1ZHZ
| Structure of yeast oxysterol binding protein Osh4 in complex with ergosterol | Descriptor: | ERGOSTEROL, KES1 protein, LEAD (II) ION | Authors: | Im, Y.J, Raychaudhuri, S, Prinz, W.A, Hurley, J.H. | Deposit date: | 2005-04-26 | Release date: | 2005-09-06 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural mechanism for sterol sensing and transport by OSBP-related proteins Nature, 437, 2005
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1ZHY
| Structure of yeast oxysterol binding protein Osh4 in complex with cholesterol | Descriptor: | CHOLESTEROL, KES1 protein, LEAD (II) ION | Authors: | Im, Y.J, Raychaudhuri, S, Prinz, W.A, Hurley, J.H. | Deposit date: | 2005-04-26 | Release date: | 2005-09-06 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural mechanism for sterol sensing and transport by OSBP-related proteins Nature, 437, 2005
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1ZHT
| Structure of yeast oxysterol binding protein Osh4 in complex with 7-hydroxycholesterol | Descriptor: | 7-HYDROXYCHOLESTEROL, KES1 protein | Authors: | Im, Y.J, Raychaudhuri, S, Prinz, W.A, Hurley, J.H. | Deposit date: | 2005-04-26 | Release date: | 2005-09-06 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural mechanism for sterol sensing and transport by OSBP-related proteins Nature, 437, 2005
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1Z2O
| Inositol 1,3,4-trisphosphate 5/6-Kinase in complex with mg2+/ADP/Ins(1,3,4,6)P4 | Descriptor: | (1S,3R,4R,6S)-1,3,4,6-TETRAPKISPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Miller, G.J, Wilson, M.P, Majerus, P.W, Hurley, J.H. | Deposit date: | 2005-03-08 | Release date: | 2005-04-19 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.24 Å) | Cite: | Specificity determinants in inositol polyphosphate synthesis: crystal structure of inositol 1,3,4-trisphosphate 5/6-kinase. Mol.Cell, 18, 2005
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1ZB1
| Structure basis for endosomal targeting by the Bro1 domain | Descriptor: | BRO1 protein | Authors: | Kim, J, Sitaraman, S, Hierro, A, Beach, B.M, Odorizzi, G, Hurley, J.H. | Deposit date: | 2005-04-07 | Release date: | 2005-06-14 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural basis for endosomal targeting by the Bro1 domain. Dev.Cell, 8, 2005
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1JUQ
| GGA3 VHS domain complexed with C-terminal peptide from cation-dependent Mannose 6-phosphate receptor | Descriptor: | ADP-RIBOSYLATION FACTOR BINDING PROTEIN GGA3, Cation-dependent mannose-6-phosphate receptor | Authors: | Misra, S, Puertollano, R, Bonifacino, J.S, Hurley, J.H. | Deposit date: | 2001-08-26 | Release date: | 2002-02-27 | Last modified: | 2016-10-12 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural basis for acidic-cluster-dileucine sorting-signal recognition by VHS domains. Nature, 415, 2002
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1JPL
| GGA3 VHS domain complexed with C-terminal peptide from cation-independent mannose 6-phosphate receptor | Descriptor: | ADP-RIBOSYLATION FACTOR BINDING PROTEIN GGA3, Cation-Independent Mannose 6-phosphate receptor | Authors: | Misra, S, Puertollano, R, Bonifacino, J.S, Hurley, J.H. | Deposit date: | 2001-08-02 | Release date: | 2002-02-27 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural basis for acidic-cluster-dileucine sorting-signal recognition by VHS domains. Nature, 415, 2002
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1LF8
| Complex of GGA3-VHS Domain and CI-MPR C-terminal Phosphopeptide | Descriptor: | ADP-ribosylation factor binding protein GGA3, Cation-independent mannose-6-phosphate receptor | Authors: | Kato, Y, Misra, S, Puertollano, R, Hurley, J.H, Bonifacino, J.S. | Deposit date: | 2002-04-10 | Release date: | 2002-06-26 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Phosphoregulation of sorting signal-VHS domain interactions by a direct electrostatic mechanism. Nat.Struct.Biol., 9, 2002
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1MN3
| Cue domain of yeast Vps9p | Descriptor: | Vacuolar protein sorting-associated protein VPS9 | Authors: | Prag, G, Misra, S, Jones, E, Ghirlando, R, Davies, B.A, Horazdovsky, B.F, Hurley, J.H. | Deposit date: | 2002-09-04 | Release date: | 2003-06-10 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Mechanism of Ubiquitin Recognition by the CUE Domain of Vps9p Cell(Cambridge,Mass.), 113, 2003
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1MLV
| Structure and Catalytic Mechanism of a SET Domain Protein Methyltransferase | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Ribulose-1,5 biphosphate carboxylase/oxygenase large subunit N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE | Authors: | Trievel, R.C, Beach, B.M, Dirk, L.M.A, Houtz, R.L, Hurley, J.H. | Deposit date: | 2002-08-30 | Release date: | 2002-10-30 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure and catalytic mechanism of a SET domain protein methyltransferase. Cell(Cambridge,Mass.), 111, 2002
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1NWM
| GAT domain of human GGA1 | Descriptor: | ADP-ribosylation factor binding protein GGA1 | Authors: | Suer, S, Misra, S, Saidi, L.F, Hurley, J.H. | Deposit date: | 2003-02-06 | Release date: | 2003-03-25 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure of the GAT domain of human GGA1: a syntaxin amino-terminal domain fold in an endosomal trafficking adaptor. Proc.Natl.Acad.Sci.USA, 100, 2003
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1P0Y
| Crystal structure of the SET domain of LSMT bound to MeLysine and AdoHcy | Descriptor: | N-METHYL-LYSINE, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast, ... | Authors: | Trievel, R.C, Flynn, E.M, Houtz, R.L, Hurley, J.H. | Deposit date: | 2003-04-11 | Release date: | 2003-07-01 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Mechanism of multiple lysine methylation by the SET domain enzyme Rubisco LSMT Nat.Struct.Biol., 10, 2003
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1P4U
| CRYSTAL STRUCTURE OF GGA3 GAE DOMAIN IN COMPLEX WITH RABAPTIN-5 PEPTIDE | Descriptor: | ADP-ribosylation factor binding protein GGA3, Rabaptin-5 | Authors: | Miller, G.J, Mattera, R, Bonifacino, J.S, Hurley, J.H. | Deposit date: | 2003-04-24 | Release date: | 2003-07-29 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | RECOGNITION OF ACCESSORY PROTEIN MOTIFS BY THE GAMMA-ADAPTIN EAR DOMAIN OF GGA3 Nat.Struct.Biol., 10, 2003
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7JTL
| Structure of SARS-CoV-2 ORF8 accessory protein | Descriptor: | ORF8 protein, SODIUM ION | Authors: | Flower, T.G, Buffalo, C.Z, Hooy, R.M, Allaire, M, Ren, X, Hurley, J.H. | Deposit date: | 2020-08-18 | Release date: | 2020-08-26 | Last modified: | 2021-02-10 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | Structure of SARS-CoV-2 ORF8, a rapidly evolving immune evasion protein. Proc.Natl.Acad.Sci.USA, 118, 2021
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5PTP
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5L1Z
| TAR complex with HIV-1 Tat-AFF4-P-TEFb | Descriptor: | AF4/FMR2 family member 4, Cyclin-T1, Cyclin-dependent kinase 9, ... | Authors: | Schulze-Gahmen, U, Hurley, J. | Deposit date: | 2016-07-29 | Release date: | 2016-10-26 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (5.9 Å) | Cite: | Insights into HIV-1 proviral transcription from integrative structure and dynamics of the Tat:AFF4:P-TEFb:TAR complex. Elife, 5, 2016
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7R4H
| phospho-STING binding to adaptor protein complex-1 | Descriptor: | ADP-ribosylation factor 1, AP-1 complex subunit beta-1, AP-1 complex subunit gamma-1, ... | Authors: | Xu, P, Ablasser, A. | Deposit date: | 2022-02-08 | Release date: | 2022-09-14 | Last modified: | 2022-11-09 | Method: | ELECTRON MICROSCOPY (2.34 Å) | Cite: | Clathrin-associated AP-1 controls termination of STING signalling. Nature, 610, 2022
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7UX2
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7UXC
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7UXH
| cryo-EM structure of the mTORC1-TFEB-Rag-Ragulator complex | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | Authors: | Cui, Z, Hurley, J. | Deposit date: | 2022-05-05 | Release date: | 2022-11-30 | Last modified: | 2023-03-01 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex. Nature, 614, 2023
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4N7H
| Crystal Structure of the Complex of 3rd WW domain of Human Nedd4 and 1st PPXY Motif of ARRDC3 | Descriptor: | Arrestin domain-containing protein 3, E3 ubiquitin-protein ligase NEDD4, GUANIDINE | Authors: | Qi, S, O'Hayre, M, Gutkind, J.S, Hurley, J. | Deposit date: | 2013-10-15 | Release date: | 2014-01-08 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.698 Å) | Cite: | Structural and biochemical basis for ubiquitin ligase recruitment by arrestin-related domain-containing protein-3 (ARRDC3). J.Biol.Chem., 289, 2014
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4N7F
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1BL5
| ISOCITRATE DEHYDROGENASE FROM E. COLI SINGLE TURNOVER LAUE STRUCTURE OF RATE-LIMITED PRODUCT COMPLEX, 10 MSEC TIME RESOLUTION | Descriptor: | 2-OXOGLUTARIC ACID, ISOCITRATE DEHYDROGENASE, MAGNESIUM ION, ... | Authors: | Stoddard, B.L, Cohen, B, Brubaker, M, Mesecar, A, Koshland Junior, D.E. | Deposit date: | 1998-07-23 | Release date: | 1999-05-04 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Millisecond Laue structures of an enzyme-product complex using photocaged substrate analogs. Nat.Struct.Biol., 5, 1998
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4R7X
| Crystal structure of N-lobe of human ARRDC3(1-180) | Descriptor: | Arrestin domain-containing protein 3, PHOSPHATE ION | Authors: | Qi, S, Hurley, J. | Deposit date: | 2014-08-28 | Release date: | 2014-10-01 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.61 Å) | Cite: | Insights into beta 2-adrenergic receptor binding from structures of the N-terminal lobe of ARRDC3. Protein Sci., 23, 2014
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1IDE
| ISOCITRATE DEHYDROGENASE Y160F MUTANT STEADY-STATE INTERMEDIATE COMPLEX (LAUE DETERMINATION) | Descriptor: | ISOCITRATE DEHYDROGENASE, ISOCITRIC ACID, MAGNESIUM ION, ... | Authors: | Bolduc, J.M, Dyer, D.H, Scott, W.G, Singer, P, Sweet, R.M, Koshland Junior, D.E, Stoddard, B.L. | Deposit date: | 1995-01-18 | Release date: | 1996-03-08 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Mutagenesis and Laue structures of enzyme intermediates: isocitrate dehydrogenase. Science, 268, 1995
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