1BEC

BETA CHAIN OF A T CELL ANTIGEN RECEPTOR

Summary for 1BEC

• Entry DOI: 10.2210/pdb1bec/pdb
• Descriptor: 14.3.D T CELL ANTIGEN RECEPTOR (2 entities in total)
• Functional Keywords: t cell receptor, receptor
• Biological source: Mus musculus (house mouse)
• Total number of polymer chains: 1
• Total formula weight: 26568.49

Authors

Bentley, G.A.,Boulot, G.,Karjalainen, K.,Mariuzza, R.A. (deposition date: 1995-02-28, release date: 1995-10-25, Last modification date: 2024-10-23)

Primary citation

Bentley, G.A.,Boulot, G.,Karjalainen, K.,Mariuzza, R.A.
Crystal structure of the beta chain of a T cell antigen receptor.
Science, 267:1984-1987, 1995

PubMed Abstract: The crystal structure of the extracellular portion of the beta chain of a murine T cell antigen receptor (TCR), determined at a resolution of 1.7 angstroms, shows structural homology to immunoglobulins. The structure of the first and second hypervariable loops suggested that, in general, they adopt more restricted sets of conformations in TCR beta chains than those found in immunoglobulins; the third hypervariable loop had certain structural characteristics in common with those of immunoglobulin heavy chain variable domains. The variable and constant domains were in close contact, presumably restricting the flexibility of the beta chain. This may facilitate signal transduction from the TCR to the associated CD3 molecules in the TCR-CD3 complex.

PubMed: 7701320

Experimental method

X-RAY DIFFRACTION (1.7 Å)