6JSH
| Apo-state Fatty Acid Synthase | Descriptor: | Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta | Authors: | Qiu, S.W, Liu, S. | Deposit date: | 2019-04-08 | Release date: | 2019-09-25 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (5.1 Å) | Cite: | Modulation of fatty acid synthase by ATR checkpoint kinase Rad3. J Mol Cell Biol, 11, 2019
|
|
6JSI
| Co-purified Fatty Acid Synthase | Descriptor: | Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta | Authors: | Qiu, S.W, Liu, S. | Deposit date: | 2019-04-08 | Release date: | 2019-09-25 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (4.7 Å) | Cite: | Modulation of fatty acid synthase by ATR checkpoint kinase Rad3. J Mol Cell Biol, 11, 2019
|
|
5JJU
| Crystal structure of Rv2837c complexed with 5'-pApA and 5'-AMP | Descriptor: | ADENOSINE MONOPHOSPHATE, MANGANESE (II) ION, RNA (5'-R(P*AP*A)-3'), ... | Authors: | Wang, F, He, Q, Liu, S, Gu, L. | Deposit date: | 2016-04-25 | Release date: | 2016-05-04 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.312 Å) | Cite: | Structural and biochemical insight into the mechanism of Rv2837c from Mycobacterium tuberculosis as a c-di-NMP phosphodiesterase J.Biol.Chem., 291, 2016
|
|
2KWF
| The structure of E-protein activation domain 1 bound to the KIX domain of CBP/p300 elucidates leukemia induction by E2A-PBX1 | Descriptor: | CREB-binding protein, Transcription factor 4 | Authors: | Denis, C.M, Chitayat, S, Plevin, M.J, Liu, S, Spencer, H.L, Ikura, M, LeBrun, D.P, Smith, S.P. | Deposit date: | 2010-04-08 | Release date: | 2011-07-20 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | The structure of E-protein activation domain 1 bound to the KIX domain of CBP/p300 elucidates leukemia induction by E2A-PBX1 To be Published
|
|
4OHE
| LEOPARD Syndrome-Associated SHP2/G464A mutant | Descriptor: | Tyrosine-protein phosphatase non-receptor type 11 | Authors: | Yu, Z.H, Zhang, R.Y, Walls, C.D, Chen, L, Zhang, S, Wu, L, Wang, L, Liu, S, Zhang, Z.Y. | Deposit date: | 2014-01-17 | Release date: | 2014-09-24 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.506 Å) | Cite: | Molecular basis of gain-of-function LEOPARD syndrome-associated SHP2 mutations. Biochemistry, 53, 2014
|
|
4OHD
| LEOPARD Syndrome-Associated SHP2/A461T mutant | Descriptor: | Tyrosine-protein phosphatase non-receptor type 11 | Authors: | Yu, Z.H, Zhang, R.Y, Walls, C.D, Chen, L, Zhang, S, Wu, L, Wang, L, Liu, S, Zhang, Z.Y. | Deposit date: | 2014-01-17 | Release date: | 2014-09-24 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Molecular basis of gain-of-function LEOPARD syndrome-associated SHP2 mutations. Biochemistry, 53, 2014
|
|
4OHI
| LEOPARD Syndrome-Associated SHP2/Q510E mutant | Descriptor: | Tyrosine-protein phosphatase non-receptor type 11 | Authors: | Yu, Z.H, Zhang, R.Y, Walls, C.D, Chen, L, Zhang, S, Wu, L, Wang, L, Liu, S, Zhang, Z.Y. | Deposit date: | 2014-01-17 | Release date: | 2014-09-24 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Molecular basis of gain-of-function LEOPARD syndrome-associated SHP2 mutations. Biochemistry, 53, 2014
|
|
4OHH
| LEOPARD Syndrome-Associated SHP2/Q506P mutant | Descriptor: | Tyrosine-protein phosphatase non-receptor type 11 | Authors: | Yu, Z.H, Zhang, R.Y, Walls, C.D, Chen, L, Zhang, S, Wu, L, Wang, L, Liu, S, Zhang, Z.Y. | Deposit date: | 2014-01-17 | Release date: | 2014-09-24 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Molecular basis of gain-of-function LEOPARD syndrome-associated SHP2 mutations. Biochemistry, 53, 2014
|
|
4OHL
| LEOPARD Syndrome-Associated SHP2/T468M mutant | Descriptor: | Tyrosine-protein phosphatase non-receptor type 11 | Authors: | Yu, Z.H, Zhang, R.Y, Walls, C.D, Chen, L, Zhang, S, Wu, L, Wang, L, Liu, S, Zhang, Z.Y. | Deposit date: | 2014-01-17 | Release date: | 2014-09-24 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Molecular basis of gain-of-function LEOPARD syndrome-associated SHP2 mutations. Biochemistry, 53, 2014
|
|
3F8S
| Crystal structure of dipeptidyl peptidase IV in complex with inhibitor | Descriptor: | 2-(4-{(3S,5S)-5-[(3,3-difluoropyrrolidin-1-yl)carbonyl]pyrrolidin-3-yl}piperazin-1-yl)pyrimidine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Ammirati, M.J, Liu, S, Piotrowski, D.W. | Deposit date: | 2008-11-13 | Release date: | 2009-06-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.43 Å) | Cite: | (3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin-2-yl]-methanone: a potent, selective, orally active dipeptidyl peptidase IV inhibitor. Bioorg.Med.Chem.Lett., 19, 2009
|
|
3HSM
| Crystal structure of distal N-terminal beta-trefoil domain of Ryanodine Receptor type 1 | Descriptor: | Ryanodine receptor 1 | Authors: | Amador, F.J, Liu, S, Ishiyama, N, Plevin, M.J, Wilson, A, MacLennan, D.H, Ikura, M. | Deposit date: | 2009-06-10 | Release date: | 2009-07-28 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of type I ryanodine receptor amino-terminal beta-trefoil domain reveals a disease-associated mutation "hot spot" loop Proc.Natl.Acad.Sci.USA, 106, 2009
|
|
8HPF
| |
8HQ7
| |
8HPU
| |
8HP9
| |
8HPQ
| |
8HPV
| |
7XF3
| The structure of HLA-B*1501/BM58-66AF9 | Descriptor: | 9-mer peptide from Matrix protein 1, Beta-2-microglobulin, MHC class I antigen | Authors: | Zhao, Y.Z, Xiao, W.L, Wu, Y.N, Fan, W.F, Yue, C, Zhang, Q.X, Zhang, D.N, Yuan, X.J, Yao, S.J, Liu, S, Li, M, Wang, P.Y, Zhang, H.J, Zhang, J, Zhao, M, Zheng, X.Q, Liu, W.J, Gao, G.F, Liu, W.L. | Deposit date: | 2022-03-31 | Release date: | 2023-02-08 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Parallel T Cell Immunogenic Regions in Influenza B and A Viruses with Distinct Nuclear Export Signal Functions: The Balance between Viral Life Cycle and Immune Escape. J Immunol., 210, 2023
|
|
3P2M
| Crystal Structure of a Novel Esterase Rv0045c from Mycobacterium tuberculosis | Descriptor: | POSSIBLE HYDROLASE | Authors: | Zheng, X.D, Guo, J, Xu, L, Li, H, Zhang, D, Zhang, K, Sun, F, Wen, T, Liu, S, Pang, H. | Deposit date: | 2010-10-03 | Release date: | 2011-07-06 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal Structure of a Novel Esterase Rv0045c from Mycobacterium tuberculosis Plos One, 6, 2011
|
|
5CET
| Crystal structure of Rv2837c | Descriptor: | Bifunctional oligoribonuclease and PAP phosphatase NrnA, MANGANESE (II) ION | Authors: | Wang, F, He, Q, Zhu, D, Liu, S, Gu, L. | Deposit date: | 2015-07-07 | Release date: | 2015-12-23 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural and Biochemical Insight into the Mechanism of Rv2837c from Mycobacterium tuberculosis as a c-di-NMP Phosphodiesterase J.Biol.Chem., 291, 2016
|
|
4GO3
| |
4GO4
| Crystal structure of PnpE in complex with Nicotinamide adenine dinucleotide | Descriptor: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Putative gamma-hydroxymuconic semialdehyde dehydrogenase | Authors: | Su, J, Zhang, C, Liu, S, Zhu, D, Gu, L. | Deposit date: | 2012-08-18 | Release date: | 2013-09-04 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.099 Å) | Cite: | Crystal structure of PnpE in complex with Nicotinamide adenine dinucleotide To be Published
|
|
3U1Y
| Potent Inhibitors of LpxC for the Treatment of Gram-Negative Infections | Descriptor: | (2R)-N-hydroxy-2-methyl-2-(methylsulfonyl)-4-{4'-[3-(morpholin-4-yl)propoxy]biphenyl-4-yl}butanamide, UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ZINC ION | Authors: | Brown, M, Abramite, J, Liu, S. | Deposit date: | 2011-09-30 | Release date: | 2012-01-04 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Potent inhibitors of LpxC for the treatment of Gram-negative infections. J.Med.Chem., 55, 2012
|
|
3UHM
| |
6J8R
| Metallo-Beta-Lactamase VIM-2 in complex with Dual MBL/SBL Inhibitor MS01 | Descriptor: | Beta-lactamase class B VIM-2, FORMIC ACID, GLYCEROL, ... | Authors: | Li, G.-B, Liu, S. | Deposit date: | 2019-01-21 | Release date: | 2019-07-17 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.575 Å) | Cite: | Structure-Based Development of (1-(3'-Mercaptopropanamido)methyl)boronic Acid Derived Broad-Spectrum, Dual-Action Inhibitors of Metallo- and Serine-beta-lactamases. J.Med.Chem., 62, 2019
|
|