Search by PDB author

Structure of the midlink and cap-binding domains of influenza A polymerase PB2 subunit with a bound azaindazole cap-binding inhibitor
Descriptor:	(2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, Polymerase basic protein 2, SULFATE ION
Authors:	Cusack, S, Gaudon, S.
Deposit date:	2017-10-31
Release date:	2017-12-13
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (3 Å)
Cite:	Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors. Nucleic Acids Res., 46, 2018

Crystal structure of the cap-binding domain of the PB2 subunit of influenza A/H5N1 polymerase bound to an azaindazole inhibitor
Descriptor:	(2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, GLYCEROL, Polymerase basic protein 2
Authors:	Cusack, S, Gaudon, S.
Deposit date:	2017-10-31
Release date:	2017-12-13
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (1 Å)
Cite:	Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors. Nucleic Acids Res., 46, 2018

Crystal structure of bat influenza A/H17N10 polymerase with viral RNA promoter and cap analogue m7GTP
Descriptor:	7-METHYL-GUANOSINE-5'-TRIPHOSPHATE, PHOSPHATE ION, Polymerase acidic protein, ...
Authors:	Pflug, A, Cusack, S.
Deposit date:	2017-11-01
Release date:	2017-12-13
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (2.9 Å)
Cite:	Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors. Nucleic Acids Res., 46, 2018

Crystal structure of the human TRIM25 PRYSPRY domain
Descriptor:	CHLORIDE ION, E3 ubiquitin/ISG15 ligase TRIM25, SULFATE ION
Authors:	Cusack, S, Kowalinski, E.
Deposit date:	2018-01-26
Release date:	2018-05-23
Method:	X-RAY DIFFRACTION (2.009 Å)
Cite:	Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition. Nat Commun, 9, 2018