4ZJS
Crystal structure of a chimeric acetylcholine binding protein from Aplysia Californica (Ac-AChBP) containing the main immunogenic region (MIR) from the human alpha 1 subunit of the muscle nicotinic acetylcholine receptor in complex with anatoxin-A.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E (A, B, C, D, E) | Acetylcholine receptor subunit alpha,Soluble acetylcholine receptor,Acetylcholine receptor subunit alpha,Soluble acetylcholine receptor | polymer | 230 | 26309.2 | 5 | UniProt (P02708) UniProt (Q8WSF8) Pfam (PF02931) | Homo sapiens (Human) | |
| 2 | F, G, H (B, D, E) | 1-[(1R,6R)-9-azabicyclo[4.2.1]non-2-en-2-yl]ethanone | non-polymer | 165.2 | 3 | Chemie (4P0) | |||
| 3 | I, J, K, L, M (A, B, C, D, E) | water | water | 18.0 | 181 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E: 1 - 30 (UniProt: P02708)
A, B, C, D, E: 31 - 60 (UniProt: Q8WSF8)
A, B, C, D, E: 61 - 81 (UniProt: P02708)
A, B, C, D, E: 82 - 219 (UniProt: Q8WSF8)
| PDB | External Database | Details |
|---|---|---|
| Asp -8 | - | expression tag |
| Tyr -7 | - | expression tag |
| Lys -6 | - | expression tag |
| Asp -5 | - | expression tag |
| Asp -4 | - | expression tag |
| Asp -3 | - | expression tag |
| Asp -2 | - | expression tag |
| Lys -1 | - | expression tag |
| Leu 0 | - | expression tag |
A, B, C, D, E: 61 - 81 (UniProt: P02708)
A, B, C, D, E: 82 - 219 (UniProt: Q8WSF8)
| PDB | External Database | Details |
|---|---|---|
| Ser 220 | - | cloning artifact |
| Arg 221 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 131546.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 495.7 | |
| All* | Total formula weight | 132041.9 |
