4WSY
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4WYL
| Mutant K18E of 3D polymerase from Foot-and-Moth Disease Virus | Descriptor: | ACETATE ION, GLYCEROL, MANGANESE (II) ION, ... | Authors: | Ferrer-Orta, C, Verdaguer, N, de la Higuera, I, Domingo, E. | Deposit date: | 2014-11-17 | Release date: | 2015-05-06 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Multifunctionality of a picornavirus polymerase domain: nuclear localization signal and nucleotide recognition. J.Virol., 89, 2015
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4WT6
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4X2B
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4WRS
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4WYW
| Mutant K20E of 3D polymerase from Foot-and-Mouth Disease Virus | Descriptor: | ACETATE ION, GLYCEROL, RNA-directed RNA polymerase 3D-POL, ... | Authors: | Ferrer-Orta, C, Verdaguer, N, de la Higuera, I, Domingo, E. | Deposit date: | 2014-11-18 | Release date: | 2015-05-06 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Multifunctionality of a picornavirus polymerase domain: nuclear localization signal and nucleotide recognition. J.Virol., 89, 2015
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8GCC
| T. cruzi topoisomerase II alpha bound to dsDNA and the covalent inhibitor CT1 | Descriptor: | 2-{3-[(Z)-iminomethyl]-1H-1,2,4-triazol-1-yl}-1-{(3M)-3-[2-(trifluoromethyl)phenyl]-6H-pyrrolo[3,4-b]pyridin-6-yl}ethan-1-one, DNA (28-MER), DNA topoisomerase 2 | Authors: | Schenk, A, Deniston, C, Noeske, J. | Deposit date: | 2023-03-01 | Release date: | 2023-07-12 | Method: | ELECTRON MICROSCOPY (2.94 Å) | Cite: | Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections. Science, 380, 2023
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4X5T
| alpha 1 glycine receptor transmembrane structure fused to the extracellular domain of GLIC | Descriptor: | ACETATE ION, CHLORIDE ION, NICKEL (II) ION, ... | Authors: | Sauguet, L, Corringer, P.J, Huon, C, Delarue, M. | Deposit date: | 2014-12-05 | Release date: | 2015-02-25 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Allosteric and hyperekplexic mutant phenotypes investigated on an alpha 1 glycine receptor transmembrane structure. Proc.Natl.Acad.Sci.USA, 112, 2015
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4WWD
| High-resolution structure of the Co-bound form of the Y135F mutant of C. metallidurans CnrXs | Descriptor: | CARBON DIOXIDE, CHLORIDE ION, COBALT (II) ION, ... | Authors: | Volbeda, A, Coves, J, Maillard, A.P, Kuennemann, S, Grosse, C, Schleuder, G, Petit-Haertlein, I, de Rosny, E, Nies, D.H. | Deposit date: | 2014-11-10 | Release date: | 2015-02-11 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Response of CnrX from Cupriavidus metallidurans CH34 to nickel binding. Metallomics, 7, 2015
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4WYJ
| Adenovirus 3 head domain mutant V239D | Descriptor: | Fiber protein, SULFATE ION | Authors: | Lieber, A, Zubieta, C, Fender, P. | Deposit date: | 2014-11-17 | Release date: | 2015-07-01 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Preclinical safety and efficacy studies with an affinity-enhanced epithelial junction opener and PEGylated liposomal doxorubicin. Mol Ther Methods Clin Dev, 2, 2015
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4WZM
| Mutant K18E of RNA dependent RNA polymerase from Foot-and-Mouth Disease Virus complexed with RNA | Descriptor: | ACETATE ION, GLYCEROL, MANGANESE (II) ION, ... | Authors: | Verdaguer, N, Ferrer-Orta, C, de la Higuera, N. | Deposit date: | 2014-11-20 | Release date: | 2015-05-06 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.52 Å) | Cite: | Multifunctionality of a picornavirus polymerase domain: nuclear localization signal and nucleotide recognition. J.Virol., 89, 2015
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4X5X
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4WWB
| High-resolution structure of the Ni-bound form of the Y135F mutant of C. metallidurans CnrXs | Descriptor: | CARBON DIOXIDE, CHLORIDE ION, FORMIC ACID, ... | Authors: | Volbeda, A, Coves, J, Maillard, A.P, Kuennemann, S, Grosse, C, Schleuder, G, Petit-Haertlein, I, de Rosny, E, Nies, D.H. | Deposit date: | 2014-11-10 | Release date: | 2015-02-11 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.11 Å) | Cite: | Response of CnrX from Cupriavidus metallidurans CH34 to nickel binding. Metallomics, 7, 2015
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4WZQ
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4X5W
| HLA-DR1 with CLIP102-120(M107W) | Descriptor: | HLA class II histocompatibility antigen gamma chain, HLA class II histocompatibility antigen, DR alpha chain, ... | Authors: | Guenther, S, Freund, C. | Deposit date: | 2014-12-06 | Release date: | 2016-03-09 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.34 Å) | Cite: | MHC class II complexes sample intermediate states along the peptide exchange pathway. Nat Commun, 7, 2016
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4Y2A
| Crystal Structure of Coxsackie Virus B3 3D polymerase in complex with GPC-N114 inhibitor | Descriptor: | 2,2'-[(4-chlorobenzene-1,2-diyl)bis(oxy)]bis(5-nitrobenzonitrile), 3D polymerase, GLYCEROL, ... | Authors: | Vives-Adrian, L, Ferrer-Orta, C, Verdaguer, N. | Deposit date: | 2015-02-09 | Release date: | 2015-04-01 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family. Plos Pathog., 11, 2015
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4X9Z
| Dimeric conotoxin alphaD-GeXXA | Descriptor: | alphaD-conotoxin GeXXA from the venom of Conus generalis | Authors: | Xu, S, Zhang, T, Kompella, S, Adams, D, Ding, J, Wang, C. | Deposit date: | 2014-12-12 | Release date: | 2015-12-02 | Last modified: | 2020-02-05 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Conotoxin alpha D-GeXXA utilizes a novel strategy to antagonize nicotinic acetylcholine receptors Sci Rep, 5, 2015
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1AFE
| HUMAN ALPHA-THROMBIN INHIBITION BY CBZ-PRO-AZALYS-ONP | Descriptor: | 2-[N'-(4-AMINO-BUTYL)-HYDRAZINOCARBONYL]-PYRROLIDINE-1-CARBOXYLIC ACID BENZYL ESTER, 2-acetamido-2-deoxy-beta-D-glucopyranose, ALPHA-THROMBIN (LARGE SUBUNIT), ... | Authors: | De Simone, G, Balliano, G, Milla, P, Gallina, C, Giordano, C, Tarricone, C, Rizzi, M, Bolognesi, M, Ascenzi, P. | Deposit date: | 1997-03-06 | Release date: | 1997-12-03 | Last modified: | 2023-08-02 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Human alpha-thrombin inhibition by the highly selective compounds N-ethoxycarbonyl-D-Phe-Pro-alpha-azaLys p-nitrophenyl ester and N-carbobenzoxy-Pro-alpha-azaLys p-nitrophenyl ester: a kinetic, thermodynamic and X-ray crystallographic study. J.Mol.Biol., 269, 1997
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1AE8
| HUMAN ALPHA-THROMBIN INHIBITION BY EOC-D-PHE-PRO-AZALYS-ONP | Descriptor: | 1-ETHOXYCARBONYL-D-PHE-PRO-2(4-AMINOBUTYL)HYDRAZINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ALPHA-THROMBIN (LARGE SUBUNIT), ... | Authors: | De Simone, G, Balliano, G, Milla, P, Gallina, C, Giordano, C, Tarricone, C, Rizzi, M, Bolognesi, M, Ascenzi, P. | Deposit date: | 1997-03-06 | Release date: | 1997-12-03 | Last modified: | 2023-08-02 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Human alpha-thrombin inhibition by the highly selective compounds N-ethoxycarbonyl-D-Phe-Pro-alpha-azaLys p-nitrophenyl ester and N-carbobenzoxy-Pro-alpha-azaLys p-nitrophenyl ester: a kinetic, thermodynamic and X-ray crystallographic study. J.Mol.Biol., 269, 1997
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1BHR
| 2'-DEOXY-ISOGUANOSINE BASE PAIRED TO THYMIDINE, NMR, MINIMIZED AVERAGE STRUCTURE | Descriptor: | DNA (5'-D(*CP*GP*CP*IGUP*AP*AP*TP*TP*TP*GP*CP*G)-3') | Authors: | Robinson, H, Gao, Y.-G, Bauer, C, Roberts, C, Switzer, C, Wang, A.H.-J. | Deposit date: | 1998-06-10 | Release date: | 1998-11-04 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | 2'-Deoxyisoguanosine adopts more than one tautomer to form base pairs with thymidine observed by high-resolution crystal structure analysis. Biochemistry, 37, 1998
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4RQF
| human Seryl-tRNA synthetase dimer complexed with one molecule of tRNAsec | Descriptor: | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, SERINE, Serine--tRNA ligase, ... | Authors: | Xie, W, Wang, C, Guo, Y, Tian, Q, Jia, Q. | Deposit date: | 2014-11-03 | Release date: | 2015-11-04 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.503 Å) | Cite: | SerRS-tRNASec complex structures reveal mechanism of the first step in selenocysteine biosynthesis. Nucleic Acids Res., 43, 2015
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8G59
| Cryo-EM structure of the TUG891 bound GPR120-Giq complex | Descriptor: | 3-{4-[(4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]phenyl}propanoic acid, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Mao, C, Xiao, P, Tao, X, Qin, J, He, Q, Zhang, C, Yu, X, Zhang, Y, Sun, J. | Deposit date: | 2023-02-12 | Release date: | 2023-03-08 | Last modified: | 2023-04-19 | Method: | ELECTRON MICROSCOPY (2.64 Å) | Cite: | Unsaturated bond recognition leads to biased signal in a fatty acid receptor. Science, 380, 2023
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4RWS
| Crystal structure of CXCR4 and viral chemokine antagonist vMIP-II complex (PSI Community Target) | Descriptor: | C-X-C chemokine receptor type 4/Endolysin chimeric protein, Viral macrophage inflammatory protein 2 | Authors: | Qin, L, Kufareva, I, Holden, L, Wang, C, Zheng, Y, Wu, H, Fenalti, G, Han, G.W, Cherezov, V, Abagyan, R, Stevens, R.C, Handel, T.M, GPCR Network (GPCR) | Deposit date: | 2014-12-05 | Release date: | 2015-02-11 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural biology. Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine. Science, 347, 2015
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4RLV
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4RLY
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