6U9K
 
 | | MLL1 SET N3861I/Q3867L bound to inhibitor 18 (TC-5153) | | Descriptor: | 5'-([(3S)-3-amino-3-carboxypropyl]{[1-(3,3-diphenylpropyl)azetidin-3-yl]methyl}amino)-5'-deoxyadenosine, GLYCEROL, Histone-lysine N-methyltransferase, ... | | Authors: | Petrunak, E.M, Stuckey, J.A. | | Deposit date: | 2019-09-09 | | Release date: | 2020-07-01 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Discovery of Potent Small-Molecule Inhibitors of MLL Methyltransferase.
Acs Med.Chem.Lett., 11, 2020
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6U9N
 | | MLL1 SET N3861I/Q3867L bound to inhibitor 14 (TC-5139) | | Descriptor: | 5'-{[(3S)-3-amino-3-carboxypropyl]({1-[(4-chlorophenyl)methyl]azetidin-3-yl}methyl)amino}-5'-deoxyadenosine, Histone-lysine N-methyltransferase, ZINC ION | | Authors: | Petrunak, E.M, Stuckey, J.A. | | Deposit date: | 2019-09-09 | | Release date: | 2020-07-01 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Discovery of Potent Small-Molecule Inhibitors of MLL Methyltransferase.
Acs Med.Chem.Lett., 11, 2020
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6U9R
 | | MLL1 SET N3861I/Q3867L bound to inhibitor 12 (TC-5140) | | Descriptor: | 5'-{[(3S)-3-amino-3-carboxypropyl]({1-[(3-chlorophenyl)methyl]azetidin-3-yl}methyl)amino}-5'-deoxyadenosine, Histone-lysine N-methyltransferase, ZINC ION | | Authors: | Petrunak, E.M, Stuckey, J.A. | | Deposit date: | 2019-09-09 | | Release date: | 2020-07-01 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Discovery of Potent Small-Molecule Inhibitors of MLL Methyltransferase.
Acs Med.Chem.Lett., 11, 2020
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6U9M
 | | MLL1 SET N3861I/Q3867L bound to inhibitor 16 (TC-5109) | | Descriptor: | 5'-{[(3S)-3-amino-3-carboxypropyl]({1-[(thiophen-2-yl)methyl]azetidin-3-yl}methyl)amino}-5'-deoxyadenosine, GLYCEROL, Histone-lysine N-methyltransferase, ... | | Authors: | Petrunak, E.M, Stuckey, J.A. | | Deposit date: | 2019-09-09 | | Release date: | 2020-07-01 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Discovery of Potent Small-Molecule Inhibitors of MLL Methyltransferase.
Acs Med.Chem.Lett., 11, 2020
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7X14
 | | Crystal structure of phospho-FFAT motif of MIGA2 bound to VAPB | | Descriptor: | MIGA2 phospho FFAT motif, SULFATE ION, Vesicle-associated membrane protein-associated protein B | | Authors: | Kim, H, Lee, C. | | Deposit date: | 2022-02-23 | | Release date: | 2022-09-14 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.675 Å) | | Cite: | Structural basis for mitoguardin-2 mediated lipid transport at ER-mitochondrial membrane contact sites.
Nat Commun, 13, 2022
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2W8R
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7X15
 | | Crystal structure of MIGA2 LD targeting domain | | Descriptor: | DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE, FORMIC ACID, Mitoguardin 2 | | Authors: | Kim, H, Lee, C. | | Deposit date: | 2022-02-23 | | Release date: | 2022-09-14 | | Method: | X-RAY DIFFRACTION (2.852 Å) | | Cite: | Structural basis for mitoguardin-2 mediated lipid transport at ER-mitochondrial membrane contact sites.
Nat Commun, 13, 2022
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2W8Q
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2W8P
 | | The crystal structure of human C340A SSADH | | Descriptor: | GLYCEROL, SUCCINIC SEMIALDEHYDE DEHYDROGENASE MITOCHONDRIAL, SULFATE ION | | Authors: | Kim, Y.-G, Kim, K.-J. | | Deposit date: | 2009-01-19 | | Release date: | 2009-06-09 | | Last modified: | 2013-08-07 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Redox-Switch Modulation of Human Ssadh by Dynamic Catalytic Loop.
Embo J., 28, 2009
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2W8O
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2W8N
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6VOV
 | | Crystal structure of Syk in complex with GS-9876 | | Descriptor: | 6-(6-aminopyrazin-2-yl)-N-{4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl}imidazo[1,2-a]pyrazin-8-amine, Tyrosine-protein kinase SYK | | Authors: | Lansdon, E.B. | | Deposit date: | 2020-01-31 | | Release date: | 2020-03-11 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Discovery of Lanraplenib (GS-9876): A Once-Daily Spleen Tyrosine Kinase Inhibitor for Autoimmune Diseases.
Acs Med.Chem.Lett., 11, 2020
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6WKN
 | | PL-bound rat TRPV2 in nanodiscs | | Descriptor: | Transient receptor potential cation channel subfamily V member 2, piperlongumine | | Authors: | Pumroy, R.P, Moiseenkova-Bell, V.Y. | | Deposit date: | 2020-04-16 | | Release date: | 2021-04-21 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.46 Å) | | Cite: | Allosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression.
Acs Cent.Sci., 7, 2021
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2XXN
 | | Structure of the vIRF4-HAUSP TRAF domain complex | | Descriptor: | K10, UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 7 | | Authors: | Choi, W.C, Hwang, J, Kim, M.H. | | Deposit date: | 2010-11-11 | | Release date: | 2011-11-09 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Bilateral Inhibition of Hausp Deubiquitinase by a Viral Interferon Regulatory Factor Protein
Nat.Struct.Mol.Biol., 18, 2011
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6NRE
 | | Monomeric Lipocalin Can F 6 | | Descriptor: | Lipocalin-Can f 6 allergen | | Authors: | Clayton G, M, Kappler J, W, Chan, S. | | Deposit date: | 2019-01-23 | | Release date: | 2019-09-25 | | Method: | X-RAY DIFFRACTION (2.06 Å) | | Cite: | Structural characteristics of lipocalin allergens: Crystal structure of the immunogenic dog allergen Can f 6.
Plos One, 14, 2019
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6A07
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6A02
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6A09
 | | Salmonella Typhi YfdX in the P222 space group | | Descriptor: | YfdX protein | | Authors: | Ku, B, Lee, H.S, Kim, S.J. | | Deposit date: | 2018-06-05 | | Release date: | 2019-02-06 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.293 Å) | | Cite: | Structural and Physiological Exploration ofSalmonellaTyphi YfdX Uncovers Its Dual Function in Bacterial Antibiotic Stress and Virulence.
Front Microbiol, 9, 2018
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8DFQ
 | | Ectodomain of full-length KIT(T417I,delta418-419)-SCF dimers | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 2 of Mast/stem cell growth factor receptor Kit, ... | | Authors: | Krimmer, S.G, Bertoletti, N, Mi, W, Schlessinger, J. | | Deposit date: | 2022-06-22 | | Release date: | 2023-03-29 | | Last modified: | 2023-04-05 | | Method: | ELECTRON MICROSCOPY (3.96 Å) | | Cite: | Cryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8DFP
 | | Ectodomain of full-length KIT(DupA502,Y503)-SCF dimers | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 2 of Mast/stem cell growth factor receptor Kit, ... | | Authors: | Bertoletti, N, Krimmer, S.G, Mi, W, Schlessinger, J. | | Deposit date: | 2022-06-22 | | Release date: | 2023-03-29 | | Last modified: | 2023-04-05 | | Method: | ELECTRON MICROSCOPY (3.17 Å) | | Cite: | Cryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8DFM
 | | Ectodomain of full-length wild-type KIT-SCF dimers | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 2 of Mast/stem cell growth factor receptor Kit, ... | | Authors: | Krimmer, S.G, Bertoletti, N, Mi, W, Schlessinger, J. | | Deposit date: | 2022-06-22 | | Release date: | 2023-03-29 | | Last modified: | 2023-04-05 | | Method: | ELECTRON MICROSCOPY (3.45 Å) | | Cite: | Cryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention.
Proc.Natl.Acad.Sci.USA, 120, 2023
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7VOV
 | | The crystal structure of human forkhead box protein in complex with DNA 2 | | Descriptor: | DNA (5'-D(P*AP*AP*AP*TP*AP*TP*TP*TP*AP*TP*TP*AP*TP*CP*GP*A)-3'), DNA (5'-D(P*TP*CP*GP*AP*TP*AP*AP*TP*AP*AP*AP*TP*AP*TP*T)-3'), Forkhead box protein L2 | | Authors: | Choi, Y, Yoon, H.J, Lee, H.H. | | Deposit date: | 2021-10-15 | | Release date: | 2022-08-17 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (3.15 Å) | | Cite: | FOXL2 and FOXA1 cooperatively assemble on the TP53 promoter in alternative dimer configurations.
Nucleic Acids Res., 50, 2022
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7VOU
 | | The crystal structure of human forkhead box protein in complex with DNA 1 | | Descriptor: | DNA (5'-D(*AP*CP*TP*TP*GP*TP*TP*TP*AP*CP*AP*TP*TP*TP*TP*G)-3'), DNA (5'-D(*CP*AP*AP*AP*AP*TP*GP*TP*AP*AP*AP*CP*AP*AP*GP*T)-3'), Forkhead box protein L2 | | Authors: | Choi, Y, Yoon, H.J, Lee, H.H. | | Deposit date: | 2021-10-14 | | Release date: | 2022-08-17 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | FOXL2 and FOXA1 cooperatively assemble on the TP53 promoter in alternative dimer configurations.
Nucleic Acids Res., 50, 2022
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7VOX
 | | The crystal structure of human forkhead box protein A in complex with DNA 2 | | Descriptor: | DNA (5'-D(P*AP*AP*AP*TP*AP*TP*TP*TP*AP*TP*TP*AP*TP*CP*GP*A)-3'), DNA (5'-D(P*TP*CP*GP*AP*TP*AP*AP*TP*AP*AP*AP*TP*AP*TP*TP*T)-3'), Hepatocyte nuclear factor 3-alpha, ... | | Authors: | Choi, Y, Yoon, H.J, Lee, H.H. | | Deposit date: | 2021-10-15 | | Release date: | 2022-08-17 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | FOXL2 and FOXA1 cooperatively assemble on the TP53 promoter in alternative dimer configurations.
Nucleic Acids Res., 50, 2022
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2L4M
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