6NE1
| Designed repeat protein in complex with Fz4 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Frizzled-4, Pfs, ... | 著者 | Miao, Y, Jude, K.M, Garcia, K.C. | 登録日 | 2018-12-15 | 公開日 | 2019-05-15 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.011 Å) | 主引用文献 | Receptor subtype discrimination using extensive shape complementary designed interfaces. Nat.Struct.Mol.Biol., 26, 2019
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6NE4
| Designed repeat protein specifically in complex with Fz7CRD | 分子名称: | 1,2-ETHANEDIOL, Designed repeat binding protein, Frizzled-7, ... | 著者 | Miao, Y, Jude, K.M, Garcia, K.C. | 登録日 | 2018-12-16 | 公開日 | 2019-05-15 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.648 Å) | 主引用文献 | Receptor subtype discrimination using extensive shape complementary designed interfaces. Nat.Struct.Mol.Biol., 26, 2019
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8CTG
| Extracellular architecture of an engineered canonical Wnt signaling ternary complex | 分子名称: | Frizzled-8, Low-density lipoprotein receptor-related protein 6, PALMITOLEIC ACID, ... | 著者 | Tsutsumi, N, Jude, K.M, Garcia, K.C. | 登録日 | 2022-05-14 | 公開日 | 2023-03-15 | 最終更新日 | 2023-03-22 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structure of the Wnt-Frizzled-LRP6 initiation complex reveals the basis for coreceptor discrimination. Proc.Natl.Acad.Sci.USA, 120, 2023
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8CX4
| TCR-antigen complex AS8.4-YEIH-HLA*B27 | 分子名称: | AS8.4a, AS8.4b, Beta-2-microglobulin, ... | 著者 | Yang, X, Jude, K.M, Garcia, K.C. | 登録日 | 2022-05-19 | 公開日 | 2022-12-07 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides. Nature, 612, 2022
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4XL1
| Complex of Notch1 (EGF11-13) bound to Delta-like 4 (N-EGF1) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Luca, V.C, Jude, K.M, Garcia, K.C. | 登録日 | 2015-01-13 | 公開日 | 2015-03-04 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural biology. Structural basis for Notch1 engagement of Delta-like 4. Science, 347, 2015
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4XLW
| Complex of Notch1 (EGF11-13) bound to Delta-like 4 (N-EGF2) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Delta-like protein, ... | 著者 | Luca, V.C, Jude, K.M, Garcia, K.C. | 登録日 | 2015-01-13 | 公開日 | 2015-03-04 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3.39 Å) | 主引用文献 | Structural biology. Structural basis for Notch1 engagement of Delta-like 4. Science, 347, 2015
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4XT3
| Structure of a viral GPCR bound to human chemokine CX3CL1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fractalkine, G-protein coupled receptor homolog US28, ... | 著者 | Burg, J.S, Jude, K.M, Waghray, D, Garcia, K.C. | 登録日 | 2015-01-22 | 公開日 | 2015-03-04 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.801 Å) | 主引用文献 | Structural biology. Structural basis for chemokine recognition and activation of a viral G protein-coupled receptor. Science, 347, 2015
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4XT1
| Structure of a nanobody-bound viral GPCR bound to human chemokine CX3CL1 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CHOLESTEROL, Fractalkine, ... | 著者 | Burg, J.S, Jude, K.M, Waghray, D, Garcia, K.C. | 登録日 | 2015-01-22 | 公開日 | 2015-03-04 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.886 Å) | 主引用文献 | Structural biology. Structural basis for chemokine recognition and activation of a viral G protein-coupled receptor. Science, 347, 2015
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4YUE
| Mouse IL-2 Bound to S4B6 Fab Fragment | 分子名称: | GLYCEROL, Interleukin-2, S4B6 Fab heavy chain, ... | 著者 | Spangler, J.B, Jude, K.M, Garcia, K.C. | 登録日 | 2015-03-18 | 公開日 | 2015-07-01 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.194 Å) | 主引用文献 | Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms. Immunity, 42, 2015
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8ENT
| Interleukin-21 signaling complex with IL-21R and IL-2Rg | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Abhiraman, G.C, Jude, K.M, Garcia, K.C. | 登録日 | 2022-09-30 | 公開日 | 2023-06-28 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.83 Å) | 主引用文献 | A structural blueprint for interleukin-21 signal modulation. Cell Rep, 42, 2023
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4YQX
| Mouse IL-2 Bound to JES6-1 scFv Fragment | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-2, JES6-1 VH domain, ... | 著者 | Spangler, J.B, Luca, V.C, Jude, K.M, Garcia, K.C. | 登録日 | 2015-03-13 | 公開日 | 2015-07-01 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.826 Å) | 主引用文献 | Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms. Immunity, 42, 2015
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6BGA
| 2B4 I-Ek TCR-MHC complex with affinity-enhancing Velcro peptide | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2B4 peptide,MHC I-Ek B chain, ... | 著者 | Gee, M.H, Sibener, L.V, Birnbaum, M.E, Jude, K.M, Garcia, K.C. | 登録日 | 2017-10-27 | 公開日 | 2018-07-18 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.307 Å) | 主引用文献 | Stress-testing the relationship between T cell receptor/peptide-MHC affinity and cross-reactivity using peptide velcro. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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5T5W
| Structure of an affinity matured lambda-IFN/IFN-lambdaR1/IL-10Rbeta receptor complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interferon lambda receptor 1, Interferon lambda-3, ... | 著者 | Mendoza, J.L, Jude, K.M, Garcia, K.C. | 登録日 | 2016-08-31 | 公開日 | 2017-03-29 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.847 Å) | 主引用文献 | The IFN-lambda-IFN-lambda R1-IL-10R beta Complex Reveals Structural Features Underlying Type III IFN Functional Plasticity. Immunity, 46, 2017
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7R84
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7R86
| Structure of mouse BAI1 (ADGRB1) in complex with mouse Nogo receptor (RTN4R) | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-AMINOBENZOIC ACID, ... | 著者 | Miao, Y, Jude, K.M, Garcia, K.C. | 登録日 | 2021-06-26 | 公開日 | 2021-11-10 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | RTN4/NoGo-receptor binding to BAI adhesion-GPCRs regulates neuronal development. Cell, 184, 2021
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7R85
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7RKN
| Structure of CX3CL1-US28-Gi-scFv16 in OC-state | 分子名称: | Antibody fragment scFv16, Fractalkine, G-protein coupled receptor homolog US28, ... | 著者 | Tsutsumi, N, Qu, Q, Jude, K.M, Skiniotis, G, Garcia, K.C. | 登録日 | 2021-07-22 | 公開日 | 2022-01-26 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins Sci Adv, 8, 2022
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7RKM
| Structure of CX3CL1-US28-Gi-scFv16 in C-state | 分子名称: | Antibody fragment scFv16, CHOLESTEROL, Fractalkine, ... | 著者 | Tsutsumi, N, Qu, Q, Jude, K.M, Skiniotis, G, Garcia, K.C. | 登録日 | 2021-07-22 | 公開日 | 2022-01-26 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins Sci Adv, 8, 2022
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7RKX
| Structure of US27-Gi-scFv16 in CL-state | 分子名称: | Antibody fragment scFv16, G-protein coupled receptor homolog US27, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Tsutsumi, N, Jude, K.M, Garcia, K.C. | 登録日 | 2021-07-22 | 公開日 | 2022-01-26 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins Sci Adv, 8, 2022
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7RKY
| Binding mode of US27-Gi-scFv16 in OCL-state | 分子名称: | Antibody fragment scFv16, G-protein coupled receptor homolog US27, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Tsutsumi, N, Jude, K.M, Garcia, K.C. | 登録日 | 2021-07-22 | 公開日 | 2022-01-26 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins Sci Adv, 8, 2022
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7S2S
| nanobody bound to Interleukin-2Rbeta | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, IL2Rb-binding nanobody, Interleukin-2 receptor subunit beta, ... | 著者 | Glassman, C.R, Jude, K.M, Yen, M, Garcia, K.C. | 登録日 | 2021-09-03 | 公開日 | 2022-03-30 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Facile discovery of surrogate cytokine agonists. Cell, 185, 2022
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7S2R
| nanobody bound to IL-2Rg | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cytokine receptor common subunit gamma, ... | 著者 | Glassman, C.R, Jude, K.M, Yen, M, Garcia, K.C. | 登録日 | 2021-09-03 | 公開日 | 2022-03-30 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | 主引用文献 | Facile discovery of surrogate cytokine agonists. Cell, 185, 2022
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7T6F
| Structure of active Janus Kinase (JAK) dimer complexed with cytokine receptor intracellular domain | 分子名称: | ADENOSINE, ADENOSINE-5'-DIPHOSPHATE, Interferon lambda receptor 1, ... | 著者 | Glassman, C.R, Tsutsumi, N, Jude, K.M, Garcia, K.C. | 登録日 | 2021-12-13 | 公開日 | 2022-03-16 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation. Science, 376, 2022
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5IWL
| CD47-diabody complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5F9 diabody, Leukocyte surface antigen CD47, ... | 著者 | Di, W, Jude, K.M, Garcia, K.C. | 登録日 | 2016-03-22 | 公開日 | 2016-06-29 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer. J.Clin.Invest., 126, 2016
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1BJV
| BETA-TRYPSIN COMPLEXED WITH APPU | 分子名称: | 1-(2-AMIDINOPHENYL)-3-(PHENOXYPHENYL)UREA, BETA-TRYPSIN, CALCIUM ION, ... | 著者 | Presnell, S, Patil, G, Mura, C, Jude, K, Conley, J, Kam, C, Bertrand, J, Powers, J, Williams, L. | 登録日 | 1998-06-29 | 公開日 | 1998-12-02 | 最終更新日 | 2023-08-02 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Oxyanion-mediated inhibition of serine proteases. Biochemistry, 37, 1998
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