8AZA

Structure of RIP2K dimer bound to the XIAP BIR2 domain

Summary for 8AZA

Entry DOI	10.2210/pdb8aza/pdb
EMDB information	15757
Descriptor	E3 ubiquitin-protein ligase XIAP, Receptor-interacting serine/threonine-protein kinase 2, ZINC ION (3 entities in total)
Functional Keywords	kinase, bir2, complex, dimer, immune system
Biological source	Homo sapiens (human) More
Total number of polymer chains	3
Total formula weight	83120.68
Authors	Pellegrini, E.,Cusack, S. (deposition date: 2022-09-05, release date: 2022-10-26, Last modification date: 2023-09-20)
Primary citation	Lethier, M.,Huard, K.,Hons, M.,Favier, A.,Brutscher, B.,Boeri Erba, E.,Abbott, D.W.,Cusack, S.,Pellegrini, E. Structure shows that the BIR2 domain of E3 ligase XIAP binds across the RIPK2 kinase dimer interface. Life Sci Alliance, 6:-, 2023 Cited by PubMed: 37673444 DOI: 10.26508/lsa.202201784 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.15 Å)

Structure validation