4ZJS

Crystal structure of a chimeric acetylcholine binding protein from Aplysia Californica (Ac-AChBP) containing the main immunogenic region (MIR) from the human alpha 1 subunit of the muscle nicotinic acetylcholine receptor in complex with anatoxin-A.

Summary for 4ZJS

• Entry DOI: 10.2210/pdb4zjs/pdb
• Descriptor: Acetylcholine receptor subunit alpha,Soluble acetylcholine receptor,Acetylcholine receptor subunit alpha,Soluble acetylcholine receptor, 1-[(1R,6R)-9-azabicyclo[4.2.1]non-2-en-2-yl]ethanone (3 entities in total)
• Functional Keywords: anatoxin-a, nicotinic, receptor, acetylcholine, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 5
• Total formula weight: 132041.90

Authors

Talley, T.T.,Bobango, J.,Wu, J.,Park, J.F.,Luo, J.,Lindsatrom, J.,Taylor, P. (deposition date: 2015-04-29, release date: 2015-05-13, Last modification date: 2023-09-27)

• Primary citation: Luo, J.,Taylor, P.,Losen, M.,de Baets, M.H.,Shelton, G.D.,Lindstrom, J.; Main immunogenic region structure promotes binding of conformation-dependent myasthenia gravis autoantibodies, nicotinic acetylcholine receptor conformation maturation, and agonist sensitivity.; J. Neurosci., 29:13898-13908, 2009; PubMed: 19890000; DOI: 10.1523/JNEUROSCI.2833-09.2009

Experimental method

X-RAY DIFFRACTION (2.2301 Å)