3OR7
 
 | | On the structural basis of modal gating behavior in K+channels - E71I | | 分子名称: | POTASSIUM ION, Voltage-gated potassium channel, antibody fab fragment heavy chain, ... | | 著者 | Chakrapani, S, Cordero-Morales, J.F, Jogini, V, Pan, A.C, Cortes, D.M, Roux, B, Perozo, E. | | 登録日 | 2010-09-06 | | 公開日 | 2011-01-05 | | 最終更新日 | 2018-08-29 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | On the structural basis of modal gating behavior in K(+) channels.
Nat.Struct.Mol.Biol., 18, 2011
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3OR6
 | | On the structural basis of modal gating behavior in K+channels - E71Q | | 分子名称: | POTASSIUM ION, Voltage-gated potassium channel, antibody fab fragment heavy chain, ... | | 著者 | Chakrapani, S, Cordero-Morales, J.F, Jogini, V, Perozo, E. | | 登録日 | 2010-09-06 | | 公開日 | 2011-01-05 | | 最終更新日 | 2018-08-29 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | On the structural basis of modal gating behavior in K(+) channels.
Nat.Struct.Mol.Biol., 18, 2011
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4YEU
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6NP0
 | | Cryo-EM structure of 5HT3A receptor in presence of granisetron | | 分子名称: | 1-methyl-N-[(1R,5S)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]indazole-3-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Basak, S, Chakrapani, S. | | 登録日 | 2019-01-17 | | 公開日 | 2019-07-24 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (2.92 Å) | | 主引用文献 | Molecular mechanism of setron-mediated inhibition of full-length 5-HT3Areceptor.
Nat Commun, 10, 2019
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5J0Z
 | | Crystal structure of GLIC in complex with DHA | | 分子名称: | ACETATE ION, CHLORIDE ION, DIUNDECYL PHOSPHATIDYL CHOLINE, ... | | 著者 | Basak, S, Schmandt, N, Chakrapani, S. | | 登録日 | 2016-03-28 | | 公開日 | 2017-03-15 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | | 主引用文献 | Crystal structure and dynamics of a lipid-induced potential desensitized-state of a pentameric ligand-gated channel.
Elife, 6, 2017
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7M6S
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7M6O
 | | Full length alpha1 Glycine receptor in presence of 0.1mM Glycine and 32uM Tetrahydrocannabinol | | 分子名称: | (6aR,10aR)-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCINE, ... | | 著者 | Kumar, A, Chakrapani, S. | | 登録日 | 2021-03-26 | | 公開日 | 2022-08-03 | | 最終更新日 | 2022-09-07 | | 実験手法 | ELECTRON MICROSCOPY (2.84 Å) | | 主引用文献 | Structural basis for cannabinoid-induced potentiation of alpha1-glycine receptors in lipid nanodiscs.
Nat Commun, 13, 2022
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7M6P
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7M6Q
 | | Full length alpha1 Glycine receptor in presence of 1mM Glycine and 32uM Tetrahydrocannabinol State 1 | | 分子名称: | (6aR,10aR)-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCINE, ... | | 著者 | Kumar, A, Chakrapani, S. | | 登録日 | 2021-03-26 | | 公開日 | 2022-08-03 | | 最終更新日 | 2022-09-07 | | 実験手法 | ELECTRON MICROSCOPY (2.91 Å) | | 主引用文献 | Structural basis for cannabinoid-induced potentiation of alpha1-glycine receptors in lipid nanodiscs.
Nat Commun, 13, 2022
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7M6N
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7M6M
 | | Full length alpha1 Glycine receptor in presence of 32uM Tetrahydrocannabinol | | 分子名称: | (6aR,10aR)-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glycine receptor subunit alphaZ1 | | 著者 | Kumar, A, Chakrapani, S. | | 登録日 | 2021-03-26 | | 公開日 | 2022-08-03 | | 最終更新日 | 2022-09-07 | | 実験手法 | ELECTRON MICROSCOPY (3.09 Å) | | 主引用文献 | Structural basis for cannabinoid-induced potentiation of alpha1-glycine receptors in lipid nanodiscs.
Nat Commun, 13, 2022
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7M6R
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6DG8
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6DG7
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6B5V
 | | Structure of TRPV5 in complex with econazole | | 分子名称: | 1-[(2R)-2-[(4-chlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole, CALCIUM ION, Transient receptor potential cation channel subfamily V member 5 | | 著者 | Hughes, T.E.T, Lodowski, D.T, Huynh, K.W, Yazici, A, del Rosario, J, Kapoor, A, Basak, S, Samanta, A, Chakrapani, S, Zhou, Z.H, Filizola, M, Rohacs, T, Han, S, Moiseenkova-Bell, V.Y. | | 登録日 | 2017-09-29 | | 公開日 | 2017-12-27 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | | 主引用文献 | Structural basis of TRPV5 channel inhibition by econazole revealed by cryo-EM.
Nat. Struct. Mol. Biol., 25, 2018
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7TVI
 | | Alpha1/BetaB Heteromeric Glycine Receptor in Glycine-Bound State | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCINE, Glycine receptor beta subunit 2, ... | | 著者 | Gibbs, E, Chakrapani, S, Kumar, A. | | 登録日 | 2022-02-04 | | 公開日 | 2023-03-22 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Conformational transitions and allosteric modulation in a heteromeric glycine receptor
Nat Commun, 14, 2023
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7TU9
 | | Alpha1/BetaB Heteromeric Glycine Receptor in Strychnine-Bound State | | 分子名称: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, Glycine receptor beta subunit 2, ... | | 著者 | Gibbs, E, Kumar, A, Chakrapani, S. | | 登録日 | 2022-02-02 | | 公開日 | 2023-03-22 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Conformational transitions and allosteric modulation in a heteromeric glycine receptor
Nat Commun, 14, 2023
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3FB7
 | | Open KcsA potassium channel in the presence of Rb+ ion | | 分子名称: | RUBIDIUM ION, Voltage-gated potassium channel, antibody fab fragment heavy chain, ... | | 著者 | Cuello, L.G, Jogini, V, Cortes, D.M, Pan, A.C, Gagnon, D.H, Cordero-Morales, J.F, Chakrapani, S, Roux, B, Perozo, E. | | 登録日 | 2008-11-18 | | 公開日 | 2010-07-14 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Open KcsA potassium channel in the presence of Rb+ ion
TO BE PUBLISHED
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6BE1
 | | Cryo-EM structure of serotonin receptor | | 分子名称: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Basak, S, Chakrapani, S. | | 登録日 | 2017-10-24 | | 公開日 | 2018-02-07 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (4.31 Å) | | 主引用文献 | Cryo-EM structure of 5-HT
Nat Commun, 9, 2018
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6W1M
 | | Cryo-EM structure of 5HT3A receptor in presence of Ondansetron | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(4-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-hydroxytryptamine receptor 3A, ... | | 著者 | Basak, S, Chakrapani, S. | | 登録日 | 2020-03-04 | | 公開日 | 2021-01-13 | | 実験手法 | ELECTRON MICROSCOPY (3.06 Å) | | 主引用文献 | High-resolution structures of multiple 5-HT 3A R-setron complexes reveal a novel mechanism of competitive inhibition.
Elife, 9, 2020
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6W1Y
 | | Cryo-EM structure of 5HT3A receptor in presence of Palonosetron | | 分子名称: | (3~{a}~{S})-2-[(3~{S})-1-azabicyclo[2.2.2]octan-3-yl]-3~{a},4,5,6-tetrahydro-3~{H}-benzo[de]isoquinolin-1-one, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(4-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Basak, S, Chakrapani, S. | | 登録日 | 2020-03-04 | | 公開日 | 2021-01-13 | | 実験手法 | ELECTRON MICROSCOPY (3.35 Å) | | 主引用文献 | High-resolution structures of multiple 5-HT 3A R-setron complexes reveal a novel mechanism of competitive inhibition.
Elife, 9, 2020
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6W1J
 | | Cryo-EM structure of 5HT3A receptor in presence of Alosetron | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(4-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-hydroxytryptamine receptor 3A, ... | | 著者 | Basak, S, Chakrapani, S. | | 登録日 | 2020-03-04 | | 公開日 | 2021-01-13 | | 実験手法 | ELECTRON MICROSCOPY (2.92 Å) | | 主引用文献 | High-resolution structures of multiple 5-HT 3A R-setron complexes reveal a novel mechanism of competitive inhibition.
Elife, 9, 2020
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8FSB
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8FRX
 | | Full-length mouse 5-HT3A receptor in complex with SMP100, pre-activated | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-[(1R,3S,4R)-1-azabicyclo[2.2.2]octan-3-yl]-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indazol-6-one, 5-hydroxytryptamine receptor 3A | | 著者 | Felt, K.C, Chakrapani, S. | | 登録日 | 2023-01-09 | | 公開日 | 2023-12-27 | | 最終更新日 | 2024-01-17 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Structural basis for partial agonism in 5-HT 3A receptors.
Nat.Struct.Mol.Biol., 2024
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8FRZ
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