4HEM
| Llama vHH-02 binder of ORF49 (RBP) from lactococcal phage TP901-1 | Descriptor: | Anti-baseplate TP901-1 Llama vHH 02, BPP | Authors: | Desmyter, A, Spinelli, S, Farenc, C, Blangy, S, Bebeacua, C, van Sinderen, D, Mahony, J, Cambillau, C. | Deposit date: | 2012-10-04 | Release date: | 2013-03-20 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Viral infection modulation and neutralization by camelid nanobodies Proc.Natl.Acad.Sci.USA, 110, 2013
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3BFH
| Crystal structure of a pheromone binding protein from Apis mellifera in complex with hexadecanoic acid | Descriptor: | CHLORIDE ION, PALMITIC ACID, Pheromone-binding protein ASP1 | Authors: | Pesenti, M.E, Spinelli, S, Bezirard, V, Briand, L, Pernollet, J.C, Tegoni, M, Cambillau, C. | Deposit date: | 2007-11-21 | Release date: | 2008-06-10 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis of the honey bee PBP pheromone and pH-induced conformational change J.Mol.Biol., 380, 2008
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3BFB
| Crystal structure of a pheromone binding protein from Apis mellifera in complex with the 9-keto-2(E)-decenoic acid | Descriptor: | (2Z)-9-oxodec-2-enoic acid, CHLORIDE ION, GLYCEROL, ... | Authors: | Pesenti, M.E, Spinelli, S, Bezirard, V, Briand, L, Pernollet, J.C, Tegoni, M, Cambillau, C. | Deposit date: | 2007-11-21 | Release date: | 2008-06-10 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Structural basis of the honey bee PBP pheromone and pH-induced conformational change J.Mol.Biol., 380, 2008
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3BFA
| Crystal structure of a pheromone binding protein from Apis mellifera in complex with the Queen mandibular pheromone | Descriptor: | (2Z)-9-oxodec-2-enoic acid, GLYCEROL, Pheromone-binding protein ASP1 | Authors: | Pesenti, M.E, Spinelli, S, Bezirard, V, Briand, L, Pernollet, J.C, Tegoni, M, Cambillau, C. | Deposit date: | 2007-11-21 | Release date: | 2008-06-10 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structural basis of the honey bee PBP pheromone and pH-induced conformational change J.Mol.Biol., 380, 2008
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5M2J
| Complex between human TNF alpha and Llama VHH2 | Descriptor: | Anti-(ED-B) scFV, Tumor necrosis factor | Authors: | Cambillau, C, Spinelli, S, Desmyter, A, de Haard, H. | Deposit date: | 2016-10-13 | Release date: | 2017-08-30 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Bivalent Llama Single-Domain Antibody Fragments against Tumor Necrosis Factor Have Picomolar Potencies due to Intramolecular Interactions. Front Immunol, 8, 2017
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5M2I
| Structure of human Tumor Necrosis Factor (TNF) in complex with the Llama VHH1 | Descriptor: | Tumor necrosis factor, VHH1 | Authors: | Cambillau, C, Spinelli, S, Desmyter, A, de Haard, H. | Deposit date: | 2016-10-13 | Release date: | 2017-08-30 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Bivalent Llama Single-Domain Antibody Fragments against Tumor Necrosis Factor Have Picomolar Potencies due to Intramolecular Interactions. Front Immunol, 8, 2017
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5M2W
| Structure of nanobody nb18 raised against TssK from E. coli T6SS | Descriptor: | Llama nanobody nb8 against TssK from T6SS, SULFATE ION | Authors: | Cambillau, C, Nguyen, V.S, Spinelli, S, Desmyter, A. | Deposit date: | 2016-10-13 | Release date: | 2017-06-28 | Last modified: | 2017-08-30 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Type VI secretion TssK baseplate protein exhibits structural similarity with phage receptor-binding proteins and evolved to bind the membrane complex. Nat Microbiol, 2, 2017
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5M2Y
| Structure of TssK C-terminal domain from E. coli T6SS | Descriptor: | TssK C | Authors: | Cambillau, C, Nguyen, V.S, Spinelli, S, Desmyter, A, Legrand, P. | Deposit date: | 2016-10-13 | Release date: | 2017-06-28 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.61 Å) | Cite: | Type VI secretion TssK baseplate protein exhibits structural similarity with phage receptor-binding proteins and evolved to bind the membrane complex. Nat Microbiol, 2, 2017
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5MWN
| Structure of the EAEC T6SS component TssK N-terminal domain in complex with llama nanobodies nbK18 and nbK27 | Descriptor: | PHOSPHATE ION, Type VI secretion protein, llama nanobody raised against TssK, ... | Authors: | Cambillau, C, Nguyen, V.S, Spinelli, S, Legrand, P. | Deposit date: | 2017-01-18 | Release date: | 2017-06-28 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Type VI secretion TssK baseplate protein exhibits structural similarity with phage receptor-binding proteins and evolved to bind the membrane complex. Nat Microbiol, 2, 2017
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5LY8
| Structure of the CBM2 module of Lactobacillus casei BL23 phage J-1 evolved Dit. | Descriptor: | MAGNESIUM ION, Tail component | Authors: | Cambillau, C, Spinelli, S, Dieterle, M.-E, Piuri, M. | Deposit date: | 2016-09-26 | Release date: | 2017-03-22 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.28 Å) | Cite: | Evolved distal tail carbohydrate binding modules of Lactobacillus phage J-1: a novel type of anti-receptor widespread among lactic acid bacteria phages. Mol. Microbiol., 104, 2017
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5M2M
| Complex between human TNF alpha and Llama VHH3 | Descriptor: | Llama nanobody VHH3, Tumor necrosis factor | Authors: | Cambillau, C, Spinelli, S, Desmyter, A, de Haard, H. | Deposit date: | 2016-10-13 | Release date: | 2017-08-30 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Bivalent Llama Single-Domain Antibody Fragments against Tumor Necrosis Factor Have Picomolar Potencies due to Intramolecular Interactions. Front Immunol, 8, 2017
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1P28
| The crystal structure of a pheromone binding protein from the cockroach Leucophaea maderae in complex with a component of the pheromonal blend: 3-hydroxy-butan-2-one. | Descriptor: | R,3-HYDROXYBUTAN-2-ONE, S,3-HYDROXYBUTAN-2-ONE, pheromone binding protein | Authors: | Lartigue, A, Gruez, A, Spinelli, S, Riviere, S, Brossut, R, Tegoni, M, Cambillau, C. | Deposit date: | 2003-04-15 | Release date: | 2003-08-05 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | THE CRYSTAL STRUCTURE OF A COCKROACH PHEROMONE-BINDING PROTEIN SUGGESTS A NEW LIGAND BINDING AND RELEASE MECHANISM J.Biol.Chem., 278, 2003
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1ORG
| The crystal structure of a pheromone binding protein from the cockroach Leucophaea maderae reveals a new mechanism of pheromone binding | Descriptor: | GLYCEROL, pheromone binding protein | Authors: | Lartigue, A, Gruez, A, Spinelli, S, Riviere, S, Brossut, R, Tegoni, M, Cambillau, C. | Deposit date: | 2003-03-13 | Release date: | 2003-08-05 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | THE CRYSTAL STRUCTURE OF A COCKROACH PHEROMONE-BINDING PROTEIN SUGGESTS A NEW LIGAND BINDING AND RELEASE MECHANISM J.Biol.Chem., 278, 2003
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3FE6
| Crystal structure of a pheromone binding protein from Apis mellifera with a serendipitous ligand at pH 5.5 | Descriptor: | (20S)-20-methyldotetracontane, CHLORIDE ION, GLYCEROL, ... | Authors: | Pesenti, M.E, Spinelli, S, Bezirard, V, Briand, L, Pernollet, J.C, Tegoni, M, Cambillau, C. | Deposit date: | 2008-11-27 | Release date: | 2009-12-01 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Queen bee pheromone binding protein pH induced domain-swapping favors pheromone release To be Published
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3FE9
| Crystal structure of a pheromone binding protein from Apis mellifera with a serendipitous ligand soaked at pH 7.0 | Descriptor: | (20S)-20-methyldotetracontane, CHLORIDE ION, Pheromone-binding protein ASP1 | Authors: | Pesenti, M.E, Spinelli, S, Bezirard, V, Briand, L, Pernollet, J.C, Tegoni, M, Cambillau, C. | Deposit date: | 2008-11-28 | Release date: | 2009-12-01 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Queen bee pheromone binding protein pH induced domain-swapping favors pheromone release To be Published
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3D78
| Dimeric crystal structure of a pheromone binding protein mutant D35N, from apis mellifera, at pH 7.0 | Descriptor: | 1,2-ETHANEDIOL, N-BUTYL-BENZENESULFONAMIDE, Pheromone-binding protein ASP1 | Authors: | Pesenti, M.E, Spinelli, S, Bezirard, V, Briand, L, Pernollet, J.C, Tegoni, M, Cambillau, C. | Deposit date: | 2008-05-20 | Release date: | 2009-05-26 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Queen bee pheromone binding protein pH-induced domain swapping favors pheromone release J.Mol.Biol., 390, 2009
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3D73
| Crystal structure of a pheromone binding protein mutant D35A, from Apis mellifera, at pH 7.0 | Descriptor: | N-BUTYL-BENZENESULFONAMIDE, Pheromone-binding protein ASP1 | Authors: | Pesenti, M.E, Spinelli, S, Bezirard, V, Briand, L, Pernollet, J.C, Tegoni, M, Cambillau, C. | Deposit date: | 2008-05-20 | Release date: | 2009-05-26 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Queen bee pheromone binding protein pH-induced domain swapping favors pheromone release J.Mol.Biol., 390, 2009
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4R90
| Anti CD70 Llama glama Fab 27B3 | Descriptor: | Anti CD70 Llama glama Fab 27B3 Heavy chain, Anti CD70 Llama glama Fab 27B3 Light chain, CALCIUM ION, ... | Authors: | Klarenbeek, A, El Mazouari, K, Desmyter, A, Blanchetot, C, Hultberg, A, Roovers, R.C, Cambillau, C, Spinelli, S, Del-Favero, J, Verrips, T, de Haard, H, Achour, I. | Deposit date: | 2014-09-03 | Release date: | 2015-06-24 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.746 Å) | Cite: | Camelid Ig V genes reveal significant human homology not seen in therapeutic target genes, providing for a powerful therapeutic antibody platform. MAbs, 7, 2015
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3FE8
| Crystal structure of a pheromone binding protein from Apis mellifera with a serendipitous ligand soaked at pH 4.0 | Descriptor: | (20S)-20-methyldotetracontane, CHLORIDE ION, GLYCEROL, ... | Authors: | Pesenti, M.E, Spinelli, S, Bezirard, V, Briand, L, Pernollet, J.C, Tegoni, M, Cambillau, C. | Deposit date: | 2008-11-28 | Release date: | 2009-12-01 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Queen bee pheromone binding protein pH induced domain-swapping favors pheromone release To be Published
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4R96
| Structure of a Llama Glama Fab 48A2 against human cMet | Descriptor: | Llama glama Fab 48A2 against human cMet H chain, Llama glama Fab 48A2 against human cMet L chain | Authors: | Klarenbeek, A, El Mazouari, K, Desmyter, A, Blanchetot, C, Hultberg, A, Roovers, R.C, Cambillau, C, Spinelli, S, Del-Favero, J, Verrips, T, de Haard, H, Achour, I. | Deposit date: | 2014-09-03 | Release date: | 2015-06-24 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.31 Å) | Cite: | Camelid Ig V genes reveal significant human homology not seen in therapeutic target genes, providing for a powerful therapeutic antibody platform. MAbs, 7, 2015
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3D77
| Crystal structure of a pheromone binding protein mutant D35N, from Apis mellifera, soaked at pH 4.0 | Descriptor: | 1,2-ETHANEDIOL, N-BUTYL-BENZENESULFONAMIDE, Pheromone-binding protein ASP1, ... | Authors: | Pesenti, M.E, Spinelli, S, Bezirard, V, Briand, L, Pernollet, J.C, Tegoni, M, Cambillau, C. | Deposit date: | 2008-05-20 | Release date: | 2009-05-26 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Queen bee pheromone binding protein pH-induced domain swapping favors pheromone release J.Mol.Biol., 390, 2009
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3D74
| Crystal structure of a pheromone binding protein mutant D35A, from Apis mellifera, soaked at pH 5.5 | Descriptor: | N-BUTYL-BENZENESULFONAMIDE, Pheromone-binding protein ASP1 | Authors: | Pesenti, M.E, Spinelli, S, Bezirard, V, Briand, L, Pernollet, J.C, Tegoni, M, Cambillau, C. | Deposit date: | 2008-05-20 | Release date: | 2009-05-26 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Queen bee pheromone binding protein pH-induced domain swapping favors pheromone release J.Mol.Biol., 390, 2009
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4O9H
| Structure of Interleukin-6 in complex with a Camelid Fab fragment | Descriptor: | Heavy Chain of the Camelid Fab fragment 61H7, Interleukin-6, Light Chain of the Camelid Fab fragment 61H7 | Authors: | Klarenbeek, A, Blanchetot, C, Schragel, G, Sadi, A.S, Ongenae, N, Hemrika, W, Wijdenes, J, Spinelli, S, Desmyter, A, Cambillau, C, Hultberg, A, Kretz-rommel, A, Dreier, T, De haard, H.J.W, Roovers, R.C. | Deposit date: | 2014-01-02 | Release date: | 2015-04-15 | Last modified: | 2015-04-29 | Method: | X-RAY DIFFRACTION (2.42 Å) | Cite: | Combining residues of naturally-occurring Camelid somatic affinity variants yields ultra-potent human therapeutic IL-6 antibodies To be Published
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3D75
| Crystal structure of a pheromone binding protein mutant D35N, from Apis mellifera, at pH 5.5 | Descriptor: | N-BUTYL-BENZENESULFONAMIDE, Pheromone-binding protein ASP1 | Authors: | Pesenti, M.E, Spinelli, S, Bezirard, V, Briand, L, Pernollet, J.C, Tegoni, M, Cambillau, C. | Deposit date: | 2008-05-20 | Release date: | 2009-05-26 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Queen bee pheromone binding protein pH-induced domain swapping favors pheromone release J.Mol.Biol., 390, 2009
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4QGY
| Camelid (llama) nanobody n25 (VHH) against type 6 secretion system TssM protein | Descriptor: | nanobody n25, VH domain | Authors: | Nguyen, V.S, Desmyter, A, Le, T.T.H, Durand, E, Kellenberger, C, Douzi, B, Spinelli, S, Cascales, E, Cambillau, C, Roussel, A. | Deposit date: | 2014-05-26 | Release date: | 2015-04-08 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.38 Å) | Cite: | Inhibition of Type VI Secretion by an Anti-TssM Llama Nanobody. Plos One, 10, 2015
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