1VFE
HUMAN LACTOFERRIN, N-TERMINAL LOBE MUTANT WITH ARG 121 REPLACED BY SER (R121S)
Summary for 1VFE
| Entry DOI | 10.2210/pdb1vfe/pdb |
| Descriptor | HUMAN LACTOFERRIN, FE (III) ION, CARBONATE ION, ... (4 entities in total) |
| Functional Keywords | transferrin, iron transport, glycoprotein, metal-binding, recombinant half molecule, mutant |
| Biological source | Homo sapiens (human) |
| Cellular location | Isoform 1: Secreted. Isoform DeltaLf: Cytoplasm: P02788 |
| Total number of polymer chains | 1 |
| Total formula weight | 37066.77 |
| Authors | Faber, H.R.,Day, C.L.,Baker, E.N. (deposition date: 1996-10-01, release date: 1997-04-01, Last modification date: 2023-08-09) |
| Primary citation | Faber, H.R.,Baker, C.J.,Day, C.L.,Tweedie, J.W.,Baker, E.N. Mutation of arginine 121 in lactoferrin destabilizes iron binding by disruption of anion binding: crystal structures of R121S and R121E mutants. Biochemistry, 35:14473-14479, 1996 Cited by PubMed: 8931543DOI: 10.1021/bi961729g PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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