5D2N
| Crystal structure of C25-NLV-HLA-A2 complex | 分子名称: | ASN-LEU-VAL-PRO-MET-VAL-ALA-THR-VAL, Beta-2-microglobulin, C25 alpha, ... | 著者 | Mariuzza, R.A, Yang, X. | 登録日 | 2015-08-05 | 公開日 | 2015-10-07 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.099 Å) | 主引用文献 | Structural Basis for Clonal Diversity of the Public T Cell Response to a Dominant Human Cytomegalovirus Epitope. J.Biol.Chem., 290, 2015
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1NBY
| Crystal Structure of HyHEL-63 complexed with HEL mutant K96A | 分子名称: | Lysozyme C, antibody kappa light chain, immunoglobulin gamma 1 chain | 著者 | Mariuzza, R.A, Li, Y, Urrutia, M, Smith-Gill, S.J. | 登録日 | 2002-12-04 | 公開日 | 2003-04-01 | 最終更新日 | 2021-10-27 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Dissection of binding interactions in the complex between the anti-lysozyme antibody HyHEL-63 and its antigen Biochemistry, 42, 2003
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1NDG
| Crystal structure of Fab fragment of antibody HyHEL-8 complexed with its antigen lysozyme | 分子名称: | ACETIC ACID, Lysozyme C, antibody kappa light chain, ... | 著者 | Mariuzza, R.A, Li, Y, Li, H, Yang, F, Smith-Gill, S.J. | 登録日 | 2002-12-09 | 公開日 | 2003-06-03 | 最終更新日 | 2021-10-27 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | X-ray snapshots of the maturation of an antibody response to a protein antigen Nat.Struct.Biol., 10, 2003
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1NDM
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1NBZ
| Crystal Structure of HyHEL-63 complexed with HEL mutant K97A | 分子名称: | Lysozyme C, antibody kappa light chain, immunoglobulin gamma 1 chain | 著者 | Mariuzza, R.A, Li, Y, Urrutia, M, Smith-Gill, S.J. | 登録日 | 2002-12-04 | 公開日 | 2003-04-01 | 最終更新日 | 2021-10-27 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Dissection of binding interactions in the complex between the anti-lysozyme antibody HyHEL-63 and its antigen Biochemistry, 42, 2003
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1BEC
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8SO3
| CryoEM structure of a therapeutic antibody (favezelimab) bound to human LAG3 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Lymphocyte activation gene 3 protein, favezelimab Fab heavy chain, ... | 著者 | Mishra, A.K, Shahid, S, Karade, S.S, Mariuzza, R.A. | 登録日 | 2023-04-28 | 公開日 | 2023-09-06 | 最終更新日 | 2023-10-18 | 実験手法 | ELECTRON MICROSCOPY (3.61 Å) | 主引用文献 | CryoEM structure of a therapeutic antibody (favezelimab) bound to human LAG3 determined using a bivalent Fab as fiducial marker. Structure, 31, 2023
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8SR0
| CryoEM structure of a therapeutic antibody (favezelimab) bound to human LAG3 local refined | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Lymphocyte activation gene 3 protein, favezelimab Fab heavy chain, ... | 著者 | Mishra, A.K, Shahid, S, Karade, S.S, Mariuzza, R.A. | 登録日 | 2023-05-05 | 公開日 | 2023-09-06 | 最終更新日 | 2023-10-18 | 実験手法 | ELECTRON MICROSCOPY (3.53 Å) | 主引用文献 | CryoEM structure of a therapeutic antibody (favezelimab) bound to human LAG3 determined using a bivalent Fab as fiducial marker. Structure, 31, 2023
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1AC6
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1A2Y
| HEN EGG WHITE LYSOZYME, D18A MUTANT, IN COMPLEX WITH MOUSE MONOCLONAL ANTIBODY D1.3 | 分子名称: | IGG1-KAPPA D1.3 FV (HEAVY CHAIN), IGG1-KAPPA D1.3 FV (LIGHT CHAIN), LYSOZYME, ... | 著者 | Tsuchiya, D, Mariuzza, R.A. | 登録日 | 1998-01-13 | 公開日 | 1998-04-29 | 最終更新日 | 2023-08-02 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | A mutational analysis of binding interactions in an antigen-antibody protein-protein complex. Biochemistry, 37, 1998
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4E41
| Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor G4 | 分子名称: | HLA class II histocompatibility antigen, DR alpha chain, DRB1-1 beta chain, ... | 著者 | Deng, L, Langley, R.J, Wang, Q, Topalian, S.L, Mariuzza, R.A. | 登録日 | 2012-03-11 | 公開日 | 2012-08-29 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor G4 Proc.Natl.Acad.Sci.USA, 2012
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5TEZ
| TCR F50 recgonizing M1-HLA-A2 | 分子名称: | Beta-2-microglobulin, GLY-ILE-LEU-GLY-PHE-VAL-PHE-THR-LEU, HLA class I histocompatibility antigen, ... | 著者 | Yang, X, Mariuzza, R.A. | 登録日 | 2016-09-23 | 公開日 | 2017-09-27 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structural basis for clonal diversity of the human T-cell response to a dominant influenza virus epitope. J. Biol. Chem., 292, 2017
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4K5U
| Recognition of the BG-H Antigen by a Lamprey Variable Lymphocyte Receptor | 分子名称: | Variable lymphocyte receptor, beta-D-galactopyranose | 著者 | Luo, M, Velikovsky, C.A, Yang, X.B, Mariuzza, R.A. | 登録日 | 2013-04-15 | 公開日 | 2013-06-26 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.698 Å) | 主引用文献 | Recognition of the thomsen-friedenreich pancarcinoma carbohydrate antigen by a lamprey variable lymphocyte receptor. J.Biol.Chem., 288, 2013
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7RD2
| Co-crystal structure of Chaetomium glucosidase with compound 2 | 分子名称: | (2R,3R,4R,5S)-1-{[4-({4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2-nitroanilino}methyl)phenyl]methyl}-2-(hydroxymethyl)piperidine-3,4,5-triol, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Chaetomium alpha glucosidase, ... | 著者 | Karade, S.S, Mariuzza, R.A. | 登録日 | 2021-07-09 | 公開日 | 2023-02-22 | 最終更新日 | 2023-03-01 | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | 主引用文献 | Structure-Based Design of Potent Iminosugar Inhibitors of Endoplasmic Reticulum alpha-Glucosidase I with Anti-SARS-CoV-2 Activity. J.Med.Chem., 66, 2023
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7T68
| Co-crystal structure of Chaetomium glucosidase with compound UV-5 | 分子名称: | (2R,3R,4R,5S)-1-[6-(4-azido-2-nitroanilino)hexyl]-2-(hydroxymethyl)piperidine-3,4,5-triol, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Karade, S.S, Mariuzza, R.A. | 登録日 | 2021-12-13 | 公開日 | 2022-05-04 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | 主引用文献 | Identification of Endoplasmic Reticulum alpha-Glucosidase I from a Thermophilic Fungus as a Platform for Structure-Guided Antiviral Drug Design. Biochemistry, 61, 2022
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7T66
| Co-crystal structure of Chaetomium glucosidase with compound UV-4 | 分子名称: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Chaetomium alpha glucosidase, ... | 著者 | Karade, S.S, Mariuzza, R.A. | 登録日 | 2021-12-13 | 公開日 | 2022-05-04 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | 主引用文献 | Identification of Endoplasmic Reticulum alpha-Glucosidase I from a Thermophilic Fungus as a Platform for Structure-Guided Antiviral Drug Design. Biochemistry, 61, 2022
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7T6W
| Crystal structure of Chaetomium Glucosidase I (apo) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Chaetomium alpha glucosidase, GLYCEROL, ... | 著者 | Karade, S.S, Mariuzza, R.A. | 登録日 | 2021-12-14 | 公開日 | 2022-05-04 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Identification of Endoplasmic Reticulum alpha-Glucosidase I from a Thermophilic Fungus as a Platform for Structure-Guided Antiviral Drug Design. Biochemistry, 61, 2022
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7T8V
| Co-crystal structure of Chaetomium glucosidase I with EB-0159 | 分子名称: | (1S,2S,3R,4S,5S)-1-(hydroxymethyl)-5-[(6-{[2-nitro-4-(1H-1,2,3-triazol-1-yl)phenyl]amino}hexyl)amino]cyclohexane-1,2,3,4-tetrol, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Karade, S.S, Mariuzza, R.A. | 登録日 | 2021-12-17 | 公開日 | 2022-05-04 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Identification of Endoplasmic Reticulum alpha-Glucosidase I from a Thermophilic Fungus as a Platform for Structure-Guided Antiviral Drug Design. Biochemistry, 61, 2022
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3T0E
| Crystal structure of a complete ternary complex of T cell receptor, peptide-MHC and CD4 | 分子名称: | HLA class II histocompatibility antigen, DR alpha chain, DRB1-4 beta chain, ... | 著者 | Yin, Y, Mariuzza, R.A. | 登録日 | 2011-07-20 | 公開日 | 2012-03-07 | 最終更新日 | 2017-11-08 | 実験手法 | X-RAY DIFFRACTION (4 Å) | 主引用文献 | Crystal structure of a complete ternary complex of T-cell receptor, peptide-MHC, and CD4. Proc.Natl.Acad.Sci.USA, 109, 2012
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7N1A
| SARS-CoV-2 YLQ peptide binds to HLA-A2 | 分子名称: | Beta-2-microglobulin, MHC class I antigen, A-2 alpha chain, ... | 著者 | Wu, D, Mariuzza, R.A. | 登録日 | 2021-05-27 | 公開日 | 2021-07-28 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.065 Å) | 主引用文献 | Structural assessment of HLA-A2-restricted SARS-CoV-2 spike epitopes recognized by public and private T-cell receptors. Nat Commun, 13, 2022
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7N1B
| SARS-CoV-2 RLQ peptide binds to HLA-A2 | 分子名称: | Beta-2-microglobulin, MHC class I antigen, A-2 alpha chain, ... | 著者 | Wu, D, Mariuzza, R.A. | 登録日 | 2021-05-27 | 公開日 | 2021-07-28 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | 主引用文献 | Structural assessment of HLA-A2-restricted SARS-CoV-2 spike epitopes recognized by public and private T-cell receptors. Nat Commun, 13, 2022
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7N1E
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7N1C
| SARS-CoV-2 RLQ peptide-specific TCR pRLQ3 | 分子名称: | pRLQ3 T cell receptor alpha chain, pRLQ3 T cell receptor beta chain | 著者 | Wu, D, Mariuzza, R.A. | 登録日 | 2021-05-27 | 公開日 | 2021-07-28 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.881 Å) | 主引用文献 | Structural assessment of HLA-A2-restricted SARS-CoV-2 spike epitopes recognized by public and private T-cell receptors. Nat Commun, 13, 2022
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7N1D
| SARS-CoV-2 YLQ peptide-specific TCR pYLQ7 | 分子名称: | pYLQ7 T cell receptor alpha chain, pYLQ7 T cell receptor beta chain | 著者 | Wu, D, Mariuzza, R.A. | 登録日 | 2021-05-27 | 公開日 | 2021-07-28 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Structural assessment of HLA-A2-restricted SARS-CoV-2 spike epitopes recognized by public and private T-cell receptors. Nat Commun, 13, 2022
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7N1F
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