2DCT
 
 | | Crystal structure of the TT1209 from Thermus thermophilus HB8 | | Descriptor: | CHLORIDE ION, SODIUM ION, hypothetical protein TTHA0104 | | Authors: | Asada, Y, Sugahara, M, Shimizu, K, Yamamoto, H, Shimada, H, Nakamoto, T, Ono, N, Kunishima, N, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2006-01-12 | | Release date: | 2006-01-24 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.45 Å) | | Cite: | Crystal structure of the TT1209 from Thermus thermophilus HB8
To be Published
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2EL3
 | | Structural study of Project ID PH0725 from Pyrococcus horikoshii OT3 (L242M) | | Descriptor: | S-ADENOSYL-L-HOMOCYSTEINE, SODIUM ION, diphthine synthase | | Authors: | Asada, Y, Matsuura, Y, Ono, N, Shimada, H, Kunishima, N, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-03-26 | | Release date: | 2007-10-02 | | Last modified: | 2021-11-10 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural study of Project ID PH0725 from Pyrococcus horikoshii OT3 (L242M)
To be Published
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2EKZ
 | | Structural study of Project ID TTHB049 from Thermus thermophilus HB8 (L52M) | | Descriptor: | Alpha-ribazole-5'-phosphate phosphatase | | Authors: | Asada, Y, Matsuura, Y, Ono, N, Nakamoto, T, Kunishima, N, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-03-26 | | Release date: | 2007-10-02 | | Last modified: | 2021-11-10 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Structural study of Project ID TTHB049 from Thermus thermophilus HB8 (L52M)
To be Published
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2EL1
 | | Structural study of Project ID PH0725 from Pyrococcus horikoshii OT3 (L44M) | | Descriptor: | S-ADENOSYL-L-HOMOCYSTEINE, SODIUM ION, diphthine synthase | | Authors: | Asada, Y, Taketa, M, Ono, N, Matsuura, Y, Kunishima, N, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-03-26 | | Release date: | 2007-10-02 | | Last modified: | 2021-11-10 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural study of Project ID PH0725 from Pyrococcus horikoshii OT3 (L44M)
To be Published
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2EJZ
 | | Structural study of Project ID PH0725 from Pyrococcus horikoshii OT3 (Y11M) | | Descriptor: | GLYCEROL, S-ADENOSYL-L-HOMOCYSTEINE, SODIUM ION, ... | | Authors: | Asada, Y, Taketa, M, Ono, N, Matsuura, Y, Kunishima, N, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-03-22 | | Release date: | 2007-09-25 | | Last modified: | 2021-11-10 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Structural study of Project ID PH0725 from Pyrococcus horikoshii OT3 (Y11M)
To be Published
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2EL0
 | | Structural study of Project ID PH0725 from Pyrococcus horikoshii OT3 (L21M) | | Descriptor: | S-ADENOSYL-L-HOMOCYSTEINE, diphthine synthase | | Authors: | Asada, Y, Matsuura, Y, Ono, N, Shimada, H, Kunishima, N, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-03-26 | | Release date: | 2007-10-02 | | Last modified: | 2021-11-10 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural study of Project ID PH0725 from Pyrococcus horikoshii OT3 (L21M)
To be Published
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2EOA
 | | Structural study of Project ID TTHB049 from Thermus thermophilus HB8 (W85H) | | Descriptor: | Alpha-ribazole-5'-phosphate phosphatase | | Authors: | Asada, Y, Taketa, M, Ono, N, Matsuura, Y, Kunishima, N, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-03-29 | | Release date: | 2007-10-02 | | Last modified: | 2021-11-10 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Structural study of Project ID TTHB049 from Thermus thermophilus HB8 (W85H)
To be Published
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2OWK
 | | Crystal structure of PH0725 from Pyrococcus horikoshii OT3 | | Descriptor: | S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, diphthine synthase | | Authors: | Sugahara, M, Matsuura, Y, Ono, N, Nakamoto, T, Kunishima, N, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-02-16 | | Release date: | 2007-08-21 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure of PH0725 from Pyrococcus horikoshii OT3
To be Published
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2P5C
 | | Crystal structure of PH0725 from Pyrococcus horikoshii OT3 | | Descriptor: | GLYCEROL, S-ADENOSYL-L-HOMOCYSTEINE, diphthine synthase | | Authors: | Yamamoto, H, Taketa, M, Ono, N, Matsuura, Y, Kunishima, N, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-03-15 | | Release date: | 2007-09-18 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal structure of PH0725 from Pyrococcus horikoshii OT3
To be Published
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2PCH
 | | Crystal structure of PH0725 from Pyrococcus horikoshii OT3 | | Descriptor: | Probable diphthine synthase, S-ADENOSYL-L-HOMOCYSTEINE, SODIUM ION | | Authors: | Sugahara, M, Taketa, M, Ono, N, Matsuura, Y, Kunishima, N, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-03-29 | | Release date: | 2007-10-02 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure of PH0725 from Pyrococcus horikoshii OT3
To be Published
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2OWD
 | | Crystal structure of TTHB049 from Thermus thermophilus HB8 | | Descriptor: | Alpha-ribazole-5'-phosphate phosphatase, GLYCEROL, SODIUM ION | | Authors: | Sugahara, M, Taketa, M, Ono, N, Matsuura, Y, Kunishima, N, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-02-16 | | Release date: | 2007-08-21 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Crystal structure of TTHB049 from Thermus thermophilus HB8
To be Published
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2P2X
 | | Crystal structure of PH0725 from Pyrococcus horikoshii OT3 | | Descriptor: | Probable diphthine synthase, S-ADENOSYL-L-HOMOCYSTEINE | | Authors: | Sugahara, M, Ono, N, Taketa, M, Matsuura, Y, Kunishima, N, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-03-08 | | Release date: | 2007-09-11 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Crystal structure of PH0725 from Pyrococcus horikoshii OT3
To be Published
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3B26
 | | Hsp90 alpha N-terminal domain in complex with an inhibitor Ro1127850 | | Descriptor: | 4-(1H,3H-benzo[de]isochromen-6-yl)-6-methylpyrimidin-2-amine, Heat shock protein HSP 90-alpha | | Authors: | Fukami, T.A, Ono, N. | | Deposit date: | 2011-07-21 | | Release date: | 2011-09-14 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Lead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug design
Bioorg.Med.Chem.Lett., 21, 2011
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3B24
 | | Hsp90 alpha N-terminal domain in complex with an aminotriazine fragment molecule | | Descriptor: | 4-(ethylsulfanyl)-6-methyl-1,3,5-triazin-2-amine, Heat shock protein HSP 90-alpha, MAGNESIUM ION | | Authors: | Fukami, T.A, Ono, N. | | Deposit date: | 2011-07-21 | | Release date: | 2011-09-14 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Lead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug design
Bioorg.Med.Chem.Lett., 21, 2011
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3B27
 | | Hsp90 alpha N-terminal domain in complex with an inhibitor Ro4919127 | | Descriptor: | 4-(2-chlorophenyl)-6-(methylsulfanyl)-1,3,5-triazin-2-amine, Heat shock protein HSP 90-alpha | | Authors: | Fukami, T.A, Ono, N. | | Deposit date: | 2011-07-21 | | Release date: | 2011-09-14 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Lead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug design
Bioorg.Med.Chem.Lett., 21, 2011
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3B25
 | | Hsp90 alpha N-terminal domain in complex with an inhibitor CH4675194 | | Descriptor: | 4-Methyl-6-(toluene-4-sulfonyl)-pyrimidin-2-ylamine, Heat shock protein HSP 90-alpha | | Authors: | Fukami, T.A, Ono, N. | | Deposit date: | 2011-07-21 | | Release date: | 2011-09-14 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Lead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug design
Bioorg.Med.Chem.Lett., 21, 2011
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3B28
 | | Hsp90 alpha N-terminal domain in complex with an inhibitor CH5015765 | | Descriptor: | 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(methylsulfanyl)-1,3,5-triazin-2-amine, GLYCEROL, Heat shock protein HSP 90-alpha, ... | | Authors: | Fukami, T.A, Ono, N. | | Deposit date: | 2011-07-21 | | Release date: | 2011-09-14 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.35 Å) | | Cite: | Lead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug design
Bioorg.Med.Chem.Lett., 21, 2011
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3VHA
 | | Hsp90 alpha N-terminal domain in complex with a macrocyclic inhibitor | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 22-methyl-13,18-dioxa-7-thia-3,5-diazatetracyclo[17.3.1.1~2,6~.1~8,12~]pentacosa-1(23),2(25),3,5,8(24),9,11,19,21-nonaen-4-amine, Heat shock protein HSP 90-alpha | | Authors: | Fukami, T.A, Ono, N. | | Deposit date: | 2011-08-24 | | Release date: | 2012-07-18 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.39 Å) | | Cite: | Design and synthesis of novel macrocyclic 2-amino-6-arylpyrimidine Hsp90 inhibitors
Bioorg.Med.Chem.Lett., 22, 2012
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3VHC
 | | Hsp90 alpha N-terminal domain in complex with a macrocyclic inhibitor | | Descriptor: | 4-amino-20,22-dimethyl-13-oxa-7-thia-3,5,17-triazatetracyclo[17.3.1.1~2,6~.1~8,12~]pentacosa-1(23),2(25),3,5,8(24),9,11,19,21-nonaen-18-one, Heat shock protein HSP 90-alpha, MAGNESIUM ION | | Authors: | Fukami, T.A, Ono, N. | | Deposit date: | 2011-08-24 | | Release date: | 2012-07-18 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.41 Å) | | Cite: | Design and synthesis of novel macrocyclic 2-amino-6-arylpyrimidine Hsp90 inhibitors
Bioorg.Med.Chem.Lett., 22, 2012
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3WHA
 | | Hsp90 alpha N-terminal domain in complex with a tricyclic inhibitor | | Descriptor: | 4-{[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-1,3,5-triazin-2-yl]sulfanyl}butanamide, GLYCEROL, Heat shock protein HSP 90-alpha, ... | | Authors: | Fukami, T.A, Ono, N. | | Deposit date: | 2013-08-23 | | Release date: | 2014-01-29 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Design and synthesis of 2-amino-6-(1H,3H-benzo[de]isochromen-6-yl)-1,3,5-triazines as novel Hsp90 inhibitors
Bioorg.Med.Chem., 22, 2014
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3VHD
 | | Hsp90 alpha N-terminal domain in complex with a macrocyclic inhibitor, CH5164840 | | Descriptor: | 4-amino-18,20-dimethyl-7-thia-3,5,11,15-tetraazatricyclo[15.3.1.1(2,6)]docosa-1(20),2,4,6(22),17(21),18-hexaene-10,16-dione, Heat shock protein HSP 90-alpha | | Authors: | Fukami, T.A, Ono, N. | | Deposit date: | 2011-08-24 | | Release date: | 2012-07-18 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.52 Å) | | Cite: | Design and synthesis of novel macrocyclic 2-amino-6-arylpyrimidine Hsp90 inhibitors
Bioorg.Med.Chem.Lett., 22, 2012
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1R2C
 | | PHOTOSYNTHETIC REACTION CENTER BLASTOCHLORIS VIRIDIS (ATCC) | | Descriptor: | 15-cis-1,2-dihydroneurosporene, BACTERIOCHLOROPHYLL B, BACTERIOPHEOPHYTIN B, ... | | Authors: | Baxter, R.H, Ponomarenko, N, Pahl, R, Srajer, V, Moffat, K, Norris, J.R. | | Deposit date: | 2003-09-26 | | Release date: | 2004-04-27 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.86 Å) | | Cite: | Time-resolved crystallographic studies of light-induced structural changes in the photosynthetic reaction center.
Proc.Natl.Acad.Sci.USA, 101, 2004
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6RZ5
 | | XFEL crystal structure of the human cysteinyl leukotriene receptor 1 in complex with zafirlukast | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Cysteinyl leukotriene receptor 1,Soluble cytochrome b562,Cysteinyl leukotriene receptor 1, OLEIC ACID, ... | | Authors: | Luginina, A, Gusach, A, Marin, E, Mishin, A, Brouillette, R, Popov, P, Shiryaeva, A, Besserer-Offroy, E, Longpre, J.M, Lyapina, E, Ishchenko, A, Patel, N, Polovinkin, V, Safronova, N, Bogorodskiy, A, Edelweiss, E, Liu, W, Batyuk, A, Gordeliy, V, Han, G.W, Sarret, P, Katritch, V, Borshchevskiy, V, Cherezov, V. | | Deposit date: | 2019-06-12 | | Release date: | 2019-10-30 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.53 Å) | | Cite: | Structure-based mechanism of cysteinyl leukotriene receptor inhibition by antiasthmatic drugs.
Sci Adv, 5, 2019
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6RZ4
 | | Crystal structure of cysteinyl leukotriene receptor 1 in complex with pranlukast | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Cysteinyl leukotriene receptor 1,Soluble cytochrome b562,Cysteinyl leukotriene receptor 1, OLEIC ACID, ... | | Authors: | Luginina, A, Gusach, A, Marin, E, Mishin, A, Brouillette, R, Popov, P, Shiryaeva, A, Besserer-Offroy, E, Longpre, J.M, Lyapina, E, Ishchenko, A, Patel, N, Polovinkin, V, Safronova, N, Bogorodskiy, A, Edelweiss, E, Liu, W, Batyuk, A, Gordeliy, V, Han, G.W, Sarret, P, Katritch, V, Borshchevskiy, V, Cherezov, V. | | Deposit date: | 2019-06-12 | | Release date: | 2019-10-30 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structure-based mechanism of cysteinyl leukotriene receptor inhibition by antiasthmatic drugs.
Sci Adv, 5, 2019
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8GH5
 | | Implementing Logic Gates in DNA Crystal Engineering | | Descriptor: | DNA (5'-D(*AP*GP*AP*CP*G)-3'), DNA (5'-D(*CP*TP*AP*CP*G)-3'), DNA (5'-D(P*CP*GP*TP*GP*GP*A)-3'), ... | | Authors: | Zhang, C, Paluzzi, V.E, Sha, R, Jonoska, N, Mao, C. | | Deposit date: | 2023-03-09 | | Release date: | 2023-06-07 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.64 Å) | | Cite: | Implementing Logic Gates by DNA Crystal Engineering.
Adv Mater, 35, 2023
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