4W8Y
 
 | | Structure of full length Cmr2 from Pyrococcus furiosus (Manganese bound form) | | 分子名称: | CRISPR system Cmr subunit Cmr2, MANGANESE (II) ION, ZINC ION | | 著者 | Benda, C, Ebert, J, Baumgaertner, M, Conti, E. | | 登録日 | 2014-08-26 | | 公開日 | 2014-10-15 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structural Model of a CRISPR RNA-Silencing Complex Reveals the RNA-Target Cleavage Activity in Cmr4.
Mol.Cell, 56, 2014
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6YVH
 | | CWC22-CWC27-EIF4A3 Complex | | 分子名称: | Eukaryotic initiation factor 4A-III, Pre-mRNA-splicing factor CWC22 homolog, Spliceosome-associated protein CWC27 homolog | | 著者 | Basquin, J, Busetto, V, LeHir, H, Conti, E. | | 登録日 | 2020-04-28 | | 公開日 | 2020-05-13 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (3.19 Å) | | 主引用文献 | Structural and functional insights into CWC27/CWC22 heterodimer linking the exon junction complex to spliceosomes.
Nucleic Acids Res., 48, 2020
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6H25
 | | Human nuclear RNA exosome EXO-10-MPP6 complex | | 分子名称: | Exosome complex component CSL4, Exosome complex component MTR3, Exosome complex component RRP4, ... | | 著者 | Gerlach, P, Schuller, J.M, Falk, S, Basquin, J, Conti, E. | | 登録日 | 2018-07-13 | | 公開日 | 2018-08-15 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Distinct and evolutionary conserved structural features of the human nuclear exosome complex.
Elife, 7, 2018
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6RO1
 | | X-ray crystal structure of the MTR4 NVL complex | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, Exosome RNA helicase MTR4, ... | | 著者 | Lingaraju, M, Langer, L.M, Basquin, J, Falk, S, Conti, E. | | 登録日 | 2019-05-10 | | 公開日 | 2019-07-03 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (3.07 Å) | | 主引用文献 | The MTR4 helicase recruits nuclear adaptors of the human RNA exosome using distinct arch-interacting motifs.
Nat Commun, 10, 2019
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8R8R
 | | Cryo-EM structure of the human mPSF with PAPOA C-terminus peptide (PAPOAc) | | 分子名称: | Cleavage and polyadenylation specificity factor subunit 1, Cleavage and polyadenylation specificity factor subunit 4, RNA (5'-R(P*AP*AP*UP*AP*AP*A)-3'), ... | | 著者 | Todesca, S, Sandmeir, F, Keidel, A, Conti, E. | | 登録日 | 2023-11-29 | | 公開日 | 2024-04-10 | | 実験手法 | ELECTRON MICROSCOPY (2.79 Å) | | 主引用文献 | Molecular basis of human polyA polymerase recruitment by mPSF.
Rna, 2024
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8RXB
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4ZKE
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4ZKD
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5MC6
 | | Cryo-EM structure of a native ribosome-Ski2-Ski3-Ski8 complex from S. cerevisiae | | 分子名称: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | | 著者 | Schmidt, C, Kowalinski, E, Shanmuganathan, V, Defenouillere, Q, Braunger, K, Heuer, A, Pech, M, Namane, A, Berninghausen, O, Fromont-Racine, M, Jacquier, A, Conti, E, Becker, T, Beckmann, R. | | 登録日 | 2016-11-09 | | 公開日 | 2017-01-18 | | 最終更新日 | 2019-12-11 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | The cryo-EM structure of a ribosome-Ski2-Ski3-Ski8 helicase complex.
Science, 354, 2016
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4ZRL
 | | Structure of the non canonical Poly(A) polymerase complex GLD-2 - GLD-3 | | 分子名称: | CHLORIDE ION, Defective in germ line development protein 3, Poly(A) RNA polymerase gld-2 | | 著者 | Nakel, K, Bonneau, F, Eckmann, C.R, Conti, E. | | 登録日 | 2015-05-12 | | 公開日 | 2015-07-08 | | 最終更新日 | 2017-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | | 主引用文献 | Structural basis for the activation of the C. elegans noncanonical cytoplasmic poly(A)-polymerase GLD-2 by GLD-3.
Proc.Natl.Acad.Sci.USA, 112, 2015
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6R5K
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2XZP
 | | Upf1 helicase | | 分子名称: | GLYCEROL, MALONATE ION, REGULATOR OF NONSENSE TRANSCRIPTS 1 | | 著者 | Chakrabarti, S, Jayachandran, U, Bonneau, F, Fiorini, F, Basquin, C, Domcke, S, Le Hir, H, Conti, E. | | 登録日 | 2010-11-26 | | 公開日 | 2011-03-30 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.72 Å) | | 主引用文献 | Molecular Mechanisms for the RNA-Dependent ATPase Activity of Upf1 and its Regulation by Upf2.
Mol.Cell, 41, 2011
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2XZL
 | | Upf1-RNA complex | | 分子名称: | 5- R(*UP*UP*UP*UP*UP*UP*UP*UP*U) -3, ADENOSINE-5'-DIPHOSPHATE, ATP-DEPENDENT HELICASE NAM7, ... | | 著者 | Chakrabarti, S, Jayachandran, U, Bonneau, F, Fiorini, F, Basquin, C, Domcke, S, Le Hir, H, Conti, E. | | 登録日 | 2010-11-26 | | 公開日 | 2011-03-30 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Molecular Mechanisms for the RNA-Dependent ATPase Activity of Upf1 and its Regulation by Upf2.
Mol.Cell, 41, 2011
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2XGJ
 | | Structure of Mtr4, a DExH helicase involved in nuclear RNA processing and surveillance | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ATP-DEPENDENT RNA HELICASE DOB1, RNA (5'-(*AP*AP*AP*AP*A)-3') | | 著者 | Weir, J.R, Bonneau, F, Hentschel, J, Conti, E. | | 登録日 | 2010-06-04 | | 公開日 | 2010-06-23 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structural Analysis Reveals the Characteristic Features of Mtr4, a Dexh Helicase Involved in Nuclear RNA Processing and Surveillance.
Proc.Natl.Acad.Sci.USA, 107, 2010
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6Z3R
 | | Structure of SMG1-8-9 kinase complex bound to UPF1-LSQ | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Langer, L.M, Gat, Y, Conti, E. | | 登録日 | 2020-05-21 | | 公開日 | 2020-06-24 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (2.97 Å) | | 主引用文献 | Structure of substrate-bound SMG1-8-9 kinase complex reveals molecular basis for phosphorylation specificity.
Elife, 9, 2020
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7AQO
 | | yeast THO-Sub2 complex dimer | | 分子名称: | BJ4_G0025130.mRNA.1.CDS.1, EM14S01-3B_G0007820.mRNA.1.CDS.1, TEX1 isoform 1, ... | | 著者 | Schuller, S.K, Schuller, J.M, Prabu, R.J, Baumgartner, M, Bonneau, F, basquin, J, Conti, E. | | 登録日 | 2020-10-22 | | 公開日 | 2020-12-02 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | | 主引用文献 | Structural insights into the nucleic acid remodeling mechanisms of the yeast THO-Sub2 complex.
Elife, 9, 2020
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7APX
 | | yeast THO-Sub2 complex | | 分子名称: | ATP-dependent RNA helicase SUB2, Protein TEX1, THO complex subunit 2,Tho2, ... | | 著者 | Schuller, S.K, Schuller, J.M, Prabu, R.J, Baumgartner, M, Bonneau, F, basquin, J, Conti, E. | | 登録日 | 2020-10-20 | | 公開日 | 2020-12-02 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structural insights into the nucleic acid remodeling mechanisms of the yeast THO-Sub2 complex.
Elife, 9, 2020
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7Z52
 | | Human NEXT dimer - focused reconstruction of the single MTR4 | | 分子名称: | Exosome RNA helicase MTR4, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, RNA (5'-R(P*UP*UP*UP*UP*U)-3'), ... | | 著者 | Gerlach, P, Lingaraju, M, Salerno-Kochan, A, Bonneau, F, Basquin, J, Conti, E. | | 登録日 | 2022-03-07 | | 公開日 | 2022-06-22 | | 最終更新日 | 2022-07-20 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structure and regulation of the nuclear exosome targeting complex guides RNA substrates to the exosome.
Mol.Cell, 82, 2022
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7Z4Y
 | | Human NEXT dimer - overall reconstruction of the core complex | | 分子名称: | Exosome RNA helicase MTR4, Zinc finger CCHC domain-containing protein 8 | | 著者 | Gerlach, P, Lingaraju, M, Salerno-Kochan, A, Bonneau, F, Basquin, J, Conti, E. | | 登録日 | 2022-03-06 | | 公開日 | 2022-06-22 | | 最終更新日 | 2022-07-20 | | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | | 主引用文献 | Structure and regulation of the nuclear exosome targeting complex guides RNA substrates to the exosome.
Mol.Cell, 82, 2022
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7Z4Z
 | | Human NEXT dimer - focused reconstruction of the dimerization module | | 分子名称: | Exosome RNA helicase MTR4, Zinc finger CCHC domain-containing protein 8 | | 著者 | Gerlach, P, Lingaraju, M, Salerno-Kochan, A, Bonneau, F, Basquin, J, Conti, E. | | 登録日 | 2022-03-06 | | 公開日 | 2022-06-22 | | 最終更新日 | 2022-07-20 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Structure and regulation of the nuclear exosome targeting complex guides RNA substrates to the exosome.
Mol.Cell, 82, 2022
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2BR2
 | | RNase PH core of the archaeal exosome | | 分子名称: | CHLORIDE ION, EXOSOME COMPLEX EXONUCLEASE 1, EXOSOME COMPLEX EXONUCLEASE 2 | | 著者 | lorentzen, E, Fribourg, S, Conti, E. | | 登録日 | 2005-04-30 | | 公開日 | 2005-06-06 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | The Archaeal Exosome Core is a Hexameric Ring Structure with Three Catalytic Subunits.
Nat.Struct.Mol.Biol., 12, 2005
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4Q8H
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4Q8G
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4TXD
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4U4C
 | | The molecular architecture of the TRAMP complex reveals the organization and interplay of its two catalytic activities | | 分子名称: | 1,2-ETHANEDIOL, ATP-dependent RNA helicase DOB1, CHLORIDE ION, ... | | 著者 | Falk, S, Weir, J.R, Hentschel, J, Reichelt, P, Bonneau, F, Conti, E. | | 登録日 | 2014-07-23 | | 公開日 | 2014-09-24 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | The Molecular Architecture of the TRAMP Complex Reveals the Organization and Interplay of Its Two Catalytic Activities.
Mol.Cell, 55, 2014
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