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1H2V
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BU of 1h2v by Molmil
Structure of the human nuclear cap-binding-complex (CBC)
Descriptor: 20 KDA NUCLEAR CAP BINDING PROTEIN, 80 KDA NUCLEAR CAP BINDING PROTEIN
Authors:Mazza, C, Segref, A, Mattaj, I.W, Cusack, S.
Deposit date:2002-08-16
Release date:2002-10-17
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Large-Scale Induced Fit Recognition of an M(7)Gpppg CAP Analogue by the Human Nuclear CAP-Binding Complex
Embo J., 21, 2002
5FMZ
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BU of 5fmz by Molmil
Crystal structure of Influenza B polymerase with bound 5' vRNA
Descriptor: 5'-R(*AP*GP*UP*AP*GP*UP*AP*AP*CP*AP*AP*GP)-3', POLYMERASE ACIDIC PROTEIN, POLYMERASE BASIC PROTEIN 2, ...
Authors:Guilligay, D, Cusack, S.
Deposit date:2015-11-10
Release date:2016-01-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of Pb2 Domains.
Mol.Cell, 61, 2016
1E6O
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BU of 1e6o by Molmil
Crystal structure of Fab13B5 against HIV-1 capsid protein p24
Descriptor: IMMUNOGLOBULIN HEAVY CHAIN, IMMUNOGLOBULIN LIGHT CHAIN
Authors:Monaco-Malbet, S, Berthet-Colominas, C, Novelli, A, Battai, N, Piga, N, Mallet, F, Cusack, S.
Deposit date:2000-08-21
Release date:2000-11-27
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mutual Conformational Adaptations in Antigen and Antibody Upon Complex Formation between an Fab and HIV-1 Capsid Protein P24
Structure, 8, 2000
8AZA
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BU of 8aza by Molmil
Structure of RIP2K dimer bound to the XIAP BIR2 domain
Descriptor: E3 ubiquitin-protein ligase XIAP, Receptor-interacting serine/threonine-protein kinase 2, ZINC ION
Authors:Pellegrini, E, Cusack, S.
Deposit date:2022-09-05
Release date:2022-10-26
Last modified:2023-09-20
Method:ELECTRON MICROSCOPY (3.15 Å)
Cite:Structure shows that the BIR2 domain of E3 ligase XIAP binds across the RIPK2 kinase dimer interface.
Life Sci Alliance, 6, 2023
7PQK
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BU of 7pqk by Molmil
Co-Crystal Structure of M. tuberculosis LeuRS in Complex with the Adduct Formed by Prodrug Cmpd1 with Adenosine-monophosphate
Descriptor: (S)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3H)-ol, 1,2-ETHANEDIOL, Leucine--tRNA ligase
Authors:Palencia, A, Cusack, S.
Deposit date:2021-09-17
Release date:2023-01-18
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Adenosine-Dependent Activation Mechanism of Prodrugs Targeting an Aminoacyl-tRNA Synthetase.
J.Am.Chem.Soc., 145, 2023
1H2T
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BU of 1h2t by Molmil
Structure of the human nuclear cap-binding-complex (CBC) in complex with a cap analogue m7GpppG
Descriptor: 20 KDA NUCLEAR CAP BINDING PROTEIN, 7N-METHYL-8-HYDROGUANOSINE-5'-MONOPHOSPHATE, 80 KDA NUCLEAR CAP BINDING PROTEIN, ...
Authors:Mazza, C, Segref, A, Mattaj, I.W, Cusack, S.
Deposit date:2002-08-16
Release date:2002-10-17
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Large-Scale Induced Fit Recognition of an M(7)Gpppg CAP Analogue by the Human Nuclear CAP-Binding Complex
Embo J., 21, 2002
1H2U
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BU of 1h2u by Molmil
Structure of the human nuclear cap-binding-complex (CBC) in complex with a cap analogue m7GpppG
Descriptor: 20 KDA NUCLEAR CAP BINDING PROTEIN, 7N-METHYL-8-HYDROGUANOSINE-5'-MONOPHOSPHATE, 80 KDA NUCLEAR CAP BINDING PROTEIN, ...
Authors:Mazza, C, Segref, A, Mattaj, I.W, Cusack, S.
Deposit date:2002-08-16
Release date:2002-10-17
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Large-Scale Induced Fit Recognition of an M(7)Gpppg CAP Analogue by the Human Nuclear CAP-Binding Complex
Embo J., 21, 2002
8PTJ
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BU of 8ptj by Molmil
Tilapia Lake Virus polymerase in vRNA pre-initiation state mode B (close core | partial replicase conformation)
Descriptor: 3' vRNA end - vRNA loop (40-mer), Polymerase acidic protein (PA-like), Putative PB1, ...
Authors:Arragain, B, Cusack, S.
Deposit date:2023-07-14
Release date:2023-12-27
Method:ELECTRON MICROSCOPY (2.86 Å)
Cite:Structural and functional analysis of the minimal orthomyxovirus-like polymerase of Tilapia Lake Virus from the highly diverged Amnoonviridae family.
Nat Commun, 14, 2023
8PSQ
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BU of 8psq by Molmil
Tilapia Lake Virus polymerase in cRNA pre-initiation state mode A (core only)
Descriptor: 5' cRNA end - cRNA loop (40-mer), MAGNESIUM ION, Polymerase acidic protein (PA-like), ...
Authors:Arragain, B, Cusack, S.
Deposit date:2023-07-13
Release date:2023-12-27
Method:ELECTRON MICROSCOPY (2.65 Å)
Cite:Structural and functional analysis of the minimal orthomyxovirus-like polymerase of Tilapia Lake Virus from the highly diverged Amnoonviridae family.
Nat Commun, 14, 2023
8PSX
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BU of 8psx by Molmil
Tilapia Lake Virus polymerase in vRNA elongation state (transcriptase conformation)
Descriptor: 5' vRNA end - vRNA loop (40-mer), MAGNESIUM ION, Polymerase acidic protein (PA-like), ...
Authors:Arragain, B, Cusack, S.
Deposit date:2023-07-13
Release date:2023-12-27
Method:ELECTRON MICROSCOPY (2.96 Å)
Cite:Structural and functional analysis of the minimal orthomyxovirus-like polymerase of Tilapia Lake Virus from the highly diverged Amnoonviridae family.
Nat Commun, 14, 2023
8PSS
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BU of 8pss by Molmil
Tilapia Lake Virus polymerase in cRNA pre-initiation state mode B (core-endo only)
Descriptor: 5' cRNA end - cRNA loop (40-mer), MAGNESIUM ION, Polymerase acidic protein (PA-like), ...
Authors:Arragain, B, Cusack, S.
Deposit date:2023-07-13
Release date:2023-12-27
Method:ELECTRON MICROSCOPY (2.83 Å)
Cite:Structural and functional analysis of the minimal orthomyxovirus-like polymerase of Tilapia Lake Virus from the highly diverged Amnoonviridae family.
Nat Commun, 14, 2023
8PT6
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BU of 8pt6 by Molmil
Tilapia Lake Virus polymerase in vRNA initiation state (replicase conformation)
Descriptor: 5' vRNA end - vRNA loop (40-mer), DNA (5'-D(*(CTP))-3'), MAGNESIUM ION, ...
Authors:Arragain, B, Cusack, S.
Deposit date:2023-07-13
Release date:2023-12-27
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.03 Å)
Cite:Structural and functional analysis of the minimal orthomyxovirus-like polymerase of Tilapia Lake Virus from the highly diverged Amnoonviridae family.
Nat Commun, 14, 2023
8PSO
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BU of 8pso by Molmil
Tilapia Lake Virus polymerase in vRNA initiation state (core only)
Descriptor: 5' vRNA end - vRNA loop (40-mer), DNA (5'-D(*(CTP))-3'), MAGNESIUM ION, ...
Authors:Arragain, B, Cusack, S.
Deposit date:2023-07-13
Release date:2023-12-27
Method:ELECTRON MICROSCOPY (2.4 Å)
Cite:Structural and functional analysis of the minimal orthomyxovirus-like polymerase of Tilapia Lake Virus from the highly diverged Amnoonviridae family.
Nat Commun, 14, 2023
8PT2
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BU of 8pt2 by Molmil
Tilapia Lake Virus polymerase in vRNA pre-initiation state mode B (transcriptase conformation)
Descriptor: 5' vRNA end - vRNA loop (40-mer), Polymerase acidic protein (PA-like), Putative PB1, ...
Authors:Arragain, B, Cusack, S.
Deposit date:2023-07-13
Release date:2023-12-27
Method:ELECTRON MICROSCOPY (2.59 Å)
Cite:Structural and functional analysis of the minimal orthomyxovirus-like polymerase of Tilapia Lake Virus from the highly diverged Amnoonviridae family.
Nat Commun, 14, 2023
8PSN
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BU of 8psn by Molmil
Tilapia Lake Virus polymerase in vRNA initiation state (transcriptase conformation)
Descriptor: 5' vRNA end - vRNA loop (40-mer), DNA (5'-D(*(CTP))-3'), MAGNESIUM ION, ...
Authors:Arragain, B, Cusack, S.
Deposit date:2023-07-13
Release date:2023-12-27
Method:ELECTRON MICROSCOPY (2.73 Å)
Cite:Structural and functional analysis of the minimal orthomyxovirus-like polymerase of Tilapia Lake Virus from the highly diverged Amnoonviridae family.
Nat Commun, 14, 2023
8PSU
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BU of 8psu by Molmil
Tilapia Lake Virus polymerase in vRNA pre-initiation state mode A (core only)
Descriptor: 5' vRNA end - vRNA loop (40-mer), Polymerase acidic protein (PA-like), Putative PB1, ...
Authors:Arragain, B, Cusack, S.
Deposit date:2023-07-13
Release date:2023-12-27
Method:ELECTRON MICROSCOPY (3.18 Å)
Cite:Structural and functional analysis of the minimal orthomyxovirus-like polymerase of Tilapia Lake Virus from the highly diverged Amnoonviridae family.
Nat Commun, 14, 2023
8PTH
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BU of 8pth by Molmil
Tilapia Lake Virus polymerase in vRNA pre-initiation state mode B (open core | partial replicase conformation)
Descriptor: 3' vRNA end - vRNA loop (40-mer), Polymerase acidic protein (PA-like), Putative PB1, ...
Authors:Arragain, B, Cusack, S.
Deposit date:2023-07-14
Release date:2023-12-27
Method:ELECTRON MICROSCOPY (2.73 Å)
Cite:Structural and functional analysis of the minimal orthomyxovirus-like polymerase of Tilapia Lake Virus from the highly diverged Amnoonviridae family.
Nat Commun, 14, 2023
8PT7
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BU of 8pt7 by Molmil
Tilapia Lake Virus polymerase in cRNA pre-initiation state mode A (core-endo only)
Descriptor: 5'/3' cRNA ends - cRNA loop (40-mer), MAGNESIUM ION, Polymerase acidic protein (PA-like), ...
Authors:Arragain, B, Cusack, S.
Deposit date:2023-07-13
Release date:2023-12-27
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structural and functional analysis of the minimal orthomyxovirus-like polymerase of Tilapia Lake Virus from the highly diverged Amnoonviridae family.
Nat Commun, 14, 2023
1JID
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BU of 1jid by Molmil
Human SRP19 in complex with helix 6 of Human SRP RNA
Descriptor: HELIX 6 OF HUMAN SRP RNA, MAGNESIUM ION, SIGNAL RECOGNITION PARTICLE 19 KDA PROTEIN
Authors:Wild, K, Sinning, I, Cusack, S.
Deposit date:2001-07-02
Release date:2001-10-19
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of an early protein-RNA assembly complex of the signal recognition particle.
Science, 294, 2001
8PSZ
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BU of 8psz by Molmil
Tilapia Lake Virus polymerase in vRNA elongation state with additional mode B promoter (transcriptase conformation)
Descriptor: 5' vRNA end - vRNA loop (40-mer), MAGNESIUM ION, Polymerase acidic protein (PA-like), ...
Authors:Arragain, B, Cusack, S.
Deposit date:2023-07-13
Release date:2024-01-10
Method:ELECTRON MICROSCOPY (2.42 Å)
Cite:Structural and functional analysis of the minimal orthomyxovirus-like polymerase of Tilapia Lake Virus from the highly diverged Amnoonviridae family.
Nat Commun, 14, 2023
8PMP
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BU of 8pmp by Molmil
Structure of the human nuclear cap-binding complex bound to ARS2[147-871] and m7GTP
Descriptor: 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, Nuclear cap-binding protein subunit 1, Nuclear cap-binding protein subunit 2, ...
Authors:Dubiez, E, Pellegrini, E, Foucher, A.E, Cusack, S, Kadlec, J.
Deposit date:2023-06-29
Release date:2024-01-17
Method:ELECTRON MICROSCOPY (3.43 Å)
Cite:Structural basis for competitive binding of productive and degradative co-transcriptional effectors to the nuclear cap-binding complex.
Cell Rep, 43, 2024
8PNT
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BU of 8pnt by Molmil
Structure of the human nuclear cap-binding complex bound to PHAX and m7G-capped RNA
Descriptor: 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, Nuclear cap-binding protein subunit 1, Nuclear cap-binding protein subunit 2, ...
Authors:Dubiez, E, Pellegrini, E, Foucher, A.E, Cusack, S, Kadlec, J.
Deposit date:2023-07-01
Release date:2024-01-17
Method:ELECTRON MICROSCOPY (3.46 Å)
Cite:Structural basis for competitive binding of productive and degradative co-transcriptional effectors to the nuclear cap-binding complex.
Cell Rep, 43, 2024
8QZ8
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BU of 8qz8 by Molmil
Tilapia Lake Virus polymerase in vRNA pre-termination state (transcriptase conformation)
Descriptor: MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, Polymerase acidic protein (PA-like), ...
Authors:Arragain, B, Cusack, S.
Deposit date:2023-10-26
Release date:2023-12-27
Method:ELECTRON MICROSCOPY (3.13 Å)
Cite:Structural and functional analysis of the minimal orthomyxovirus-like polymerase of Tilapia Lake Virus from the highly diverged Amnoonviridae family.
Nat Commun, 14, 2023
1J1U
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BU of 1j1u by Molmil
Crystal structure of archaeal tyrosyl-tRNA synthetase complexed with tRNA(Tyr) and L-tyrosine
Descriptor: MAGNESIUM ION, TYROSINE, Tyrosyl-tRNA synthetase, ...
Authors:Kobayashi, T, Nureki, O, Ishitani, R, Tukalo, M, Cusack, S, Sakamoto, K, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2002-12-17
Release date:2003-06-03
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural basis for orthogonal tRNA specificities of tyrosyl-tRNA synthetases for genetic code expansion
NAT.STRUCT.BIOL., 10, 2003
1QHV
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BU of 1qhv by Molmil
HUMAN ADENOVIRUS SEROTYPE 2 FIBRE HEAD
Descriptor: PROTEIN (ADENOVIRUS FIBRE), SULFATE ION
Authors:Van Raaij, M.J, Louis, N, Chroboczek, J, Cusack, S.
Deposit date:1999-05-28
Release date:1999-09-29
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.51 Å)
Cite:Structure of the human adenovirus serotype 2 fiber head domain at 1.5 A resolution.
Virology, 262, 1999

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