8SR0

CryoEM structure of a therapeutic antibody (favezelimab) bound to human LAG3 local refined

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (X, D)	Lymphocyte activation gene 3 protein	polymer	525	57508.3	2	UniProt (P18627)	Homo sapiens (human)	LAG-3
2	B, E (Y, H)	favezelimab Fab heavy chain	polymer	252	27245.7	2		Mus musculus (mouse)
3	C, F (Z, L)	favezelimab Fab light chain	polymer	238	25915.6	2		Mus musculus (mouse)
4	G, H (X, D)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	221339.2
Non-Polymers*	Number of molecules	2
	Total formula weight	442.4
All*	Total formula weight	221781.7

*Water molecules are not included.