4YCU
 
 | | Crystal structure of cladosporin in complex with human lysyl-tRNA synthetase | | 分子名称: | Aminoacyl tRNA synthase complex-interacting multifunctional protein 2, GLYCEROL, LYSINE, ... | | 著者 | Fang, P, Wang, J, Guo, M. | | 登録日 | 2015-02-20 | | 公開日 | 2015-06-10 | | 最終更新日 | 2019-12-25 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural Basis for Specific Inhibition of tRNA Synthetase by an ATP Competitive Inhibitor.
Chem. Biol., 22, 2015
|
|
4YCV
 | |
4YCW
 | | Crystal structure of cladosporin in complex with plasmodium like human lysyl-tRNA synthetase mutant | | 分子名称: | Aminoacyl tRNA synthase complex-interacting multifunctional protein 2, LYSINE, Lysine--tRNA ligase, ... | | 著者 | Fang, P, Wang, J, Guo, M. | | 登録日 | 2015-02-20 | | 公開日 | 2015-06-10 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structural Basis for Specific Inhibition of tRNA Synthetase by ATP Competitive Inhibitor
Chem.Biol., 22, 2015
|
|
4P3O
 | | Structural Basis for Full-Spectrum Inhibition of Threonyl-tRNA Synthetase by Borrelidin 2 | | 分子名称: | (1R,2R)-2-[(2S,4E,6E,8R,9S,11R,13S,15S,16S)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl]cyclopentanecarboxylic acid, GLYCEROL, Threonine--tRNA ligase, ... | | 著者 | Fang, P, Yu, X, Chen, K, Chen, X, Guo, M. | | 登録日 | 2014-03-09 | | 公開日 | 2015-03-11 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.505 Å) | | 主引用文献 | Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase.
Nat Commun, 6, 2015
|
|
4P3P
 | | Structural Basis for Full-Spectrum Inhibition of Threonyl-tRNA Synthetase by Borrelidin 3 | | 分子名称: | (1R,2R)-2-[(2S,4E,6E,8R,9S,11R,13S,15S,16S)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl]cyclopentanecarboxylic acid, GLYCEROL, Threonine--tRNA ligase, ... | | 著者 | Fang, P, Yu, X, Chen, K, Chen, X, Guo, M. | | 登録日 | 2014-03-09 | | 公開日 | 2015-03-11 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase.
Nat Commun, 6, 2015
|
|
4P3N
 | | Structural Basis for Full-Spectrum Inhibition of Threonyl-tRNA Synthetase by Borrelidin 1 | | 分子名称: | (1R,2R)-2-[(2S,4E,6E,8R,9S,11R,13S,15S,16S)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl]cyclopentanecarboxylic acid, Threonine--tRNA ligase, cytoplasmic, ... | | 著者 | Fang, P, Yu, X, Chen, K, Chen, X, Guo, M. | | 登録日 | 2014-03-09 | | 公開日 | 2015-03-11 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase.
Nat Commun, 6, 2015
|
|
3LBF
 | | Crystal structure of Protein L-isoaspartyl methyltransferase from Escherichia coli | | 分子名称: | GLYCEROL, PHOSPHATE ION, Protein-L-isoaspartate O-methyltransferase, ... | | 著者 | Fang, P, Li, X, Wang, J, Niu, L, Teng, M. | | 登録日 | 2010-01-08 | | 公開日 | 2010-09-08 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystal structure of the protein L-isoaspartyl methyltransferase from Escherichia coli
Cell Biochem.Biophys., 58, 2010
|
|
3MNM
 | | Crystal structure of GAE domain of GGA2p from Saccharomyces cerevisiae | | 分子名称: | ADP-ribosylation factor-binding protein GGA2, GLYCEROL, SULFATE ION | | 著者 | Fang, P, Wang, J, Li, X, Niu, L, Teng, M. | | 登録日 | 2010-04-21 | | 公開日 | 2010-09-08 | | 最終更新日 | 2014-03-05 | | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | | 主引用文献 | Structural basis for the specificity of the GAE domain of yGGA2 for its accessory proteins Ent3 and Ent5
Biochemistry, 49, 2010
|
|
4TTV
 | | Crystal structure of human ThrRS complexing with a bioengineered macrolide BC194 | | 分子名称: | (1R,2R)-2-[(2S,6E,8R,9S,11R,13S,15S,16S)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadec-6-en-2-yl]cyclobutanecarboxylic acid, Threonine--tRNA ligase, cytoplasmic, ... | | 著者 | Fang, P, Guo, M. | | 登録日 | 2014-06-23 | | 公開日 | 2015-09-30 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Aminoacyl-tRNA synthetase dependent angiogenesis revealed by a bioengineered macrolide inhibitor.
Sci Rep, 5, 2015
|
|
4DPG
 | | Crystal Structure of Human LysRS: P38/AIMP2 Complex I | | 分子名称: | ALANINE, Aminoacyl tRNA synthase complex-interacting multifunctional protein 2, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ... | | 著者 | Fang, P, Wang, J, Bennett, S.P, Guo, M. | | 登録日 | 2012-02-13 | | 公開日 | 2013-02-13 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.844 Å) | | 主引用文献 | Structural Switch of Lysyl-tRNA Synthetase between Translation and Transcription.
Mol.Cell, 49, 2013
|
|
5YZX
 | | Crystal structure of E.coli LysU T146D mutant | | 分子名称: | BIS(ADENOSINE)-5'-TETRAPHOSPHATE, CALCIUM ION, Lysine--tRNA ligase, ... | | 著者 | Fang, P, Guo, M. | | 登録日 | 2017-12-16 | | 公開日 | 2018-12-19 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | A proposed role for MSC to reserve the canonical function in high eukaryotes prior to stimuli
To Be Published
|
|
7D8R
 | | MITF HLHLZ structure | | 分子名称: | Microphthalmia-associated transcription factor,Methionyl-tRNA synthetase beta subunit | | 著者 | Guo, M, Fang, P, Wang, J. | | 登録日 | 2020-10-09 | | 公開日 | 2021-10-13 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy.
Cell Res., 33, 2023
|
|
8GS1
 | | Crystal structure of AziU2-U3 complex from Streptomyces sahachiroi NRRL2485 | | 分子名称: | Azi28, Azi29, FORMIC ACID, ... | | 著者 | Cheng, Y, Li, P, Liu, W, Fang, P. | | 登録日 | 2022-09-04 | | 公開日 | 2023-09-06 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Oxidase Heterotetramer Completes 1-Azabicyclo[3.1.0]hexane Formation with the Association of a Nonribosomal Peptide Synthetase.
J.Am.Chem.Soc., 145, 2023
|
|
8IL0
 | | Crystal structure of LmbT from Streptomyces lincolnensis NRRL ISP-5355 | | 分子名称: | Glycosyltransferase | | 著者 | Dai, Y, Li, P, Qiao, H, Xia, M, Liu, W, Fang, P. | | 登録日 | 2023-03-01 | | 公開日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | | 主引用文献 | Structural Basis of Low-Molecular-Weight Thiol Glycosylation in Lincomycin A Biosynthesis.
Acs Chem.Biol., 18, 2023
|
|
8I0C
 | | Crystal structure of Aldo-keto reductase 1C3 complexed with compound S0703 | | 分子名称: | 1-[4-[3,5-bis(chloranyl)phenyl]-3-fluoranyl-phenyl]cyclopropane-1-carboxylic acid, Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Jiang, J, He, S, Liu, Y, Fang, P, Sun, H. | | 登録日 | 2023-01-10 | | 公開日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | | 主引用文献 | Development of Biaryl-Containing Aldo-Keto Reductase 1C3 (AKR1C3) Inhibitors for Reversing AKR1C3-Mediated Drug Resistance in Cancer Treatment.
J.Med.Chem., 66, 2023
|
|
7D8T
 | | MITF bHLHLZ complex with M-box DNA | | 分子名称: | DNA (5'-D(*TP*GP*TP*AP*AP*CP*AP*TP*GP*TP*GP*TP*CP*CP*CP*C)-3'), DNA (5'-D(P*GP*GP*GP*AP*CP*AP*CP*AP*TP*GP*TP*TP*AP*CP*AP*G)-3'), Microphthalmia-associated transcription factor,Methionyl-tRNA synthetase beta subunit | | 著者 | Guo, M, Fang, P, Wang, J. | | 登録日 | 2020-10-09 | | 公開日 | 2021-10-13 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (3.201 Å) | | 主引用文献 | A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy.
Cell Res., 33, 2023
|
|
7D8S
 | | MITF bHLHLZ apo structure | | 分子名称: | Microphthalmia-associated transcription factor,Methionyl-tRNA synthetase beta subunit, SULFATE ION | | 著者 | Guo, M, Fang, P, Wang, J. | | 登録日 | 2020-10-09 | | 公開日 | 2021-10-13 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | | 主引用文献 | A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy.
Cell Res., 33, 2023
|
|
8ILA
 | | Crystal structure of LmbT from Streptomyces lincolnensis NRRL ISP-5355 in complex with substrates | | 分子名称: | (2~{S})-3-[2-[(2~{S},3~{R},4~{S},5~{R},6~{R})-6-[(1~{R},2~{R})-1-azanyl-2-oxidanyl-propyl]-3,4,5-tris(oxidanyl)oxan-2-yl]sulfanyl-1~{H}-imidazol-5-yl]-2-(trimethyl-$l^{4}-azanyl)propanoic acid, GUANOSINE-5'-DIPHOSPHATE, Glycosyltransferase | | 著者 | Dai, Y, Qiao, H, Xia, M, Fang, P, Liu, W. | | 登録日 | 2023-03-03 | | 公開日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.79 Å) | | 主引用文献 | Structural Basis of Low-Molecular-Weight Thiol Glycosylation in Lincomycin A Biosynthesis.
Acs Chem.Biol., 18, 2023
|
|
7EOD
 | | MITF HLHLZ Delta AKE | | 分子名称: | GLYCEROL, Isoform M1 of Microphthalmia-associated transcription factor | | 著者 | Li, P, Liu, Z, Fang, P, Wang, J. | | 登録日 | 2021-04-22 | | 公開日 | 2022-04-27 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy.
Cell Res., 33, 2023
|
|
8H98
 | | Crystal structure of chemically modified E. coli ThrS catalytic domain 1 | | 分子名称: | N-(2,3-dihydroxybenzoyl)-4-(4-nitrophenyl)-L-threonine, Threonine--tRNA ligase, ZINC ION | | 著者 | Qiao, H, Xia, M, Wang, J, Fang, P. | | 登録日 | 2022-10-25 | | 公開日 | 2023-02-08 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Tyrosine-targeted covalent inhibition of a tRNA synthetase aided by zinc ion.
Commun Biol, 6, 2023
|
|
8H9B
 | | Crystal structure of chemically modified E. coli ThrS catalytic domain 3 | | 分子名称: | N-(2,3-dihydroxybenzoyl)-4-(4-nitrophenyl)-L-threonine, Threonine--tRNA ligase, ZINC ION | | 著者 | Qiao, H, Xia, M, Wang, J, Fang, P. | | 登録日 | 2022-10-25 | | 公開日 | 2023-02-08 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | | 主引用文献 | Tyrosine-targeted covalent inhibition of a tRNA synthetase aided by zinc ion.
Commun Biol, 6, 2023
|
|
8H9A
 | | Crystal structure of chemically modified E. coli ThrS catalytic domain 2 | | 分子名称: | N-(2,3-dihydroxybenzoyl)-4-(4-nitrophenyl)-L-threonine, Threonine--tRNA ligase, ZINC ION | | 著者 | Qiao, H, Xia, M, Wang, J, Fang, P. | | 登録日 | 2022-10-25 | | 公開日 | 2023-02-08 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Tyrosine-targeted covalent inhibition of a tRNA synthetase aided by zinc ion.
Commun Biol, 6, 2023
|
|
8H9C
 | | Crystal structure of chemically modified E. coli ThrS catalytic domain 4 | | 分子名称: | N-(2,3-dihydroxybenzoyl)-4-(4-nitrophenyl)-L-threonine, Threonine--tRNA ligase, ZINC ION | | 著者 | Qiao, H, Xia, M, Wang, J, Fang, P. | | 登録日 | 2022-10-25 | | 公開日 | 2023-02-08 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Tyrosine-targeted covalent inhibition of a tRNA synthetase aided by zinc ion.
Commun Biol, 6, 2023
|
|
8H99
 | | Crystal structure of E. coli ThrS catalytic domain mutant | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, IMIDAZOLE, MAGNESIUM ION, ... | | 著者 | Qiao, H, Xia, M, Wang, J, Fang, P. | | 登録日 | 2022-10-25 | | 公開日 | 2023-02-08 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | | 主引用文献 | Tyrosine-targeted covalent inhibition of a tRNA synthetase aided by zinc ion.
Commun Biol, 6, 2023
|
|
8HK0
 | | Crystal structure of Fic32-33 complex from Streptomyces ficellus NRRL 8067 | | 分子名称: | Acyl-CoA dehydrogenase, Dehydrogenase, FLAVIN-ADENINE DINUCLEOTIDE, ... | | 著者 | Cheng, Y, Qiao, H, Liu, W, Fang, P. | | 登録日 | 2022-11-24 | | 公開日 | 2023-04-26 | | 最終更新日 | 2023-05-10 | | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | | 主引用文献 | Oxidase Heterotetramer Completes 1-Azabicyclo[3.1.0]hexane Formation with the Association of a Nonribosomal Peptide Synthetase.
J.Am.Chem.Soc., 145, 2023
|
|
