8PMP

Structure of the human nuclear cap-binding complex bound to ARS2[147-871] and m7GTP

Summary for 8PMP

Entry DOI	10.2210/pdb8pmp/pdb
EMDB information	17763
Descriptor	Nuclear cap-binding protein subunit 1, Nuclear cap-binding protein subunit 2, Serrate RNA effector molecule homolog, ... (4 entities in total)
Functional Keywords	nuclear cap-binding complex, ars2, pol ii transcript metabolism, rna binding protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	3
Total formula weight	191410.68
Authors	Dubiez, E.,Pellegrini, E.,Foucher, A.E.,Cusack, S.,Kadlec, J. (deposition date: 2023-06-29, release date: 2024-01-17)
Primary citation	Dubiez, E.,Pellegrini, E.,Finderup Brask, M.,Garland, W.,Foucher, A.E.,Huard, K.,Heick Jensen, T.,Cusack, S.,Kadlec, J. Structural basis for competitive binding of productive and degradative co-transcriptional effectors to the nuclear cap-binding complex. Cell Rep, 43:113639-113639, 2024 Cited by PubMed: 38175753 DOI: 10.1016/j.celrep.2023.113639 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.43 Å)

Structure validation