8SR0

CryoEM structure of a therapeutic antibody (favezelimab) bound to human LAG3 local refined

Summary for 8SR0

Entry DOI	10.2210/pdb8sr0/pdb
EMDB information	40716
Descriptor	Lymphocyte activation gene 3 protein, favezelimab Fab heavy chain, favezelimab Fab light chain, ... (4 entities in total)
Functional Keywords	lymphocyte activation gene 3 protein, favezelimab-lag3 complex, cryoem, single particle reconstruction., immunosuppressant
Biological source	Homo sapiens (human) More
Total number of polymer chains	6
Total formula weight	221781.66
Authors	Mishra, A.K.,Shahid, S.,Karade, S.S.,Mariuzza, R.A. (deposition date: 2023-05-05, release date: 2023-09-06, Last modification date: 2023-10-18)
Primary citation	Mishra, A.K.,Shahid, S.,Karade, S.S.,Agnihotri, P.,Kolesnikov, A.,Hasan, S.S.,Mariuzza, R.A. CryoEM structure of a therapeutic antibody (favezelimab) bound to human LAG3 determined using a bivalent Fab as fiducial marker. Structure, 31:1149-, 2023 Cited by PubMed: 37619561 DOI: 10.1016/j.str.2023.07.013 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.53 Å)

Structure validation