1QST
| CRYSTAL STRUCTURE OF TETRAHYMENA GCN5 | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, TGCN5 HISTONE ACETYL TRANSFERASE | 著者 | Rojas, J.R, Trievel, R.C, Zhou, J, Mo, Y, Li, X, Berger, S.L, David Allis, C, Marmorstein, R. | 登録日 | 1999-06-23 | 公開日 | 1999-09-08 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structure of Tetrahymena GCN5 bound to coenzyme A and a histone H3 peptide. Nature, 401, 1999
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1QSN
| CRYSTAL STRUCTURE OF TETRAHYMENA GCN5 WITH BOUND COENZYME A AND HISTONE H3 PEPTIDE | 分子名称: | COENZYME A, HISTONE H3, TGCN5 HISTONE ACETYL TRANSFERASE | 著者 | Rojas, J.R, Trievel, R.C, Zhou, J, Mo, Y, Li, X, Berger, S.L, David Allis, C, Marmorstein, R. | 登録日 | 1999-06-22 | 公開日 | 1999-09-08 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure of Tetrahymena GCN5 bound to coenzyme A and a histone H3 peptide. Nature, 401, 1999
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1S5P
| Structure and substrate binding properties of cobB, a Sir2 homolog protein deacetylase from Eschericia coli. | 分子名称: | HISTONE H4 (RESIDUES 12-19), NAD-dependent deacetylase, ZINC ION | 著者 | Zhao, K, Chai, X, Marmorstein, R. | 登録日 | 2004-01-21 | 公開日 | 2004-03-23 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | Structure and Substrate Binding Properties of cobB, a Sir2 Homolog Protein Deacetylase from Eschericia coli. J.Mol.Biol., 337, 2004
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8V0F
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5KJ2
| The novel p300/CBP inhibitor A-485 uncovers a unique mechanism of action to target AR in castrate resistant prostate cancer | 分子名称: | Histone acetyltransferase p300, N-[(4-fluorophenyl)methyl]-2-{(1R)-5-[(methylcarbamoyl)amino]-2',4'-dioxo-2,3-dihydro-3'H-spiro[indene-1,5'-[1,3]oxazolidin]-3'-yl}-N-[(2S)-1,1,1-trifluoropropan-2-yl]acetamide, SODIUM ION | 著者 | Jakob, C.G, Qiu, W, Edalji, R.P, Sun, C. | 登録日 | 2016-06-17 | 公開日 | 2017-09-27 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours. Nature, 550, 2017
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7LJE
| Discovery of Spirohydantoins as Selective, Orally Bioavailable Inhibitors of p300/CBP Histone Acetyltransferases | 分子名称: | 2-[4-[(3'R,4S)-3'-fluoro-1-[2-[(4-fluorophenyl)methyl-[(1S)-2,2,2-trifluoro-1-methyl-ethyl]amino]-2-oxo-ethyl]-2,5-dioxo-spiro[imidazolidine-4,1'-indane]-5'-yl]pyrazol-1-yl]-N-methyl-acetamide, Histone acetyltransferase p300 | 著者 | Jakob, C.G. | 登録日 | 2021-01-29 | 公開日 | 2021-03-17 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.607 Å) | 主引用文献 | Discovery of spirohydantoins as selective, orally bioavailable inhibitors of p300/CBP histone acetyltransferases. Bioorg.Med.Chem.Lett., 39, 2021
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4KVO
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4KVM
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4KVX
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8G5C
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3PUP
| Structure of Glycogen Synthase Kinase 3 beta (GSK3B) in complex with a ruthenium octasporine ligand (OS1) | 分子名称: | Glycogen synthase kinase-3 beta, Ruthenium octasporine | 著者 | Filippakopoulos, P, Kraling, K, Essen, L.O, Meggers, E, Knapp, S. | 登録日 | 2010-12-06 | 公開日 | 2010-12-22 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.99 Å) | 主引用文献 | Structurally sophisticated octahedral metal complexes as highly selective protein kinase inhibitors. J.Am.Chem.Soc., 133, 2011
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2OD7
| Crystal Structure of yHst2 bound to the intermediate analogue ADP-HPD, and and aceylated H4 peptide | 分子名称: | 5'-O-[(S)-{[(S)-{[(2R,3R,4S)-3,4-DIHYDROXYPYRROLIDIN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]ADENOSINE, Acetylated histone H4 peptide, NAD-dependent deacetylase HST2, ... | 著者 | Marmorstein, R.Q, Sanders, B.D. | 登録日 | 2006-12-21 | 公開日 | 2007-02-27 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural basis for nicotinamide inhibition and base exchange in sir2 enzymes. Mol.Cell, 25, 2007
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5DEY
| Crystal structure of PAK1 in complex with an inhibitor compound G-5555 | 分子名称: | 8-[(trans-5-amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methylpyridin-2-yl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one, Serine/threonine-protein kinase PAK 1 | 著者 | Oh, A, Tam, C, Wang, W. | 登録日 | 2015-08-26 | 公開日 | 2016-01-27 | 最終更新日 | 2016-06-01 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pK a Polar Moiety. Acs Med.Chem.Lett., 6, 2015
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1BD8
| STRUCTURE OF CDK INHIBITOR P19INK4D | 分子名称: | P19INK4D CDK4/6 INHIBITOR | 著者 | Baumgartner, R, Fernandez-Catalan, C, Winoto, A, Huber, R, Engh, R, Holak, T.A. | 登録日 | 1998-05-12 | 公開日 | 1998-10-14 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structure of human cyclin-dependent kinase inhibitor p19INK4d: comparison to known ankyrin-repeat-containing structures and implications for the dysfunction of tumor suppressor p16INK4a. Structure, 6, 1998
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5YJE
| Crystal structure of HIRA(644-1017) | 分子名称: | Protein HIRA, SULFATE ION | 著者 | Sato, Y, Senda, M, Senda, T. | 登録日 | 2017-10-10 | 公開日 | 2018-06-20 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Functional activity of the H3.3 histone chaperone complex HIRA requires trimerization of the HIRA subunit Nat Commun, 9, 2018
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6UUZ
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2FH9
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2OD2
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3COQ
| Structural Basis for Dimerization in DNA Recognition by Gal4 | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, DNA (5'-D(*DAP*DCP*DCP*DGP*DGP*DAP*DGP*DGP*DAP*DCP*DAP*DGP*DTP*DCP*DCP*DTP*DCP*DCP*DGP*DG)-3'), DNA (5'-D(*DTP*DCP*DCP*DGP*DGP*DAP*DGP*DGP*DAP*DCP*DTP*DGP*DTP*DCP*DCP*DTP*DCP*DCP*DGP*DG)-3'), ... | 著者 | Hong, M, Fitzgerald, M.X, Harper, S, Luo, C, Speicher, D.W. | 登録日 | 2008-03-29 | 公開日 | 2008-07-01 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural basis for dimerization in DNA recognition by gal4. Structure, 16, 2008
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3EXJ
| Crystal Structure of a p53 Core Tetramer Bound to DNA | 分子名称: | 5'-D(*DTP*DTP*DGP*DAP*DGP*DCP*DAP*DTP*DGP*DCP*DTP*DC)-3', 5'-D(P*DGP*DAP*DGP*DCP*DAP*DTP*DGP*DCP*DTP*DCP*DA)-3', CITRATE ANION, ... | 著者 | Malecka, K.A. | 登録日 | 2008-10-16 | 公開日 | 2008-12-16 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structure of a p53 core tetramer bound to DNA. Oncogene, 28, 2009
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3F8K
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3EXL
| Crystal Structure of a p53 Core Tetramer Bound to DNA | 分子名称: | 5'-D(*DGP*DAP*DGP*DCP*DAP*DTP*DGP*DCP*DTP*DCP*DA)-3', 5'-D(*DTP*DTP*DGP*DAP*DGP*DCP*DAP*DTP*DGP*DCP*DTP*DC)-3', CITRATE ANION, ... | 著者 | Malecka, K.A. | 登録日 | 2008-10-16 | 公開日 | 2008-12-16 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structure of a p53 core tetramer bound to DNA. Oncogene, 28, 2009
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