7XJY
| Cryo-EM structure of Oryza sativa plastid glycyl-tRNA synthetase (apo form) | Descriptor: | Glycine--tRNA ligase | Authors: | Yu, Z, Wu, Z, Li, Y, Lu, G, Lin, J. | Deposit date: | 2022-04-19 | Release date: | 2023-05-03 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structural basis of a two-step tRNA recognition mechanism for plastid glycyl-tRNA synthetase. Nucleic Acids Res., 51, 2023
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7XK1
| Cryo-EM structure of Oryza sativa plastid glycyl-tRNA synthetase in complex with two tRNAs (both in tRNA binding states) | Descriptor: | Glycine--tRNA ligase, tRNA(gly) | Authors: | Yu, Z, Wu, Z, Li, Y, Lu, G, Lin, J. | Deposit date: | 2022-04-19 | Release date: | 2023-05-03 | Last modified: | 2023-05-24 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Structural basis of a two-step tRNA recognition mechanism for plastid glycyl-tRNA synthetase. Nucleic Acids Res., 51, 2023
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7XK0
| Cryo-EM strucrture of Oryza sativa plastid glycyl-tRNA synthetase in complex with tRNA (tRNA locked state) | Descriptor: | Glycine--tRNA ligase, tRNA(gly) | Authors: | Yu, Z, Wu, Z, Li, Y, Lu, G, Lin, J. | Deposit date: | 2022-04-19 | Release date: | 2023-05-03 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.59 Å) | Cite: | Structural basis of a two-step tRNA recognition mechanism for plastid glycyl-tRNA synthetase. Nucleic Acids Res., 51, 2023
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7XBK
| Structure and mechanism of a mitochondrial AAA+ disaggregase CLPB | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Isoform 2 of Caseinolytic peptidase B protein homolog, MAGNESIUM ION, ... | Authors: | Wu, D, Liu, Y, Dai, Y, Wang, G, Lu, G, Chen, Y, Li, N, Lin, J, Gao, N. | Deposit date: | 2022-03-21 | Release date: | 2023-01-25 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Comprehensive structural characterization of the human AAA+ disaggregase CLPB in the apo- and substrate-bound states reveals a unique mode of action driven by oligomerization. Plos Biol., 21, 2023
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7XC5
| Crystal structure of the ANK domain of CLPB | Descriptor: | Isoform 2 of Caseinolytic peptidase B protein homolog | Authors: | Liu, Y, Wu, D, Lu, G, Gao, N, Lin, J. | Deposit date: | 2022-03-23 | Release date: | 2023-01-18 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Comprehensive structural characterization of the human AAA+ disaggregase CLPB in the apo- and substrate-bound states reveals a unique mode of action driven by oligomerization. Plos Biol., 21, 2023
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2GAS
| Crystal Structure of Isoflavone Reductase | Descriptor: | isoflavone reductase | Authors: | Wang, X, He, X, Lin, J, Shao, H, Chang, Z, Dixon, R.A. | Deposit date: | 2006-03-09 | Release date: | 2006-04-25 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Crystal Structure of Isoflavone Reductase from Alfalfa (Medicago sativa L.) J.Mol.Biol., 358, 2006
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7A5V
| CryoEM structure of a human gamma-aminobutyric acid receptor, the GABA(A)R-beta3 homopentamer, in complex with histamine and megabody Mb25 in lipid nanodisc | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | Authors: | Nakane, T, Kotecha, A, Sente, A, Yamashita, K, McMullan, G, Masiulis, S, Brown, P.M.G.E, Grigoras, I.T, Malinauskaite, L, Malinauskas, T, Miehling, J, Yu, L, Karia, D, Pechnikova, E.V, de Jong, E, Keizer, J, Bischoff, M, McCormack, J, Tiemeijer, P, Hardwick, S.W, Chirgadze, D.Y, Murshudov, G, Aricescu, A.R, Scheres, S.H.W. | Deposit date: | 2020-08-22 | Release date: | 2020-11-18 | Last modified: | 2020-11-25 | Method: | ELECTRON MICROSCOPY (1.7 Å) | Cite: | Single-particle cryo-EM at atomic resolution. Nature, 587, 2020
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7A4M
| Cryo-EM structure of mouse heavy-chain apoferritin at 1.22 A | Descriptor: | FE (III) ION, Ferritin heavy chain, ZINC ION | Authors: | Nakane, T, Kotecha, A, Sente, A, Yamashita, K, McMullan, G, Masiulis, S, Brown, P.M.G.E, Grigoras, I.T, Malinauskaite, L, Malinauskas, T, Miehling, J, Yu, L, Karia, D, Pechnikova, E.V, de Jong, E, Keizer, J, Bischoff, M, McCormack, J, Tiemeijer, P, Hardwick, S.W, Chirgadze, D.Y, Murshudov, G, Aricescu, A.R, Scheres, S.H.W. | Deposit date: | 2020-08-20 | Release date: | 2020-10-28 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (1.22 Å) | Cite: | Single-particle cryo-EM at atomic resolution. Nature, 587, 2020
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6ZAK
| Room temperature XFEL Isopenicillin N synthase structure in complex with the Fe(IV)=O mimic VO and ACV. | Descriptor: | Isopenicillin N synthase, L-D-(A-AMINOADIPOYL)-L-CYSTEINYL-D-VALINE, SULFATE ION, ... | Authors: | Rabe, P, Kamps, J.J.A.G, Sutherlin, K, Pharm, C, McDonough, M.A, Leissing, T.M, Aller, P, Butryn, A, Linyard, J, Lang, P, Brem, J, Fuller, F.D, Batyuk, A, Hunter, M.S, Pettinati, I, Clifton, I.J, Alonso-Mori, R, Gul, S, Young, I, Kim, I, Bhowmick, A, ORiordan, L, Brewster, A.S, Claridge, T.D.W, Sauter, N.K, Yachandra, V, Yano, J, Kern, J.F, Orville, A.M, Schofield, C.J. | Deposit date: | 2020-06-05 | Release date: | 2022-01-12 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.54 Å) | Cite: | Room temperature XFEL Isopenicillin N synthase structure in complex with the Fe(IV)=O mimic VO and ACV. To Be Published
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1Q1E
| The ATPase component of E. coli maltose transporter (MalK) in the nucleotide-free form | Descriptor: | Maltose/maltodextrin transport ATP-binding protein malK | Authors: | Chen, J, Lu, G, Lin, J, Davidson, A.L, Quiocho, F.A. | Deposit date: | 2003-07-19 | Release date: | 2003-09-30 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | A tweezers-like motion of the ATP-binding cassette dimer in an ABC transport cycle Mol.Cell, 12, 2003
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1Q12
| Crystal Structure of the ATP-bound E. coli MalK | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Maltose/maltodextrin transport ATP-binding protein malK | Authors: | Chen, J, Lu, G, Lin, J, Davidson, A.L, Quiocho, F.A. | Deposit date: | 2003-07-18 | Release date: | 2003-09-30 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | A tweezers-like motion of the ATP-binding cassette dimer in an ABC transport cycle Mol.Cell, 12, 2003
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1Q1B
| Crystal structure of E. coli MalK in the nucleotide-free form | Descriptor: | Maltose/maltodextrin transport ATP-binding protein malK | Authors: | Chen, J, Lu, G, Lin, J, Davidson, A.L, Quiocho, F.A. | Deposit date: | 2003-07-18 | Release date: | 2003-09-30 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | A tweezer-like motion of the ATP-binding cassette dimer in an ABC transport cycle Mol.Cell, 12, 2003
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6Y8K
| Crystal structure of CD137 in complex with the cyclic peptide BCY10916 | Descriptor: | 1,1',1''-(1,3,5-triazinane-1,3,5-triyl)tripropan-1-one, 1,2-ETHANEDIOL, ACETATE ION, ... | Authors: | Upadhyaya, P, Kublin, J, Dods, R, Kristensson, J, Lahdenranta, J, Kleyman, M, Repash, E, Ma, J, Mudd, G, Van Rietschoten, K, Haines, E, Harrison, H, Beswick, P, Chen, L, McDonnell, K, Battula, S, Hurov, K, Keen, N. | Deposit date: | 2020-03-05 | Release date: | 2021-02-03 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.011 Å) | Cite: | Anticancer immunity induced by a synthetic tumor-targeted CD137 agonist. J Immunother Cancer, 9, 2021
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4URK
| PI3Kg in complex with AZD6482 | Descriptor: | 2-[[(1R)-1-(7-methyl-2-morpholin-4-yl-4-oxidanylidene-pyrido[1,2-a]pyrimidin-9-yl)ethyl]amino]benzoic acid, PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM | Authors: | Giordanetto, F, Barlaam, B, Berglund, S, Edman, K, Karlsson, O, Lindberg, J, Nylander, S, Inghardt, T. | Deposit date: | 2014-06-30 | Release date: | 2014-10-22 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Discovery of 9-(1-Phenoxyethyl)-2-Morpholino-4-Oxo-Pyrido[1, 2-A]Pyrimidine-7-Carboxamides as Oral Pi3Kbeta Inhibitors, Useful as Antiplatelet Agents. Bioorg.Med.Chem.Lett., 24, 2014
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1MUT
| NMR STUDY OF MUTT ENZYME, A NUCLEOSIDE TRIPHOSPHATE PYROPHOSPHOHYDROLASE | Descriptor: | NUCLEOSIDE TRIPHOSPHATE PYROPHOSPHOHYDROLASE | Authors: | Abeygunawardana, C, Weber, D.J, Gittis, A.G, Frick, D.N, Lin, J, Miller, A.-F, Bessman, M.J, Mildvan, A.S. | Deposit date: | 1995-09-14 | Release date: | 1996-04-03 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structure of the MutT enzyme, a nucleoside triphosphate pyrophosphohydrolase. Biochemistry, 34, 1995
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1GG6
| CRYSTAL STRUCTURE OF GAMMA CHYMOTRYPSIN WITH N-ACETYL-PHENYLALANINE TRIFLUOROMETHYL KETONE BOUND AT THE ACTIVE SITE | Descriptor: | 1,1,1-TRIFLUORO-3-ACETAMIDO-4-PHENYL BUTAN-2-ONE(N-ACETYL-L-PHENYLALANYL TRIFLUOROMETHYL KETONE), 1,2-ETHANEDIOL, GAMMA CHYMOTRYPSIN, ... | Authors: | Neidhart, D, Wei, Y, Cassidy, C, Lin, J, Cleland, W.W, Frey, P.A. | Deposit date: | 2000-07-31 | Release date: | 2000-09-20 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Correlation of low-barrier hydrogen bonding and oxyanion binding in transition state analogue complexes of chymotrypsin. Biochemistry, 40, 2001
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1GGD
| CRYSTAL STRUCTURE OF GAMMA CHYMOTRYPSIN WITH N-ACETYL-LEUCIL-PHENYLALANINE ALDEHYDE BOUND AT THE ACTIVE SITE | Descriptor: | 2-ACETYLAMINO-4-METHYL-PENTANOIC ACID (1-FORMYL-2-PHENYL-ETHYL)-AMIDE, GAMMA CHYMOTRYPSIN, SULFATE ION | Authors: | Neidhart, D, Wei, Y, Cassidy, C, Lin, J, Cleland, W.W, Frey, P.A. | Deposit date: | 2000-08-14 | Release date: | 2000-09-20 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Correlation of low-barrier hydrogen bonding and oxyanion binding in transition state analogue complexes of chymotrypsin. Biochemistry, 40, 2000
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4TWE
| Structure of ligand-free N-acetylated-alpha-linked-acidic-dipeptidase like protein (NAALADaseL) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Tykvart, J, Barinka, C, Lubkowski, J, Sacha, P, Konvalinka, J. | Deposit date: | 2014-06-30 | Release date: | 2015-03-18 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structural and biochemical characterization of a novel aminopeptidase from human intestine. J.Biol.Chem., 290, 2015
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6Y6S
| Mouse Galactocerebrosidase complexed with galacto-noeurostegine GNS at pH 6.8 | Descriptor: | (1~{R},2~{S},3~{S},4~{R},5~{R})-4-(hydroxymethyl)-8-azabicyclo[3.2.1]octane-1,2,3-triol, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Deane, J.E, McLoughlin, J. | Deposit date: | 2020-02-27 | Release date: | 2021-01-13 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The Bicyclic Form of galacto -Noeurostegine Is a Potent Inhibitor of beta-Galactocerebrosidase. Acs Med.Chem.Lett., 12, 2021
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2XZ0
| The Structure of the 2:1 (Partially Occupied) Complex Between Stearoyl Acyl Carrier Protein Desaturase from Ricinus Communis (Castor Bean) and Acyl Carrier Protein. | Descriptor: | 1,2-ETHANEDIOL, ACYL CARRIER PROTEIN 1, CHLOROPLASTIC, ... | Authors: | Moche, M, Guy, J.E, Whittle, E, Lengqvist, J, Shanklin, J, Lindqvist, Y. | Deposit date: | 2010-11-22 | Release date: | 2011-09-07 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Remote Control of Regioselectivity in Acyl-Acyl Carrier Protein-Desaturases. Proc.Natl.Acad.Sci.USA, 108, 2011
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6Y6T
| Mouse Galactocerebrosidase complexed with galacto-noeurostegine GNS at pH 4.6 | Descriptor: | (1~{R},2~{S},3~{S},4~{R},5~{R})-4-(hydroxymethyl)-8-azabicyclo[3.2.1]octane-1,2,3-triol, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Deane, J.E, McLoughlin, J. | Deposit date: | 2020-02-27 | Release date: | 2021-01-13 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | The Bicyclic Form of galacto -Noeurostegine Is a Potent Inhibitor of beta-Galactocerebrosidase. Acs Med.Chem.Lett., 12, 2021
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2XZ1
| The Structure of the 2:2 (Fully Occupied) Complex Between Stearoyl Acyl Carrier Protein Desaturase from Ricinus Communis (Castor Bean) and Acyl Carrier Protein. | Descriptor: | (2R)-2,4-dihydroxy-3,3-dimethyl-N-{3-oxo-3-[(2-sulfanylethyl)amino]propyl}butanamide, ACYL CARRIER PROTEIN 1, CHLOROPLASTIC, ... | Authors: | Guy, J.E, Moche, M, Whittle, E, Lengqvist, J, Shanklin, J, Lindqvist, Y. | Deposit date: | 2010-11-22 | Release date: | 2011-09-07 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.35 Å) | Cite: | Remote Control of Regioselectivity in Acyl-Acyl Carrier Protein-Desaturases. Proc.Natl.Acad.Sci.USA, 108, 2011
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8D1U
| E. coli beta-ketoacyl-[acyl carrier protein] synthase III (FabH) with an acetylated cysteine and in complex with oxa(dethia)-Coenzyme A | Descriptor: | 3-oxoacyl-[acyl-carrier-protein] synthase 3, CHLORIDE ION, oxa(dethia)-CoA | Authors: | Benjamin, A.B, Stunkard, L.M, Ling, J, Nice, J.N, Lohman, J.R. | Deposit date: | 2022-05-27 | Release date: | 2022-06-15 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.302 Å) | Cite: | Structures of chloramphenicol acetyltransferase III and Escherichia coli beta-ketoacylsynthase III co-crystallized with partially hydrolysed acetyl-oxa(dethia)CoA. Acta Crystallogr.,Sect.F, 79, 2023
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8F6T
| Cryo-EM structure of alkane 1-monooxygenase AlkB-AlkG complex from Fontimonas thermophila | Descriptor: | Alkane 1-monooxygenase, DODECANE, FE (III) ION | Authors: | Chai, J, Guo, G, McSweeney, S, Shanklin, J, Liu, Q. | Deposit date: | 2022-11-17 | Release date: | 2023-04-05 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (2.76 Å) | Cite: | Structural basis for enzymatic terminal C-H bond functionalization of alkanes. Nat.Struct.Mol.Biol., 30, 2023
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8GHT
| Cryo-electron microscopy structure of the zinc transporter from Bordetella bronchiseptica | Descriptor: | CADMIUM ION, PHOSPHATIDYLETHANOLAMINE, Putative membrane protein | Authors: | Liu, Q, Chai, J, Pang, C.X, Shanklin, J. | Deposit date: | 2023-03-12 | Release date: | 2023-06-21 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.05 Å) | Cite: | Structural mechanism of intracellular autoregulation of zinc uptake in ZIP transporters. Nat Commun, 14, 2023
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