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6JSH
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Apo-state Fatty Acid Synthase
分子名称: Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta
著者Qiu, S.W, Liu, S.
登録日2019-04-08
公開日2019-09-25
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (5.1 Å)
主引用文献Modulation of fatty acid synthase by ATR checkpoint kinase Rad3.
J Mol Cell Biol, 11, 2019
6JSI
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Co-purified Fatty Acid Synthase
分子名称: Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta
著者Qiu, S.W, Liu, S.
登録日2019-04-08
公開日2019-09-25
最終更新日2024-04-24
実験手法ELECTRON MICROSCOPY (4.7 Å)
主引用文献Modulation of fatty acid synthase by ATR checkpoint kinase Rad3.
J Mol Cell Biol, 11, 2019
5JJU
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Crystal structure of Rv2837c complexed with 5'-pApA and 5'-AMP
分子名称: ADENOSINE MONOPHOSPHATE, MANGANESE (II) ION, RNA (5'-R(P*AP*A)-3'), ...
著者Wang, F, He, Q, Liu, S, Gu, L.
登録日2016-04-25
公開日2016-05-04
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.312 Å)
主引用文献Structural and biochemical insight into the mechanism of Rv2837c from Mycobacterium tuberculosis as a c-di-NMP phosphodiesterase
J.Biol.Chem., 291, 2016
2KWF
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BU of 2kwf by Molmil
The structure of E-protein activation domain 1 bound to the KIX domain of CBP/p300 elucidates leukemia induction by E2A-PBX1
分子名称: CREB-binding protein, Transcription factor 4
著者Denis, C.M, Chitayat, S, Plevin, M.J, Liu, S, Spencer, H.L, Ikura, M, LeBrun, D.P, Smith, S.P.
登録日2010-04-08
公開日2011-07-20
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献The structure of E-protein activation domain 1 bound to the KIX domain of CBP/p300 elucidates leukemia induction by E2A-PBX1
To be Published
4OHE
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BU of 4ohe by Molmil
LEOPARD Syndrome-Associated SHP2/G464A mutant
分子名称: Tyrosine-protein phosphatase non-receptor type 11
著者Yu, Z.H, Zhang, R.Y, Walls, C.D, Chen, L, Zhang, S, Wu, L, Wang, L, Liu, S, Zhang, Z.Y.
登録日2014-01-17
公開日2014-09-24
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.506 Å)
主引用文献Molecular basis of gain-of-function LEOPARD syndrome-associated SHP2 mutations.
Biochemistry, 53, 2014
4OHD
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LEOPARD Syndrome-Associated SHP2/A461T mutant
分子名称: Tyrosine-protein phosphatase non-receptor type 11
著者Yu, Z.H, Zhang, R.Y, Walls, C.D, Chen, L, Zhang, S, Wu, L, Wang, L, Liu, S, Zhang, Z.Y.
登録日2014-01-17
公開日2014-09-24
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Molecular basis of gain-of-function LEOPARD syndrome-associated SHP2 mutations.
Biochemistry, 53, 2014
4OHI
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LEOPARD Syndrome-Associated SHP2/Q510E mutant
分子名称: Tyrosine-protein phosphatase non-receptor type 11
著者Yu, Z.H, Zhang, R.Y, Walls, C.D, Chen, L, Zhang, S, Wu, L, Wang, L, Liu, S, Zhang, Z.Y.
登録日2014-01-17
公開日2014-09-24
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Molecular basis of gain-of-function LEOPARD syndrome-associated SHP2 mutations.
Biochemistry, 53, 2014
4OHH
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LEOPARD Syndrome-Associated SHP2/Q506P mutant
分子名称: Tyrosine-protein phosphatase non-receptor type 11
著者Yu, Z.H, Zhang, R.Y, Walls, C.D, Chen, L, Zhang, S, Wu, L, Wang, L, Liu, S, Zhang, Z.Y.
登録日2014-01-17
公開日2014-09-24
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Molecular basis of gain-of-function LEOPARD syndrome-associated SHP2 mutations.
Biochemistry, 53, 2014
4OHL
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LEOPARD Syndrome-Associated SHP2/T468M mutant
分子名称: Tyrosine-protein phosphatase non-receptor type 11
著者Yu, Z.H, Zhang, R.Y, Walls, C.D, Chen, L, Zhang, S, Wu, L, Wang, L, Liu, S, Zhang, Z.Y.
登録日2014-01-17
公開日2014-09-24
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Molecular basis of gain-of-function LEOPARD syndrome-associated SHP2 mutations.
Biochemistry, 53, 2014
3F8S
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Crystal structure of dipeptidyl peptidase IV in complex with inhibitor
分子名称: 2-(4-{(3S,5S)-5-[(3,3-difluoropyrrolidin-1-yl)carbonyl]pyrrolidin-3-yl}piperazin-1-yl)pyrimidine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Ammirati, M.J, Liu, S, Piotrowski, D.W.
登録日2008-11-13
公開日2009-06-23
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.43 Å)
主引用文献(3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin-2-yl]-methanone: a potent, selective, orally active dipeptidyl peptidase IV inhibitor.
Bioorg.Med.Chem.Lett., 19, 2009
3HSM
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BU of 3hsm by Molmil
Crystal structure of distal N-terminal beta-trefoil domain of Ryanodine Receptor type 1
分子名称: Ryanodine receptor 1
著者Amador, F.J, Liu, S, Ishiyama, N, Plevin, M.J, Wilson, A, MacLennan, D.H, Ikura, M.
登録日2009-06-10
公開日2009-07-28
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of type I ryanodine receptor amino-terminal beta-trefoil domain reveals a disease-associated mutation "hot spot" loop
Proc.Natl.Acad.Sci.USA, 106, 2009
8HPF
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BU of 8hpf by Molmil
Cryo-EM structure of SARS-CoV-2 Omicron BA.2 RBD in complex with fab L4.65 and L5.34
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S2', fab L4.65, ...
著者Gao, G.F, Liu, S.
登録日2022-12-12
公開日2023-12-20
最終更新日2024-01-31
実験手法ELECTRON MICROSCOPY (2.34 Å)
主引用文献Dosing interval regimen shapes potency and breadth of antibody repertoire after vaccination of SARS-CoV-2 RBD protein subunit vaccine.
Cell Discov, 9, 2023
8HQ7
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BU of 8hq7 by Molmil
Cryo-EM structure of SARS-CoV-2 Omicron Prototype RBD in complex with fab L4.65 and L5.34
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, fab L4.65, ...
著者Gao, G.F, Liu, S.
登録日2022-12-13
公開日2023-12-20
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (2.7 Å)
主引用文献Dosing interval regimen shapes potency and breadth of antibody repertoire after vaccination of SARS-CoV-2 RBD protein subunit vaccine.
Cell Discov, 9, 2023
8HPU
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Cryo-EM structure of SARS-CoV-2 Omicron BA.4 RBD in complex with fab L4.65 and L5.34
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S2', fab L4.65, ...
著者Gao, G.F, Liu, S.
登録日2022-12-13
公開日2023-12-20
最終更新日2024-01-31
実験手法ELECTRON MICROSCOPY (2.56 Å)
主引用文献Dosing interval regimen shapes potency and breadth of antibody repertoire after vaccination of SARS-CoV-2 RBD protein subunit vaccine.
Cell Discov, 9, 2023
8HP9
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Cryo-EM structure of SARS-CoV-2 Omicron BA.2 S-trimer in complex with fab L4.65 and L5.34
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S2', fab L4.65, ...
著者Gao, G.F, Liu, S.
登録日2022-12-12
公開日2024-01-31
実験手法ELECTRON MICROSCOPY (2.75 Å)
主引用文献Dosing interval regimen shapes potency and breadth of antibody repertoire after vaccination of SARS-CoV-2 RBD protein subunit vaccine.
Cell Discov, 9, 2023
8HPQ
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BU of 8hpq by Molmil
Cryo-EM structure of SARS-CoV-2 Omicron BA.4 S-trimer in complex with fab L4.65 and L5.34
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S2', fab L4.65, ...
著者Gao, G.F, Liu, S.
登録日2022-12-12
公開日2024-01-31
実験手法ELECTRON MICROSCOPY (2.85 Å)
主引用文献Dosing interval regimen shapes potency and breadth of antibody repertoire after vaccination of SARS-CoV-2 RBD protein subunit vaccine.
Cell Discov, 9, 2023
8HPV
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BU of 8hpv by Molmil
Cryo-EM structure of SARS-CoV-2 Omicron Prototype S-trimer in complex with fab L4.65 and L5.34
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S2', fab L4.65, ...
著者Gao, G.F, Liu, S.
登録日2022-12-13
公開日2024-01-31
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (2.65 Å)
主引用文献Dosing interval regimen shapes potency and breadth of antibody repertoire after vaccination of SARS-CoV-2 RBD protein subunit vaccine.
Cell Discov, 9, 2023
7XF3
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BU of 7xf3 by Molmil
The structure of HLA-B*1501/BM58-66AF9
分子名称: 9-mer peptide from Matrix protein 1, Beta-2-microglobulin, MHC class I antigen
著者Zhao, Y.Z, Xiao, W.L, Wu, Y.N, Fan, W.F, Yue, C, Zhang, Q.X, Zhang, D.N, Yuan, X.J, Yao, S.J, Liu, S, Li, M, Wang, P.Y, Zhang, H.J, Zhang, J, Zhao, M, Zheng, X.Q, Liu, W.J, Gao, G.F, Liu, W.L.
登録日2022-03-31
公開日2023-02-08
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献Parallel T Cell Immunogenic Regions in Influenza B and A Viruses with Distinct Nuclear Export Signal Functions: The Balance between Viral Life Cycle and Immune Escape.
J Immunol., 210, 2023
3P2M
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Crystal Structure of a Novel Esterase Rv0045c from Mycobacterium tuberculosis
分子名称: POSSIBLE HYDROLASE
著者Zheng, X.D, Guo, J, Xu, L, Li, H, Zhang, D, Zhang, K, Sun, F, Wen, T, Liu, S, Pang, H.
登録日2010-10-03
公開日2011-07-06
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal Structure of a Novel Esterase Rv0045c from Mycobacterium tuberculosis
Plos One, 6, 2011
5CET
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Crystal structure of Rv2837c
分子名称: Bifunctional oligoribonuclease and PAP phosphatase NrnA, MANGANESE (II) ION
著者Wang, F, He, Q, Zhu, D, Liu, S, Gu, L.
登録日2015-07-07
公開日2015-12-23
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural and Biochemical Insight into the Mechanism of Rv2837c from Mycobacterium tuberculosis as a c-di-NMP Phosphodiesterase
J.Biol.Chem., 291, 2016
4GO3
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Crystal structure of PnpE from Pseudomonas sp. WBC-3
分子名称: Putative gamma-hydroxymuconic semialdehyde dehydrogenase
著者Su, J, Zhang, C, Liu, S, Zhu, D, Gu, L.
登録日2012-08-18
公開日2014-02-26
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.704 Å)
主引用文献Crystal structure of PnpE from Pseudomonas sp. WBC-3
To be Published
4GO4
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Crystal structure of PnpE in complex with Nicotinamide adenine dinucleotide
分子名称: NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Putative gamma-hydroxymuconic semialdehyde dehydrogenase
著者Su, J, Zhang, C, Liu, S, Zhu, D, Gu, L.
登録日2012-08-18
公開日2013-09-04
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (3.099 Å)
主引用文献Crystal structure of PnpE in complex with Nicotinamide adenine dinucleotide
To be Published
3U1Y
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Potent Inhibitors of LpxC for the Treatment of Gram-Negative Infections
分子名称: (2R)-N-hydroxy-2-methyl-2-(methylsulfonyl)-4-{4'-[3-(morpholin-4-yl)propoxy]biphenyl-4-yl}butanamide, UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ZINC ION
著者Brown, M, Abramite, J, Liu, S.
登録日2011-09-30
公開日2012-01-04
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Potent inhibitors of LpxC for the treatment of Gram-negative infections.
J.Med.Chem., 55, 2012
3UHM
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UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase in complex with inhibitor
分子名称: (2R)-N-hydroxy-2-methyl-2-(methylsulfonyl)-4-(2-oxo-4-phenylpyridin-1(2H)-yl)butanamide, 1,2-ETHANEDIOL, GUANIDINE, ...
著者Montgomery, J, Liu, S.
登録日2011-11-03
公開日2012-02-01
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.26 Å)
主引用文献Pyridone methylsulfone hydroxamate LpxC inhibitors for the treatment of serious gram-negative infections.
J.Med.Chem., 55, 2012
6J8R
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Metallo-Beta-Lactamase VIM-2 in complex with Dual MBL/SBL Inhibitor MS01
分子名称: Beta-lactamase class B VIM-2, FORMIC ACID, GLYCEROL, ...
著者Li, G.-B, Liu, S.
登録日2019-01-21
公開日2019-07-17
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.575 Å)
主引用文献Structure-Based Development of (1-(3'-Mercaptopropanamido)methyl)boronic Acid Derived Broad-Spectrum, Dual-Action Inhibitors of Metallo- and Serine-beta-lactamases.
J.Med.Chem., 62, 2019

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