5CU6

Crystal Structure of CK2alpha

Summary for 5CU6

Entry DOI	10.2210/pdb5cu6/pdb
Descriptor	Casein kinase II subunit alpha, ADENOSINE-5'-TRIPHOSPHATE, ACETATE ION, ... (4 entities in total)
Functional Keywords	ck2alpha, ck2a, fragment based drug discovery, high concentration screening, selective atp competitive inhibitors, surface entrophy reduction, transferase
Biological source	Homo sapiens (Human)
Cellular location	Nucleus : P68400
Total number of polymer chains	1
Total formula weight	39656.66
Authors	Brear, P.,De Fusco, C.,Georgiou, K.H.,Spring, D.,Hyvonen, M. (deposition date: 2015-07-24, release date: 2016-07-27, Last modification date: 2024-01-10)
Primary citation	Brear, P.,De Fusco, C.,Hadje Georgiou, K.,Francis-Newton, N.J.,Stubbs, C.J.,Sore, H.F.,Venkitaraman, A.R.,Abell, C.,Spring, D.R.,Hyvonen, M. Specific inhibition of CK2 alpha from an anchor outside the active site. Chem Sci, 7:6839-6845, 2016 Cited by PubMed: 28451126 DOI: 10.1039/c6sc02335e PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.36 Å)

Structure validation