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Structure of the m17 leucyl aminopeptidase from malaria complexed with a hydroxamic acid-based inhibitor
分子名称:	3-amino-N-{(1R)-2-(hydroxyamino)-2-oxo-1-[4-(1H-pyrazol-1-yl)phenyl]ethyl}benzamide, CARBONATE ION, M17 family aminopeptidase, ...
著者	Drinkwater, N, Mcgowan, S.
登録日	2014-08-27
公開日	2014-10-29
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (2.5 Å)
主引用文献	Two-Pronged Attack: Dual Inhibition of Plasmodium falciparum M1 and M17 Metalloaminopeptidases by a Novel Series of Hydroxamic Acid-Based Inhibitors. J.Med.Chem., 57, 2014

4R5T

Structure of the m1 alanylaminopeptidase from malaria complexed with a hydroxamic acid-based inhibitor
分子名称:	DIMETHYL SULFOXIDE, GLYCEROL, M1 family aminopeptidase, ...
著者	Drinkwater, N, Mcgowan, S.
登録日	2014-08-22
公開日	2014-10-29
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (1.98 Å)
主引用文献	Two-Pronged Attack: Dual Inhibition of Plasmodium falciparum M1 and M17 Metalloaminopeptidases by a Novel Series of Hydroxamic Acid-Based Inhibitors. J.Med.Chem., 57, 2014

4R6T

Structure of the m17 leucyl aminopeptidase from malaria complexed with a hydroxamic acid-based inhibitor
分子名称:	CARBONATE ION, DIMETHYL SULFOXIDE, M17 leucyl aminopeptidase, ...
著者	Drinkwater, N, Mcgowan, S.
登録日	2014-08-26
公開日	2014-10-29
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (2.6 Å)
主引用文献	Two-Pronged Attack: Dual Inhibition of Plasmodium falciparum M1 and M17 Metalloaminopeptidases by a Novel Series of Hydroxamic Acid-Based Inhibitors. J.Med.Chem., 57, 2014

4I8A

Alanine-glyoxylate aminotransferase variant S187F
分子名称:	GLYCEROL, Serine-pyruvate aminotransferase
著者	Fodor, K, Oppici, E, Williams, C, Cellini, B, Wilmanns, M.
登録日	2012-12-03
公開日	2013-05-01
最終更新日	2023-12-06
実験手法	X-RAY DIFFRACTION (2.9 Å)
主引用文献	Crystal structure of the S187F variant of human liver alanine: Aminotransferase associated with primary hyperoxaluria type I and its functional implications. Proteins, 81, 2013

4IOB

Crystal structure of the GGDEF domain of PA1120 (YfiN or TpbB) from Pseudomonas aeruginosa at 2.7 Ang.
分子名称:	Diguanylate cyclase TpbB, GLYCEROL, TERTIARY-BUTYL ALCOHOL
著者	Giardina, G, Cutruzzola, F.
登録日	2013-01-07
公開日	2013-12-04
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (2.78 Å)
主引用文献	Investigating the Allosteric Regulation of YfiN from Pseudomonas aeruginosa: Clues from the Structure of the Catalytic Domain. Plos One, 8, 2013

4K5N

Phosphonic Arginine Mimetics as Inhibitors of the M1 Aminopeptidases from Plasmodium falciparum
分子名称:	GLYCEROL, M1 family aminopeptidase, MAGNESIUM ION, ...
著者	McGowan, S.
登録日	2013-04-15
公開日	2013-06-12
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (1.91 Å)
主引用文献	Synthesis and Structure-Activity Relationships of Phosphonic Arginine Mimetics as Inhibitors of the M1 and M17 Aminopeptidases from Plasmodium falciparum. J.Med.Chem., 56, 2013

4K5P

Phosphonic Arginine Mimetics as Inhibitors of the M1 Aminopeptidases from Plasmodium falciparum
分子名称:	GLYCEROL, M1 family aminopeptidase, MAGNESIUM ION, ...
著者	McGowan, S.
登録日	2013-04-15
公開日	2013-06-12
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (1.85 Å)
主引用文献	Synthesis and Structure-Activity Relationships of Phosphonic Arginine Mimetics as Inhibitors of the M1 and M17 Aminopeptidases from Plasmodium falciparum. J.Med.Chem., 56, 2013

4K3N

Phosphonic Arginine Mimetics as Inhibitors of the M17 Aminopeptidases from Plasmodium falciparum
分子名称:	CARBONATE ION, M17 leucyl aminopeptidase, NONAETHYLENE GLYCOL, ...
著者	McGowan, S.
登録日	2013-04-11
公開日	2013-06-12
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Synthesis and Structure-Activity Relationships of Phosphonic Arginine Mimetics as Inhibitors of the M1 and M17 Aminopeptidases from Plasmodium falciparum. J.Med.Chem., 56, 2013

4K5M

Phosphonic Arginine Mimetics as Inhibitors of the M1 Aminopeptidases from Plasmodium falciparum
分子名称:	GLYCEROL, M1 family aminopeptidase, MAGNESIUM ION, ...
著者	McGowan, S.
登録日	2013-04-14
公開日	2013-06-12
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (1.75 Å)
主引用文献	Synthesis and Structure-Activity Relationships of Phosphonic Arginine Mimetics as Inhibitors of the M1 and M17 Aminopeptidases from Plasmodium falciparum. J.Med.Chem., 56, 2013

4K5L

Phosphonic Arginine Mimetics as Inhibitors of the M1 Aminopeptidases from Plasmodium falciparum
分子名称:	M1 family aminopeptidase, MAGNESIUM ION, ZINC ION, ...
著者	McGowan, S.
登録日	2013-04-14
公開日	2013-06-12
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (1.91 Å)
主引用文献	Synthesis and Structure-Activity Relationships of Phosphonic Arginine Mimetics as Inhibitors of the M1 and M17 Aminopeptidases from Plasmodium falciparum. J.Med.Chem., 56, 2013

4K5O

Phosphonic Arginine Mimetics as Inhibitors of the M1 Aminopeptidases from Plasmodium falciparum
分子名称:	GLYCEROL, M1 family aminopeptidase, MAGNESIUM ION, ...
著者	McGowan, S.
登録日	2013-04-15
公開日	2013-06-12
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Synthesis and Structure-Activity Relationships of Phosphonic Arginine Mimetics as Inhibitors of the M1 and M17 Aminopeptidases from Plasmodium falciparum. J.Med.Chem., 56, 2013

4LNL

Structure of Escherichia coli Threonine Aldolase in Complex with Allo-Thr
分子名称:	4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, Low-specificity L-threonine aldolase, ...
著者	Safo, M.K.
登録日	2013-07-11
公開日	2013-11-06
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (2.1 Å)
主引用文献	On the catalytic mechanism and stereospecificity of Escherichia coli l-threonine aldolase. Febs J., 281, 2014

4LNJ

Structure of Escherichia coli Threonine Aldolase in Unliganded Form
分子名称:	(5-HYDROXY-4,6-DIMETHYLPYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Low-specificity L-threonine aldolase, ...
著者	Safo, M.K, Contestabile, R, Remesh, S.G.
登録日	2013-07-11
公開日	2013-11-06
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (2.1 Å)
主引用文献	On the catalytic mechanism and stereospecificity of Escherichia coli l-threonine aldolase. Febs J., 281, 2014

4LNM

Structure of Escherichia coli Threonine Aldolase in Complex with Serine
分子名称:	(5-HYDROXY-4,6-DIMETHYLPYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CALCIUM ION, ...
著者	Safo, M.K, Contestabile, R, Remesh, S.G.
登録日	2013-07-11
公開日	2013-11-06
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (2.1 Å)
主引用文献	On the catalytic mechanism and stereospecificity of Escherichia coli l-threonine aldolase. Febs J., 281, 2014

4ZQT

Crystal structure of PfA-M1 with virtual ligand inhibitor
分子名称:	(2R)-2-{[(R)-[(R)-amino(phenyl)methyl](hydroxy)phosphoryl]methyl}-4-methylpentanoic acid, GLYCEROL, M1 family aminopeptidase, ...
著者	Ruggeri, C, Drinkwater, N, McGowan, S.
登録日	2015-05-11
公開日	2015-10-07
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (1.981 Å)
主引用文献	Identification and Validation of a Potent Dual Inhibitor of the P. falciparum M1 and M17 Aminopeptidases Using Virtual Screening. Plos One, 10, 2015

4ZW5

X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 9f
分子名称:	M1 family aminopeptidase, MAGNESIUM ION, ZINC ION, ...
著者	Drinkwater, N, McGowan, S.
登録日	2015-05-19
公開日	2016-03-30
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZX5

X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 10q
分子名称:	DIMETHYL SULFOXIDE, GLYCEROL, M1 family aminopeptidase, ...
著者	Drinkwater, N, McGowan, S.
登録日	2015-05-20
公開日	2016-03-30
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (1.95 Å)
主引用文献	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZW6

X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 9q
分子名称:	DIMETHYL SULFOXIDE, GLYCEROL, M1 family aminopeptidase, ...
著者	Drinkwater, N, McGowan, S.
登録日	2015-05-19
公開日	2016-03-30
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZW3

X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 9b
分子名称:	GLYCEROL, M1 family aminopeptidase, MAGNESIUM ION, ...
著者	Drinkwater, N, McGowan, S.
登録日	2015-05-19
公開日	2016-03-30
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZX4

X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 10o
分子名称:	DIMETHYL SULFOXIDE, GLYCEROL, M1 family aminopeptidase, ...
著者	Drinkwater, N, McGowan, S.
登録日	2015-05-20
公開日	2016-03-30
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZX8

X-ray crystal structure of PfA-M17 in complex with hydroxamic acid-based inhibitor 9b
分子名称:	CARBONATE ION, DIMETHYL SULFOXIDE, GLYCEROL, ...
著者	Drinkwater, N, McGowan, S.
登録日	2015-05-20
公開日	2016-03-30
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (2.7 Å)
主引用文献	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZW8

X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 9r
分子名称:	DIMETHYL SULFOXIDE, GLYCEROL, M1 family aminopeptidase, ...
著者	Drinkwater, N, McGowan, S.
登録日	2015-05-19
公開日	2016-03-30
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZW7

X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 9m
分子名称:	DIMETHYL SULFOXIDE, GLYCEROL, M1 family aminopeptidase, ...
著者	Drinkwater, N, McGowan, S.
登録日	2015-05-19
公開日	2016-03-30
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (1.95 Å)
主引用文献	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZY0

X-ray crystal structure of PfA-M17 in complex with hydroxamic acid-based inhibitor 10q
分子名称:	CARBONATE ION, GLYCEROL, N-{(1R)-2-(hydroxyamino)-2-oxo-1-[4-(thiophen-3-yl)phenyl]ethyl}-2,2-dimethylpropanamide, ...
著者	Drinkwater, N, McGowan, S.
登録日	2015-05-21
公開日	2016-03-30
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (2.2 Å)
主引用文献	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

4ZYQ

X-ray crystal structure of PfA-M17 in complex with hydroxamic acid-based inhibitor 10s
分子名称:	CARBONATE ION, N-{(1R)-2-(hydroxyamino)-1-[3'-(N'-hydroxycarbamimidoyl)biphenyl-4-yl]-2-oxoethyl}-2,2-dimethylpropanamide, PENTAETHYLENE GLYCOL, ...
著者	Drinkwater, N, McGowan, S.
登録日	2015-05-22
公開日	2016-03-30
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (2.6 Å)
主引用文献	Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110, 2016

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