7MH1
| Human CTPS2 bound to CTP | Descriptor: | CTP synthase 2, CYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION | Authors: | Lynch, E.M, Kollman, J.M. | Deposit date: | 2021-04-14 | Release date: | 2021-10-13 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structural basis for isoform-specific inhibition of human CTPS1. Proc.Natl.Acad.Sci.USA, 118, 2021
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7MIU
| Mouse CTPS2 bound to inhibitor R80 | Descriptor: | CTP synthase 2, GLUTAMINE, MAGNESIUM ION, ... | Authors: | Lynch, E.M, Dimattia, M.A, Kollman, J.M. | Deposit date: | 2021-04-17 | Release date: | 2021-10-13 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Structural basis for isoform-specific inhibition of human CTPS1. Proc.Natl.Acad.Sci.USA, 118, 2021
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7MIP
| Mouse CTPS1 bound to inhibitor R80 | Descriptor: | CTP synthase 1, GLUTAMINE, MAGNESIUM ION, ... | Authors: | Lynch, E.M, Dimattia, M.A, Kollman, J.M. | Deposit date: | 2021-04-17 | Release date: | 2021-10-13 | Method: | ELECTRON MICROSCOPY (2.4 Å) | Cite: | Structural basis for isoform-specific inhibition of human CTPS1. Proc.Natl.Acad.Sci.USA, 118, 2021
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7MGZ
| Human CTPS1 bound to UTP, AMPPNP, and glutamine | Descriptor: | CTP synthase 1, GLUTAMINE, MAGNESIUM ION, ... | Authors: | Lynch, E.M, Dimattia, M.A, Kollman, J.M. | Deposit date: | 2021-04-14 | Release date: | 2021-10-13 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structural basis for isoform-specific inhibition of human CTPS1. Proc.Natl.Acad.Sci.USA, 118, 2021
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7MIF
| Human CTPS1 bound to inhibitor R80 | Descriptor: | CTP synthase 1, GLUTAMINE, MAGNESIUM ION, ... | Authors: | Lynch, E.M, Dimattia, M.A, Kollman, J.M. | Deposit date: | 2021-04-16 | Release date: | 2021-10-13 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis for isoform-specific inhibition of human CTPS1. Proc.Natl.Acad.Sci.USA, 118, 2021
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6BQW
| AlfA Filament bound to AMPPNP | Descriptor: | Bacterial actin AlfA, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | Authors: | Usluer, G.D, Kollman, J.M, DiMaio, F. | Deposit date: | 2017-11-28 | Release date: | 2018-02-28 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Cryo-EM structure of the bacterial actin AlfA reveals unique assembly and ATP-binding interactions and the absence of a conserved subdomain. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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5U05
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5U03
| Cryo-EM structure of the human CTP synthase filament | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CTP synthase 1, URIDINE 5'-TRIPHOSPHATE | Authors: | Lynch, E.M, Kollman, J.M. | Deposit date: | 2016-11-22 | Release date: | 2017-04-26 | Last modified: | 2018-07-18 | Method: | ELECTRON MICROSCOPY (6.1 Å) | Cite: | Human CTP synthase filament structure reveals the active enzyme conformation. Nat. Struct. Mol. Biol., 24, 2017
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8DBI
| Human PRPS1 with Phosphate, ATP, and R5P; Hexamer | Descriptor: | 5-O-phosphono-alpha-D-ribofuranose, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Hvorecny, K.L, Kollman, J.M. | Deposit date: | 2022-06-14 | Release date: | 2023-02-15 | Last modified: | 2023-03-29 | Method: | ELECTRON MICROSCOPY (2 Å) | Cite: | Human PRPS1 filaments stabilize allosteric sites to regulate activity. Nat.Struct.Mol.Biol., 30, 2023
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8DBH
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8DBG
| Human PRPS1 with Phosphate and ATP; Hexamer | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ... | Authors: | Hvorecny, K.L, Kollman, J.M. | Deposit date: | 2022-06-14 | Release date: | 2023-02-15 | Last modified: | 2023-03-29 | Method: | ELECTRON MICROSCOPY (2.2 Å) | Cite: | Human PRPS1 filaments stabilize allosteric sites to regulate activity. Nat.Struct.Mol.Biol., 30, 2023
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8DBE
| Human PRPS1 with ADP; Hexamer | Descriptor: | 5-O-phosphono-alpha-D-ribofuranose, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Hvorecny, K.L, Kollman, J.M. | Deposit date: | 2022-06-14 | Release date: | 2023-02-15 | Last modified: | 2023-03-29 | Method: | ELECTRON MICROSCOPY (2.1 Å) | Cite: | Human PRPS1 filaments stabilize allosteric sites to regulate activity. Nat.Struct.Mol.Biol., 30, 2023
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8DBK
| Human PRPS1 with Phosphate, ATP, and R5P; Hexamer with resolved catalytic loops | Descriptor: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 5-O-phosphono-alpha-D-ribofuranose, ADENOSINE MONOPHOSPHATE, ... | Authors: | Hvorecny, K.L, Kollman, J.M. | Deposit date: | 2022-06-14 | Release date: | 2023-02-15 | Last modified: | 2023-03-29 | Method: | ELECTRON MICROSCOPY (2.1 Å) | Cite: | Human PRPS1 filaments stabilize allosteric sites to regulate activity. Nat.Struct.Mol.Biol., 30, 2023
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8DBF
| Human PRPS1 with ADP; Filament Interface | Descriptor: | 5-O-phosphono-alpha-D-ribofuranose, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Hvorecny, K.L, Kollman, J.M. | Deposit date: | 2022-06-14 | Release date: | 2023-02-15 | Last modified: | 2023-03-29 | Method: | ELECTRON MICROSCOPY (2.2 Å) | Cite: | Human PRPS1 filaments stabilize allosteric sites to regulate activity. Nat.Struct.Mol.Biol., 30, 2023
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8DBN
| Human PRPS1-E307A engineered mutation with Phosphate, ATP, and R5P; Hexamer | Descriptor: | 5-O-phosphono-alpha-D-ribofuranose, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Hvorecny, K.L, Kollman, J.M. | Deposit date: | 2022-06-14 | Release date: | 2023-02-15 | Last modified: | 2023-03-29 | Method: | ELECTRON MICROSCOPY (2.4 Å) | Cite: | Human PRPS1 filaments stabilize allosteric sites to regulate activity. Nat.Struct.Mol.Biol., 30, 2023
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8DBM
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8DBL
| Human PRPS1 with Phosphate and PRPP; Hexamer | Descriptor: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, MAGNESIUM ION, PHOSPHATE ION, ... | Authors: | Hvorecny, K.L, Kollman, J.M. | Deposit date: | 2022-06-14 | Release date: | 2023-02-15 | Last modified: | 2023-03-29 | Method: | ELECTRON MICROSCOPY (2.4 Å) | Cite: | Human PRPS1 filaments stabilize allosteric sites to regulate activity. Nat.Struct.Mol.Biol., 30, 2023
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8DBC
| Human PRPS1 with Phosphate; Hexamer | Descriptor: | PHOSPHATE ION, Ribose-phosphate pyrophosphokinase 1 | Authors: | Hvorecny, K.L, Kollman, J.M. | Deposit date: | 2022-06-14 | Release date: | 2023-02-15 | Last modified: | 2023-03-29 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Human PRPS1 filaments stabilize allosteric sites to regulate activity. Nat.Struct.Mol.Biol., 30, 2023
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8DBJ
| Human PRPS1 with Phosphate, ATP, and R5P; Filament Interface | Descriptor: | 5-O-phosphono-alpha-D-ribofuranose, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Hvorecny, K.L, Kollman, J.M. | Deposit date: | 2022-06-14 | Release date: | 2023-02-15 | Last modified: | 2023-03-29 | Method: | ELECTRON MICROSCOPY (2 Å) | Cite: | Human PRPS1 filaments stabilize allosteric sites to regulate activity. Nat.Struct.Mol.Biol., 30, 2023
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8DBO
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8DBD
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7RKH
| Yeast CTP Synthase (URA8) tetramer bound to ATP/UTP at neutral pH | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CTP synthase, MAGNESIUM ION, ... | Authors: | Hansen, J.M, Lynch, E.M, Farrell, D.P, DiMaio, F, Quispe, J, Kollman, J.M. | Deposit date: | 2021-07-22 | Release date: | 2021-11-24 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Cryo-EM structures of CTP synthase filaments reveal mechanism of pH-sensitive assembly during budding yeast starvation. Elife, 10, 2021
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7RMV
| Yeast CTP Synthase (Ura7) H360R Filament bound to Substrates | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CTP synthase, URIDINE 5'-TRIPHOSPHATE | Authors: | Hansen, J.M, Lynch, E.M, Farrell, D.P, DiMaio, F, Quispe, J, Kollman, J.M. | Deposit date: | 2021-07-28 | Release date: | 2021-11-24 | Method: | ELECTRON MICROSCOPY (6.7 Å) | Cite: | Cryo-EM structures of CTP synthase filaments reveal mechanism of pH-sensitive assembly during budding yeast starvation. Elife, 10, 2021
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7RMO
| Yeast CTP Synthase (Ura7) Bundle bound to Products at low pH | Descriptor: | CTP synthase, CYTIDINE-5'-TRIPHOSPHATE | Authors: | Hansen, J.M, Lynch, E.M, Farrell, D.P, DiMaio, F, Quispe, J, Kollman, J.M. | Deposit date: | 2021-07-27 | Release date: | 2021-11-24 | Method: | ELECTRON MICROSCOPY (7 Å) | Cite: | Cryo-EM structures of CTP synthase filaments reveal mechanism of pH-sensitive assembly during budding yeast starvation. Elife, 10, 2021
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7RMK
| Yeast CTP Synthase (Ura7) Bundle bound to substrates at low pH | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CTP synthase, URIDINE 5'-TRIPHOSPHATE | Authors: | Hansen, J.M, Lynch, E.M, Farrell, D.P, DiMaio, F, Quispe, J, Kollman, J.M. | Deposit date: | 2021-07-27 | Release date: | 2021-11-24 | Method: | ELECTRON MICROSCOPY (6.6 Å) | Cite: | Cryo-EM structures of CTP synthase filaments reveal mechanism of pH-sensitive assembly during budding yeast starvation. Elife, 10, 2021
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