6C9M
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6C9D
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7L1K
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4DAW
| Crystal structure of PAK1 kinase domain with the ruthenium phthalimide complex | Descriptor: | Serine/threonine-protein kinase PAK 1, [1,3-dioxo-6-(pyridin-2-yl-kappaN)-2,3-dihydro-1H-isoindol-5-yl-kappaC~5~][(thioxomethylidene)azanido-kappaN](1,4,7-trithionane-kappa~3~S~1~,S~4~,S~7~)ruthenium | Authors: | Maksimoska, J, Marmorstein, R. | Deposit date: | 2012-01-13 | Release date: | 2012-03-14 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The art of filling protein pockets efficiently with octahedral metal complexes. Angew.Chem.Int.Ed.Engl., 51, 2012
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4E26
| BRAF in complex with an organic inhibitor 7898734 | Descriptor: | 5-chloro-7-[(R)-furan-2-yl(pyridin-2-ylamino)methyl]quinolin-8-ol, Serine/threonine-protein kinase B-raf | Authors: | Qin, J, Xie, P, Ventocilla, C, Zhou, G, Vultur, A, Chen, Q, Herlyn, M, Winkler, J, Marmorstein, R. | Deposit date: | 2012-03-07 | Release date: | 2012-05-09 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Identification of a Novel Family of BRAF(V600E) Inhibitors. J.Med.Chem., 55, 2012
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4EQC
| Crystal structure of PAK1 kinase domain in complex with FRAX597 inhibitor | Descriptor: | 6-[2-chloro-4-(1,3-thiazol-5-yl)phenyl]-8-ethyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one, CHLORIDE ION, Serine/threonine-protein kinase PAK 1 | Authors: | Maksimoska, J, Marmorstein, R. | Deposit date: | 2012-04-18 | Release date: | 2013-08-28 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | FRAX597, a Small Molecule Inhibitor of the p21-activated Kinases, Inhibits Tumorigenesis of Neurofibromatosis Type 2 (NF2)-associated Schwannomas. J.Biol.Chem., 288, 2013
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4GS4
| Structure of the alpha-tubulin acetyltransferase, alpha-TAT1 | Descriptor: | ACETYL COENZYME *A, Alpha-tubulin N-acetyltransferase | Authors: | Friedmann, D.R, Fan, J, Marmorstein, R. | Deposit date: | 2012-08-27 | Release date: | 2012-10-17 | Last modified: | 2013-08-28 | Method: | X-RAY DIFFRACTION (2.112 Å) | Cite: | Structure of the alpha-tubulin acetyltransferase, alpha TAT1, and implications for tubulin-specific acetylation. Proc.Natl.Acad.Sci.USA, 109, 2012
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3TOA
| Human MOF crystal structure with active site lysine partially acetylated | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, ZINC ION, ... | Authors: | Yuan, H, Ding, E.C, Marmorstein, R. | Deposit date: | 2011-09-04 | Release date: | 2011-11-09 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (3.004 Å) | Cite: | MYST protein acetyltransferase activity requires active site lysine autoacetylation. Embo J., 31, 2011
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3TO6
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1QP9
| STRUCTURE OF HAP1-PC7 COMPLEXED TO THE UAS OF CYC7 | Descriptor: | CYP1(HAP1-PC7) ACTIVATORY PROTEIN, DNA (5'-D(*AP*CP*GP*CP*TP*AP*TP*TP*AP*TP*CP*GP*CP*TP*AP*TP*TP*AP*GP*T)-3'), DNA (5'-D(*AP*CP*TP*AP*AP*TP*AP*GP*CP*GP*AP*TP*AP*AP*TP*AP*GP*CP*GP*T)-3'), ... | Authors: | Lukens, A, King, D, Marmorstein, R. | Deposit date: | 1999-06-01 | Release date: | 2000-10-09 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure of HAP1-PC7 bound to DNA: implications for DNA recognition and allosteric effects of DNA-binding on transcriptional activation. Nucleic Acids Res., 28, 2000
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2R7G
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2RC4
| Crystal Structure of the HAT domain of the human MOZ protein | Descriptor: | ACETYL COENZYME *A, Histone acetyltransferase MYST3, ZINC ION | Authors: | Holbert, M.A, Sikorski, T, Snowflack, D, Marmorstein, R. | Deposit date: | 2007-09-19 | Release date: | 2007-11-13 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | The human monocytic leukemia zinc finger histone acetyltransferase domain contains DNA-binding activity implicated in chromatin targeting. J.Biol.Chem., 282, 2007
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4K2J
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4LX9
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1TRO
| CRYSTAL STRUCTURE OF TRP REPRESSOR OPERATOR COMPLEX AT ATOMIC RESOLUTION | Descriptor: | DNA (5'-D(*TP*GP*TP*AP*CP*TP*AP*GP*TP*TP*AP*AP*CP*TP*AP*GP*T P*AP*C)-3'), PROTEIN (TRP REPRESSOR), TRYPTOPHAN | Authors: | Otwinowski, Z, Schevitz, R.W, Zhang, R.-G, Lawson, C.L, Joachimiak, A, Marmorstein, R, Luisi, B.F, Sigler, P.B. | Deposit date: | 1992-08-30 | Release date: | 1994-01-31 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of trp repressor/operator complex at atomic resolution. Nature, 335, 1988
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7RB3
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7RMP
| Structure of ACLY D1026A - substrates-asym | Descriptor: | (3S)-citryl-Coenzyme A, ADENOSINE-5'-DIPHOSPHATE, ATP-citrate synthase, ... | Authors: | Wei, X, Marmorstein, R. | Deposit date: | 2021-07-28 | Release date: | 2023-05-10 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Allosteric role of the citrate synthase homology domain of ATP citrate lyase. Nat Commun, 14, 2023
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7RIG
| Structure of ACLY-D1026A-substrates | Descriptor: | (3S)-citryl-Coenzyme A, ADENOSINE-5'-DIPHOSPHATE, ATP-citrate synthase, ... | Authors: | Wei, X, Marmorstein, R. | Deposit date: | 2021-07-19 | Release date: | 2023-05-10 | Last modified: | 2023-05-31 | Method: | ELECTRON MICROSCOPY (2.2 Å) | Cite: | Allosteric role of the citrate synthase homology domain of ATP citrate lyase. Nat Commun, 14, 2023
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7RKZ
| Structure of ACLY D1026A-substrates-asym-int | Descriptor: | (3S)-citryl-Coenzyme A, ADENOSINE-5'-DIPHOSPHATE, ATP-citrate synthase, ... | Authors: | Wei, X, Marmorstein, R. | Deposit date: | 2021-07-22 | Release date: | 2023-05-10 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Allosteric role of the citrate synthase homology domain of ATP citrate lyase. Nat Commun, 14, 2023
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7SNI
| Structure of G6PD-D200N tetramer bound to NADP+ and G6P | Descriptor: | 6-O-phosphono-beta-D-glucopyranose, Glucose-6-phosphate 1-dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Wei, X, Marmorstein, R. | Deposit date: | 2021-10-28 | Release date: | 2022-07-13 | Last modified: | 2022-08-03 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Allosteric role of a structural NADP + molecule in glucose-6-phosphate dehydrogenase activity. Proc.Natl.Acad.Sci.USA, 119, 2022
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7SNG
| structure of G6PD-WT tetramer | Descriptor: | Glucose-6-phosphate 1-dehydrogenase | Authors: | Wei, X, Marmorstein, R. | Deposit date: | 2021-10-28 | Release date: | 2022-07-13 | Last modified: | 2022-08-03 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Allosteric role of a structural NADP + molecule in glucose-6-phosphate dehydrogenase activity. Proc.Natl.Acad.Sci.USA, 119, 2022
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7SNH
| Structure of G6PD-D200N tetramer bound to NADP+ | Descriptor: | Glucose-6-phosphate 1-dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Wei, X, Marmorstein, R. | Deposit date: | 2021-10-28 | Release date: | 2022-07-13 | Last modified: | 2022-08-03 | Method: | ELECTRON MICROSCOPY (2.2 Å) | Cite: | Allosteric role of a structural NADP + molecule in glucose-6-phosphate dehydrogenase activity. Proc.Natl.Acad.Sci.USA, 119, 2022
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7SNF
| Structure of G6PD-WT dimer | Descriptor: | Glucose-6-phosphate 1-dehydrogenase | Authors: | Wei, X, Marmorstein, R. | Deposit date: | 2021-10-28 | Release date: | 2022-07-13 | Last modified: | 2022-08-03 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Allosteric role of a structural NADP + molecule in glucose-6-phosphate dehydrogenase activity. Proc.Natl.Acad.Sci.USA, 119, 2022
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7STX
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7UAL
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