6UMC
 
 | | Crystal structure of human GAC in complex with inhibitor UPGL00012 | | Descriptor: | 2-phenyl-N-{5-[(3R)-3-({5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl}oxy)pyrrolidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide, Glutaminase kidney isoform, mitochondrial | | Authors: | Huang, Q, Cerione, R.A. | | Deposit date: | 2019-10-09 | | Release date: | 2020-10-14 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Crystal structure of human GAC in complex with inhibitor UPGL00012
To Be Published
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6UMF
 | | Crystal structure of human GAC in complex with inhibitor UPGL00012 | | Descriptor: | Glutaminase kidney isoform, mitochondrial, N-(5-{[1-(5-amino-1,3,4-thiadiazol-2-yl)piperidin-4-yl]oxy}-1,3,4-thiadiazol-2-yl)-2-phenylacetamide | | Authors: | Huang, Q, Cerione, R.A. | | Deposit date: | 2019-10-09 | | Release date: | 2020-10-14 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.68 Å) | | Cite: | Crystal structure of human GAC in complex with inhibitor UPGL00012
To Be Published
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6UKB
 | | Crystal structure of human GAC in complex with inhibitor UPGL00012 | | Descriptor: | Glutaminase kidney isoform, mitochondrial, N-[5-(4-{[5-(acetylamino)-1,3,4-thiadiazol-2-yl]oxy}piperidin-1-yl)-1,3,4-thiadiazol-2-yl]acetamide | | Authors: | Huang, Q, Cerione, R.A. | | Deposit date: | 2019-10-04 | | Release date: | 2020-10-07 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Crystal structure of human GAC in complex with inhibitor UPGL00020
To Be Published
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6OYA
 | | Structure of the Rhodopsin-Transducin-Nanobody Complex | | Descriptor: | Camelid antibody VHH fragment, Gt-alpha/Gi1-alpha chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Gao, Y, Hu, H, Ramachandran, S, Erickson, J.W, Cerione, R.A, Skiniotis, G. | | Deposit date: | 2019-05-14 | | Release date: | 2019-07-24 | | Last modified: | 2019-12-04 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structures of the Rhodopsin-Transducin Complex: Insights into G-Protein Activation.
Mol.Cell, 75, 2019
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6OY9
 | | Structure of the Rhodopsin-Transducin Complex | | Descriptor: | Gt-alpha/Gi1-alpha chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(T) subunit gamma-T1, ... | | Authors: | Gao, Y, Hu, H, Ramachandran, S, Erickson, J.W, Cerione, R.A, Skiniotis, G. | | Deposit date: | 2019-05-14 | | Release date: | 2019-07-24 | | Last modified: | 2019-12-04 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structures of the Rhodopsin-Transducin Complex: Insights into G-Protein Activation.
Mol.Cell, 75, 2019
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3FEY
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3FEX
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5WJ6
 | | Crystal structure of glutaminase C in complex with inhibitor 2-phenyl-N-{5-[4-({5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl}amino)piperidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide (UPGL-00004) | | Descriptor: | 2-phenyl-N-{5-[4-({5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl}amino)piperidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide, Glutaminase kidney isoform, mitochondrial | | Authors: | Huang, Q, Cerione, R.A. | | Deposit date: | 2017-07-21 | | Release date: | 2018-01-10 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.445 Å) | | Cite: | Characterization of the interactions of potent allosteric inhibitors with glutaminase C, a key enzyme in cancer cell glutamine metabolism.
J. Biol. Chem., 293, 2018
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2GCO
 | | Crystal structure of the human RhoC-GppNHp complex | | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Rho-related GTP-binding protein RhoC | | Authors: | Dias, S.M.G, Cerione, R.A. | | Deposit date: | 2006-03-14 | | Release date: | 2007-03-27 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | X-ray Crystal Structures Reveal Two Activated States for RhoC.
Biochemistry, 46, 2007
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2GCN
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2GCP
 | | Crystal structure of the human RhoC-GSP complex | | Descriptor: | 1,2-ETHANEDIOL, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Dias, S.M.G, Cerione, R.A. | | Deposit date: | 2006-03-14 | | Release date: | 2007-03-27 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | X-ray Crystal Structures Reveal Two Activated States for RhoC.
Biochemistry, 46, 2007
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3V00
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1NI2
 | | Structure of the active FERM domain of Ezrin | | Descriptor: | Ezrin | | Authors: | Smith, W.J, Nassar, N, Bretscher, A.P, Cerione, R.A, Karplus, P.A. | | Deposit date: | 2002-12-20 | | Release date: | 2003-02-25 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structure of the Active N-terminal Domain of Ezrin. CONFORMATIONAL AND MOBILITY CHANGES IDENTIFY KEYSTONE INTERACTIONS.
J.Biol.Chem., 278, 2003
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1PZD
 | | Structural Identification of a conserved appendage domain in the carboxyl-terminus of the COPI gamma-subunit. | | Descriptor: | Coatomer gamma subunit, SULFATE ION | | Authors: | Hoffman, G.R, Rahl, P.B, Collins, R.N, Cerione, R.A. | | Deposit date: | 2003-07-10 | | Release date: | 2003-10-14 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.31 Å) | | Cite: | Conserved Structural Motifs in Intracellular Trafficking Pathways. Structure of the gammaCOP Appendage Domain.
Mol.Cell, 12, 2003
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1GRN
 | | CRYSTAL STRUCTURE OF THE CDC42/CDC42GAP/ALF3 COMPLEX. | | Descriptor: | ALUMINUM FLUORIDE, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Nassar, N, Hoffman, G.R, Clardy, J.C, Cerione, R.A. | | Deposit date: | 1998-07-30 | | Release date: | 1999-12-22 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structures of Cdc42 bound to the active and catalytically compromised forms of Cdc42GAP.
Nat.Struct.Biol., 5, 1998
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2NGR
 | | TRANSITION STATE COMPLEX FOR GTP HYDROLYSIS BY CDC42: COMPARISONS OF THE HIGH RESOLUTION STRUCTURES FOR CDC42 BOUND TO THE ACTIVE AND CATALYTICALLY COMPROMISED FORMS OF THE CDC42-GAP. | | Descriptor: | ALUMINUM FLUORIDE, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Nassar, N, Hoffman, G, Clardy, J, Cerione, R. | | Deposit date: | 1998-07-31 | | Release date: | 1999-01-06 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structures of Cdc42 bound to the active and catalytically compromised forms of Cdc42GAP.
Nat.Struct.Biol., 5, 1998
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1AN0
 | | CDC42HS-GDP COMPLEX | | Descriptor: | CDC42HS-GDP, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | | Authors: | Kongsaeree, P, Cerione, R, Clardy, J. | | Deposit date: | 1997-06-26 | | Release date: | 1999-01-13 | | Last modified: | 2021-11-03 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | The Structure Determination of Cdc42Hs and Gdp Complex
To be Published
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3RIG
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1DOA
 | | Structure of the rho family gtp-binding protein cdc42 in complex with the multifunctional regulator rhogdi | | Descriptor: | GERAN-8-YL GERAN, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Hoffman, G.R, Nassar, N, Cerione, R.C. | | Deposit date: | 1999-12-20 | | Release date: | 2000-02-09 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structure of the Rho family GTP-binding protein Cdc42 in complex with the multifunctional regulator RhoGDI.
Cell(Cambridge,Mass.), 100, 2000
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1AJW
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4F4U
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4F56
 | | The bicyclic intermediate structure provides insights into the desuccinylation mechanism of SIRT5 | | Descriptor: | 3-[(2R,3aR,5R,6R,6aR)-5-({[(S)-{[(S)-{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}methyl)-2,6-dihydroxytetrahydrofuro[2,3-d][1,3]oxathiol-2-yl]propanoic acid, NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial, ... | | Authors: | Zhou, Y, Hao, Q. | | Deposit date: | 2012-05-11 | | Release date: | 2012-06-20 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | The Bicyclic Intermediate Structure Provides Insights into the Desuccinylation Mechanism of Human Sirtuin 5 (SIRT5)
J.Biol.Chem., 287, 2012
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3RIY
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1CC0
 | | CRYSTAL STRUCTURE OF THE RHOA.GDP-RHOGDI COMPLEX | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, rho GDP dissociation inhibitor alpha, ... | | Authors: | Longenecker, K.L, Read, P, Derewenda, U, Dauter, Z, Garrard, S, Walker, L, Somlyo, A.V, Somlyo, A.P, Nakamoto, R.K, Derewenda, Z.S. | | Deposit date: | 1999-03-03 | | Release date: | 2000-01-07 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (5 Å) | | Cite: | How RhoGDI binds Rho.
Acta Crystallogr.,Sect.D, 55, 1999
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1EES
 | | SOLUTION STRUCTURE OF CDC42HS COMPLEXED WITH A PEPTIDE DERIVED FROM P-21 ACTIVATED KINASE, NMR, 20 STRUCTURES | | Descriptor: | GTP-BINDING PROTEIN, P21-ACTIVATED KINASE | | Authors: | Gizachew, D, Guo, W, Chohan, K.C, Sutcliffe, M.J, Oswald, R.E. | | Deposit date: | 2000-02-02 | | Release date: | 2000-03-29 | | Last modified: | 2022-02-16 | | Method: | SOLUTION NMR | | Cite: | Structure of the complex of Cdc42Hs with a peptide derived from P-21 activated kinase.
Biochemistry, 39, 2000
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