4F4U
The bicyclic intermediate structure provides insights into the desuccinylation mechanism of SIRT5
Summary for 4F4U
Entry DOI | 10.2210/pdb4f4u/pdb |
Related | 4F56 |
Descriptor | NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial, peptide from Histone H3.1, ZINC ION, ... (4 entities in total) |
Functional Keywords | zn-binding domain, rossmann fold domain, nad-dependent demalonylase and desuccinylase, mitochondrial sirtuin, hydrolase |
Biological source | Homo sapiens (human) More |
Cellular location | Mitochondrion matrix. Isoform 1: Cytoplasm . Isoform 2: Mitochondrion : Q9NXA8 Nucleus: P68431 |
Total number of polymer chains | 4 |
Total formula weight | 62151.38 |
Authors | |
Primary citation | Zhou, Y.,Zhang, H.,He, B.,Du, J.,Lin, H.,Cerione, R.A.,Hao, Q. The Bicyclic Intermediate Structure Provides Insights into the Desuccinylation Mechanism of Human Sirtuin 5 (SIRT5) J.Biol.Chem., 287:28307-28314, 2012 Cited by PubMed: 22767592DOI: 10.1074/jbc.M112.384511 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
Download full validation report