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2QZ8
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BU of 2qz8 by Molmil
Crystal structure of Mycobacterium tuberculosis Leucine response regulatory protein (LrpA)
分子名称: Probable transcriptional regulatory protein
著者Manchi, C.M.R, Gokulan, K, Ioerger, T, Jacobs Jr, W.R, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
登録日2007-08-16
公開日2007-11-06
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.16 Å)
主引用文献Crystal structure of Mycobacterium tuberculosis LrpA, a leucine-responsive global regulator associated with starvation response.
Protein Sci., 17, 2008
1SBF
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BU of 1sbf by Molmil
SOYBEAN AGGLUTININ
分子名称: CALCIUM ION, MANGANESE (II) ION, SOYBEAN AGGLUTININ, ...
著者Olsen, L.R, Dessen, A, Gupta, D, Sabesan, S, Brewer, C.F, Sacchettini, J.C.
登録日1997-10-21
公開日1998-04-22
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.43 Å)
主引用文献X-ray crystallographic studies of unique cross-linked lattices between four isomeric biantennary oligosaccharides and soybean agglutinin.
Biochemistry, 36, 1997
2SBA
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BU of 2sba by Molmil
SOYBEAN AGGLUTININ COMPLEXED WITH 2,6-PENTASACCHARIDE
分子名称: CALCIUM ION, Lectin, MANGANESE (II) ION, ...
著者Dessen, A, Gupta, D, Sabesan, S, Brewer, C.F, Sacchettini, J.C.
登録日1998-12-03
公開日1998-12-09
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献X-ray crystal structure of the soybean agglutinin cross-linked with a biantennary analog of the blood group I carbohydrate antigen.
Biochemistry, 34, 1995
1SBE
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BU of 1sbe by Molmil
SOYBEAN AGGLUTININ FROM GLYCINE MAX
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, MANGANESE (II) ION, ...
著者Dessen, A, Olsen, L.R, Gupta, D, Sabesan, S, Sacchettini, J.C, Brewer, C.F.
登録日1995-07-13
公開日1998-04-22
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献X-ray crystallographic studies of unique cross-linked lattices between four isomeric biantennary oligosaccharides and soybean agglutinin.
Biochemistry, 36, 1997
1SBD
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BU of 1sbd by Molmil
SOYBEAN AGGLUTININ COMPLEXED WITH 2,4-PENTASACCHARIDE
分子名称: CALCIUM ION, MANGANESE (II) ION, SOYBEAN AGGLUTININ, ...
著者Dessen, A, Olsen, L.R, Gupta, D, Sabesan, S, Brewer, C.F, Sacchettini, J.C.
登録日1995-07-13
公開日1998-04-22
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.52 Å)
主引用文献X-ray crystallographic studies of unique cross-linked lattices between four isomeric biantennary oligosaccharides and soybean agglutinin.
Biochemistry, 36, 1997
1UBY
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BU of 1uby by Molmil
STRUCTURE OF FARNESYL PYROPHOSPHATE SYNTHETASE
分子名称: DIMETHYLALLYL DIPHOSPHATE, FARNESYL DIPHOSPHATE SYNTHASE, MAGNESIUM ION
著者Tarshis, L.C, Proteau, P, Poulter, C.D, Sacchettini, J.C.
登録日1996-10-14
公開日1997-03-12
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Regulation of product chain length by isoprenyl diphosphate synthases.
Proc.Natl.Acad.Sci.USA, 93, 1996
1UBV
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BU of 1ubv by Molmil
STRUCTURE OF FARNESYL PYROPHOSPHATE SYNTHETASE
分子名称: FARNESYL DIPHOSPHATE SYNTHASE
著者Tarshis, L.C, Proteau, P, Poulter, C.D, Sacchettini, J.C.
登録日1996-10-14
公開日1997-03-12
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Regulation of product chain length by isoprenyl diphosphate synthases.
Proc.Natl.Acad.Sci.USA, 93, 1996
1UBX
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BU of 1ubx by Molmil
STRUCTURE OF FARNESYL PYROPHOSPHATE SYNTHETASE
分子名称: FARNESYL DIPHOSPHATE, FARNESYL DIPHOSPHATE SYNTHASE, MAGNESIUM ION
著者Tarshis, L.C, Proteau, P, Poulter, C.D, Sacchettini, J.C.
登録日1996-10-14
公開日1997-03-12
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Regulation of product chain length by isoprenyl diphosphate synthases.
Proc.Natl.Acad.Sci.USA, 93, 1996
1UBW
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BU of 1ubw by Molmil
STRUCTURE OF FARNESYL PYROPHOSPHATE SYNTHETASE
分子名称: FARNESYL DIPHOSPHATE SYNTHASE, GERANYL DIPHOSPHATE, MAGNESIUM ION
著者Tarshis, L.C, Proteau, P, Poulter, C.D, Sacchettini, J.C.
登録日1996-10-14
公開日1997-03-12
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Regulation of product chain length by isoprenyl diphosphate synthases.
Proc.Natl.Acad.Sci.USA, 93, 1996
1MAS
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BU of 1mas by Molmil
PURINE NUCLEOSIDE HYDROLASE
分子名称: INOSINE-URIDINE NUCLEOSIDE N-RIBOHYDROLASE, POTASSIUM ION
著者Degano, M, Gopaul, D.N, Scapin, G, Schramm, V.L, Sacchettini, J.C.
登録日1995-12-18
公開日1996-08-17
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Three-dimensional structure of the inosine-uridine nucleoside N-ribohydrolase from Crithidia fasciculata.
Biochemistry, 35, 1996
1OPR
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BU of 1opr by Molmil
THE CRYSTAL STRUCTURE OF THE OROTATE PHOSPHORIBOSYLTRANSFERASE COMPLEXED WITH OROTATE AND ALPHA-D-5-PHOSPHORIBOSYL-1-PYROPHOSPHATE
分子名称: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, MAGNESIUM ION, OROTATE PHOSPHORIBOSYLTRANSFERASE, ...
著者Scapin, G, Sacchettini, J.C.
登録日1995-01-06
公開日1996-01-06
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The crystal structure of the orotate phosphoribosyltransferase complexed with orotate and alpha-D-5-phosphoribosyl-1-pyrophosphate.
Biochemistry, 34, 1995
4P4L
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BU of 4p4l by Molmil
Crystal Structure of Mycobacterium tuberculosis Shikimate Dehydrogenase
分子名称: (3R,4S,5R)-3,4,5-TRIHYDROXYCYCLOHEX-1-ENE-1-CARBOXYLIC ACID, SULFATE ION, Shikimate 5-dehydrogenase AroE (5-dehydroshikimate reductase)
著者Lalgondar, M, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
登録日2014-03-12
公開日2015-03-18
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.009 Å)
主引用文献Structure of Mycobacterium tuberculosis Shikimate Dehydrogenase
To Be Published
4P4G
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BU of 4p4g by Molmil
Crystal Structure of Mycobacterium tuberculosis Shikimate Dehydrogenase
分子名称: (3R,4S,5R)-3,4,5-TRIHYDROXYCYCLOHEX-1-ENE-1-CARBOXYLIC ACID, BROMIDE ION, SULFATE ION, ...
著者Lalgondar, M, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
登録日2014-03-12
公開日2015-03-18
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal Structure of Mycobacterium tuberculosis Shikimate Dehydrogenase
To Be Published
4P4N
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BU of 4p4n by Molmil
Crystal Structure of Mycobacterium tuberculosis Shikimate Dehydrogenase
分子名称: SULFATE ION, Shikimate 5-dehydrogenase AroE (5-dehydroshikimate reductase)
著者Lalgondar, M, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
登録日2014-03-12
公開日2015-03-18
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structure of Mycobacterium tuberculosis Shikimate Dehydrogenase
To Be Published
4QXM
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BU of 4qxm by Molmil
Crystal structure of the InhA:GSK_SB713 complex
分子名称: Enoyl-[acyl-carrier-protein] reductase [NADH], N-(2-chloro-4-fluorobenzyl)-4-[(3,5-dimethyl-1H-pyrazol-1-yl)methyl]benzamide, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
著者Gulten, G, Sacchettini, J.C.
登録日2014-07-21
公開日2015-07-22
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.196 Å)
主引用文献N-Benzyl-4-((heteroaryl)methyl)benzamides: A New Class of Direct NADH-Dependent 2-trans Enoyl-Acyl Carrier Protein Reductase (InhA) Inhibitors with Antitubercular Activity.
Chemmedchem, 11, 2016
7M7V
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BU of 7m7v by Molmil
Crystal Structure of Mtb Pks13 Thioesterase domain in complex with Compound 6
分子名称: 5-hydroxy-2-(4-hydroxyphenyl)-N-methyl-4-[(2-oxa-6-azaspiro[3.4]octan-6-yl)methyl]-1-benzofuran-3-carboxamide, Polyketide synthase Pks13
著者Aggarwal, A, Sacchettini, J.C.
登録日2021-03-29
公開日2022-02-16
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.29 Å)
主引用文献Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target.
J.Med.Chem., 65, 2022
1LD9
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BU of 1ld9 by Molmil
THE THREE-DIMENSIONAL STRUCTURE OF AN H-2LD PEPTIDE COMPLEX EXPLAINS THE UNIQUE INTERACTION OF LD WITH BETA2M AND PEPTIDE
分子名称: BETA-2 MICROGLOBULIN, MHC CLASS I H-2LD HEAVY CHAIN, NANO-PEPTIDE
著者Balendiran, G.K, Solheim, J.C, Young, A.C.M, Hansen, T.H, Nathenson, S.G, Sacchettini, J.C.
登録日1997-04-24
公開日1998-05-06
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献The three-dimensional structure of an H-2Ld-peptide complex explains the unique interaction of Ld with beta-2 microglobulin and peptide.
Proc.Natl.Acad.Sci.USA, 94, 1997
5CAK
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BU of 5cak by Molmil
Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 2-hydroxy-3-(1H-indol-3-yl)propanoic acid
分子名称: (2R)-2-hydroxy-3-(1H-indol-3-yl)propanoic acid, MAGNESIUM ION, Malate synthase G
著者Huang, H.-L, Sacchettini, J.C.
登録日2015-06-29
公開日2016-08-10
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange.
J. Biol. Chem., 291, 2016
7N8M
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BU of 7n8m by Molmil
PptT PAP(CoA) 8978B complex
分子名称: 4'-phosphopantetheinyl transferase PptT, COENZYME A, DIMETHYL SULFOXIDE, ...
著者Mosior, J.W, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
登録日2021-06-15
公開日2022-02-02
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.57 Å)
主引用文献In Vitro and In Vivo Inhibition of the Mycobacterium tuberculosis Phosphopantetheinyl Transferase PptT by Amidinoureas.
J.Med.Chem., 65, 2022
7N8L
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BU of 7n8l by Molmil
PptT PAP(CoA) 9016 complex
分子名称: 4'-phosphopantetheinyl transferase PptT, COENZYME A, DIMETHYL SULFOXIDE, ...
著者Mosior, J.W, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
登録日2021-06-15
公開日2022-02-02
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.26 Å)
主引用文献In Vitro and In Vivo Inhibition of the Mycobacterium tuberculosis Phosphopantetheinyl Transferase PptT by Amidinoureas.
J.Med.Chem., 65, 2022
7N8E
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BU of 7n8e by Molmil
PptT PAP(CoA) 9056 complex
分子名称: 4'-phosphopantetheinyl transferase PptT, COENZYME A, DIMETHYL SULFOXIDE, ...
著者Mosior, J.W, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
登録日2021-06-14
公開日2022-02-02
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.74 Å)
主引用文献In Vitro and In Vivo Inhibition of the Mycobacterium tuberculosis Phosphopantetheinyl Transferase PptT by Amidinoureas.
J.Med.Chem., 65, 2022
1NNT
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BU of 1nnt by Molmil
STRUCTURAL EVIDENCE FOR A PH-SENSITIVE DI-LYSINE TRIGGER IN THE HEN OVOTRANSFERRIN N-LOBE: IMPLICATIONS FOR TRANSFERRIN IRON RELEASE
分子名称: CARBONATE ION, FE (III) ION, OVOTRANSFERRIN
著者Dewan, J.C, Mikami, B, Sacchettini, J.C.
登録日1993-09-15
公開日1994-10-15
最終更新日2019-08-14
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural evidence for a pH-sensitive dilysine trigger in the hen ovotransferrin N-lobe: implications for transferrin iron release.
Biochemistry, 32, 1993
1VRW
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BU of 1vrw by Molmil
Crystal structure analysis of plasmodium falciparum enoyl-acyl-carrier-protein reductase with nadh
分子名称: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ENOYL-ACYL CARRIER REDUCTASE
著者Perozzo, R, Kuo, M, Sidhu, A.S, Valiyaveettil, J.T, Bittman, R, Jacobs Jr, W.R, Fidock, D.A, Sacchettini, J.C.
登録日2005-06-30
公開日2005-07-05
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural Elucidation of the Specificity of the Antibacterial Agent Triclosan for Malarial Enoyl Acyl Carrier Protein Reductase
J.Biol.Chem., 277, 2002
1XJU
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BU of 1xju by Molmil
Crystal structure of secreted inactive form of P1 phage endolysin Lyz
分子名称: Lysozyme, SULFATE ION
著者Arockiasamy, A, Sacchettini, J.C.
登録日2004-09-24
公開日2005-01-11
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (1.07 Å)
主引用文献Disulfide isomerization after membrane release of its SAR domain activates P1 lysozyme.
Science, 307, 2005
1XJT
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BU of 1xjt by Molmil
Crystal structure of active form of P1 phage endolysin Lyz
分子名称: CITRIC ACID, Lysozyme
著者Arockiasamy, A, Sacchettini, J.C.
登録日2004-09-24
公開日2005-01-11
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Disulfide isomerization after membrane release of its SAR domain activates P1 lysozyme.
Science, 307, 2005

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