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1RRJ
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BU of 1rrj by Molmil
Structural Mechanisms of Camptothecin Resistance by Mutations in Human Topoisomerase I
分子名称: (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE, 2-(1-DIMETHYLAMINOMETHYL-2-HYDROXY-8-HYDROXYMETHYL-9-OXO-9,11-DIHYDRO-INDOLIZINO[1,2-B]QUINOLIN-7-YL)-2-HYDROXY-BUTYRIC ACID, 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T*GP*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', ...
著者Chrencik, J.E, Staker, B.L, Burgin, A.B, Stewart, L, Redinbo, M.R.
登録日2003-12-08
公開日2004-07-06
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Mechanisms of camptothecin resistance by human topoisomerase I mutations
J.Mol.Biol., 339, 2004
1RR8
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BU of 1rr8 by Molmil
Structural Mechanisms of Camptothecin Resistance by Mutations in Human Topoisomerase I
分子名称: (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE, 2-(1-DIMETHYLAMINOMETHYL-2-HYDROXY-8-HYDROXYMETHYL-9-OXO-9,11-DIHYDRO-INDOLIZINO[1,2-B]QUINOLIN-7-YL)-2-HYDROXY-BUTYRIC ACID, 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T*GP*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', ...
著者Chrencik, J.E, Staker, B.L, Burgin, A.B, Stewart, L, Redinbo, M.R.
登録日2003-12-08
公開日2004-07-06
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Mechanisms of camptothecin resistance by human topoisomerase I mutations
J.Mol.Biol., 339, 2004
1SKX
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BU of 1skx by Molmil
Structural Disorder in the Complex of Human PXR and the Macrolide Antibiotic Rifampicin
分子名称: Orphan nuclear receptor PXR, RIFAMPICIN
著者Chrencik, J.E, Xue, Y, Orans, J.O, Redinbo, M.R.
登録日2004-03-05
公開日2005-03-08
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural disorder in the complex of human pregnane x receptor and the macrolide antibiotic rifampicin
Mol.Endocrinol., 19, 2005
4K59
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BU of 4k59 by Molmil
Crystal Structure of Pseudomonas Aeruginosa RsmF
分子名称: RNA BINDING PROTEIN RsmF
著者Betts, L, Walton, W.G, Redinbo, M.R.
登録日2013-04-14
公開日2013-08-28
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.22 Å)
主引用文献An unusual CsrA family member operates in series with RsmA to amplify posttranscriptional responses in Pseudomonas aeruginosa.
Proc.Natl.Acad.Sci.USA, 110, 2013
2DQZ
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BU of 2dqz by Molmil
Crystal structure of human carboxylesterase in complex with homatropine, coenzyme A, and palmitate
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, COENZYME A, FLUORIDE ION, ...
著者Bencharit, S, Redinbo, M.R.
登録日2006-06-02
公開日2006-08-29
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Multisite promiscuity in the processing of endogenous substrates by human carboxylesterase 1
J.Mol.Biol., 363, 2006
2DQY
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Crystal structure of human carboxylesterase in complex with cholate and palmitate
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLIC ACID, Liver carboxylesterase 1, ...
著者Bencharit, S, Edwards, C.C, Morton, C.L, Howard-Williams, E.L, Potter, P.M, Redinbo, M.R.
登録日2006-06-02
公開日2006-08-29
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Multisite promiscuity in the processing of endogenous substrates by human carboxylesterase 1
J.Mol.Biol., 363, 2006
2DR0
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BU of 2dr0 by Molmil
Crystal structure of human carboxylesterase in complex with taurocholate
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Liver carboxylesterase 1, N-acetyl-alpha-neuraminic acid, ...
著者Bencharit, S, Redinbo, M.R.
登録日2006-06-02
公開日2006-08-29
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Multisite promiscuity in the processing of endogenous substrates by human carboxylesterase 1
J.Mol.Biol., 363, 2006
2H7C
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BU of 2h7c by Molmil
Crystal structure of human carboxylesterase in complex with Coenzyme A
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, COENZYME A, ...
著者Bencharit, S, Edwards, C.C, Morton, C.L, Howard-Williams, E.L, Potter, P.M, Redinbo, M.R.
登録日2006-06-02
公開日2006-08-29
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Multisite promiscuity in the processing of endogenous substrates by human carboxylesterase 1
J.Mol.Biol., 363, 2006
2HRR
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BU of 2hrr by Molmil
Crystal structure of Human Liver Carboxylesterase 1 (hCE1) in covalent complex with the nerve agent Tabun (GA)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Liver carboxylesterase 1, N-acetyl-alpha-neuraminic acid, ...
著者Fleming, C.D, Redinbo, M.R.
登録日2006-07-20
公開日2007-05-01
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal Structures of Human Carboxylesterase 1 in Covalent Complexes with the Chemical Warfare Agents Soman and Tabun.
Biochemistry, 46, 2007
2Q7U
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BU of 2q7u by Molmil
Crystal Structure of the F plasmid TraI Relaxase Domain with the Scissile Thymidine Base and Imidodiphosphate
分子名称: IMIDO DIPHOSPHATE, MAGNESIUM ION, Protein traI, ...
著者Lujan, S.A, Redinbo, M.R.
登録日2007-06-07
公開日2008-05-20
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Disrupting antibiotic resistance propagation by inhibiting the conjugative DNA relaxase.
Proc.Natl.Acad.Sci.Usa, 104, 2007
2Q1H
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BU of 2q1h by Molmil
Ancestral Corticoid Receptor in Complex with Aldosterone
分子名称: ALDOSTERONE, AncCR, GLYCEROL, ...
著者Ortlund, E.A, Bridgham, J.T, Redinbo, M.R, Thornton, J.W.
登録日2007-05-24
公開日2007-09-04
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure of an ancient protein: evolution by conformational epistasis.
Science, 317, 2007
2Q1V
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BU of 2q1v by Molmil
Ancestral corticoid receptor in complex with cortisol
分子名称: 17,21-DIHYDROXYPREGNA-1,4-DIENE-3,11,20-TRIONE, AncCR, GLYCEROL
著者Ortlund, E.A, Redinbo, M.R.
登録日2007-05-25
公開日2007-09-04
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Crystal structure of an ancient protein: evolution by conformational epistasis.
Science, 317, 2007
2Q3Y
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BU of 2q3y by Molmil
Ancestral Corticiod Receptor in Complex with DOC
分子名称: Ancestral Corticiod Receptor, DESOXYCORTICOSTERONE, GLYCEROL, ...
著者Ortlund, E.A, Bridgham, J.T, Redinbo, M.R, Thornton, J.W.
登録日2007-05-30
公開日2007-09-04
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal structure of an ancient protein: evolution by conformational epistasis
Science, 317, 2007
2Q7T
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BU of 2q7t by Molmil
Crystal Structure of the F plasmid TraI Relaxase Domain with the Scissile Thymidine Base
分子名称: MAGNESIUM ION, Protein traI, THYMIDINE-5'-PHOSPHATE
著者Lujan, S.A, Redinbo, M.R.
登録日2007-06-07
公開日2008-05-20
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.42 Å)
主引用文献Disrupting antibiotic resistance propagation by inhibiting the conjugative DNA relaxase.
Proc.Natl.Acad.Sci.Usa, 104, 2007
2QNV
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BU of 2qnv by Molmil
Crystal Structure of the Pregnane X Receptor bound to Colupulone
分子名称: 3,5-dihydroxy-4,6,6-tris(3-methylbut-2-en-1-yl)-2-(2-methylpropanoyl)cyclohexa-2,4-dien-1-one, Orphan nuclear receptor PXR
著者Teotico, D.G, Bischof, J, Redinbo, M.R.
登録日2007-07-19
公開日2008-07-29
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal Structure of the Pregnane X Receptor bound to Colupulone
TO BE PUBLISHED
8DHV
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BU of 8dhv by Molmil
Treponema lecithinolyticum beta-glucuronidase
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, Glycosyl hydrolase family 2, ...
著者Lietzan, A.D, Redinbo, M.R.
登録日2022-06-28
公開日2023-05-17
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Microbial beta-glucuronidases drive human periodontal disease etiology.
Sci Adv, 9, 2023
8DHW
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BU of 8dhw by Molmil
Treponema lecithinolyticum beta-glucuronidase in complex with a UNC4917-glucuronide conjugate
分子名称: 4-(4-beta-D-glucopyranuronosylpiperazin-1-yl)-2,7-bis(methylamino)pyrido[3',2':4,5]thieno[3,2-d]pyrimidine, Glycosyl hydrolase family 2, TIM barrel domain protein, ...
著者Lietzan, A.D, Redinbo, M.R.
登録日2022-06-28
公開日2023-05-17
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Microbial beta-glucuronidases drive human periodontal disease etiology.
Sci Adv, 9, 2023
8DHL
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BU of 8dhl by Molmil
Tannerella forsythia beta-glucuronidase (L2)
分子名称: 1,2-ETHANEDIOL, CALCIUM ION, Glycosyl hydrolase family 2, ...
著者Lietzan, A.D, Redinbo, M.R.
登録日2022-06-27
公開日2023-05-17
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Microbial beta-glucuronidases drive human periodontal disease etiology.
Sci Adv, 9, 2023
8DHE
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BU of 8dhe by Molmil
Tannerella forsythia beta-glucuronidase (mL1)
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, GLYCEROL, ...
著者Lietzan, A.D, Redinbo, M.R.
登録日2022-06-27
公開日2023-05-17
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Microbial beta-glucuronidases drive human periodontal disease etiology.
Sci Adv, 9, 2023
8E72
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Treponema lecithinolyticum beta-glucuronidase in complex with a ciprofloxacin-glucuronide conjugate
分子名称: 3-carboxy-1-cyclopropyl-6-fluoro-7-(4-beta-D-glucopyranuronosyl-3,4-dihydropyrazin-1(2H)-yl)-4-oxo-1,4-dihydroquinoline, Glycosyl hydrolase family 2, TIM barrel domain protein, ...
著者Lietzan, A.D, Redinbo, M.R.
登録日2022-08-23
公開日2023-06-21
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Microbial beta-glucuronidases drive human periodontal disease etiology.
Sci Adv, 9, 2023
8ESI
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Bile Salt Hydrolase from B. longum with covalent inhibitor bound
分子名称: (1R,3aS,3bR,5aR,7R,9aS,9bS,11aR)-1-[(2R)-6-fluoro-5-oxohexan-2-yl]-9a,11a-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-7-yl hydrogen sulfate (non-preferred name), Conjugated bile acid hydrolase
著者Walker, M.E, Lim, L, Redinbo, M.R.
登録日2022-10-14
公開日2023-11-01
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Structural diversity of bile salt hydrolases reveals rationale for substrate selectivity
To Be Published
8ESG
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Bile Salt Hydrolase B from Lactobacillus gasseri with covalent inhibitor bound
分子名称: (1R,3aS,3bR,5aR,7R,9aS,9bS,11aR)-1-[(2R)-6-fluoro-5-oxohexan-2-yl]-9a,11a-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-7-yl hydrogen sulfate (non-preferred name), Choloylglycine hydrolase
著者Walker, M.E, Redinbo, M.R.
登録日2022-10-14
公開日2023-11-01
実験手法X-RAY DIFFRACTION (2.18 Å)
主引用文献Structural diversity of bile salt hydrolases reveals rationale for substrate selectivity
To Be Published
8ETF
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BU of 8etf by Molmil
Bile Salt Hydrolase B from Lactobacillus gasseri with covalent inhibitor bound
分子名称: (5R)-1-fluoro-5-[(1R,3aS,3bR,5aR,7R,9aS,9bS,11aR)-7-hydroxy-9a,11a-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]hexan-2-one (non-preferred name), Choloylglycine hydrolase, NICKEL (II) ION
著者Walker, M.E, Redinbo, M.R.
登録日2022-10-17
公開日2023-11-01
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献Structural diversity of bile salt hydrolases reveals rationale for substrate selectivity
To Be Published
8ETK
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Bile salt hydrolase A from Lactobacillus gasseri bound to covalent probe
分子名称: (5R)-5-[(1R,3aS,3bR,5aR,7R,9aS,9bS,11aR)-9a,11a-dimethyl-7-(2-{2-[(prop-2-yn-1-yl)oxy]ethoxy}ethoxy)hexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]-1-fluorohexan-2-one (non-preferred name), Conjugated bile salt hydrolase, SODIUM ION
著者Walker, M.E, Grundy, M.K, Redinbo, M.R.
登録日2022-10-17
公開日2023-11-01
実験手法X-RAY DIFFRACTION (1.83 Å)
主引用文献Structural diversity of bile salt hydrolases reveals rationale for substrate selectivity
To Be Published
8ETE
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BU of 8ete by Molmil
Bile Salt Hydrolase from B. longum with covalent inhibitor bound
分子名称: (5R)-1-fluoro-5-[(1R,3aS,3bR,5aR,7R,9aS,9bS,11aR)-7-hydroxy-9a,11a-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]hexan-2-one (non-preferred name), Conjugated bile acid hydrolase
著者Walker, M.E, Redinbo, M.R.
登録日2022-10-17
公開日2023-11-01
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural diversity of bile salt hydrolases reveals rationale for substrate selectivity
To Be Published

219869

件を2024-05-15に公開中

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