4ZJS

Crystal structure of a chimeric acetylcholine binding protein from Aplysia Californica (Ac-AChBP) containing the main immunogenic region (MIR) from the human alpha 1 subunit of the muscle nicotinic acetylcholine receptor in complex with anatoxin-A.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E	Acetylcholine receptor subunit alpha,Soluble acetylcholine receptor,Acetylcholine receptor subunit alpha,Soluble acetylcholine receptor	polymer	230	26309.2	5	UniProt (P02708) UniProt (Q8WSF8) Pfam (PF02931) In PDB	Homo sapiens (Human)
2	B, D, E	1-[(1R,6R)-9-azabicyclo[4.2.1]non-2-en-2-yl]ethanone	non-polymer		165.2	3	Chemie (4P0)
3		water	water		18.0	181	Chemie (HOH)

Sequence modifications

A, B, C, D, E: 1 - 30 (UniProt: P02708)

PDB	External Database	Details
Asp -8	-	expression tag
Tyr -7	-	expression tag
Lys -6	-	expression tag
Asp -5	-	expression tag
Asp -4	-	expression tag
Asp -3	-	expression tag
Asp -2	-	expression tag
Lys -1	-	expression tag
Leu 0	-	expression tag

A, B, C, D, E: 31 - 60 (UniProt: Q8WSF8)
A, B, C, D, E: 61 - 81 (UniProt: P02708)
A, B, C, D, E: 82 - 219 (UniProt: Q8WSF8)

PDB	External Database	Details
Ser 220	-	cloning artifact
Arg 221	-	cloning artifact

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	131546.2
Non-Polymers*	Number of molecules	3
	Total formula weight	495.7
All*	Total formula weight	132041.9

*Water molecules are not included.