, 2010
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3L8Z
 | | H-Ras wildtype new crystal form | | 分子名称: | CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... | | 著者 | Rosnizeck, I.C, Graf, T, Spoerner, M, Traenkle, J, Filchtinski, D, Herrmann, C, Gremer, L, Vetter, I.R, Wittinghofer, A, Koenig, B, Kalbitzer, H.R. | | 登録日 | 2010-01-04 | | 公開日 | 2011-01-05 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.44 Å) | | 主引用文献 | Stabilizing a weak binding state for effectors in the human ras protein by cyclen complexes
Angew.Chem.Int.Ed.Engl., 49, 2010
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3LVR
 | | The crystal structure of ASAP3 in complex with Arf6 in transition state soaked with Calcium | | 分子名称: | ALUMINUM FLUORIDE, Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3, ... | | 著者 | Ismail, S.A, Vetter, I.R, Sot, B, Wittinghofer, A. | | 登録日 | 2010-02-22 | | 公開日 | 2010-06-09 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (3.38 Å) | | 主引用文献 | The structure of an Arf-ArfGAP complex reveals a Ca2+ regulatory mechanism
Cell(Cambridge,Mass.), 141, 2010
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1IAQ
 | | C-H-RAS P21 PROTEIN MUTANT WITH THR 35 REPLACED BY SER (T35S) COMPLEXED WITH GUANOSINE-5'-[B,G-IMIDO] TRIPHOSPHATE | | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, TRANSFORMING PROTEIN P21/H-RAS-1 | | 著者 | Spoerner, M, Herrmann, C, Vetter, I.R, Kalbitzer, H.R, Wittinghofer, A. | | 登録日 | 2001-03-23 | | 公開日 | 2001-06-06 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Dynamic properties of the Ras switch I region and its importance for binding to effectors.
Proc.Natl.Acad.Sci.USA, 98, 2001
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6SZQ
 | | Crystal structure of human DDAH-1 | | 分子名称: | N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 | | 著者 | Hennig, S, Vetter, I.R, Schade, D. | | 登録日 | 2019-10-02 | | 公開日 | 2019-12-25 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.412 Å) | | 主引用文献 | Discovery ofN-(4-Aminobutyl)-N'-(2-methoxyethyl)guanidine as the First Selective, Nonamino Acid, Catalytic Site Inhibitor of Human Dimethylarginine Dimethylaminohydrolase-1 (hDDAH-1).
J.Med.Chem., 63, 2020
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6SZP
 | | High resolution crystal structure of human DDAH-1 in complex with N-(4-Aminobutyl)-N'-(2-Methoxyethyl)guanidine | | 分子名称: | (1~{S})-~{N}'-(4-azanylbutyl)-~{N}"-(2-methoxyethyl)methanetriamine, GLYCEROL, N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 | | 著者 | Hennig, S, Vetter, I.R, Schade, D. | | 登録日 | 2019-10-02 | | 公開日 | 2019-12-25 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | | 主引用文献 | Discovery ofN-(4-Aminobutyl)-N'-(2-methoxyethyl)guanidine as the First Selective, Nonamino Acid, Catalytic Site Inhibitor of Human Dimethylarginine Dimethylaminohydrolase-1 (hDDAH-1).
J.Med.Chem., 63, 2020
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2K0C
 | | Zinc-finger 2 of Nup153 | | 分子名称: | Nuclear pore complex protein Nup153, ZINC ION | | 著者 | Bangert, J.A, Schrader, N, Vetter, I.R, Stoll, R. | | 登録日 | 2008-01-31 | | 公開日 | 2008-07-01 | | 最終更新日 | 2022-03-16 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The Crystal Structure of the Ran-Nup153ZnF2 Complex: a General Ran Docking Site at the Nuclear Pore Complex.
Structure, 16, 2008
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1S1C
 | | Crystal structure of the complex between the human RhoA and Rho-binding domain of human ROCKI | | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Rho-associated, ... | | 著者 | Dvorsky, R, Blumenstein, L, Vetter, I.R, Ahmadian, M.R. | | 登録日 | 2004-01-06 | | 公開日 | 2004-02-10 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural Insights into the Interaction of ROCKI with the Switch Regions of RhoA.
J.Biol.Chem., 279, 2004
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1SRQ
 | | Crystal Structure of the Rap1GAP catalytic domain | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, GTPase-activating protein 1, SULFATE ION | | 著者 | Daumke, O, Weyand, M, Chakrabarti, P.P, Vetter, I.R, Wittinghofer, A. | | 登録日 | 2004-03-23 | | 公開日 | 2004-05-25 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | The GTPase activating protein Rap1GAP uses a catalytic asparagine
Nature, 429, 2004
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1V9D
 | | Crystal structure of the core FH2 domain of mouse mDia1 | | 分子名称: | Diaphanous protein homolog 1, SULFATE ION | | 著者 | Shimada, A, Nyitrai, M, Vetter, I.R, Kuhlmann, D, Bugyi, B, Narumiya, S, Geeves, M.A, Wittinghofer, A. | | 登録日 | 2004-01-24 | | 公開日 | 2004-03-09 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | The core FH2 domain of diaphanous-related formins is an elongated actin binding protein that inhibits polymerization.
Mol.Cell, 13, 2004
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6QNN
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6QNP
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3T1Q
 | | MglA bound to GppNHp in complex with MglB | | 分子名称: | Gliding protein MglB, Gliding protein mglA, MAGNESIUM ION, ... | | 著者 | Miertzschke, M, Vetter, I.R, Koerner, C, Wittinghofer, A. | | 登録日 | 2011-07-22 | | 公開日 | 2011-08-31 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural analysis of the Ras-like G protein MglA and its cognate GAP MglB and implications for bacterial polarity.
Embo J., 30, 2011
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3T1T
 | | MglA bound to GDP in P1 tetrameric arrangement | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, Gliding protein mglA | | 著者 | Miertzschke, M, Vetter, I.R, Koerner, C, Wittinghofer, A. | | 登録日 | 2011-07-22 | | 公開日 | 2011-08-31 | | 最終更新日 | 2011-11-02 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural analysis of the Ras-like G protein MglA and its cognate GAP MglB and implications for bacterial polarity.
Embo J., 30, 2011
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3T1X
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3T1S
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3T1R
 | | MglB with tetrameric arrangement | | 分子名称: | Gliding protein MglB, MAGNESIUM ION | | 著者 | Miertzschke, M, Vetter, I.R, Koerner, C, Wittinghofer, A. | | 登録日 | 2011-07-22 | | 公開日 | 2011-08-31 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural analysis of the Ras-like G protein MglA and its cognate GAP MglB and implications for bacterial polarity.
Embo J., 30, 2011
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3T1O
 | | MglA bound to GDP | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, GUANOSINE-5'-DIPHOSPHATE, Gliding protein mglA, ... | | 著者 | Miertzschke, M, Vetter, I.R, Koerner, C, Wittinghofer, A. | | 登録日 | 2011-07-22 | | 公開日 | 2011-08-31 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural analysis of the Ras-like G protein MglA and its cognate GAP MglB and implications for bacterial polarity.
Embo J., 30, 2011
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3T1V
 | | MglA bound to GDP in P2(1) tetrameric arrangement | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, Gliding protein mglA | | 著者 | Miertzschke, M, Vetter, I.R, Koerner, C, Wittinghofer, A. | | 登録日 | 2011-07-22 | | 公開日 | 2011-08-31 | | 最終更新日 | 2011-11-02 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural analysis of the Ras-like G protein MglA and its cognate GAP MglB and implications for bacterial polarity.
Embo J., 30, 2011
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3T12
 | | MglA in complex with MglB in transition state | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, Gliding protein MglB, Gliding protein mglA, ... | | 著者 | Miertzschke, M, Vetter, I.R, Koerner, C, Wittinghofer, A. | | 登録日 | 2011-07-21 | | 公開日 | 2011-08-31 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structural analysis of the Ras-like G protein MglA and its cognate GAP MglB and implications for bacterial polarity.
Embo J., 30, 2011
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3U0V
 | | Crystal Structure Analysis of human LYPLAL1 | | 分子名称: | Lysophospholipase-like protein 1 | | 著者 | Burger, M, Zimmermann, T.J, Kondoh, Y, Stege, P, Watanabe, N, Osada, H, Waldmann, H, Vetter, I.R. | | 登録日 | 2011-09-29 | | 公開日 | 2011-11-16 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | | 主引用文献 | Crystal structure of the predicted phospholipase LYPLAL1 reveals unexpected functional plasticity despite close relationship to acyl protein thioesterases
J.Lipid Res., 53, 2012
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6EQT
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6EZT
 | | Crystal structure of GH20 Exo beta-N-Acetylglucosaminidase D437A inactive mutant from Vibrio harveyi | | 分子名称: | Beta-N-acetylglucosaminidase Nag2, DI(HYDROXYETHYL)ETHER, TETRAETHYLENE GLYCOL | | 著者 | Porfetye, A.T, Meekrathok, P, Burger, M, Vetter, I.R, Suginta, W. | | 登録日 | 2017-11-16 | | 公開日 | 2018-12-12 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Crystal structure of GH20 Exo beta-N-Acetylglucosaminidase from Vibrio harveyi
To Be Published
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