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5C0R
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BU of 5c0r by Molmil
Crystal Structure of a Generation 3 Influenza Hemagglutinin Stabilized Stem Complexed with the Broadly Neutralizing Antibody C179
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, C179 Fab heavy chain, ...
Authors:Boyington, J.C, kwong, P.D, Nabel, G.J, Mascola, J.R.
Deposit date:2015-06-12
Release date:2015-09-02
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.188 Å)
Cite:Hemagglutinin-stem nanoparticles generate heterosubtypic influenza protection.
Nat. Med., 21, 2015
5C0S
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BU of 5c0s by Molmil
Crystal structure of a generation 4 influenza hemagglutinin stabilized stem in complex with the broadly neutralizing antibody CR6261
Descriptor: CR6261 antibody heavy chain, CR6261 antibody light chain, Hemagglutinin, ...
Authors:Boyington, J.C, Kwong, P.D, Nabel, G.J, Mascola, J.R.
Deposit date:2015-06-12
Release date:2015-09-02
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (4.3 Å)
Cite:Hemagglutinin-stem nanoparticles generate heterosubtypic influenza protection.
Nat. Med., 21, 2015
5DT1
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BU of 5dt1 by Molmil
Crystal structure of human Fab CAP256-VRC26.25, a potent V1V2-directed HIV-1 broadly neutralizing antibody
Descriptor: Fab Heavy chain of broadly neutralizing antibody VRC26.25, Fab Light chain of broadly neutralizing antibody VRC26.25, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Gorman, J, Kwong, P.D.
Deposit date:2015-09-17
Release date:2015-10-21
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.954 Å)
Cite:New Member of the V1V2-Directed CAP256-VRC26 Lineage That Shows Increased Breadth and Exceptional Potency.
J.Virol., 90, 2015
6XM0
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BU of 6xm0 by Molmil
Consensus structure of SARS-CoV-2 spike at pH 5.5
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:Zhou, T, Tsybovsky, Y, Olia, A, Kwong, P.D.
Deposit date:2020-06-29
Release date:2020-08-12
Last modified:2021-12-15
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains.
Cell Host Microbe, 28, 2020
6XLU
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BU of 6xlu by Molmil
Structure of SARS-CoV-2 spike at pH 4.0
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:Zhou, T, Tsybovsky, Y, Olia, A, Kwong, P.D.
Deposit date:2020-06-29
Release date:2020-08-12
Last modified:2021-12-15
Method:ELECTRON MICROSCOPY (2.4 Å)
Cite:Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains.
Cell Host Microbe, 28, 2020
6XM3
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BU of 6xm3 by Molmil
Structure of SARS-CoV-2 spike at pH 5.5, single RBD up, conformation 1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:Zhou, T, Tsybovsky, Y, Olia, A, Kwong, P.D.
Deposit date:2020-06-29
Release date:2020-08-12
Last modified:2021-12-15
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains.
Cell Host Microbe, 28, 2020
6XM5
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BU of 6xm5 by Molmil
Structure of SARS-CoV-2 spike at pH 5.5, all RBDs down
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:Zhou, T, Tsybovsky, Y, Olia, A, Kwong, P.D.
Deposit date:2020-06-29
Release date:2020-07-29
Last modified:2021-12-15
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains.
Cell Host Microbe, 28, 2020
6XM4
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BU of 6xm4 by Molmil
Structure of SARS-CoV-2 spike at pH 5.5, single RBD up, conformation 2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:Zhou, T, Tsybovsky, Y, Olia, A, Kwong, P.D.
Deposit date:2020-06-29
Release date:2020-08-12
Last modified:2021-12-15
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains.
Cell Host Microbe, 28, 2020
6PDR
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BU of 6pdr by Molmil
Vaccine-elicited murine FP-targeting antibody vFP25.18 in complex with HIV fusion peptide (residue 512-519)
Descriptor: HIV fusion peptide residue 512-519, antibody vFP25.18 heavy chain, antibody vFP25.18 light chain
Authors:Xu, K, Liu, K, Wang, Y, Kwong, P.D.
Deposit date:2019-06-19
Release date:2020-06-24
Method:X-RAY DIFFRACTION (1.555 Å)
Cite:Modular recognition of antigens provides a mechanism that improves vaccine-elicited antibody-class frequencies
To Be Published
6PDU
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BU of 6pdu by Molmil
Vaccine-elicited NHP FP-targeting antibody 13N024-a.01 in complex with HIV fusion peptide (residue 512-519)
Descriptor: HIV-1 fusion peptide residue 512-519, antibody 13N024-a.01, heavy chain, ...
Authors:Xu, K, Liu, K, Wang, Y, Kwong, P.D.
Deposit date:2019-06-19
Release date:2020-06-24
Method:X-RAY DIFFRACTION (1.953 Å)
Cite:Modular recognition of antigens provides a mechanism that improves vaccine-elicited antibody-class frequencies
To Be Published
6Q0S
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BU of 6q0s by Molmil
Crystal Structure of RSV strain B18537 Prefusion-stabilized glycoprotein F Variant DS-Cav1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion glycoprotein F0, SULFATE ION
Authors:Joyce, M.G, Bao, A, Kwong, P.D.
Deposit date:2019-08-02
Release date:2020-01-22
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Crystal Structure and Immunogenicity of the DS-Cav1-Stabilized Fusion Glycoprotein From Respiratory Syncytial Virus Subtype B.
Pathog Immun, 4, 2019
1WIP
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BU of 1wip by Molmil
STRUCTURE OF T-CELL SURFACE GLYCOPROTEIN CD4, MONOCLINIC CRYSTAL FORM
Descriptor: T-CELL SURFACE GLYCOPROTEIN CD4
Authors:Wu, H, Kwong, P.D, Hendrickson, W.A.
Deposit date:1996-12-18
Release date:1997-07-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (4 Å)
Cite:Dimeric association and segmental variability in the structure of human CD4.
Nature, 387, 1997
1WIO
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BU of 1wio by Molmil
STRUCTURE OF T-CELL SURFACE GLYCOPROTEIN CD4, TETRAGONAL CRYSTAL FORM
Descriptor: T-CELL SURFACE GLYCOPROTEIN CD4
Authors:Wu, H, Kwong, P.D, Hendrickson, W.A.
Deposit date:1996-12-18
Release date:1997-07-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Dimeric association and segmental variability in the structure of human CD4.
Nature, 387, 1997
1YYM
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BU of 1yym by Molmil
crystal structure of F23, a scorpion-toxin mimic of CD4, in complex with HIV-1 YU2 gp120 envelope glycoprotein and anti-HIV-1 antibody 17b
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Exterior membrane glycoprotein(GP120),Exterior membrane glycoprotein(GP120),Exterior membrane glycoprotein(GP120), ...
Authors:Huang, C.C, Stricher, F, Martin, L, Decker, J.M, Majeed, S, Barthe, P, Hendrickson, W.A, Robinson, J, Roumestand, C, Sodroski, J, Wyatt, R, Shaw, G.M, Vita, C, Kwong, P.D.
Deposit date:2005-02-25
Release date:2005-05-03
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Scorpion-toxin mimics of CD4 in complex with human immunodeficiency virus gp120 crystal structures, molecular mimicry, and neutralization breadth.
Structure, 13, 2005
2ADI
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BU of 2adi by Molmil
Crystal structure of monoclonal anti-CD4 antibody Q425 in complex with Barium
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BARIUM ION, Q425 Fab Heavy chain, ...
Authors:Zhou, T, Hamer, D.H, Hendrickson, W.A, Sattentau, Q.J, Kwong, P.D.
Deposit date:2005-07-20
Release date:2005-09-20
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Interfacial metal and antibody recognition.
Proc.Natl.Acad.Sci.Usa, 102, 2005
2ADG
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BU of 2adg by Molmil
Crystal structure of monoclonal anti-CD4 antibody Q425
Descriptor: Q425 Fab Light chain, Q425 Fab heavy chain
Authors:Zhou, T, Hamer, D.H, Hendrickson, W.A, Sattentau, Q.J, Kwong, P.D.
Deposit date:2005-07-20
Release date:2005-09-20
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Interfacial metal and antibody recognition.
Proc.Natl.Acad.Sci.Usa, 102, 2005
1YYL
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BU of 1yyl by Molmil
crystal structure of CD4M33, a scorpion-toxin mimic of CD4, in complex with HIV-1 YU2 gp120 envelope glycoprotein and anti-HIV-1 antibody 17b
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CD4M33, scorpion-toxin mimic of CD4, ...
Authors:Huang, C.C, Stricher, F, Martin, L, Decker, J.M, Majeed, S, Barthe, P, Hendrickson, W.A, Robinson, J, Roumestand, C, Sodroski, J, Wyatt, R, Shaw, G.M, Vita, C, Kwong, P.D.
Deposit date:2005-02-25
Release date:2005-05-03
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Scorpion-toxin mimics of CD4 in complex with human immunodeficiency virus gp120 crystal structures, molecular mimicry, and neutralization breadth.
Structure, 13, 2005
2ADJ
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BU of 2adj by Molmil
Crystal structure of monoclonal anti-CD4 antibody Q425 in complex with Calcium
Descriptor: CALCIUM ION, Q425 Fab Heavy chain, Q425 Fab Light chain
Authors:Zhou, T, Hamer, D.H, Hendrickson, W.A, Sattentau, Q.J, Kwong, P.D.
Deposit date:2005-07-20
Release date:2005-09-20
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Interfacial metal and antibody recognition.
Proc.Natl.Acad.Sci.Usa, 102, 2005
2B4C
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BU of 2b4c by Molmil
Crystal structure of HIV-1 JR-FL gp120 core protein containing the third variable region (V3) complexed with CD4 and the X5 antibody
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, T-cell surface glycoprotein CD4, ...
Authors:Huang, C, Tang, M, Zhang, M.Y, Majeed, S, Montabana, E, Stanfield, R.L, Dimitrov, D.S, Korber, B, Sodroski, J, Wilson, I.A, Wyatt, R, Kwong, P.D.
Deposit date:2005-09-23
Release date:2005-11-15
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structure of a V3-containing HIV-1 gp120 core.
Science, 310, 2005
6MQC
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BU of 6mqc by Molmil
Vaccine-elicited NHP FP-targeting neutralizing antibody 0PV-c.01 in complex with FP (residue 512-519)
Descriptor: 0PV-C.01 antibody Fab heavy chain, 0PV-C.01 antibody Fab light chain, HIV fusion peptide residue 512-519
Authors:Xu, K, Wang, Y, Kwong, P.D.
Deposit date:2018-10-09
Release date:2019-07-31
Last modified:2019-11-13
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization.
Cell, 178, 2019
6MPH
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BU of 6mph by Molmil
Cryo-EM structure at 3.8 A resolution of HIV-1 fusion peptide-directed antibody, DF1W-a.01, elicited by vaccination of Rhesus macaques, in complex with stabilized HIV-1 Env BG505 DS-SOSIP, which was also bound to antibodies VRC03 and PGT122
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DF1W-a.01 Light chain, ...
Authors:Acharya, P, Xu, K, Kwong, P.D.
Deposit date:2018-10-06
Release date:2019-07-24
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization.
Cell, 178, 2019
6MTO
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BU of 6mto by Molmil
Crystal structure of VRC42.01 Fab in complex with T117-F MPER scaffold
Descriptor: Antibody VRC42.01 Fab heavy chain, Antibody VRC42.01 Fab light chain, VRC42 epitope T117-F scaffold
Authors:Kwon, Y.D, Druz, A, Law, W.H, Peng, D, Zhang, B, Doria-Rose, N.A, Kwong, P.D.
Deposit date:2018-10-21
Release date:2019-03-27
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.634 Å)
Cite:Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual.
Immunity, 50, 2019
6MTR
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BU of 6mtr by Molmil
Crystal structure of VRC43.01 Fab
Descriptor: Antibody VRC43.01 Fab heavy chain, Antibody VRC43.01 Fab light chain
Authors:Kwon, Y.D, Druz, A, Law, W.H, Peng, D, Zhang, B, Doria-Rose, N.A, Kwong, P.D.
Deposit date:2018-10-21
Release date:2019-03-27
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.798 Å)
Cite:Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual.
Immunity, 50, 2019
6MUG
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BU of 6mug by Molmil
Crystal Structure of HIV-1 B41 SOSIP.664 Prefusion Env Trimer Bound to Small Molecule HIV-1 Entry Inhibitor BMS-386150 in Complex with Human Antibodies 3H109L and 35O22 at 3.8 Angstrom
Descriptor: 1-[4-(benzenecarbonyl)piperazin-1-yl]-2-(4-bromo-7-fluoro-1H-indol-3-yl)ethane-1,2-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Lai, Y.-T, Kwong, P.D.
Deposit date:2018-10-23
Release date:2019-01-16
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.954 Å)
Cite:Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry.
Nat Commun, 10, 2019
6MTS
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BU of 6mts by Molmil
Crystal structure of VRC43.03 Fab
Descriptor: Antibody VRC43.03 Fab heavy chain, Antibody VRC43.03 Fab light chain
Authors:Kwon, Y.D, Druz, A, Law, W.H, Peng, D, Doria-Rose, N.A, Kwong, P.D.
Deposit date:2018-10-21
Release date:2019-03-27
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.437 Å)
Cite:Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual.
Immunity, 50, 2019

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