1LCT
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1CWW
| SOLUTION STRUCTURE OF THE CASPASE RECRUITMENT DOMAIN (CARD) FROM APAF-1 | Descriptor: | APOPTOTIC PROTEASE ACTIVATING FACTOR 1 | Authors: | Day, C.L, Dupont, C, Lackmann, M, Vaux, D.L, Hinds, M.G. | Deposit date: | 1999-08-26 | Release date: | 2000-01-21 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structure and mutagenesis of the caspase recruitment domain (CARD) from Apaf-1. Cell Death Differ., 6, 1999
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1DEB
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1WSX
| Solution structure of MCL-1 | Descriptor: | myeloid cell leukemia sequence 1 | Authors: | Day, C.L, Chen, L, Richardson, S.J, Harrison, P.J, Huang, D.C, Hinds, M.G. | Deposit date: | 2004-11-12 | Release date: | 2004-11-23 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution Structure of Prosurvival Mcl-1 and Characterization of Its Binding by Proapoptotic BH3-only Ligands J.Biol.Chem., 280, 2005
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2ROC
| Solution structure of Mcl-1 Complexed with Puma | Descriptor: | Bcl-2-binding component 3, Induced myeloid leukemia cell differentiation protein Mcl-1 homolog | Authors: | Day, C.L, Smits, C, Fan, F.C, Lee, E.F, Fairlie, W.D, Hinds, M.G. | Deposit date: | 2008-03-17 | Release date: | 2008-07-08 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Structure of the BH3 Domains from the p53-Inducible BH3-Only Proteins Noxa and Puma in Complex with Mcl-1 J.Mol.Biol., 380, 2008
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2ROD
| Solution Structure of MCL-1 Complexed with NoxaA | Descriptor: | Induced myeloid leukemia cell differentiation protein Mcl-1 homolog, Noxa | Authors: | Day, C.L, Smits, C, Fan, F.C, Lee, E.F, Fairlie, W.D, Hinds, M.G. | Deposit date: | 2008-03-17 | Release date: | 2008-07-08 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Structure of the BH3 Domains from the p53-Inducible BH3-Only Proteins Noxa and Puma in Complex with Mcl-1 J.Mol.Biol., 380, 2008
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1RE6
| Localisation of Dynein Light Chains 1 and 2 and their Pro-apoptotic Ligands | Descriptor: | dynein light chain 2 | Authors: | Day, C.L, Puthalakath, H, Skea, G, Strasser, A, Barsukov, I, Lian, L.Y, Huang, D.C, Hinds, M.G. | Deposit date: | 2003-11-06 | Release date: | 2004-03-23 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands. Biochem.J., 377, 2004
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2L9M
| Structure of cIAP1 CARD | Descriptor: | Baculoviral IAP repeat-containing protein 2 | Authors: | Day, C.L, Rautureau, G.J.P, Hinds, M.G. | Deposit date: | 2011-02-21 | Release date: | 2011-08-17 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | CARD-mediated autoinhibition of cIAP1's E3 ligase activity suppresses cell proliferation and migration. Mol.Cell, 42, 2011
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3M1D
| Structure of BIR1 from cIAP1 | Descriptor: | Baculoviral IAP repeat-containing protein 2, ZINC ION | Authors: | Mace, P.D, Day, C.L. | Deposit date: | 2010-03-04 | Release date: | 2010-05-26 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Asymmetric recruitment of cIAPs by TRAF2 J.Mol.Biol., 400, 2010
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1VFE
| HUMAN LACTOFERRIN, N-TERMINAL LOBE MUTANT WITH ARG 121 REPLACED BY SER (R121S) | Descriptor: | CARBONATE ION, FE (III) ION, HUMAN LACTOFERRIN | Authors: | Faber, H.R, Day, C.L, Baker, E.N. | Deposit date: | 1996-10-01 | Release date: | 1997-04-01 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Mutation of arginine 121 in lactoferrin destabilizes iron binding by disruption of anion binding: crystal structures of R121S and R121E mutants. Biochemistry, 35, 1996
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1VFD
| HUMAN LACTOFERRIN, N-TERMINAL LOBE MUTANT WITH ARG 121 REPLACED BY GLU (R121E) | Descriptor: | CARBONATE ION, FE (III) ION, LACTOFERRIN | Authors: | Faber, H.R, Day, C.L, Baker, E.N. | Deposit date: | 1996-10-01 | Release date: | 1997-04-21 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Mutation of arginine 121 in lactoferrin destabilizes iron binding by disruption of anion binding: crystal structures of R121S and R121E mutants. Biochemistry, 35, 1996
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8GCB
| Structure of RNF125 in complex with a UbcH5b~Ub conjugate | Descriptor: | E3 ubiquitin-protein ligase RNF125, Ubiquitin-conjugating enzyme E2 D2, ZINC ION | Authors: | Middleton, A.J, Day, C.L, Fokkens, T.J. | Deposit date: | 2023-03-01 | Release date: | 2023-07-19 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.39 Å) | Cite: | Zinc finger 1 of the RING E3 ligase, RNF125, interacts with the E2 to enhance ubiquitylation. Structure, 31, 2023
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8GBQ
| Structure of RNF125 in complex with UbcH5b | Descriptor: | E3 ubiquitin-protein ligase RNF125, GLYCEROL, Ubiquitin-conjugating enzyme E2 D2, ... | Authors: | Middleton, A.J, Day, C.L, Fokkens, T.J. | Deposit date: | 2023-02-27 | Release date: | 2023-07-19 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.74 Å) | Cite: | Zinc finger 1 of the RING E3 ligase, RNF125, interacts with the E2 to enhance ubiquitylation. Structure, 31, 2023
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5VO0
| Structure of a TRAF6-Ubc13~Ub complex | Descriptor: | POTASSIUM ION, TNF receptor-associated factor 6, Ubiquitin, ... | Authors: | Middleton, A.J, Day, C.L. | Deposit date: | 2017-05-01 | Release date: | 2017-12-06 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (3.9 Å) | Cite: | The activity of TRAF RING homo- and heterodimers is regulated by zinc finger 1. Nat Commun, 8, 2017
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5VNZ
| Structure of a TRAF6-Ubc13~Ub complex | Descriptor: | TNF receptor-associated factor 6, Ubiquitin, Ubiquitin-conjugating enzyme E2 N, ... | Authors: | Middleton, A.J, Day, C.L. | Deposit date: | 2017-05-01 | Release date: | 2017-12-06 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (3.41 Å) | Cite: | The activity of TRAF RING homo- and heterodimers is regulated by zinc finger 1. Nat Commun, 8, 2017
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3NG2
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4IC2
| Crystal structure of the XIAP RING domain | Descriptor: | E3 ubiquitin-protein ligase XIAP, NICKEL (II) ION, ZINC ION | Authors: | Linke, K, Nakatani, Y, Day, C.L. | Deposit date: | 2012-12-09 | Release date: | 2012-12-19 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Regulation of ubiquitin transfer by XIAP, a dimeric RING E3 ligase Biochem.J., 450, 2013
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4IC3
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7R70
| Crystal Structure of the UbArk2C fusion protein | Descriptor: | GLYCEROL, Ubiquitin,E3 ubiquitin-protein ligase RNF165, ZINC ION | Authors: | Paluda, A, Middleton, A.J, Mace, P.D, Day, C.L. | Deposit date: | 2021-06-24 | Release date: | 2022-03-09 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.499 Å) | Cite: | Ubiquitin and a charged loop regulate the ubiquitin E3 ligase activity of Ark2C. Nat Commun, 13, 2022
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7R71
| Crystal Structure of the UbArk2C-UbcH5b~Ub complex | Descriptor: | Ubiquitin, Ubiquitin,E3 ubiquitin-protein ligase RNF165, Ubiquitin-conjugating enzyme E2 D2, ... | Authors: | Paluda, A, Middleton, A.J, Mace, P.D, Day, C.L. | Deposit date: | 2021-06-24 | Release date: | 2022-03-09 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Ubiquitin and a charged loop regulate the ubiquitin E3 ligase activity of Ark2C. Nat Commun, 13, 2022
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3EB5
| Structure of the cIAP2 RING domain | Descriptor: | Baculoviral IAP repeat-containing protein 3, SODIUM ION, ZINC ION | Authors: | Mace, P.D, Linke, K, Smith, C.A, Day, C.L. | Deposit date: | 2008-08-27 | Release date: | 2008-09-09 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structures of the cIAP2 RING domain reveal conformational changes associated with ubiquitin-conjugating enzyme (E2) recruitment. J.Biol.Chem., 283, 2008
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3EB6
| Structure of the cIAP2 RING domain bound to UbcH5b | Descriptor: | Baculoviral IAP repeat-containing protein 3, Ubiquitin-conjugating enzyme E2 D2, ZINC ION | Authors: | Mace, P.D, Linke, K, Schumacher, F.-R, Smith, C.A, Day, C.L. | Deposit date: | 2008-08-27 | Release date: | 2008-09-09 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Structures of the cIAP2 RING Domain Reveal Conformational Changes Associated with Ubiquitin-conjugating Enzyme (E2) Recruitment. J.Biol.Chem., 283, 2008
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6CGA
| Structure of the PR-DUB complex | Descriptor: | Polycomb protein Asx, Ubiquitin carboxyl-terminal hydrolase calypso | Authors: | Foglizzo, M, Middleton, A.J, Day, C.L, Mace, P.D. | Deposit date: | 2018-02-19 | Release date: | 2018-10-03 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | A bidentate Polycomb Repressive-Deubiquitinase complex is required for efficient activity on nucleosomes. Nat Commun, 9, 2018
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5TRB
| Crystal structure of the RNF20 RING domain | Descriptor: | E3 ubiquitin-protein ligase BRE1A, ZINC ION | Authors: | Foglizzo, M, Middleton, A.J, Day, C.L. | Deposit date: | 2016-10-25 | Release date: | 2016-11-02 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure and Function of the RING Domains of RNF20 and RNF40, Dimeric E3 Ligases that Monoubiquitylate Histone H2B. J.Mol.Biol., 428, 2016
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5ULH
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