8DBO

Human PRPS1-E307A engineered mutation with ADP; Hexamer

Summary for 8DBO

Entry DOI	10.2210/pdb8dbo/pdb
EMDB information	27293
Descriptor	Ribose-phosphate pyrophosphokinase 1, PHOSPHATE ION, ADENOSINE-5'-DIPHOSPHATE, ... (5 entities in total)
Functional Keywords	phosphoribosyl pyrophosphate synthetase, adp inhibitor, filament-breaking mutation, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	6
Total formula weight	214650.41
Authors	Hvorecny, K.L.,Kollman, J.M. (deposition date: 2022-06-14, release date: 2023-02-15, Last modification date: 2024-06-12)
Primary citation	Hvorecny, K.L.,Hargett, K.,Quispe, J.D.,Kollman, J.M. Human PRPS1 filaments stabilize allosteric sites to regulate activity. Nat.Struct.Mol.Biol., 30:391-402, 2023 Cited by PubMed: 36747094 DOI: 10.1038/s41594-023-00921-z PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.5 Å)

Structure validation